0 Glyconutrients

Trehalose is a non-reducing sugar formed from two glucose units. Trehalose induces abundant autophagy in cultured cells and also reduces the rate of aggregation of the huntingtin protein in the animal model of Huntington disease, a chronic neurological disease in humans. The mechanism of this effect …

Insulin entrapped alginate-gum tragacanth (ALG-GT) hydrogels at different ALG replacement ratios (100, 75, 50, 25) were prepared through an ionotropic gelation method, followed by chitosan (CH) polyelectrolyte complexation. A mild gelation process without the use of harsh chemicals was proposed to improve insulin efficiency. Retention of almost the full amount of entrapped insulin in a simulated gastric environment and sustained insulin release in simulated intestinal buffer indicated the pH sensitivity of the gels. Insulin release from hydrogels with different formulations showed significant differences (p < 0.05). Time domain (TD) NMR relaxometry experiments also showed the differences for different formulations, and the presence of CH revealed that ALG-GT gel formulation could be used as an oral insulin carrier at optimum concentrations. The hydrogels formulated from biodegradable, biocompatible, and nontoxic natural polymers were seen as promising devices for potential oral insulin delivery.

The practice of bone implants is the standard procedure for the treatment of skeletal fissures, or to substitute and re-establish lost bone. A perfect…

Previous research indicated that fiber in the diet of men lowers plasma lipid and LDL cholesterol concentration. To further study the lipid lowering effect of fibre, we conducted an animal study using rats with diet induced hyperlipidaemia. Rats were randomly assigned to one of the three experimenta …

Learn more about TRAGACANTH uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain TRAGACANTH.

The present study introduces the ultrasonic modification of two Iranian native gum exudates, Persian gum (PG) and gum tragacanth (GT) for the first ti…

The presence of pesticide residues in vegetable and fruit products, as a consequence of inappropriate application in some cases, constitutes a risk to the health of the exposed population. In Mexico, the official norm, NOM-003-STPS-1999, only allows the use of pesticides with the phytosanitary registry, the responsible state commission for the control of the process and use of pesticides and toxic substances, which recommends doses and permitted crops. Despite the above, it is still common to find pesticide residues in some vegetable products. In this study, the following were detected: Chlorpyriphos, Dimetomorph I, Malathion, Omethoate, Carbendazim, and Imidacloprid in Nopal. The study was carried out in two collection centers located in the state of Morelos. In total, sixty samples were taken, thirty for each collection center, for a period of 10 months. To determine the pesticide residues, the analytical methodology was used, according to the guide, SANTE/11945/2015; in a laboratory accredited by the Mexican Accreditation Entity A. C. in the norm, NMX-EC-17025-IMNC-2006. The procedure for extracting analytes was carried out using the method, QuEChERS. The highest concentration of the pesticides detected in the samples obtained from the non-Certified Supply Center were Chlorpyrifos 0.309 mg/kg (MRL 0.01), Dimetomorf I 0.029 mg/kg (MRL 0.01), Malathion 0.155 mg/kg (MRL 0.01), Omethoate 0.032 (MRL 0.01), Carbendazim 0.090 mg/kg (MRL 0.01), and Imidacloprid 0.058 mg/kg (MRL 0.01). Thirty percent of the samples analyzed showed pesticide residues; the most frequent were Carbendazim. The results for the estimated daily intake (EDI) oscillated between 6.5 &times; 10&minus;5 and 1.3 &times; 10&minus;4 mg/kg body weight for the vegetable, Nopal. In principle, it could be concluded that the consumption of Nopal with pesticide residues does not represent any toxicological risk for human health, however, the risk cannot be ruled out due to the intake of other vegetables and fruits that are cultivated in the Mexican Republic, which probably present pesticide residues, which together would raise potential risks to human health.

