2016

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Oral trehalose improves histological and behavior symptoms of mucopolysaccharidosis type II in iduronate 2-sulfatase deficient mice | Scientific Reports
Oral trehalose improves histological and behavior symptoms of mucopolysaccharidosis type II in iduronate 2-sulfatase deficient mice | Scientific Reports
Mucopolysaccharidosis type II (MPS II) is caused by a deficiency in iduronate-2-sulfatase (Ids), an enzyme that catabolizes glycosaminoglycan (GAG). Ids insufficiency results in the accumulation of GAG in various organs, ultimately resulting in multisystemic disease. Trehalose, a non-reducing disaccharide, has shown protective effects against various diseases. However, its potential utility through oral administration in MPS II has not yet been explored. In the present study, to investigate the efficacy of oral trehalose in Ids-knock-out (KO) mice, Ids-KO and wild type (WT) mice were treated with 2% trehalose dissolved in distilled water ad libitum for 24 weeks. Histological analysis revealed that almost all tissues from Ids-KO mice exhibited abnormal changes, including large vacuolization, inflammatory cell infiltration, and GAG deposition. However, oral administration of trehalose significantly suppressed GAG levels, vacuolization, inflammation and apoptosis in the spleen and brain. Additionally, oral trehalose considerably improved cognitive functions, such as short-term spatial learning and working memory, alongside limited improvements in walking capacity in Ids-KO mice. These results suggest that oral trehalose can reduce GAG accumulation, vacuolization and the number of apoptotic and inflammatory cells in pathological tissues including the brain, ultimately considerably improving spontaneous alteration behavior and could be a promising treatment option for MPS II.
·nature.com·
Oral trehalose improves histological and behavior symptoms of mucopolysaccharidosis type II in iduronate 2-sulfatase deficient mice | Scientific Reports
Hempseed Water-Soluble Protein Fraction and Its Hydrolysate Display Different Biological Features
Hempseed Water-Soluble Protein Fraction and Its Hydrolysate Display Different Biological Features
Hempseeds, from the Cannabis sativa plant, and its derivates are a versatile food option for various dietary preferences. Due to their aminoacidic profile, researchers have studied the presence of bioactive peptides in hempseed proteins. In this study, the water-soluble fraction of hempseed protein was extracted, and the derived peptides were analyzed. The investigation focused on their biological function, particularly their antioxidant activity. Several biological functions have arisen, such as angiotensin-converting enzyme inhibition activity, dipeptidyl-peptidase IV, dipeptidyl-peptidase III inhibition, and ubiquitin-mediated proteolysis activation. The hydrolysates show greater 2,2-azinobis-[3-ethylbenzothiazoline-6-sulphonic acid (ABTS) radical scavenging activity compared to the proteins (97.95 ± 4.48 versus 81.04 ± 10.63). Furthermore, the impact of these proteins and peptides on the U937 cell line was evaluated to assess cell viability and their potential role in modulating inflammation associated with gastrointestinal autoimmune diseases. Protein treatment resulted in a significant reduction in cell viability, as opposed to hydrolysates, which did not affect it.
·mdpi.com·
Hempseed Water-Soluble Protein Fraction and Its Hydrolysate Display Different Biological Features
How to Naturally Enhance Blood Flow and Vascular Health - YouTube
How to Naturally Enhance Blood Flow and Vascular Health - YouTube
Dr. Nathan Bryan explains the importance of proper blood flow for overall health and provides actionable tips to improve circulation naturally. Learn about the role of nitric oxide, lifestyle changes, and foods that support vascular health. Discover how better circulation can enhance energy levels, boost heart health, and improve your overall well-being. Watch now to take control of your vascular health and unlock the secrets to better blood flow. #health #hearthealth #wellness Supercharge Your Health with Clinically Proven Nitric Oxide Solutions – Visit Now https://n1o1.com 🔔 Boost Your Health with Nitric Oxide: Unlock Its Secrets for Peak Performance & Wellbeing. Subscribe Now! https://www.youtube.com/@DrNathanSBryanNitricOxide/?sub_confirmation=1 ✅Important Links to Follow 🔗Linktree https://linktr.ee/n1o1 🔗 Bryan Nutriceuticals https://no2u.com/ ✅ Stay Connected With Us. 