Ivermectin is effective for COVID-19 meta analysis of 23 studies
Ivermectin for COVID-19. Early treatment - 78% improvement, p < 0.0001. All studies - 71% improvement, p < 0.0001. 1 in 9 trillion probability results of the 58 studies are from an ineffective treatment (p = 1.1e-13).
Ivermectin Works For COVID-19 - LATEST STUDIES - YouTube
Ivermectin Works For COVID-19 - LATEST STUDIES
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Original in-vitro study about Ivermectin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129059/
A study from bangladesh found that Ivermectin + Doxyclyclin significantly reduces mortality and morbidity in COVID-19 patients.
https://clinicaltrials.gov/ct2/show/study/NCT04523831
A systemic review of the antiviral activity of Ivermectin
https://www.nature.com/articles/s41429-020-0336-z
https://journal.chestnet.org/article/S0012-3692(20)34898-4/fulltext
PDF for the above study after it was accepted
https://journal.chestnet.org/article/S0012-3692(20)34898-4/pdf
Pre-print of the above study
https://www.medrxiv.org/content/10.1101/2020.06.06.20124461v2
A search of various Ivermectin studies for your reading pleasure
https://clinicaltrials.gov/ct2/results?cond=Covid19&term=ivermectin&cntry=&state=&city=&dist=
Iota carrageenan and Ivermectin oral drops
https://clinicaltrials.gov/ct2/show/results/NCT04425850?term=ivermectin&cond=Covid19&draw=2
JMIR Research Protocols - Efficacy and Safety of High-Dose Ivermectin for Reducing Malaria Transmission (IVERMAL) Protocol for a Double-Blind, Randomized, Placebo
Background: Innovative approaches are needed to complement existing tools for malaria elimination. Ivermectin is a broad spectrum antiparasitic endectocide clinically used for onchocerciasis and lymphatic filariasis control at single doses of 150 to 200 mcg/kg. It also shortens the lifespan of mosquitoes that feed on individuals recently treated with ivermectin. However, the effect after a 150 to 200 mcg/kg oral dose is short-lived (6 to 11 days). Modeling suggests higher doses, which prolong the mosquitocidal effects, are needed to make a significant contribution to malaria elimination. Ivermectin has a wide therapeutic index and previous studies have shown doses up to 2000 mcg/kg (ie, 10 times the US Food and Drug Administration approved dose) are well tolerated and safe; the highest dose used for onchocerciasis is a single dose of 800 mcg/kg. Objective: The aim of this study is to determine the safety, tolerability, and efficacy of ivermectin doses of 0, 300, and 600 mcg/kg/day for 3 days, when provided with a standard 3-day course of the antimalarial dihydroartemisinin-piperaquine (DP), on mosquito survival. Methods: This is a double-blind, randomized, placebo-controlled, parallel-group, 3-arm, dose-finding trial in adults with uncomplicated malaria. Monte Carlo simulations based on pharmacokinetic modeling were performed to determine the optimum dosing regimens to be tested. Modeling showed that a 3-day regimen of 600 mcg/kg/day achieved similar median (5 to 95 percentiles) maximum drug concentrations (Cmax) of ivermectin to a single of dose of 800 mcg/kg, while increasing the median time above the lethal concentration 50% (LC50, 16 ng/mL) from 1.9 days (1.0 to 5.7) to 6.8 (3.8 to 13.4) days. The 300 mcg/kg/day dose was chosen at 50% of the higher dose to allow evaluation of the dose response. Mosquito survival will be assessed daily up to 28 days in laboratory-reared Anopheles gambiae s.s. populations fed on patients’ blood taken at days 0, 2 (Cmax), 7 (primary outcome), 10, 14, 21, and 28 after the start of treatment. Safety outcomes include QT-prolongation and mydriasis. The trial will be conducted in 6 health facilities in western Kenya and requires a sample size of 141 participants (47 per arm). Sub-studies include (1) rich pharmacokinetics and (2) direct skin versus membrane feeding assays. Results: Recruitment started July 20, 2015. Data collection was completed July 2, 2016. Unblinding and analysis will commence once the database has been completed, cleaned, and locked. Conclusions: High-dose ivermectin, if found to be safe and well tolerated, might offer a promising new tool for malaria elimination.
The Approved Dose of Ivermectin Alone is not the Ideal Dose for the Treatment of COVID-19 - Schmith - 2020 - Clinical Pharmacology & Therapeutics - Wiley Online Library
Caly et al.1 reported that ivermectin inhibited severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) in vitro for up to 48 hours using ivermectin at 5 μM. The concentration resulting in 50% i...
It’s been over six weeks since Iowa dropped all state-level COVID restrictions, and surprise, surprise, hospitalized patients are down 54 percent. But if you try to Google this information, all you will see is death, dying, and it must be the end of the world because of COVID, which miraculously seems to be a cure... View Article
Ivermectin Dose For COVID (Prophylaxis, Acute Disease, Long Haulers) - YouTube
In this talk, we will discuss the possible dose of Ivermectin for prophylaxis, during the acute disease, and for the long haulers.
We will look at the dosage used by various studies, myself for my patients, and recommended by the physicians at FLCCC.net.
Note: this is not a prescription. This material is for the educational purpose only.