The aim of current study is detect the activity role of Aloe vera and Opuntia ficus extract against certain pathogenic bacteria and evaluation of Aloe vera and O. ficus extract against certain pathogenic bacteria inhibition in vitro. 100 samples were obtained from patients with different diseases at age 6 Mon. to 65 years from both genders. This study was carried out in Lab. of Biology Dept., Science College/Tikrit University, at the period from 1st of June 2019 to end of January 2020. The antimicrobial activity was performed with the agar well diffusion method. The results show the ability of Aloe vera for inhibition of bacteria according on concentration and the concentrations of 100 was caused in inhibitory effect on E. coli, Acinetobacte, S. aureus, S. epidermidis and S. haemolyticus isolates at diameter 13, 12, 11, 9.8 and 15 mm respectively. While, Opuntia ficus extract at 100% concentration was caused in inhibitory effect bacteria isolates at diameter 10, 9.7, 8.2, 7 and 12 mm respectively. The results also show Aloe vera was found to be able for inhibition of bacteria concentration of 40% was caused in inhibitory effect on E. coli, Acinetobacte, S. aureus, S. epidermidis and S. haemolyticus isolates at diameter 14, 12, 11, 9 and 15 mm respectively. While, Opuntia ficus extract at 40% concentration was caused in inhibitory effect bacteria isolates at diameter 11, 10, 8, 7 and 13 mm respectively, while other concentrations 10%, 20, 30% show less inhibitory effect compare with 100% and 40% concentrations

Cardiovascular diseases (CVD) are the first cause of death in Mexican population. Metabolic disruptions induced by diet are, in turn, associated with ..

This work determines the effect nopal consumption at different maturity stages (60, 200, 400, and 600 g) as the only calcium source in bone metabolism. The apparent mineral absorption, the biomarkers of bone metabolism, the bone mineral density at different femoral regions, and crystal properties of the bone were evaluated during the growth stage. The Ca absorption was increased with the rat age in most of the experimental groups, while Mg supplementation decreased intestinal absorption probably due to a saturation process. Intestinal Ca and Mg absorption showed an opposite trend; this result suggests that both ions can compete for vitamin D absorption sites. The percentage of absorption of K was lower in the groups fed with Nopal; nevertheless, due to supplementation, the net absorption was higher than the control group. In all groups, osteocalcin levels decreased with the rat age. Nopal consumption increased osteocalcin levels during the adolescence stage in comparison to the control group. Amino N-terminal propeptide of type I procollagen levels increased in puberty and adolescence in all groups compared to the control group. Bone mineral density in different femoral regions was lower in the groups fed with nopal at early maturity stages (N-60 and N-200) than the groups fed with nopal at late maturity stages (N-400 and N-600). The crystal size of hydroxyapatite exhibited changes for all the groups, indicating the inclusion of mono and divalent ions in calcium replacement. On this basis, the nopal at late maturity stage contributed to bone formation.

Current efforts are directed to reducing the gut dysbiosis and inflammation produced by obesity. The purpose of this study was to investigate whether consuming nopal, a vegetable rich in dietary fibre, vitamin C, and polyphenols can reduce the metabolic ...

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In this 7-day randomized controlled trial we found that a novel fiber supplement from the Mexican nopal cactus improved adequate relief in patients with IBS, irrespective of IBS subtype, sex or age, ...

