2016

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Level Up Your Joomla! Extensions with the AI Framework - The Joomla Community Magazine
Level Up Your Joomla! Extensions with the AI Framework - The Joomla Community Magazine
Adding AI to your Joomla! extensions no longer need to be complicated or tied to one provider. With the new Joomla! AI Framework, you can write your code once and let your users choose between OpenAI, Anthropic, or even local models with Ollama — all through the same interface. In this article, I’ll show you what the framework does, why it matters,...
·magazine.joomla.org·
Level Up Your Joomla! Extensions with the AI Framework - The Joomla Community Magazine
Doctronic, Your Trusted AI Doctor
Doctronic, Your Trusted AI Doctor
Doctronic is the world's most popular AI doctor. 100% Private. Get free, personalized, and immediate access to comprehensible health information with real-time issue exploration, symptom checkers, and action plans. We promote educated interactions between patients and healthcare providers, making healthcare more accessible and efficient. Experience the future of healthcare.
·doctronic.ai·
Doctronic, Your Trusted AI Doctor
Network Pharmacology as a Tool to Explore the Therapeutic Mechanism of Opuntia Ficus-Indica (Nopal) in Type 2 Diabetes and Colorectal Cancer | Bentham Science Publishers
Network Pharmacology as a Tool to Explore the Therapeutic Mechanism of Opuntia Ficus-Indica (Nopal) in Type 2 Diabetes and Colorectal Cancer | Bentham Science Publishers
Introduction Considering the shared physiological mechanisms between type 2 diabetes (T2D) and colorectal cancer (CRC), it is plausible that certain compounds may exert therapeutic effects on both diseases. Opuntia ficus-indica (nopal) has been traditionally used to manage these conditions. This study aims to elucidate the molecular mechanisms through which nopal exerts its effects on T2D and CRC. Methods Bioactive compounds of nopal, their molecular targets, and genes associated with T2D and CRC were identified from public databases. Gene Ontology (GO) analysis, metabolic pathway analysis, protein-protein interaction (PPI) network construction, and molecular docking were conducted to investigate the shared molecular targets. Results Nopal contains bioactive compounds that interact with molecular targets common to both T2D and CRC. These shared targets are implicated in lipid metabolism, apoptosis, kinase activity, interleukin-related pathways (IL-2 and IL-3), inflammation, gastrin signaling, and other critical processes. Key molecular targets identified include HSP90AA1 and MAPK8, while the principal bioactive compounds of nopal are eriodictyol and aromadendrin. Discussion The identification of eriodictyol and aromadendrin as modulators of HSP90AA1 and MAPK8 elucidates a pleiotropic mechanism underlying the link between type 2 diabetes and colorectal cancer. By modulating apoptotic and inflammatory pathways, these bioactive compounds offer a promising foundation for developing dual-action therapies targeting both metabolic and oncogenic pathways in patients with comorbid conditions. Conclusion The bioactive compounds of nopal engage multiple biological pathways relevant to T2D and CRC, suggesting that this plant may serve as a promising pharmacological candidate for the management of these diseases.
·benthamdirect.com·
Network Pharmacology as a Tool to Explore the Therapeutic Mechanism of Opuntia Ficus-Indica (Nopal) in Type 2 Diabetes and Colorectal Cancer | Bentham Science Publishers
Extraction, purification, structure characteristics and biological activities of polysaccharides from Saccharina japonica (Laminaria japonica): A review - ScienceDirect
Extraction, purification, structure characteristics and biological activities of polysaccharides from Saccharina japonica (Laminaria japonica): A review - ScienceDirect
Saccharina japonica (formerly known as Laminaria japonica) is a valuable marine resource with a triple significance: it serves not only as a food sour…
·sciencedirect.com·
Extraction, purification, structure characteristics and biological activities of polysaccharides from Saccharina japonica (Laminaria japonica): A review - ScienceDirect
A summary of the evidence against the COVID vaccines
A summary of the evidence against the COVID vaccines
Here's a quick summary of the key pieces of evidence that taken together show that the COVID vaccines are unsafe and that the medical community should not be trusted.
·kirschsubstack.com·
A summary of the evidence against the COVID vaccines
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Cursor is the best way to code with AI.
·cursor.com·
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