Kidney Disease

Diabetic nephropathy (DN) is a common microvascular complication of diabetes. Fucoidan, a polysaccharide containing fucose and sulfate group, ameliorates DN. However, the underlying mechanism has not been fully understood. This study aimed to explore the effects and mechanism of fucoidan on DN in high-fat diet-induced diabetic mice. A total of 90 C57BL/6J mice were randomly assigned to six groups (n = 15) as follows: normal control (NC), diabetes mellitus (DM), metformin (MTF), low-dose fucoidan (LFC), medium-dose fucoidan (MFC), and high-dose fucoidan (HFC). A technique based on fluorescein isothiocyanate (FITC-sinistin) elimination kinetics measured percutaneously was applied to determine the glomerular filtration rate (GFR). After 24 weeks, the mice were sacrificed and an early stage DN model was confirmed by GFR hyperfiltration, elevated urinary creatinine, normal urinary albumin, tubulointerstitial fibrosis, and glomerular hypertrophy. Fucoidan significantly improved the GFR hyperfiltration and renal fibrosis. An enriched SCFAs-producing bacteria and increased acetic concentration in cecum contents were found in fucoidan groups, as well as increased renal ATP levels and improved mitochondrial dysfunction. The renal inflammation and fibrosis were ameliorated through inhibiting the MAPKs pathway. In conclusion, fucoidan improved early stage DN targeting the microbiota–mitochondria axis by ameliorating mitochondrial oxidative stress and inhibiting the MAPKs pathway.

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Thioredoxin-interacting protein (TXNIP) is an important regulatory protein for thioredoxin (TRX) that elicits the generation of reactive oxygen species (ROS) by inhibiting the redox function of TRX...

Learn about your kidneys, how to protect them, and what to eat when you have kidney disease! Dr. Sean Hashmi is a Board Certified Nephrologist and Michele Crosmer is a Registered Dietitian and Certified Specialist in Renal Nutrition. We hope to educate and empower you to take control of your health and make proactive lifestyle choices to protect kidney health! Thanks so much for subscribing to our channel! Sean Hashmi, MD, MS, FASN and Michele Crosmer, RD, CSR

Hello, dear friends! I'm Dr. Sean Hashmi, founder of SELF Principle, a community focused on the latest research in nutrition, longevity, health, wellness, and kidney disease. As a father, husband, and kidney disease specialist, my journey in medicine began with personal loss and my family's health struggles. These experiences ignited my passion to explore the healing power of nutrition and wellness. Here, we'll delve into scientific insights, engaging expert interviews, and real stories. More than just learning, this channel is about connecting, growing, and supporting one another on the path to better health. Your thoughts, challenges, and triumphs matter to me, so please SUBSCRIBE and join our VIP list by hitting the bell. Together, we'll embark on a journey toward understanding, compassion, and wellness. With heartfelt gratitude, Sean Hashmi, MD, MS, FASN

By Richard J Johnson MD DrRichardJohnson.com Chronic kidney disease is not uncommon in the United States, with as many as 15 percent of all adults manifesting some decrease in kidney …

Fucoidin failed to protect the kidney from ischemic damage and was even nephrotoxic. It also stimulated the formation of iNOS RNA.

(NaturalHealth365) Did you know that starfruit contains a toxin that harms the kidneys and other internal organs, including the brain?

"Hit-and-run" treatment with senolytics, which in the case of D + Q have elimination half-lives

What should we eat? I ask this question in the context of the incredible rates of obesity that we are now seeing, virtually worldwide. Today we will spend time with Dr. Jason Fung author of the book The Obesity Code. This is a landmark book that powerfully lays out why we are continuing to gain weight. It dispels the notion that dietary fat threatens to make us gain weight as well as the unfounded idea of calories in versus calories out as an explanation for why we gain weight. Dr. Fung clearly focuses on the importance of the hormone, insulin, in terms of obesity, and certainly in terms of diabetes as well. He outlines a very straightforward plan that is in perfect alignment with current science. This interview is one of the most fundamental as a relates to the science of weight loss and regaining control over our blood sugar. ==== 0:00 Intro 2:36 Why Dr. Fung Pursued Weight Loss Research 8:08 Problem with Insulin 15:15 Mechanisms of Insulin 23:09 Reconsidering Low Fat Diets & Calorie Counting 37:34 Satiety Hormones 40:10 Leptin & Weight Loss 43:59 Threat of Fructose 51:23 Conclusion ==== Dr. Jason Fung is a Canadian nephrologist and a world-leading expert on intermittent fasting and low carb, especially for treating people with type 2 diabetes. Dr. Fung graduated from the University of Toronto and completed his residency at the University of California, Los Angeles. He lives and works in Toronto, Canada. Here is Dr. Fung’s website: https://thefastingmethod.com/ https://www.dietdoctor.com/intermittent-fasting https://www.dietdoctor.com/low-carb https://www.dietdoctor.com/diabetes ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

We evaluated Galectin-3 (Gal-3) as a potential early biomarker of acute kidney disease (AKI), and the effect of Gal-3 inhibition by modified citrus pe…

Highlights • In 2 different mouse models, AKI increased Gal-3 expression and induced cardiac dysfunction, cardiac and systemic inflammation, cardiac macrophage infiltration, and fibrosis. • Cardiac...