Background and objectives: Type 2 diabetes has been increasing all over the world. A healthy diet, including particular functional foods is an effective strategy to prevent this form of diabetes. Nopal (Oputia ficus) is a cactus plant that, according to traditional medicine, has antidiabetic properties. The objective of this research was to examine the effects of different fractions of nopal cladodes on postprandial glycaemic regulation in healthy volunteers. Methods: Nopal cladodes flour was separated by centrifugation into two fractions (a water insoluble and a soluble fraction). The fractions were incorporated into two different test breads, i.e. insoluble fraction bread (INB) and soluble fraction bread (SNB), and evaluated with respect to acute glycaemic properties in 17 healthy subjects with normal body mass index, applying a randomized cross-over study design. The effects on glycaemic and insulinaemic responses were compared with the responses after a control product, which composed of a similar bread lacking the nopal fractions (white wheat bread, WWB). The products were characterized with respect to starch and dietary fibre content. In addition, starch hydrolysis index (HI) was determined with an in-vitro method in order to predict glycaemic index (pGI),and elucidate possibly underlying mechanisms on postprandial glycaemia. Results: Results regarding glycaemic regulation show that insoluble nopal fractions had a beneficial effect on postprandial glucose regulation. Consequently, the incremental area under the postprandial blood glucose curve (iAUC) after INB was significantly reduced compared to after intake of the WWB during the time periods 0 – 45 and 0 – 60 minutes (p < 0.05). In addition, the iPeak value, i.e. the individual highest incremental peak concentrations, was significantly lowered after INB compared to WWB (P < 0.05). Regarding the postprandial insulin secretion, both SNB and INB lowered the postprandial iAUC compared to the WWB during the time period 0 – 45 and 0 – 60 minutes (P < 0.05). On the other hand, only the INB significantly reduced the insulin iPeak value compared to WWB (P < 0.05). In terms of HI, INB had lower HI and pGI compared to WWB and SNB. Also, INB exhibited highest total, soluble and insoluble dietary fibre contents. Conclusion: The INB promoted lower postprandial glucose and insulin response, while SNB showed beneficial effects only on postprandial insulin secretion. The beneficial effects of nopal on glycaemic regulation might be to some extent explained by the dietary fibre content, especially the INB. However, with respect to the improved postprandial insulin economy observed after the SNB, additional mechanisms are probably involved.

The use of ultrasound treatment for improving the bioactive compounds and quality properties of a Brazilian nopal beverage was studied. Physicochemica…

Introduction: The world has witnessed a global trend of increasing obesity, which is directly linked to non-communicable diseases, such as type 2 diabetes (T2D). The epidemic of obesity is largely associated with consumption of high calorie diets and low physical activity. Food choice and exercise have a big impact to prevent obesity and T2D making these diseases highly related to personal lifestyle. The diet is one of the most important modifiable lifestyle factors that may be used to prevent obesity. Nopal (Opuntia Ficus Indica) is a cactus plant that has its origin in Mexico and has been used as traditional medicine to prevent overweight and obesity. Since Nopal cladodes are rich in several bioactive compounds, it may be considered as a functional food. The objective of this study was to investigate the perceived effect of Nopal cladodes on appetite variables in healthy humans. Method: Two test-products with two different fractions of Nopal cladodes flour (soluble Nopal fraction bread (SNB) and insoluble Nopal fraction bread (INB)) and a control product (white wheat bread (WB)) were studied in healthy young volunteers (n=17). The subjective appetite variables (hunger, satiety and desire to eat) were measured repeatedly by using a Visual Analog Scale (VAS) during a time perspective of three hours post consumption. Results: The INB resulted in significantly improved response in appetite variables (p < 0.05) compared to the WB. After consumption of the INB, the feeling of hunger and desire to eat were reduced by 27% and 32% respectively, while the feeling of satiety was increased by 25% during the period between 15-180 min post consumption. Importantly, the INB test product also resulted in a significant reduction on hunger and desire to eat, and an increased feeling of satiety during the final hour (120-180 min), compared to the control WB. Conclusion: The results indicate that the insoluble fraction of Nopal flour may beneficially affect appetite variables in healthy young adults. The results thus suggest that Nopal may help to modulate food intake and therefore contribute to antidiabetic effects previously observed with this edible plant.

Healthcare Providers guide to Arterosil® - the only product in the world that has been clinically proven to rebuild the endothelial glycocalyx

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The endothelial glycocalyx has a profound influence at the vascular wall on the transmission of shear stress, on the maintenance of a selective permeability barrier and a low hydraulic conductivity, ...

Dr. Hans VInk discusses the endothelial glycocalyx: your vascular system's first line of defense.