Ivermectin Works For COVID-19 - LATEST STUDIES - YouTube
Ivermectin Works For COVID-19 - LATEST STUDIES
More lectures on drbeen.com
Looking to support my educational work? Donate here:
https://paypal.me/mobeensyed?locale.x=en_US
Start your free trial - no credit card needed:
https://members.drbeen.com/freetrial
Original in-vitro study about Ivermectin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129059/
A study from bangladesh found that Ivermectin + Doxyclyclin significantly reduces mortality and morbidity in COVID-19 patients.
https://clinicaltrials.gov/ct2/show/study/NCT04523831
A systemic review of the antiviral activity of Ivermectin
https://www.nature.com/articles/s41429-020-0336-z
https://journal.chestnet.org/article/S0012-3692(20)34898-4/fulltext
PDF for the above study after it was accepted
https://journal.chestnet.org/article/S0012-3692(20)34898-4/pdf
Pre-print of the above study
https://www.medrxiv.org/content/10.1101/2020.06.06.20124461v2
A search of various Ivermectin studies for your reading pleasure
https://clinicaltrials.gov/ct2/results?cond=Covid19&term=ivermectin&cntry=&state=&city=&dist=
Iota carrageenan and Ivermectin oral drops
https://clinicaltrials.gov/ct2/show/results/NCT04425850?term=ivermectin&cond=Covid19&draw=2
Microvascular dysfunction in COVID-19 the MYSTIC study SpringerLink
Rationale Pre-clinical and autopsy studies have fueled the hypothesis that a dysregulated vascular endothelium might play a central role in the pathogenesis of ARDS and multi-organ failure in COVID-19. Objectives To comprehensively characterize and quantify microvascular alterations in patients with COVID-19. Methods Hospitalized adult patients with moderate-to-severe or critical COVID-19 (n = 23) were enrolled non-consecutively in this prospective, observational, cross-sectional, multi-center study. Fifteen healthy volunteers served as controls. All participants underwent intravital microscopy by sidestream dark field imaging to quantify vascular density, red blood cell velocity (VRBC), and glycocalyx dimensions (perfused boundary region, PBR) in sublingual microvessels. Circulating levels of endothelial and glycocalyx-associated markers were measured by multiplex proximity extension assay and enzyme-linked immunosorbent assay. Measurements and main results COVID-19 patients showed an up to 90% reduction in vascular density, almost exclusively limited to small capillaries (diameter 4–6 µm), and also significant reductions of VRBC. Especially, patients on mechanical ventilation showed severe glycocalyx damage as indicated by higher PBR values (i.e., thinner glycocalyx) and increased blood levels of shed glycocalyx constituents. Several markers of endothelial dysfunction were increased and correlated with disease severity in COVID-19. PBR (AUC 0.75, p = 0.01), ADAMTS13 (von Willebrand factor-cleaving protease; AUC 0.74, p = 0.02), and vascular endothelial growth factor A (VEGF-A; AUC 0.73, p = 0.04) showed the best discriminatory ability to predict 60-day in-hospital mortality. Conclusions Our data clearly show severe alterations of the microcirculation and the endothelial glycocalyx in patients with COVID-19. Future therapeutic approaches should consider the importance of systemic vascular involvement in COVID-19.
Nebulizing Magnesium and other natural medicinals as Iodine, Sodium Bicarbonate, peroxide and glutathione are strong treatment options that deliver the medicinals directly to the tracheobronchial tree.
NEW Study Shows HYDR0XYCHL0R0QUlNE Cuts COVID Death Rate In Half - YouTube
It is the most controversial word on social media HYDR0X0YCHL0RQUlNE.What is the truth about this drug? Turns out there was a study done in 2005 that found it could treat another C0R0NAVlRUS known as SARS and there has now been a full peer reviewed study that proves HCQ actually cut the death rate in half. Watch and share this video before its taken down!
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Nutrients Free Full-Text Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19 HTML
There are limited proven therapies for COVID-19. Vitamin C’s antioxidant, anti-inflammatory and immunomodulating effects make it a potential therapeutic candidate, both for the prevention and amelioration of COVID-19 infection, and as an adjunctive therapy in the critical care of COVID-19. This literature review focuses on vitamin C deficiency in respiratory infections, including COVID-19, and the mechanisms of action in infectious disease, including support of the stress response, its role in preventing and treating colds and pneumonia, and its role in treating sepsis and COVID-19. The evidence to date indicates that oral vitamin C (2–8 g/day) may reduce the incidence and duration of respiratory infections and intravenous vitamin C (6–24 g/day) has been shown to reduce mortality, intensive care unit (ICU) and hospital stays, and time on mechanical ventilation for severe respiratory infections. Further trials are urgently warranted. Given the favourable safety profile and low cost of vitamin C, and the frequency of vitamin C deficiency in respiratory infections, it may be worthwhile testing patients’ vitamin C status and treating them accordingly with intravenous administration within ICUs and oral administration in hospitalised persons with COVID-19.
Opinion Early Outpatient Treatment of Symptomatic, High-Risk Covid-19 Patients that Should be Ramped-Up Immediately as Key to the Pandemic Crisis
Abstract. More than 1.6 million Americans have been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and more than 10 times that numb
Zinc and respiratory tract infections Perspectives for COVID-19 (Review)
In view of the emerging COVID-19 pandemic caused by SARS-CoV-2 virus, the search for potential protective and therapeutic antiviral strategies is of particular and urgent interest. Zinc is known to modulate antiviral and antibacterial immunity and regulate ...
Bicarbonate Proves to be Cheapest Fastest Safest COVID Treatment
One does not have to be an anti-vaxxer to see and understand that COVID vaccines are not needed. They are not required legally or for any medical or public health reason to treat or prevent COVID-19. There is a broad range of both natural and pharmaceutical treatments widely available, many already proven to be very... View Article
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread
Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available.We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection ...