End Times Chaos, Artificial Intelligence and Actor Chris Pratt's 'God' Proclamation - YouTube
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Stop Crippling Your Immune System (Biggest Mistakes People Make) - YouTube
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The Root Cause of Brain Fog, Weight Gain & Sleep Problems - YouTube
Many people believe their genes determine their health and that if something runs in the family, it’s inevitable.In this video, I explain why that belief is ...
Parents, doctors, and CHD sue AAP in one of the most important lawsuits in medical history
This lawsuit, drafted by California attorney Rick Jaffe, is without exaggeration, one of the most important lawsuits ever filed in modern medical history. I explain why in this must read article.
We Dug Deeper into Jared Kushner and Found Something Terrifying (Board of Peace Has Formed) - YouTube
Is Trump's new Board of Peace leading into Bible Prophecy? This video will show how Jared Kushner has been making VERY interesting moves behind the scenes. U...
Jonathan Cahn Prophetic Word & Warning For 2026! - YouTube
Jonathan Cahn issues his first word for 2026. A revelation of the critical prophetic moment we are in right now. A prophetic warning for the year ahead. A...
The Antichrist Timeline - Where Does Scripture Actually Place Him? - YouTube
Where does scripture place the Antichrist in the biblical timeline? When does he appear? At the beginning, middle, or end of the Tribulation period. Surprisi...
Level Up Your Joomla! Extensions with the AI Framework - The Joomla Community Magazine
Adding AI to your Joomla! extensions no longer need to be complicated or tied to one provider. With the new Joomla! AI Framework, you can write your code once and let your users choose between OpenAI, Anthropic, or even local models with Ollama — all through the same interface. In this article, I’ll show you what the framework does, why it matters,...
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Glucosamine-triggered sustainable redox process for efficient degradation of tetracycline antibiotics - ScienceDirect
Tetracycline antibiotics (TCs) are persistent pollutants that disrupt ecosystems, threaten public health, and exacerbate antimicrobial resistance in l…
Jared Kushner Announces Major Israel Peace Move.. (Are the Kings Forming?) - YouTube
It will be very interesting watching the middle east developments this year! Everything seems to be moving into place just as Jared Kushner envisioned.Months...
There are about 148 verses that appear to apply to the Psalm 83 prophecy. This is almost three times more than Ezekiel 38 and 39. These verses include prophe...
Network Pharmacology as a Tool to Explore the Therapeutic Mechanism of Opuntia Ficus-Indica (Nopal) in Type 2 Diabetes and Colorectal Cancer | Bentham Science Publishers
Introduction
Considering the shared physiological mechanisms between type 2 diabetes (T2D) and colorectal cancer (CRC), it is plausible that certain compounds may exert therapeutic effects on both diseases. Opuntia ficus-indica (nopal) has been traditionally used to manage these conditions. This study aims to elucidate the molecular mechanisms through which nopal exerts its effects on T2D and CRC.
Methods
Bioactive compounds of nopal, their molecular targets, and genes associated with T2D and CRC were identified from public databases. Gene Ontology (GO) analysis, metabolic pathway analysis, protein-protein interaction (PPI) network construction, and molecular docking were conducted to investigate the shared molecular targets.
Results
Nopal contains bioactive compounds that interact with molecular targets common to both T2D and CRC. These shared targets are implicated in lipid metabolism, apoptosis, kinase activity, interleukin-related pathways (IL-2 and IL-3), inflammation, gastrin signaling, and other critical processes. Key molecular targets identified include HSP90AA1 and MAPK8, while the principal bioactive compounds of nopal are eriodictyol and aromadendrin.
Discussion
The identification of eriodictyol and aromadendrin as modulators of HSP90AA1 and MAPK8 elucidates a pleiotropic mechanism underlying the link between type 2 diabetes and colorectal cancer. By modulating apoptotic and inflammatory pathways, these bioactive compounds offer a promising foundation for developing dual-action therapies targeting both metabolic and oncogenic pathways in patients with comorbid conditions.
Conclusion
The bioactive compounds of nopal engage multiple biological pathways relevant to T2D and CRC, suggesting that this plant may serve as a promising pharmacological candidate for the management of these diseases.
Extraction, purification, structure characteristics and biological activities of polysaccharides from Saccharina japonica (Laminaria japonica): A review - ScienceDirect
Saccharina japonica (formerly known as Laminaria japonica) is a valuable marine resource with a triple significance: it serves not only as a food sour…
Why can't anyone show us the study showing vaccines save lives?
Where is the study in the US using record-level data showing that kids who are fully vaccinated die less? According to AI, no such study exists. Vaccine mandates are all based on belief, not science.
A summary of the evidence against the COVID vaccines
Here's a quick summary of the key pieces of evidence that taken together show that the COVID vaccines are unsafe and that the medical community should not be trusted.