Aloe polysaccharide promotes osteogenesis potential of adipose-derived stromal cells via BMP-2/Smads and prevents ovariectomized-induced osteoporosis - PubMed
Aloe
Oral treatment with Aloe polysaccharide ameliorates ovalbumin-induced atopic dermatitis by restoring tight junctions in skin - PubMed
The Role of Processed Aloe vera Gel in Intestinal Tight Junction: An In Vivo and In Vitro Study - PubMed
Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications
Aloe Vera (Aloe barbadensis Miller), a historically revered medicinal plant, has garnered great scientific attention due to its polysaccharide-rich bioactive compounds with significant therapeutic potential. This review examines the role of Aloe Vera polysaccharides as therapeutic agents in biomedical applications, highlighting their benefits as well as the risks. Traditionally recognized for its anti-inflammatory and antimicrobial effects, which are very important in wound healing, the Aloe Vera relies on its polysaccharides, which confer immunomodulatory, antioxidant, and tissue-regenerative properties. These compounds have shown promise in various applications, including skin repair, tissue engineering scaffolds, and antiviral therapies, with their delivery being facilitated via gels, thin films, or oral formulations. This review explores also their mechanisms of action and applications in modern medicine, including in the development of topical gels, dietary supplements, and innovative delivery systems such as thin films and scaffolds. Despite the promising benefits, the review addresses the possible side effects too, including allergic reactions, gastrointestinal disorders, and drug interactions, emphasizing the importance of understanding these risks for their safe clinical use. Assessing both the advantages and challenges of Aloe Vera polysaccharide medical use, this review contributes to the ongoing dialog regarding the integration of natural products into therapeutic practices, ultimately supporting informed decisions regarding their clinical application.
Anti-inflammatory potential of aloe vera meatballs and their impact on rheumatoid arthritis - ScienceDirect
Rheumatoid Arthritis is an auto-immune condition resulting in the formation of autoantibodies that cause joint and systemic inflammation. Different si…
The Healing Power of Aloe Vera: Exploring Its Nutrient-Rich Composition, Therapeutic Uses, And Evidence-Based Health Benefits in Modern and Traditional Medicine
Background: Aloe vera, often dubbed the "plant of immortality," has been cherished for its healing properties throughout history.
The Role of Aloe vera L. Extract in Modulating Oxidative Stress and Inflammation in Wistar Rats on a High-Fat Diet: Insights from In Vivo and In Silico Studies
In Vitro Wound-Healing Potential of Phenolic and Polysaccharide Extracts of Aloe vera Gel
The present study aimed to conduct a comparative investigation of the biological properties of phenolic and polysaccharide extracts obtained using an ultrasound-assisted technique from Aloe vera gel and their effects on each stage of the wound healing process in in vitro experimental models. HPLC analysis showed that the phenolic extract contained aloin, ferulic, and caffeic acid, as well as quercetin dihydrate, as major compounds. Capillary zone electrophoresis indicated the prevalence of mannose and glucose in the polysaccharide extract. Cell culture testing revealed the anti-inflammatory properties of the phenolic extract at a concentration of 0.25 mg/mL through significant inhibition of pro-inflammatory cytokines—up to 28% TNF-α and 11% IL-8 secretion—in inflamed THP-1-derived macrophages, while a pro-inflammatory effect was observed at 0.5 mg/mL. The phenolic extract induced 18% stimulation of L929 fibroblast proliferation at a concentration of 0.5 mg/mL, enhanced the cell migration rate by 20%, and increased collagen type I synthesis by 18%. Moreover, the phenolic extract exhibited superior antioxidant properties by scavenging free DPPH (IC50 of 2.50 mg/mL) and ABTS (16.47 mM TE/g) radicals, and 46% inhibition of intracellular reactive oxygen species (ROS) production was achieved. The polysaccharide extract demonstrated a greater increase in collagen synthesis up to 25%, as well as antibacterial activity against Staphylococcus aureus with a bacteriostatic effect at 25 mg/mL and a bactericidal one at 50 mg/mL. All these findings indicate that the phenolic extract might be more beneficial in formulations intended for the initial phases of wound healing, such as inflammation and proliferation, while the polysaccharide extract could be more suitable for use during the remodeling stage. Moreover, they might be combined with other biomaterials, acting as efficient dressings with anti-inflammatory, antioxidant, and antibacterial properties for rapid recovery of chronic wounds.