Years of research have exposed an understanding of the function and structure of the protective gel lining in your circulatory, or vascular system, called the glycocalyx. A new, proprietary, patent-pending dietary supplement named Endocalyx, is specifically formulated to deliver the building blocks essential to maintain a healthy glycocalyx and microvascular system. The ingredients are sourced from regions around the world where people are known to live longer and live healthy active lives. Endocalyx is made from concentrated extracts of seven natural ingredients. These ingredients contain the same compounds that make up and protect the structure of the glycocalyx. It’s a specific blend, right down to the molecular structure that makes all the difference in the result of taking Endocalyx daily. This patent-pending combination of ingredients, in specific dosage amounts, stimulate three actions that restore, rejuvenate and protect your glycocalyx and microvascular system. The first result of this specific blend comes from polysaccharides that restore the protective structure of the glycocalyx. The second result comes from the amino sugars that rejuvenate your body’s ability to produce more of the glycocalyx protective gel. And the third result comes from antioxidants that work to protect the glycocalyx from breaking down. Scientific research backs up that these synergistic ingredients, when combined together, deliver these vital results in your microvascular system. In fact, several Universities and hospitals around the world are conducting research projects right now. And the list of research papers written by medical professionals continues to grow. And importantly, a growing list of researchers now understand the paradigm-shifting advantages of combining these ingredients. As Endocalyx strengthens the glycocalyx, it helps optimize the structure of the capillaries. From head to toe, optimal capillary function delivers many benefits, including clearer thinking, increased energy, improved performance, more youthful appearance, and greater comfort. The better each brain cell is supplied with oxygen and nutrients, the better your mood, the clearer your mind, the more productive your thinking.* Healthy skin, hair, and eyes depend on a steady supply of oxygen and nutrients in order to renew, grow, and stay healthy.* Skin color and tone are enhanced.* Your hair and nails are stronger and healthier.* And your eyes are clearer and brighter.* As Endocalyx strengthens the glycocalyx, the blood in your entire vascular system is better able to reach and energize each cell of your body. Then all the cells of your body, including your brain, heart, and muscles, are amply supplied with oxygen and nutrients.* This means that more blood cells, carrying more nutrients and vital oxygen to all of your muscle, skin, and nerve cells, restore warmth, feeling and comfort.* Don’t wait another minute! Wake up and listen to your body’s early warning signs that your glycocalyx and microvascular system is breaking down. Take control of tomorrow now by starting daily use of Endocalyx today. It’s not too late to restore, rejuvenate and protect your glycocalyx and microvascular system. Order now and save $20 with monthly autoship … and get free shipping at Microvascular.com. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Chronic hyperglycemia underlies microvascular complications in patients with type 1 diabetes. The mechanisms leading to these vascular complications are not fully understood. Recently, we observed that acute hyperglycemia results in endothelial glycocalyx damage. To establish whether glycocalyx is associated with microvascular damage, we performed glycocalyx perturbation volume measurements in type 1 diabetic patients with microalbuminuria (DM1-MA group; n = 7), without microalbuminuria (DM1-NA group; n = 7), and in age-matched control subjects (CON; n = 7). Systemic glycocalyx volume was determined comparing intravascular distribution volume of a glycocalyx-permeable tracer (dextran 40) to that of a glycocalyx-impermeable tracer (labeled erythrocytes). Sublingual capillaries were visualized using orthogonal polarization spectral microscopy to estimate microvascular glycocalyx. Patients and control subjects were matched according to age and BMI. Glycocalyx volume decreased in a stepwise fashion from CON, DM1-NA, and finally DM1-MA subjects (1.5 ± 0.1, 0.8 ± 0.4, and 0.2 ± 0.1 l, respectively, P < 0.05). Microvascular glycocalyx in sublingual capillaries was also decreased in type 1 diabetes versus the control group (0.5 ± 0.1 vs. 0.9 ± 0.1 μm, P < 0.05). Plasma hyaluronan, a principal glycocalyx constituent, and hyaluronidase were increased in type 1 diabetes. In conclusion, type 1 diabetic patients are characterized by endothelial glycocalyx damage, the severity of which is increased in presence of microalbuminuria.

Disruption of the endothelial glycocalyx contributes to acute lung injury in experimental sepsis but has not been well studied in humans. To study glycocalyx degradation in sepsis-induced ARDS, we measured plasma levels of syndecan-1, a marker for glycocalyx ...

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Non-invasive GlycoCheck testing technology quantifies vessel density, red blood cell concentration, blood flow and glycocalyx function.

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The endothelial glycocalyx (EG) lining the endoluminal surface of the capillaries has been proposed as a key component of the microcirculation and a major player in microvascular pathology. Recent advances in the understanding of its physiological role and clinical significance have been made upon t …