Trehalose Protects against Insuli...y in Skeletal Muscles and Kidney Ingenta Connect Fast Track Article
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Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways. - PubMed - NCBI
Dysfunction of autophagy, which regulates cellular homeostasis by degrading organelles and proteins, is associated with pathogenesis of various diseases such as cancer, neurodegeneration and metabolic disease. Trehalose, a naturally occurring nontoxic disaccharide found in plants, insects, microorga …
Trehalose protects against oxidative stress by regulating the Keap1–Nr (...)
Dysfunction of autophagy, which regulates cellular homeostasis by degrading organelles and proteins, is associated with pathogenesis of various diseas…
Trehalose protects against spinal cord injury through regulating heat shock proteins 27 and 70... - Abstract - Europe PMC
Europe PMC is an archive of life sciences journal literature.
Trehalose protects the endothelium from cadmium induced dysfunction - PubMed
The objective of the present study is to identify the possible regulatory role of trehalose (Tre) against cadmium chloride (CdCl2 )-induced endothelial cell dysfunction. To screen the dose-dependent effect of both Tre and CdCl2 , a methylthiazolyldiphenyl-tetrazolium bromide (M …
Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency Autophagy Vol 0, No ja
(2018). Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency. Autophagy: Vol. 14, No. 8, pp. 1419-1434.
Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency. - PubMed - NCBI
ANOVA: analysis of variance; Atg7: autophagy related 7; AV: autophagic vacuoles; CD68: cd68 antigen; ERG: electroretinogram; ERT: enzyme replacement therapy; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFAP: glial fibrillary acidic protein; GNAT2: guanine nucleotide binding protein, alpha trans …
Trehalose rescues glial cell dysfunction in striatal cultures from HD (...)
The pathological hallmark of Huntington disease (HD) is the intracellular aggregation of mutant huntingtin (mHTT) in striatal neurons and glia associa…
Trehalose restores functional autophagy suppressed by high glucose - ScienceDirect
Autophagy is required for neurulation, and autophagy activators with minimal toxicity, such as the natural compound trehalose, a nonreducing disacchar…
Trehalose restores functional autophagy suppressed by high glucose. - PubMed - NCBI
Autophagy is required for neurulation, and autophagy activators with minimal toxicity, such as the natural compound trehalose, a nonreducing disaccharide, possess high therapeutic value. To determine whether trehalose directly induces autophagy, FITC-labeled trehalose was used for tracing its presen …
Trehalose significantly enhances the recovery of serum and serum exosomal miRNA from a paper-based matrix. - PubMed - NCBI
The preservation of nucleic acids from clinical samples is critical to facilitate accurate molecular diagnosis. The use of a paper matrix, Flinders Technology Associates (FTA) Elute cards, to archive DNA and viral RNA is well-documented. However, the feasibility of FTA Elute cards for archiving seru …
Trehalose sugar may help prevent fatty liver disease - Medical News To (...)
Nonalcoholic fatty liver disease is linked to high fructose consumption. But trehalose, a different kind of sugar, may block the entry of sugar into liver cells, reducing the risk.
Trehalose suppresses cadmium-activated Nrf2 signaling pathway to protect against spleen injury - ScienceDirect
Cadmium (Cd), as a kind of ubiquitous and highly toxic heavy metal pollutants, has been known to result in immunotoxicity in animals. As a multifuncti…
Trehalose targets Nrf2 signal to alleviate d-galactose induced aging and improve behavioral ability - ScienceDirect
As an important factor leading to aging and chronic diseases, oxidative stress has become a hot research topic. Trehalose is a natural sugar widely fo…
Trehalose treatment accelerates the healing of UVB-irradiated corneas. Comparative immunohistochemical studies on corneal cryostat sections and cor... - PubMed - NCBI
The UVB-irradiated cornea is damaged by oxidative stress. Toxic oxygen products induced by UVB radiation in the cornea are insufficiently removed by antioxidants, whose numbers decrease with increasing UVB irradiation. In addition, the UVB-irradiated cornea suffers from hypoxic conditions because da …
Trehalose upregulates progranulin expression in human and mouse models (...)
Progranulin (PGRN) is a secreted growth factor important for neuronal survival and may do so, in part, by regulating lysosome homeostasis. Mutations in the PGRN gene (GRN) are a common cause of frontotemporal lobar degeneration (FTLD) and lead to disease ...
Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency a novel therapeutic lead to treat frontotemporal ... - PubMed - NCBI
This work reports several novel autophagy-lysosome modulators that enhance PGRN expression and identifies trehalose as a promising therapeutic for raising PGRN levels to treat multiple neurodegenerative diseases.
Trehalose – a natural sugar that could possibly be consumed for health (...)
By Vince Giuliano and James P Watson. Trehalose is a natural disaccharide sugar contained in mushrooms and many other organisms. It has remarkable health-producing and life-extending properties that work in mice and lower organisms. That is why we choose to … Continue reading →
Trehalose – Current Applications in Ophthalmology And Future Perspecti (...)