1 Pharmacological and Therapeutic Activities of Aloe vera and Its Major Active Constituent Acemannan
Kim SH, et al. Food Suppl Biomater Health. 2023 Jun;3(2):e8. https://doi.org/10.52361/fsbh.2023.3.e8
Aloe Vera – Nature’s Power
Aloe vera Ancient knowledge with new frontiers - ScienceDirect
There are many plants with interesting pharmaceutical activities but Aloe vera is probably the most applied medicinal plant worldwide. Since biblical …
Evaluation of the anticancer effects of Aloe vera and aloe emodin on B16F10 murine melanoma and NIH3T3 mouse embryogenic fibroblast cells
Spectrophotometric assessment of effect of aqueous extract of Aloe vera on rabbit erythrocytes in varying concentrations of saline
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Efficacy of Aloe Vera versus Chlorhexidine 0.12% Mouthwashes for Management of Biofilm Induced Gingivitis in Fixed Orthodontic Patients: A Randomized Clinical Trial with Microbiological Analysis.
! 1 The effect of Aloe vera juice and acemannan on postprandial lipemic, antioxidant, and inflammatory response in high-fat meal fed overweight/obese men: A randomized crossover-controlled study - ScienceDirect
This study investigated the impact of Aloe barbadensis Miller (Aloe vera) juice with acemannan on postprandial metabolic markers, antioxidant status, …
The Effect of Aloe Vera on the Healing of Diabetic Foot Ulcer: A Randomized, Double-blind Clinical Trial - PubMed
These findings are promising and suggest that Aloe vera may be a safe and effective adjunctive treatment for diabetic foot ulcers. However, further research is needed to confirm these results and to investigate the underlying mechanisms of aloe vera's therapeutic effect on diabetic foot ulcers.
Aloe and its Effects on Cancer: A Narrative Literature Review - PMC
Many years ago, Aloe Vera was cited to have a lot of therapeutic properties including; anti-microbial, anti-viral, anti-cancer, anti-oxidant, anti-inflammatory, skin protection, wound healing, and regulation of blood glucose and cholesterol. However, ...
Evaluation of the Nutritional and Metabolic Effects of Aloe vera - Herbal Medicine - NCBI Bookshelf
Aloe vera has a long history of popular and traditional use. It is used in traditional Indian medicine for constipation, colic, skin diseases, worm infestation, and infections (Heber 2007). It is also used in Trinidad and Tobago for hypertension (Lans 2006) and among Mexican Americans for the treatment of type 2 diabetes mellitus (DM; Coronado et al. 2004). In Chinese medicine, it is often recommended in the treatment of fungal diseases (Heber 2007). In Western society, Aloe vera is one of the few herbal medicines in common usage, and it has found widespread use in the cosmetic, pharmaceutical, and food industries. In the case of health, the therapeutic claims for the topical and oral application of Aloe vera cover a wide range of conditions, but few claims have been the subject of robust clinical investigation. The conditions for which clinical trials of Aloe vera have been conducted include skin conditions, management of burn and wound healing, constipation, DM, and gastrointestinal disorders.
Investigation of antimicrobial and physical properties of polyester/cotton blended knitted fabric treated with AgNO3 and aloe vera - ScienceDirect
The application of antimicrobial textiles is rising rapidly because of their healthcare, comfort, and hygienic attributes. This work aimed to develop …
Aloe Vera for Diabetes: Research, Pros, Cons, and More
Aloe vera still needs to be researched more for its use in treating diabetes, but preliminary results show that it could help lower both fasting glucose and A1C.
