Worse Than the Disease Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19 International Journal of Vaccine Theory, Practice, and Research
Operation Warp Speed brought to market in the United States two mRNA vaccines, produced by Pfizer and Moderna. Interim data suggested high efficacy for both of these vaccines, which helped legitimize Emergency Use Authorization (EUA) by the FDA. However, the exceptionally rapid movement of these vaccines through controlled trials and into mass deployment raises multiple safety concerns. In this review we first describe the technology underlying these vaccines in detail. We then review both components of and the intended biological response to these vaccines, including production of the spike protein itself, and their potential relationship to a wide range of both acute and long-term induced pathologies, such as blood disorders, neurodegenerative diseases and autoimmune diseases. Among these potential induced pathologies, we discuss the relevance of prion-protein-related amino acid sequences within the spike protein. We also present a brief review of studies supporting the potential for spike protein “shedding”, transmission of the protein from a vaccinated to an unvaccinated person, resulting in symptoms induced in the latter. We finish by addressing a common point of debate, namely, whether or not these vaccines could modify the DNA of those receiving the vaccination. While there are no studies demonstrating definitively that this is happening, we provide a plausible scenario, supported by previously established pathways for transformation and transport of genetic material, whereby injected mRNA could ultimately be incorporated into germ cell DNA for transgenerational transmission. We conclude with our recommendations regarding surveillance that will help to clarify the long-term effects of these experimental drugs and allow us to better assess the true risk/benefit ratio of these novel technologies.
Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab707/6353927
Background
Post-vaccination myocarditis and pericarditis reported after coronavirus mRNA vaccines.
The effect of accidental intravenous injection of this vaccine on the heart is unknown
Methods in mice
Compared difference between i.m. and i.v. injection of vaccine
Clinical manifestations
Histopathological changes
Tissue mRNA expression
Serum levels of cytokines and troponins
With normal saline (NS) control
Results
Intravenous SARS-CoV-2 mRNA Vaccine Administration Induced Grossly Visible Pathology in Heart
Only IV group developed histopathological changes of myopericarditis
Evidenced by cardiomyocyte degeneration
Apoptosis
Necrosis with adjacent inflammatory cell infiltration
Calcific deposits on visceral pericardium
But
Evidence of coronary artery or other cardiac pathologies was absent
Spike antigen (immunostaining) occasionally found in infiltrating immune cells of the heart
And in cardiomyocytes and intracardiac vascular endothelial cells
The histological changes of myopericarditis after the first IV-priming dose persisted for 2 weeks
and were markedly aggravated by a second IM- or IV-booster dose
Numerous inflammatory cytokines found in cardiac tissue
(interleukin (IL)-1β, interferon (IFN)-β, IL-6, and tumor necrosis factor (TNF)-α)
in the IV group but not the IM group
compatible with presence of myopericarditis in the IV group
Ballooning degeneration of hepatocytes was consistently found in the IV group.
All other organs appeared normal.
Conclusions
In vivo evidence that inadvertent intravenous injection of COVID-19 mRNA vaccines may induce myopericarditis.
Brief withdrawal of syringe plunger to exclude blood aspiration may be one possible way to reduce such risk.
Both Pfizer/BioNTech and Moderna have clearly stated that their vaccines should only be given via IM route
Current CDC and WHO guidelines no longer recommend precautionary measures during IM vaccine administration
The CDC Pink Book 2020 and WHO
2015 position paper have recommended against aspiration prior to vaccine injection so as to minimize pain
Deltoid to the vastus lateralis?
Our study indicates that IV injection of vaccines might partially contribute to this clinical phenotype,
thus warranting a reconsideration of the practice of IM injection without aspiration,
which carries the risk of inadvertent IV injection.
Thrombocytopenia in mice reported in 2006
Blood, (2006)
https://ashpublications.org/blood/article/109/7/2832/125650/Adenovirus-induced-thrombocytopenia-the-role-of
All mice received virus through a single tail vein injection
Thrombocytopenia has been consistently reported following the administration of adenoviral gene transfer vectors.