👉Facebook: https://www.facebook.com/pneumanitricoxide/ 👉Instagram: https://www.instagram.com/n1o1.by.pneuma.nitric.oxide/ 👉Website: https://drnathansbryan.com/ ============================= ✅ Recommended Playlists 👉 Redefining Medicine - Dr. Nathan Bryan https://www.youtube.com/watch?v=iK9JzHpNdHM&list=PLZm8V0VIi2Y43P1qewE4uZv8mkpW_xm_Y&pp=iAQB 👉 Shorts https://www.youtube.com/watch?v=ztMZuUVyuHk&list=PLZm8V0VIi2Y6JJMHY7CeVvlOGVVAiQqhf&pp=iAQB ✅ Other Videos You Might Be Interested In Watching: 👉 Unlocking the Power of Nitric Oxide: Transforming Modern Medicine & Patient Care https://www.youtube.com/watch?v=tmj9FZqIV2g 👉 Disclosures and transparency on companies and products in which I am and am not involved. https://www.youtube.com/watch?v=o5kr_IeWnVk&t=18s 👉 Regenacast Podcast interview with Sean Berman of Cell Surgical Network. https://www.youtube.com/watch?v=9cwx4nIM9Mw&t=29s 👉 Sugar Crush Podcast with Dr. Rick Jacoby and Dr. Nathan S Bryan https://www.youtube.com/watch?v=cwo71eKe_Ic 👉 There is only one way to deliver nitric oxide to the human body. https://www.youtube.com/watch?v=nN2275k89ic ============================= ✅ About Dr Nathan Bryan Nitric Oxide. Nathan S. Bryan, Ph.D CEO/FOUNDER OF NO2U & NITRIC OXIDE LEADING EXPERT Dr. Bryan has made many seminal discoveries in the Nitric Oxide field, resulting in over a dozen U.S. and International patents. He is also a successful entrepreneur who has brought his Nitric Oxide technology to consumers. Dr. Bryan has published many highly cited papers and authored or edited five books. His work has made him a recognized international leader in molecular medicine and Nitric Oxide biochemistry. If your body can't make Nitric Oxide, we are here to help! 🔔 Nitric oxide: Your secret weapon for health, performance & longevity. Subscribe & unlock the knowledge! https://www.youtube.com/@DrNathanSBryanNitricOxide/?sub_confirmation=1 ================================= ⚠️DISCLAIMER: We do not accept any liability for any loss or damage incurred from you acting or not acting as a result of watching any of our publications. You acknowledge that you use the information we provide at your own risk. Do your research. Copyright Notice: This video and our YouTube channel contain dialogue, music, and images that are the property of Dr Nathan Bryan Nitric Oxide. You are authorized to share the video link and channel and embed this video in your website or others as long as a link back to our YouTube channel is provided. © Dr Nathan Bryan Nitric Oxide
·youtube.com·
How to Naturally Enhance Blood Flow and Vascular Health - YouTube
What Big Pharma Doesn’t Want You to Know About Statins | Dr. Aseem Malhotra - YouTube
What Big Pharma Doesn’t Want You to Know About Statins | Dr. Aseem Malhotra - YouTube
Have you ever wondered if cholesterol-lowering statins are as effective as they claim? In this episode, Dr. Mark Hyman and Dr. Aseem Malhotra reveal the truth about these medications and the pharmaceutical industry’s influence on your health. Discover why lifestyle changes like diet and exercise can be more powerful than pills, and how misleading studies have shaped what we believe about heart health. In this episode, we discuss: -Big pharma’s influence on medical research -The benefits, drawbacks, and misuse of statins -The Role of Insulin Resistance in Heart Disease -The Importance of Lifestyle Over Medication -The Impact of Meditation on Heart Disease View Show Notes From This Episode: https://drhyman.com/blogs/content/podcast-ep1003 Get Free Weekly Health Tips from Dr. Hyman: https://drhyman.com/picks/?utm_source=podcast&utm_medium=banner&utm_campaign=shownotes Sign Up for Dr. Hyman’s Weekly Longevity Journal: https://drhyman.com/longevity/?utm_source=podcast&utm_medium=banner&utm_campaign=shownotes This episode is brought to you by BonCharge, Timeline, Paleovalley, and AirDoctor. Order BON CHARGE’s Max Red Light Therapy device today and get 15% off. Visit BonCharge.com and use code DRMARK for 15% off. Support essential mitochondrial health and save 10% on Mitopure. Visit Timeline.com/DrHyman to get 10% off today. Get nutrient-dense, whole foods. Head to Paleovalley.com/Hyman for 15% off your first purchase. Get cleaner air. Right now, you can get up to $300 off at AirDoctorPro.com/DRHYMAN.
