Biome

You’ve heard your gut changes your brain. Here are the key pathways!

(NaturalHealth365) Multiple studies reveal common food chemicals in processed foods may cause Crohn's disease, cancer, and gut inflammation.

Gastroenterologist and microbiome expert Dr. Sabine Hazan reveals that many commercial yogurts and probiotics don’t contain the gut-healthy strains they claim, raising major concerns about the yogurt and supplement industry standards. Her cutting-edge research links gut health to chronic disease and vaccine response, pointing to the microbiome as a critical—yet overlooked—piece of the medical puzzle. […]

What if tiny viruses are doing more than just invading your body—what if they're actually protecting you? In this groundbreaking presentation, microbiologist...

The overuse of antibiotics is a widespread problem within conventional medicine. Discover how these drugs can cause serious health issues.

(NaturalHealth365) Poor digestion and bad stomach bacteria have been scientifically shown to cause mental and physical illness.

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(NaturalHealth365) The excessive use of antibiotics must stop. Too many physicians are prescribing them for the wrong reasons.

Originally developed and commercialized as an antiprotozoal agent, nitazoxanide was later identified as a first-in-class broad-spectrum antiviral drug and has been repurposed for the treatment of influenza. A Phase 2b/3 clinical trial recently published ...

In this podcast episode, Dr. Henry Ealy and Dr. Brian Ardis discuss the impact of food allergies on health. Dr. Ealy shares his personal experience with delayed food allergies and the surprising resul

It seems as if there is no limit to the various body systems that are now being characterized as having a unique association with bacteria and other resident living organisms. …

(NaturalHealth365) Is chronic fatigue syndrome triggered by a leaky gut? Researchers found a connection between the gut and chronic fatigue.

Are you tired of being constantly interrupted during your precious sleep by those annoying trips to the bathroom? Well, you're not alone! In this video, we'r...

(NaturalHealth365) Discover the findings of a recent study published in ACS Chemical Biology about the dangers of a common food preservative.

Recent advances in sequencing techniques unveiled the vast potential of ribosomally synthesized and post-translationally modified peptides (RiPPs) encoded in microbiomes. Class I lantibiotics such as nisin A, widely used as a food preservative, have been investigated for their efficacy in killing pathogens. However, the impact of nisin and nisin-like class I lantibiotics on commensal bacteria residing in the human gut remains unclear. Here, we report six gut-derived class I lantibiotics that are close homologues of nisin, four of which are novel. We applied an improved lantibiotic expression platform to produce and purify these lantibiotics for antimicrobial assays. We determined their minimal inhibitory concentration (MIC) against both Gram-positive human pathogens and gut commensals and profiled the lantibiotic resistance genes in these pathogens and commensals. Structure–activity relationship (SAR) studies with analogs revealed key regions and residues that impact their antimicrobial properties. Our characterization and SAR studies of nisin-like lantibiotics against both pathogens and human gut commensals could shed light on the future development of lantibiotic-based therapeutics and food preservatives.

The highly post-translationally modified peptide nisin has been studied over the course of the last 100 years, and although it has been employed successfully as

(NaturalHealth365) Research reveals that poor gut health can increase the threat of breast cancer. Find out the role of the gut microbiome.

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The application of next generation sequencing techniques has allowed the characterization of the urinary tract microbiome and has led to the rejection of the pre-established concept of sterility in the urinary bladder. Not only have microbial communities in the urinary tract been implicated in the maintenance of health but alterations in their composition have also been associated with different urinary pathologies, such as urinary tract infections (UTI). Therefore, the study of the urinary microbiome in healthy individuals, as well as its involvement in disease through the proliferation of opportunistic pathogens, could open a potential field of study, leading to new insights into prevention, diagnosis and treatment strategies for urinary pathologies. In this review we present an overview of the current state of knowledge about the urinary microbiome in health and disease, as well as its involvement in the development of new therapeutic strategies.

(NaturalHealth365) Increasing antibiotic resistance leads to deaths due to neonatal and pediatric infections globally.

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative motor neuron disease accompanied by both systemic and central nervous system–specific…

Studies in rodents provide compelling evidence that microorganisms inhabiting the gut influence neurodevelopment. In particular, experimental manipulations that alter intestinal microbiota impact exploratory and communicative behaviors and cognitive performance. In humans, the first years of life are a dynamic time in gut colonization and brain development, but little is known about the relationship between these two processes.

Background Microorganisms in the human intestine (i.e. the gut microbiome) have an increasingly recognized impact on human health, including brain functioning. Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder associated with abnormalities in dopamine neurotransmission and deficits in reward processing and its underlying neuro-circuitry including the ventral striatum. The microbiome might contribute to ADHD etiology via the gut-brain axis. In this pilot study, we investigated potential differences in the microbiome between ADHD cases and undiagnosed controls, as well as its relation to neural reward processing. Methods We used 16S rRNA marker gene sequencing (16S) to identify bacterial taxa and their predicted gene functions in 19 ADHD and 77 control participants. Using functional magnetic resonance imaging (fMRI), we interrogated the effect of observed microbiome differences in neural reward responses in a subset of 28 participants, independent of diagnosis. Results For the first time, we describe gut microbial makeup of adolescents and adults diagnosed with ADHD. We found that the relative abundance of several bacterial taxa differed between cases and controls, albeit marginally significant. A nominal increase in the Bifidobacterium genus was observed in ADHD cases. In a hypothesis-driven approach, we found that the observed increase was linked to significantly enhanced 16S-based predicted bacterial gene functionality encoding cyclohexadienyl dehydratase in cases relative to controls. This enzyme is involved in the synthesis of phenylalanine, a precursor of dopamine. Increased relative abundance of this functionality was significantly associated with decreased ventral striatal fMRI responses during reward anticipation, independent of ADHD diagnosis and age. Conclusions Our results show increases in gut microbiome predicted function of dopamine precursor synthesis between ADHD cases and controls. This increase in microbiome function relates to decreased neural responses to reward anticipation. Decreased neural reward anticipation constitutes one of the hallmarks of ADHD.

Cardiovascular disease (CVD) is the leading cause of death worldwide. The human body is populated by a diverse community of microbes, dominated by bacteria, but also including viruses and fungi. The largest and most complex of these communities is located in the gastrointestinal system and, with its associated genome, is known as the gut microbiome. Gut microbiome perturbations and related dysbiosis have been implicated in the progression and pathogenesis of CVD, including atherosclerosis, hypertension, and heart failure. Although there have been advances in the characterization and analysis of the gut microbiota and associated bacterial metabolites, the exact mechanisms through which they exert their action are not well understood. This review will focus on the role of the gut microbiome and associated functional components in the development and progression of atherosclerosis. Potential treatments to alter the gut microbiome to prevent or treat atherosclerosis and CVD are also discussed.

(NaturalHealth365) Scientists believe delayed gut microbiota maturation is responsible for childhood allergies.