2016

C-diff is a bacterium that causes a life-threatening infection. Though the bacterium can infect healthy individuals, it is of particular concern to those who are hospitalized or are taking

Researchers have discovered that the devastating bacterial superbug Clostridioides difficile hijacks the human wound healing system in order to cause serious and persistent disease, opening up the development of new therapies to treat the disease.

c ribotypes of C. difficile harbour mutations or have acquired extra genes that mean these strains can utilize lower concentrations of bioavailable trehalose, providing a competitive metabolic advantage in some CDI animal models. By contrast, evidence has emerged to show that trehalose-induced microbiota changes can help protect/reduce CDI in other models. In addition, C. difficile trehalose metabolic variants are widespread among epidemic and nonepidemic ribotypes alike, and the occurrence of these trehalose variants was not associated with increase disease severity or mortality. Summary Currently, there is no proven causal association between the incidence or severity of human CDI and the presence of trehalose metabolism variants. Furthermore, microbial metabolism reduces trehalose bioavailability, potentially removing this competitive advantage for C. difficile trehalose metabolism variants. Taken together, trehalose consumed as part of a normal diet has no increased risk of CDI....

Fidaxomicin has been scrutinized because of its high acquisition cost. Real-world experience is needed to determine whether fidaxomicin has value in patients with Clostridium difficile–associated diarrhea (CDAD) and certain risk factors.In this ...

Clostridium difficile disease has recently increased to become a dominant nosocomial pathogen in North America and Europe, although little is known about what has driven this emergence. Here we show that two epidemic ribotypes (RT027 and RT078) have acquired unique mechanisms to metabolize low conce …

The consumption of dietary supplements and cold therapies containing high concentrations of zinc is now being called into question, following research that suggests it may worsen Clostridium difficile infection.

Two hypervirulent ribotypes of the enteric pathogen Clostridium difficile, RT027 and RT078, have independently acquired unique mechanisms to metabolize low concentrations of the disaccharide trehalose, suggesting a correlation between the emergence of these ribotypes and the widespread adoption of trehalose in the human diet.

This Medical News article discusses whether trehalose, a sugar manufactured from cornstarch used to sweeten and texturize foods, has contributed to the emergence of epidemic strains of Clostridium difficile infection (CDI).

The increasing frequency and severity of healthcare-associated outbreaks caused by bacterium Clostridium difficile have been linked to the widely used...

Learn more about this infectious disease that is becoming more common and often affects older adults in a health care facility, often after antibiotic use.

Rough notes from the webinar The Scientist: Precision Medicine Learning Lessons from the Microbiome (now available online)

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What is fidaxomicin? (Dificid/Dificlr) Why is it effective against C Difficile? Find out more about the drug and the disease here

National Institute for Health Research. Gut model experiments only: Hayashibara Co. Ltd.

Abstract. In a case–control study of patients with Clostridium difficile infection, we found no statistically significant association between the presence of tr

Bile acids, which are altered by bacteria normally living in the large intestine, inhibit the growth of Clostridium difficile, new research indicates. The work sheds light on the ways in which some commonly used antibiotics can promote C. diff infections by killing off the bile acid-altering microbes.

Abstract. Whole-genome sequencing was used to determine whether the reductions in recurrence of Clostridium difficile infection observed with fidaxomicin in piv

C.Difficile sickens 500,000 every year. It contributes to the death of up to 30,000. Discover what you can do to prevent, treat and understand c diff

Dr. Doug Spiel Talks Stem Cell & Regenerative Therapies in Orlando

Duncan Ross, Ph D , Douglas Spiel, MD sit and discuss Exosomes and Biomass indexing.

Dr. Duncan Ross and Dr. Doug Spiel talk anti-aging and longevity implications of placental derived mesenchymal stem cell exosomes

Treatment of burn injuries with Mesenchymal stem cells (MSCs) is a great promise due to their unique properties. As two natural and functional wound d…

Researchers have isolated a human monoclonal antibody that can 'neutralize' the West Nile virus and potentially prevent a leading cause of viral encephalitis (brain inflammation) in the United States.

Dr. Jason Sanders gives an overview of his perspective of regenerative aesthetics and some of the emerging applications of MSC Exosomes.

Take a quick tour through the last 20 years of regenerative medicine, bone marrow transplantation, amniotic fluid exosomes and purified exosome derived growth factors. The future of stem cells is cell free, and Kimera Labs has been providing purified exosomes for that goal since 2014, pioneering what will become the penicillin of our generation. Here's how we do it.

Exosomes released from different types of host cells have different biological effects. We report that exosomes released from retinal astroglial cells (RACs) suppress retinal vessel leakage and inhibit choroidal neovascularization (CNV) in a laser-induced ...