·youtube.com·
What Big Pharma Doesn’t Want You to Know About Statins | Dr. Aseem Malhotra - YouTube
Energy Enhancement System Eagle and Boise Idaho · Eagle Regenerative Medicine - Eagle, Idaho
Energy Enhancement System Eagle and Boise Idaho · Eagle Regenerative Medicine - Eagle, Idaho
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·eagleregenerativemedicine.com·
Energy Enhancement System Eagle and Boise Idaho · Eagle Regenerative Medicine - Eagle, Idaho
Review of Calls for Market Removal of COVID-19 Vaccines Intensify: Risks Far Outweigh Theoretical Benefits - Science, Public Health Policy and the Law
Review of Calls for Market Removal of COVID-19 Vaccines Intensify: Risks Far Outweigh Theoretical Benefits - Science, Public Health Policy and the Law
COVID-19 vaccination campaigns around the globe have failed to meet fundamental standards of safety and efficacy, leading to mounting evidence of significant
·publichealthpolicyjournal.com·
Review of Calls for Market Removal of COVID-19 Vaccines Intensify: Risks Far Outweigh Theoretical Benefits - Science, Public Health Policy and the Law
10 Bad Things STATIN Drugs do in Your Body (Statin Side Effects) - 2024 - YouTube
10 Bad Things STATIN Drugs do in Your Body (Statin Side Effects) - 2024 - YouTube
You may be under the impression that statin drugs are safe and side-effect free. In fact, you doctor may even believe this. Fact is, statin drugs have numerous side effects, some quite serious. This video explains 10 worrisome things that statin drugs can do to your body. Everyone taking a statin needs this video shared with them... The research supporting statin drugs is very weak, and the statin side effects often make the possible benefit not worth the risk. Don't blindly believe high cholesterol is bad for your health, do your research. LIES MY DOCTOR TOLD ME: https://amzn.to/3CgUbo8 Daily Minerals: https://bit.ly/MineralFix (discount) Research: *Lower Vitamin K2 Production in Kidney: https://academic.oup.com/jn/article/149/3/416/5310051 *Lower Testosterone: https://care.diabetesjournals.org/content/32/4/541 https://www.ncbi.nlm.nih.gov/pubmed/24462564 *Increase Diabetes Risk: https://www.ncbi.nlm.nih.gov/pubmed/20167359/ https://onlinelibrary.wiley.com/doi/full/10.1002/dmrr.3189 *Lower CoQ-10: https://www.ncbi.nlm.nih.gov/pubmed/26192349 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096178/ *Increase Liver Enzymes: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766774/ *Lower Energy Level: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1183454 https://www.ncbi.nlm.nih.gov/pubmed/29040646 *Lowers DHEA: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348753/ *Worsens Memory: https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/1918928 *Increase Shingles Risk: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198263 https://academic.oup.com/cid/article/58/3/350/340216 *Increase E.D.: https://www.ncbi.nlm.nih.gov/pubmed/11818357 https://www.ncbi.nlm.nih.gov/pubmed/19530745 COMMON SENSE LABS Book: https://amzn.to/3PcTe9b Become a PATRON & Ask Dr Berry your questions: https://bit.ly/DrBerrysCommunity Common Statin Drugs: - atorvastatin (Lipitor) - fluvastatin (Lescol) - lovastatin (Altoprev) - pravastatin (Pravachol) - rosuvastatin (Crestor) - simvastatin (Zocor) - pitavastatin (Livalo) PHD/BBB&E Tshirts/Tanks/Hoodies: https://ShopPHD.com Eat REAL SALT: https://shop.redmond.life/?afmc=DRBERRY (discount) ------- Join me and let's optimize your health! -------- Eat Real Meat: https://bit.ly/USmeatDiscount (discount = BERRY) Thanks so much to our Prime & Champion Patrons, Chris B, 2KrazyKetos, Rob P, Linda W, Margaret B, Kim S, Vaneesa C, Ben & Carla, Jennifer M, Bob C, Denise M, Jamie S, Shawn J, Tonya B, Shahem Z, B B, Lori B, Shannon H, Suzanne C, William K, Mitzi C, Sam B, Julie L, Tia G, Dean Z, John C, Rumi K, Doyle R, Jeff P, Molly K, Jose A and Amanda W for helping make this video possible. 🍶 All KETO/Low-Carb things we LOVE⏩ https://www.amazon.com/shop/neishalovesit 🍳 FACEBOOK: https://www.facebook.com/kendberry.md/ INSTAGRAM: https://www.instagram.com/kendberry.md/ TWITTER: https://twitter.com/KenDBerryMD VERO:@kendberrymd TikTok:@kendberrymd Ken D Berry, MD, is a Family Physician with over 20 years of clinical practice.
·youtube.com·
10 Bad Things STATIN Drugs do in Your Body (Statin Side Effects) - 2024 - YouTube