Link to featured video
https://www.youtube.com/watch?v=ctwX1cz_-dw&t=323s
Link to Wefwafwa’s channel
https://www.youtube.com/channel/UCzsLklGgOttU3Se-WGLp7ow
(he needs more subscribers)
Link to support Wefwafwa’s work in Africa
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Drugs Shown to Inhibit SARS-CoV-2 in COVID-19 Disease: Comparative Basic and Clinical Pharmacology of Molnupiravir and Ivermectin
https://austinpublishinggroup.com/pharmacology-therapeutics/fulltext/ajpt-v9-id1149.pdf
https://www.linkedin.com/in/leslie-adesuyi-ajayi-md-phd-fbpharmacols-fwacp-69154a38/
There are still many nations where vaccines are not yet widely available,
There is a gradual shift in focus, to antiviral drugs,
Adjunctive chemoprophylaxis
Active treatment of new SARS-CoV-2 infections
Post -vaccination breakthrough COVID-19 cases
The two ways to get new drugs
Develop novel antiviral drugs for SARS-CoV-2
Repurpose existing FDA -approved drugs to treat COVID-19
Ivermectin is the most studied “repurposed” medication globally,
in randomized clinical trials, retrospective studies and meta- analyses.
Molnupiravir and Ivermectin Anti-SARS- CoV-2 Mechanisms, Pharmacokinetics and Pharmacodynamics
Molnupiravir is a broad spectrum antiviral agent against SARS- CoV-2, SARS-CoV,
seasonal or pandemic influenza and MERS corona virus
Ivermectin is an FDA-approved, WHO essential drug used as broad spectrum antiparasitic, antibiotic
and which has demonstrated broad spectrum antiviral activity against RNA viruses, including HIV, Zika, MERS corona virus
The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro
https://www.sciencedirect.com/science/article/pii/S0166354220302011
5000-fold inhibition of SARS-CoV-2, (99.98% at 48 hours
The inhibitory concentration IC50 of Molnupiravir shows it to be a more potent anti-SARS-CoV-2 agent, compared to Ivermectin in vitro.
Both molnupiravir and ivermectin are well absorbed after oral dosing
Tmax of molnupiravir being 1-1.75 hours,
With a half life of 7 hours
Tmax of ivermectin is 4-6 hours
Very long half life of 81-91 hours
Ivermectin, being lipophilic has a large volume of distribution
Ivermectin has the ability to accumulate in the lungs
The anti-SARS-CoV-2 actions, both of molnupiravir and ivermectin, are dose and concentration dependent
Molnupiravir active metabolite (NHC-5’ Triphosphate), acts as a competitive alternative substrate for viral RNA
causing viral mutagenesis or mutations, which leads to viral error catastrophe and extinction of replication
There is some concern about the safety of NHC -nucleoside triphosphate, which is also mutagenic to mammalian cells
Ivermectin, multifarious actions,
Binding to SARS-CoV-2 spike protein S
Reducing cell entry via human ACE2 receptors
Reducing viral transcription
Inhibition of cytokine production and inflammation
(not yet been shown for molnupiravir)
Complimentary pharmacokinetics and pharmacodynamics of the drugs
May be additive or synergistic
This should be further investigated in anti-SARS- CoV-2 antiviral combination therapy.
A combination of molnupiravir with Ivermectin putatively, in effects on RdRP or cytokine release.
Cost
https://www.who.int/selection_medicines/committees/expert/21/reviews/Ivermectin_Review1.pdf
The cost for a package of 100 tablets of 3 mg ivermectin is $2.96.
