Oral trehalose improves histological and behavior symptoms of mucopolysaccharidosis type II in iduronate 2-sulfatase deficient mice | Scientific Reports
Mucopolysaccharidosis type II (MPS II) is caused by a deficiency in iduronate-2-sulfatase (Ids), an enzyme that catabolizes glycosaminoglycan (GAG). Ids insufficiency results in the accumulation of GAG in various organs, ultimately resulting in multisystemic disease. Trehalose, a non-reducing disaccharide, has shown protective effects against various diseases. However, its potential utility through oral administration in MPS II has not yet been explored. In the present study, to investigate the efficacy of oral trehalose in Ids-knock-out (KO) mice, Ids-KO and wild type (WT) mice were treated with 2% trehalose dissolved in distilled water ad libitum for 24 weeks. Histological analysis revealed that almost all tissues from Ids-KO mice exhibited abnormal changes, including large vacuolization, inflammatory cell infiltration, and GAG deposition. However, oral administration of trehalose significantly suppressed GAG levels, vacuolization, inflammation and apoptosis in the spleen and brain. Additionally, oral trehalose considerably improved cognitive functions, such as short-term spatial learning and working memory, alongside limited improvements in walking capacity in Ids-KO mice. These results suggest that oral trehalose can reduce GAG accumulation, vacuolization and the number of apoptotic and inflammatory cells in pathological tissues including the brain, ultimately considerably improving spontaneous alteration behavior and could be a promising treatment option for MPS II.
10 Natural Substances for Type 1 Diabetes | GreenMedInfo | Blog entry
Could long sought-after support for type 1 diabetes be as close as your kitchen cupboard? An accumulating body of scientific research appears to point in exactly that direction
Ivermectin 12 mg capsules for parasitic infections in humans and animals. Investigational use in cancer treatment. 100 capsules per bottle. High quality and purity.
Hempseed Water-Soluble Protein Fraction and Its Hydrolysate Display Different Biological Features
Hempseeds, from the Cannabis sativa plant, and its derivates are a versatile food option for various dietary preferences. Due to their aminoacidic profile, researchers have studied the presence of bioactive peptides in hempseed proteins. In this study, the water-soluble fraction of hempseed protein was extracted, and the derived peptides were analyzed. The investigation focused on their biological function, particularly their antioxidant activity. Several biological functions have arisen, such as angiotensin-converting enzyme inhibition activity, dipeptidyl-peptidase IV, dipeptidyl-peptidase III inhibition, and ubiquitin-mediated proteolysis activation. The hydrolysates show greater 2,2-azinobis-[3-ethylbenzothiazoline-6-sulphonic acid (ABTS) radical scavenging activity compared to the proteins (97.95 ± 4.48 versus 81.04 ± 10.63). Furthermore, the impact of these proteins and peptides on the U937 cell line was evaluated to assess cell viability and their potential role in modulating inflammation associated with gastrointestinal autoimmune diseases. Protein treatment resulted in a significant reduction in cell viability, as opposed to hydrolysates, which did not affect it.
What Big Pharma Doesn’t Want You to Know About Statins | Dr. Aseem Malhotra - YouTube
Have you ever wondered if cholesterol-lowering statins are as effective as they claim? In this episode, Dr. Mark Hyman and Dr. Aseem Malhotra reveal the truth about these medications and the pharmaceutical industry’s influence on your health.
Discover why lifestyle changes like diet and exercise can be more powerful than pills, and how misleading studies have shaped what we believe about heart health.
In this episode, we discuss:
-Big pharma’s influence on medical research
-The benefits, drawbacks, and misuse of statins
-The Role of Insulin Resistance in Heart Disease
-The Importance of Lifestyle Over Medication
-The Impact of Meditation on Heart Disease
View Show Notes From This Episode: https://drhyman.com/blogs/content/podcast-ep1003
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Review of Calls for Market Removal of COVID-19 Vaccines Intensify: Risks Far Outweigh Theoretical Benefits - Science, Public Health Policy and the Law
COVID-19 vaccination campaigns around the globe have failed to meet fundamental standards of safety and efficacy, leading to mounting evidence of significant
10 Bad Things STATIN Drugs do in Your Body (Statin Side Effects) - 2024 - YouTube
You may be under the impression that statin drugs are safe and side-effect free. In fact, you doctor may even believe this. Fact is, statin drugs have numerous side effects, some quite serious. This video explains 10 worrisome things that statin drugs can do to your body. Everyone taking a statin needs this video shared with them...
The research supporting statin drugs is very weak, and the statin side effects often make the possible benefit not worth the risk. Don't blindly believe high cholesterol is bad for your health, do your research.
LIES MY DOCTOR TOLD ME: https://amzn.to/3CgUbo8
Daily Minerals: https://bit.ly/MineralFix (discount)
Research:
*Lower Vitamin K2 Production in Kidney:
https://academic.oup.com/jn/article/149/3/416/5310051
*Lower Testosterone:
https://care.diabetesjournals.org/content/32/4/541
https://www.ncbi.nlm.nih.gov/pubmed/24462564
*Increase Diabetes Risk:
https://www.ncbi.nlm.nih.gov/pubmed/20167359/
https://onlinelibrary.wiley.com/doi/full/10.1002/dmrr.3189
*Lower CoQ-10:
https://www.ncbi.nlm.nih.gov/pubmed/26192349
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096178/
*Increase Liver Enzymes:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766774/
*Lower Energy Level:
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1183454
https://www.ncbi.nlm.nih.gov/pubmed/29040646
*Lowers DHEA:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348753/
*Worsens Memory:
https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/1918928
*Increase Shingles Risk:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198263
https://academic.oup.com/cid/article/58/3/350/340216
*Increase E.D.:
https://www.ncbi.nlm.nih.gov/pubmed/11818357
https://www.ncbi.nlm.nih.gov/pubmed/19530745
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Common Statin Drugs:
- atorvastatin (Lipitor)
- fluvastatin (Lescol)
- lovastatin (Altoprev)
- pravastatin (Pravachol)
- rosuvastatin (Crestor)
- simvastatin (Zocor)
- pitavastatin (Livalo)
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Ken D Berry, MD, is a Family Physician with over 20 years of clinical practice.