Fucoidan ameliorates rotenone-induced Parkinsonism in mice by regulating the microbiota-gut-brain axis - ScienceDirect
Microbiota-gut-brain axis, the bidirectional relationship between the gut microbiota and the brain, has been increasingly appreciated in the pathogene…
Melatonin – A Potential Therapeutic for Alzheimer’s Disease - David Perlmutter M.D.
Alzheimer’s disease (AD), now affecting close to 7 million Americans, has been a central focus of my interest for the past four decades. As one of the leading causes of …
A new study adds to the growing body of evidence suggesting that sildenafil (Viagra), commonly used for treating erectile dysfunction (ED), may also offer protection against Alzheimer’s disease (AD). A …
Can Creatine Boost Brain Energy? #creatine #neuroscience - YouTube
Get my Free Guide: 11 Science-Backed Steps to Help Boost Memory and Prevent Dementia: https://www.austinperlmutter.com/memoryguideCreatine aids brain energy ...
Reversing Alzheimer's: New Research Improves Cognition & Protects Brain Health | Dr.Heather Sandison - YouTube
🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Alzheimer’s dis...
Parkinson's TOTALLY Arrested: New Research Transforms our Approach to this Devastating Condition - YouTube
🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Currently, ther...
Internet Usage May Reduce Dementia Risk - David Perlmutter M.D.
In our book, Brain Wash, Dr. Austin Perlmutter and I warned about the potential risk of extensive Internet usage, especially as it relates to adolescents using excessively involved in social …
Acetylcholine: Function, Benefits, Dosage and Side Effects - Dr. Axe
If you're familiar with nootropics supplements, you may have come across the compound called acetylcholine. So what is it and what does it do? Find out.
In this podcast episode, Dr. Ardis discusses strategies for preventing and treating Parkinson's disease. He highlights supplements like taurine, selenium, and a foreign protein cleanse as potential ai
Kat Toups, M.D. Functional Medicine Psychiatry Lafayette, CA Home
Bay Area Wellness - Functional Medicine Psychiatry focuses on discovering and removing the underlying sources of inflammation in the body that affect the brain, causing Psychiatric Illness and Cognitive Problems, and helps support the immune system to get it back in balance.
The biggest myth about Alzheimer's and dementia is that they’re untreatable. If you or someone you care about is suffering from memory loss, dementia,…
Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging. The pathological hallmark of PD is neuronal inclusions termed Lewy bodies whose main component is alpha-synuclein protein. The finding of these Lewy bodies in the intestinal enteric nerves led to the hypothesis that the intestine might be an early site of PD disease in response to an environmental toxin or pathogen. One potential mechanism for environmental toxin(s) and proinflammatory luminal products to gain access to mucosal neuronal tissue and promote oxidative stress is compromised intestinal barrier integrity. However, the role of intestinal permeability in PD has never been tested. We hypothesized that PD subjects might exhibit increased intestinal permeability to proinflammatory bacterial products in the intestine. To test our hypothesis we evaluated intestinal permeability in subjects newly diagnosed with PD and compared their values to healthy subjects. In addition, we obtained intestinal biopsies from both groups and used immunohistochemistry to assess bacterial translocation, nitrotyrosine (oxidative stress), and alpha-synuclein. We also evaluated serum markers of endotoxin exposure including LPS binding protein (LBP). Our data show that our PD subjects exhibit significantly greater intestinal permeability (gut leakiness) than controls. In addition, this intestinal hyperpermeability significantly correlated with increased intestinal mucosa staining for E. coli bacteria, nitrotyrosine, and alpha-synuclein as well as serum LBP levels in PD subjects. These data represent not only the first demonstration of abnormal intestinal permeability in PD subjects but also the first correlation of increased intestinal permeability in PD with intestinal alpha–synuclein (the hallmark of PD), as well as staining for gram negative bacteria and tissue oxidative stress. Our study may thus shed new light on PD pathogenesis as well as provide a new method for earlier diagnosis of PD and suggests potential therapeutic targets in PD subjects. Trial Registration Clinicaltrials.gov NCT01155492