Trehalose, an mTOR-Independent Inducer of Autophagy, Inhibits Human Cy (...)
HCMV infects multiple cell types in vivo, establishes lifelong persistence in the host, and can cause serious health problems for fetuses and immunocompromised individuals. HCMV, like all other persistent pathogens, has to finely tune its interplay with the host cellular machinery to replicate effic …
Trehalose, sucrose and raffinose are novel activators of autophagy in (...)
Trehalose is a natural disaccharide that is found in a diverse range of organisms but not in mammals. Autophagy is a process which mediates the sequestration, lysosomal delivery and degradation of proteins and organelles. Studies have shown that trehalose exerts beneficial effects through inducing autophagy in mammalian cells. However, whether trehalose or other saccharides can activate autophagy in keratinocytes is unknown. Here, we found that trehalose treatment increased the LC3-I to LC3-II conversion, acridine orange-stained vacuoles and GFP-LC3B (LC3B protein tagged with green fluorescent protein) puncta in the HaCaT human keratinocyte cell line, indicating autophagy induction. Trehalose-induced autophagy was also observed in primary keratinocytes and the A431 epidermal cancer cell line. mTOR signalling was not affected by trehalose treatment, suggesting that trehalose induced autophagy through an mTOR-independent pathway. mTOR-independent autophagy induction was also observed in HaCaT and HeLa cells treated with sucrose or raffinose but not in glucose, maltose or sorbitol treated HaCaT cells, indicating that autophagy induction was not a general property of saccharides. Finally, although trehalose treatment had an inhibitory effect on cell proliferation, it had a cytoprotective effect on cells exposed to UVB radiation. Our study provides new insight into the saccharide-mediated regulation of autophagy in keratinocytes.
Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway. - PubMed - NCBI
Trehalose is a natural disaccharide that is found in a diverse range of organisms but not in mammals. Autophagy is a process which mediates the sequestration, lysosomal delivery and degradation of proteins and organelles. Studies have shown that trehalose exerts beneficial effects through inducing a …
Trehalose-8-hydroxyquinoline conjugates as antioxidant modulators of A (...)
Trehalose has been proven to provide protection to different proteins to various extents, inhibiting at elevated concentrations the aggregation of proteins involved in neurodegenerative disorders such Alzheimer's, Parkinson's and Huntington's diseases. Moreover, 8-hydroxyquinolines have also been found to protect a
Trehalose-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction
Trehalose (TRE) is a natural, nonreducing disaccharide synthesized by lower organisms. TRE exhibits an extraordinary ability to protect cells against …
Trehalose-Induced Structural Transition Accelerates Aggregation of a-S (...)
Fibrillation of α-synuclein proceeds through distinct stages, with oligomers combining to form the seed or the nucleus, followed by exponential and saturation phases. Osmolytes are considered to act as protein stabilizers by virtue of their ability to inhibit protein aggregation. Trehalose, a non-re …
Trehalose-Induced Structural Transition Accelerates Aggregation of a-Synuclein. - PubMed - NCBI
Fibrillation of α-synuclein proceeds through distinct stages, with oligomers combining to form the seed or the nucleus, followed by exponential and saturation phases. Osmolytes are considered to act as protein stabilizers by virtue of their ability to inhibit protein aggregation. Trehalose, a non-re …
Trehalose-mediated autophagy impairs the anti-viral function of human (...)
Human rhinovirus (HRV) is the most common cause of acute exacerbations of chronic lung diseases including asthma. Impaired anti-viral IFN-λ1 production and increased HRV replication in human asthmatic airway epithelial cells may be one of the underlying mechanisms leading to asthma exacerbations. In …
trehalose[Title] human[Title] - PubMed - NCBI
Variable Effects of Autophagy Induction by Trehalose on Herpesviruses (...)
Trehalose is a non-reducing sugar formed from two glucose units. Trehalose induces abundant autophagy in cultured cells and also reduces the rate of aggregation of the huntingtin protein in the animal model of Huntington disease, a chronic neurological disease in humans. The mechanism of this effect …
Development of pH sensitive alginategum tragacanth based hydrogels for oral insulin delivery - Journal of Agricultural and Food Chemistry (ACS Publications)
Insulin entrapped alginate-gum tragacanth (ALG-GT) hydrogels at different ALG replacement ratios (100, 75, 50, 25) were prepared through an ionotropic gelation method, followed by chitosan (CH) polyelectrolyte complexation. A mild gelation process without the use of harsh chemicals was proposed to improve insulin efficiency. Retention of almost the full amount of entrapped insulin in a simulated gastric environment and sustained insulin release in simulated intestinal buffer indicated the pH sensitivity of the gels. Insulin release from hydrogels with different formulations showed significant differences (p < 0.05). Time domain (TD) NMR relaxometry experiments also showed the differences for different formulations, and the presence of CH revealed that ALG-GT gel formulation could be used as an oral insulin carrier at optimum concentrations. The hydrogels formulated from biodegradable, biocompatible, and nontoxic natural polymers were seen as promising devices for potential oral insulin delivery.