Diabetes Type 1

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Do you suffer from diabetic neuropathy, chemo-induced neuropathy, or HIV neuropathy? Join our clinical trials. Subscribe for updates and information on clinical trials.

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱As many of you ...

What is celiac disease and how does it cause nerve damage? Learn more: https://winsantor.com/nerve-damage-and-celiac-disease-the-hidden-connection/Visit our ...

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Distal symmetric diabetic peripheral polyneuropathy (DPN) is the most common form of neuropathy in the world, affecting 30 to 50% of diabetic individuals and resulting in significant morbidity and socioeconomic costs. This review summarizes updates in ...

Diabetic nephropathy (DN) is a common microvascular complication of diabetes. Fucoidan, a polysaccharide containing fucose and sulfate group, ameliorates DN. However, the underlying mechanism has not been fully understood. This study aimed to explore the effects and mechanism of fucoidan on DN in high-fat diet-induced diabetic mice. A total of 90 C57BL/6J mice were randomly assigned to six groups (n = 15) as follows: normal control (NC), diabetes mellitus (DM), metformin (MTF), low-dose fucoidan (LFC), medium-dose fucoidan (MFC), and high-dose fucoidan (HFC). A technique based on fluorescein isothiocyanate (FITC-sinistin) elimination kinetics measured percutaneously was applied to determine the glomerular filtration rate (GFR). After 24 weeks, the mice were sacrificed and an early stage DN model was confirmed by GFR hyperfiltration, elevated urinary creatinine, normal urinary albumin, tubulointerstitial fibrosis, and glomerular hypertrophy. Fucoidan significantly improved the GFR hyperfiltration and renal fibrosis. An enriched SCFAs-producing bacteria and increased acetic concentration in cecum contents were found in fucoidan groups, as well as increased renal ATP levels and improved mitochondrial dysfunction. The renal inflammation and fibrosis were ameliorated through inhibiting the MAPKs pathway. In conclusion, fucoidan improved early stage DN targeting the microbiota–mitochondria axis by ameliorating mitochondrial oxidative stress and inhibiting the MAPKs pathway.

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Thioredoxin-interacting protein (TXNIP) is an important regulatory protein for thioredoxin (TRX) that elicits the generation of reactive oxygen species (ROS) by inhibiting the redox function of TRX...

Learn about your kidneys, how to protect them, and what to eat when you have kidney disease! Dr. Sean Hashmi is a Board Certified Nephrologist and Michele Crosmer is a Registered Dietitian and Certified Specialist in Renal Nutrition. We hope to educate and empower you to take control of your health and make proactive lifestyle choices to protect kidney health! Thanks so much for subscribing to our channel! Sean Hashmi, MD, MS, FASN and Michele Crosmer, RD, CSR

Hello, dear friends! I'm Dr. Sean Hashmi, founder of SELF Principle, a community focused on the latest research in nutrition, longevity, health, wellness, and kidney disease. As a father, husband, and kidney disease specialist, my journey in medicine began with personal loss and my family's health struggles. These experiences ignited my passion to explore the healing power of nutrition and wellness. Here, we'll delve into scientific insights, engaging expert interviews, and real stories. More than just learning, this channel is about connecting, growing, and supporting one another on the path to better health. Your thoughts, challenges, and triumphs matter to me, so please SUBSCRIBE and join our VIP list by hitting the bell. Together, we'll embark on a journey toward understanding, compassion, and wellness. With heartfelt gratitude, Sean Hashmi, MD, MS, FASN

By Richard J Johnson MD DrRichardJohnson.com Chronic kidney disease is not uncommon in the United States, with as many as 15 percent of all adults manifesting some decrease in kidney …

Fucoidin failed to protect the kidney from ischemic damage and was even nephrotoxic. It also stimulated the formation of iNOS RNA.

(NaturalHealth365) Did you know that starfruit contains a toxin that harms the kidneys and other internal organs, including the brain?

Raft-forming systems are designed to relieve reflux symptoms by forming a physical barrier on top of the stomach. The present study aimed to evaluate …

Insulin resistance, as a common pathological process of many metabolic diseases, including diabetes and obesity, has attracted much attention due to its relevant influencing factors. To date, studies have mainly focused on the shared mechanisms between mitochondrial stress and insulin resistance, and they are now being pursued as a very attractive therapeutic target due to their extensive involvement in many human clinical settings. In view of the complex pathogenesis of diabetes, natural drugs have become new players in diabetes prevention and treatment because of their wide targets and few side effects. In particular, plant phenolics have received attention because of their close relationship with oxidative stress. In this review, we briefly review the mechanisms by which mitochondrial stress leads to insulin resistance. Moreover, we list some cytokines and genes that have recently been found to play roles in mitochondrial stress and insulin resistance. Furthermore, we describe several natural drugs that are currently widely used and give a brief overview of their therapeutic mechanisms. Finally, we suggest possible ideas for future research related to the unique role that natural drugs play in the treatment of insulin resistance through the above targets.

"Hit-and-run" treatment with senolytics, which in the case of D + Q have elimination half-lives

What is collagen? The most abundant protein in the body, it's found in muscles, bones, skin and tendons. Learn about the types, sources, benefits and supplements.

Conventional insulin concentration units (IU/mL or just U/mL) are bioefficacy based, whereas the Système International (SI) units (pmol/L) are mass based. In converting between these two different approaches, there are at least 2 well-accepted ...

After 20 years of treating patients and dealing with his own vein condition, Dr. Michael Ryan demonstrates his proven method of stopping a leg cramp in 15 se...

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