0 Glyconutrients

Glycomics is the study of carbohydrates or sugars in biological systems. Learn how glycomics research at GlycoNet is helping to better understand rare genetic diseases which impacts more than 600 million people worldwide. Glycomics presents an opportunity to develop novel treatments for rare genetic diseases that arise from deficiencies in sugar metabolism, such as Gaucher’s disease and Fabry’s disease. Understanding the biochemical and molecular basis of single gene disorders has led to therapeutic strategies for rare diseases and a realization that the development of many common disorders involves altered glycosylation pathways. Developing therapies for rare diseases thus potentially impacts common disorders. The Canadian Glycomics Network (GlycoNet) aims to use the study of carbohydrates to improve human health. Find more information at www.glyconet.ca.

Altered glycosylation is a universal feature of cancer cells, and certain glycan structures are well-known markers for tumor progression. This chapter discusses some glycan biosynthetic pathways that are frequently altered in cancer cells, the correlation between altered glycosylation and clinical prognosis, the genetic basis of some of these changes, and in vitro and in vivo studies that indicate the pathological importance of these pathways.

Intestinal permeability in preterm infants represents a critical balance between absorption of nutritional agents and protection from dangerous pathogens. This study identified the relationship between feeding type (human milk and formula) and intestinal ...

Glycoprotein quality control is categorized into three kinds of reactions; the folding of nascent glycoproteins, ER-associated degradation of misfolded or unassembled glycoproteins, and transport and sorting of correctly folded glycoproteins. In all three processes, N-glycans on the glycoproteins ar …

Glycoprotein quality control is categorized into three kinds of reactions; the folding of nascent glycoproteins, ER-associated degradation of misfolded or unassembled glycoproteins, and transport and sorting of correctly folded glycoproteins. In all three ...

Glycosylation is a highly sophisticated post-translational modification of proteins that occurs in the endoplasmic reticulum (ER) and the Golgi appara …

On April 10, 2015, the Canadian Glycomics Network (GlycoNet), a national network, officially launched. A celebration was held at the University of Alberta, with a program emceed by Jay Ingram, a science broadcaster and past host of Discovery Channel's Daily Planet and CBC's Quirks and Quarks. Glycomics is the study of sugars in biological processes. In this video, Jay Ingram explains the way in which glycomics is central to everyday life, and describes its potential as an emerging scientific field. For more information about GlycoNet, visit www.glyconet.ca

camera & edit: http://www.levroi.nl | event information www.TEDxRoermond.nl "These sugars are the missing link in our food and maybe even the missing link in our medicine." Geiske de Ruig explains us about a new science: Glycobiology, the science of sugars. You musn't confuse these essential sugars with the sugars you put in your coffee or tea. These essential sugars are important for cells to communication with each other. Geiske even advocates the relation of our modern diet and shortage of sugars with the rapid growth of health issues. She will convince you to take control over your own health by adjusting your diet. Everyone can start today! About TEDx, x = independently organized event In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TEDTalks video and live speakers combine to spark deep discussion and connection in a small group. These local, self-organized events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized.

camera & edit: http://www.levroi.nl | event information www.TEDxRoermond.nl "These sugars are the missing link in our food and maybe even the missing link in our medicine." Geiske de Ruig explains us about a new science: Glycobiology, the science of sugars. You musn't confuse these essential sugars with the sugars you put in your coffee or tea. These essential sugars are important for cells to communication with each other. Geiske even advocates the relation of our modern diet and shortage of sugars with the rapid growth of health issues. She will convince you to take control over your own health by adjusting your diet. Everyone can start today! About TEDx, x = independently organized event In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TEDTalks video and live speakers combine to spark deep discussion and connection in a small group. These local, self-organized events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized.

Can gut bugs change the world? Join Warren Peters on a journey into understanding your microbiome and the new discoveries changing the way we understand diabetes, obesity, Alzheimer's disease, autism, and our everyday health and wellness. If asked, he will tell you that the first part of his medical career was in general surgery, where “if something is wrong with you, I will cut it out." The next was dedicated to lifestyle and natural medicines, where “if something is wrong with you, just try harder." And finally, the last part is dedicated to the molecular and genetic basis of obesity, where "if something is wrong with you, it is the fault of your parents and the changing environment." Within these three perspectives, reside the virtues of common sense and wisdom. He obtained his medical degree from Loma Linda University, his surgical training at the Mason Clinic in Seattle Washington, and, his Master’s degree in biostatistics and epidemiology from Loma Linda University. He is privileged to travel and lecture nationally and internationally on topics of nutrition, wholeness, and wellness. He has practiced surgical care, wholistic care, and, primary care in Washington, Maryland, Virginia, and California. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at http://ted.com/tedx

The glycocalyx of the endothelium is an intravascular compartment that creates a barrier between circulating blood and the vessel wall. The glycocalyx is suggested to play an important role in numerous physiological processes including the regulation of vascular permeability, the prevention of the margination of blood cells to the vessel wall, and the transmission of shear stress. Various theoretical models and experimental approaches provide data about changes to the structure and functions of the glycocalyx under various types of inflammatory conditions. These alterations are suggested to promote inflammatory processes in vessels and contribute to the pathogenesis of number of diseases. In this review we summarize current knowledge about the modulation of the glycocalyx under inflammatory conditions and the consequences for the course of inflammation in vessels. The structure and functions of endothelial glycocalyx are briefly discussed in the context of methodological approaches regarding the determination of endothelial glycocalyx and the uncertainty and challenges involved in glycocalyx structure determination. In addition, the modulation of glycocalyx structure under inflammatory conditions and the possible consequences for pathogenesis of selected diseases and medical conditions (in particular, diabetes, atherosclerosis, ischemia/reperfusion, and sepsis) are summarized. Finally, therapeutic strategies to ameliorate glycocalyx dysfunction suggested by various authors are discussed.

Opuntia ficus-indica, commonly referred to as prickly pear or nopal cactus, is a dicotyledonous angiosperm plant. It belongs to the Cactaceae family and is characterized by its remarkable adaptation to arid and semi-arid climates in tropical and subtropical regions of the globe. In the last decade, compelling evidence for the nutritional and health benefit potential of this cactus has been provided by academic scientists and private companies. Notably, its rich composition in polyphenols, vitamins, polyunsaturated fatty acids and amino acids has been highlighted through the use of a large panel of extraction methods. The identified natural cactus compounds and derivatives were shown to be endowed with biologically relevant activities including anti-inflammatory, antioxidant, hypoglycemic, antimicrobial and neuroprotective properties. The present review is aimed at stressing the major classes of cactus components and their medical interest through emphasis on some of their biological effects, particularly those having the most promising expected health benefit and therapeutic impacts.

In this video, we speak to Dr. Matt Macauley (University of Alberta), Dr. Chris Phenix (University of Saskatchewan), Dr. David Vocadlo (Simon Fraser University) and Dr. Jagdeep S. Walia (Queen's University) about the glycomics-based research being done on diseases like Alzheimer's disease and Parkinson's.

Current research efforts are centered on delineating the novel health benefits of naturally derived saccharides, including growing interest in their abilities to influence neurologic health. We performed a comprehensive review of the literature to consolidate ...

Polysaccharides are an important class of phytochemicals, and many studies have demonstrated their beneficial effects in the context of a number of pathologies including neurological disorders. Numerous studies have indicated that polysaccharides exhibit neuroprotection through a variety of mechanis …

Provides a unique forum dedicated to research into the biological functions of glycans, including glycoproteins, glycolipids, proteoglycans and free oligosaccha