Aloe vera Gel Ameliorates Fat-Rich and High Fructose (FRHF) Diet-Induced Pancreatic and Splenic Damage in Mice | Borneo Journal of Pharmacy
High-fat diet alone or in combination with high fructose has been known to induce diabetes, obesity, hypertension, and immune dysfunction. The study evaluates the role of Aloe vera in fat-rich and high fructose diet-induced (FRHFD) hyperglycemias in addition to testicular and splenic morphology in mice. Twenty BALB/c Mice were randomly distributed into four groups (n=5). The groups were fed on a normal diet, FRHFD, FRHFD + 10 g Aloe vera , and FRHFD + 20 g Aloe vera for 10 weeks. All the mice were sacrificed a day after the 10 weeks of treatment. The result showed that mice fed on FRHFD plus Aloe vera had a significantly lower (p
Antioxidative effect of Aloe vera Against Malathion Induced Neurotoxic Response in Wistar Rats - ScienceDirect
Insight about the impact of malathion on human physiology is still a challenge in environmental health. The present work was focused on the neurotoxic…
1 Pharmacological and Therapeutic Activities of Aloe vera and Its Major Active Constituent Acemannan
Kim SH, et al. Food Suppl Biomater Health. 2023 Jun;3:e8. https://doi.org/10.52361/fsbh.2023.3.e8
Aloe vera (L.) Burm.f. | 5 | An Important Medicinal Herb for Diabetes
Aloe vera is a perennial, succulent cacti with cosmopolitan distribution. This plant holds a long history of usages in recovering different
Toxics | Free Full-Text | Amelioration of Hepatotoxic and Neurotoxic Effect of Cartap by Aloe vera in Wistar Rats
Pesticide exposure can pose a serious risk to nontarget animals. Cartap is being broadly used in agricultural fields. The toxic effects of cartap on the levels of hepatotoxicity and neurotoxicity have not been properly studied in mammalian systems. Therefore, the present work focused on the effect of cartap on the liver and brain of Wistar rats and made an assessment of the ameliorating potential of A. vera. The experimental animals were divided into 4 groups, comprising six rats in each: Group 1—Control; Group 2—A. vera; Group 3—Cartap; and Group 4—A. vera + Cartap. The animals orally given cartap and A. vera were sacrificed after 24 h of the final treatment and histological and biochemical investigations were conducted in liver and brain of Wistar rats. Cartap at sublethal concentrations caused substantial decreases in CAT, SOD, and GST levels in the experimental rats. The activity levels of transaminases and phosphatases in cartap group were also found to be substantially altered. The AChE activity was recorded as decreasing in RBC membrane and brain of the cartap-treated animals. The TNF-α and IL-6 level in serum were increased expressively in the cartap challenged groups. Histological investigation of liver showed disorganized hepatic cords and severely congested central veins due to cartap. However, the A. vera extract was observed to significantly protect against the effects of cartap toxicity. The protective impact of A. vera against cartap toxicity may be due to the existence of antioxidants in it. These findings suggest that A. vera may be developed as a potential supplement to the appropriate medication in the treatment of cartap toxicity.
LIPID LOWERING EFFECTS OF ALOE VERA – EFFECT ON HDL-CHOLESTEROL PROTEIN EXPRESSION
The Protective Effects of Aloe Vera Gel Extract on the Sexual Tissue Damage Caused by Diabetes in Male Rats
Introduction: Diabetics usually suffer from chronic complications, including microvascular and macrovascular disorders. The capillaries supplying the sexual organs affect normal sexual functions. The erectile process has been shown to be impaired in diabetics. Vascular damage in diabetics may be associated with decreased testosterone production, sperm count, testicular weight, and seminiferous tubule diameter. In this study, we investigated the effects of Aloe vera gel extract (from Sistan and Baluchistan in Iran) on male genital in streptozocin-induced diabetic rats. Methods: Of twenty-four male Wistar rats, diabetes was induced in 12 rats by intraperitoneal injection of a single dose of STZ. The rats were divided into four groups. The first and third groups received saline (NaCl) daily by gavage. The second and fourth groups received aloe vera gel extract daily by gavage. The treatments were continued for 30 days. At the end of the treatment period, blood samples were collected and serum glucose and testosterone levels were measured by photometric methods. Histological examinations were performed on the prostate and testes. Results: Mean weight index, serum levels of glucose and testosterone, mean sperm count, germline thickness, and seminiferous tubule diameter improved significantly in the diabetes +Aloe vera group. Conclusion: We concluded that consumption of Aloe vera gel extract improved sexual complications in type 1 diabetic rats.
(PDF) Bioactive Compounds and Therapeutic Properties of Aloe vera- A Review
Aloe vera - Nature’s healer
ALOE VERA A POTENTIAL HERB USED AS TRADITIONAL MEDICINE BY TRIBAL PEOP (...)