Say, 12mg per day for 5 days = $0.53
Safety
http://www.vigiaccess.org
https://www.who-umc.org/vigibase/vigibase/
Efficacy
Ivermectin
https://pubmed.ncbi.nlm.nih.gov/34145166/
For deaths, average risk ratio 0.38, (62% benefit) (moderate-certainty evidence
https://ivmmeta.com
Early treatment
Late treatment
Prophylaxis
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD015017.pub2/epdf/full
Main results, Treating people in hospital with COVID-19
We don't know whether ivermectin compared with placebo or usual care, 28 days after treatment:–
leads to more or fewer deaths
worsens or improves patients' condition assessed by need for ventilation or oxygen
increases or reduces unwanted events
Preventing COVID-19
We don't know whether ivermectin leads to more or fewer deaths compared with no drug
The FDA has been assuming that nearly all of the adverse events reported in VAERS have been due to "over-reporting" of "background events." In short, there is nothing to see here: it's all noise. This
Fully Vaccinated Are COVID 'Super-Spreaders,' Says Inventor of mRNA
On the latest episode of "The Hidden Gateway" podcast, Dr. Robert Malone, recognized for his role in inventing mRNA vaccine technology, said, "The idea that if you have a workplace where everybody's vaccinated, you're not going to have virus spread is totally false. A total lie."
How Israeli Ministry of Health, deleted thousands of testimonies
I re-posted this from YouTube (where it will surely be censored) to Rumble where it will live on. Original video from Avi Barak Media. This video details on how Israel citizens weren't given a place t
It’s Mandate Mayhem! Southwest Airlines in Disarray; Is Biden’s Vaccine Order Legal?; The Pushback Against Tyranny Goes Viral!; Tech CEO’s New Mandate-Free Job Site Guests: Tammy Clark, Kristen Meghan, Andrew Crapuchettes
Fauci & Becerra Get Ripped A New One; Bombshell W.H.O. Exposé Through The Lens of A Pandemic; More U.S. Health Officials Jump Ship #WhoIsLyingToYou #HindSight2020 #Fauci #HughHewitt #RandPaul #XavierBecerra #NIH #DHHS #NIAID #NaturalImmunity #NaturallyAcquiredImmunity #WHO #Timewarp #SoumyaSwaminathan #GlobalVaccineSafetySummit #VaccineSafety #VaccineSideEffects #Proof #TheHighwire #DelBigtree #HW236
Leaked Dept. of Defense Document Reveals Evidence of Widespread
A leaked Department of Defense document first reported on by attorney Tom Rentz reveals high rates of "breakthrough" infections (4% of which died) and hospitalizations within a cohort of 5.6 million Medicare beneficiaries all of whom were fully vaccinated.
TFNT9 CDC and FDA vaccine committees fail to spot any safety signals (15 minute version) Steve Kirsch
I tried to tell them that there were huge safety signals being generated in VAERS and that the CDC detection algorithm was flawed. They ignored me. So now they get to star in their own video where I expose the total incompetence of all the committee members. Not only did they FAIL to spot over 1,000 safety signals on their own, but even after it was expressly pointed out to them, they couldn't recognize them either. This is unacceptable. They should all resign. America deserves better than this. Slides: https://www.skirsch.com/covid/TFNT9.pdf Full 60 minute video: https://rumble.com/vn3y22-tfnt9-cdc-and-fda-vaccine-committee-members-should-resign-for-failing-to-sp.html Follow me at gab.com/stkirsch
This video explains what the real myocarditis rates are based on the VAERS data. The rates are as high as 1 in 318 for 16-year-old boys an elevation of over 1,000 times weekly baseline. Nobody is meas
Clinical outcomes after early ambulatory multidrug therapy for high-risk SARS-CoV-2 (COVID-19) infection - PubMed
There is an emergency need for early ambulatory treatment of Coronavirus Disease 2019 (COVID-19) in acutely ill patients in an attempt to reduce disease progression and the risks of hospitalization and death. Such management should be applied in high-risk patients age > 50 years or with one or mo …
Early multidrug treatment of SARS-CoV-2 infection (COVID-19) and reduced mortality among nursing home (or outpatientambulatory) residents
The outbreak of COVID-19 from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread all over the world with tremendous morbidity and mortality in the elderly. In-hospital treatment addresses the multifaceted nature of the illness including ...