Background Galectin-3 (Gal-3) is a pleiotropic glycan-binding protein shown to be involved in sepsis and acute kidney injury (AKI). However, its role has never been elucidated in sepsis-associated AKI (S-AKI). We aimed to explore Gal-3’s role and its potential utility as a therapeutic target in S-AKI. Methods In 57 patients admitted to the intensive care unit (ICU) with sepsis, serum Gal-3 was examined as a predictor of ICU mortality and development of AKI. In a rat model of S-AKI induced by cecal ligation and puncture (CLP), 7-day mortality and serum Gal-3, Interleukin-6 (IL-6), and creatinine were examined at 2, 8, and 24 hours (h) post-CLP. Two experimental groups received the Gal-3 inhibitor modified citrus pectin (P-MCP) at 400 mg/kg/day and 1200 mg/kg/day, while the control group received water only (n = 18 in each group). Results Among 57 patients, 27 developed AKI and 8 died in the ICU. Serum Gal-3 was an independent predictor of AKI (OR = 1.2 [95% CI 1.1–1.4], p = 0.01) and ICU mortality (OR = 1.4 [95% CI 1.1–2.2], p = 0.04) before and after controlling for age, AKI, and acute physiology and chronic health evaluation (APACHE II) score. In the CLP rat experiment, serum Gal-3 peaked earlier than IL-6. Serum Gal-3 was significantly lower in both P-MCP groups compared to control at 2 h post-CLP (400 mg: p = 0.003; 1200 mg: p = 0.002), and IL-6 was significantly lower in both P-MCP groups at all time points with a maximum difference at 24 h post-CLP (400 mg: p = 0.015; 1200 mg: p = 0.02). In the Gal-3 inhibitor groups, 7-day mortality was significantly reduced from 61% in the control group to 28% (400 mg P-MCP: p = 0.03) and 22% (1200 mg P-MCP: p = 0.001). Rates of AKI per RIFLE criteria were significantly reduced from 89% in the control group to 44% in both P-MCP groups (400 mg: p = 0.007; 1200 mg: p = 0.007). Conclusions This translational study demonstrates the importance of Gal-3 in the pathogenesis of S-AKI, and its potential utility as a therapeutic target. Graphic abstract

Studies on Endocalyx Pro effectiveness are ongoing. Several studies are complete, with more launching in the future.

Plant Based Kidneys; Michele is a registered dietitian / certified specialist in renal nutrition. Self-study program, friendly plant based kidney recipes, blog.

Episode 19: Role of Vitamin K2 in Kidney Disease ⏰ Timestamps ⏰ 0:00 Introduction 0:45 What is Vitamin K and what is its role in kidney disease? 10:24 How do you get Vitamin K2 from your diet? 14:03 Why should you combine D3 with K2? 15:05 What dosage of K2 should you take? 16:30 Should you check your Vitamin K levels checked? 📱Subscribe and Listen to Plant Based Kidney Health Podcast HERE: Apple: https://apple.co/3tSO07m Spotify: https://spoti.fi/3tSGysP ⚡️Connect with us on Social Media: Sean Hashmi, MD, MS, FASN https://www.SELFPrinciple.org https://www.instragram.com/seanhashmimd Michele Crosmer, RD CSR https://plantbasedkidneys.com/ https://www.instagram.com/plantbased.kidneys/ Disclaimer The information provided on this channel is for educational purposes only, and does not substitute for professional medical advice. Please consult a medical professional or healthcare provider for medical advice, diagnoses, or treatment.

Background: Mitochondrial, lysosomal, and peroxisomal dysfunction; defective autophagy; mitophagy; and pexophagy, as well as the loss of glycocalyx integrity are known contributors to initiation and progression of diverse kidney diseases. Those cellular organelles are tightly interactive in health, and during development of a disease, damage in one

Understand acute renal failure (acute kidney injury) causes, diagnosis, and treatment with this clear medical course. Medical illustrations by Dr. Seheult.

Kidney Care - Kidney and Lymphatic Drainage

Presented byTHE BEST OFThe Kidney Health Docu-Class and The Metabolic Syndrome Docu-ClassA compilation of some of the most powerful moments from each docu-class — condensed into two amazing presentations for you to enjoy.Love what you're seeing?Click below to get the recordings of all 30 presentations plus access to transcripts and all the other great bonuses you see here...GET ACCESS TODAY!Own…

Chronic kidney disease (CKD) is a major public health concern that costs millions of lives worldwide. Natural products are consistently being explored…

Cadmium (Cd) poisoning is characterized by multiple organ dysfunction in organisms, and the kidney is the main target organ of Cd toxicity. Trehalose (Tr), a multifunctional bioactive disaccharide, possesses potential kidney protective properties. Nevertheless, the specific biological function of Tr …

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