2016

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Marine Drugs | Free Full-Text | Fucoidan as a Promising Drug for Pain Treatment: Systematic Review and Meta-Analysis
Marine Drugs | Free Full-Text | Fucoidan as a Promising Drug for Pain Treatment: Systematic Review and Meta-Analysis
Fucoidan is a polymer of L-fucose and L-fucose-4-sulphate naturally found in marine sources that inhibits p-selectin, preventing neutrophil recruitment to the site of injury. Fucoidan is employed in many studies as a tool to investigate the contribution of neutrophils to pain, showing analgesic effects. We performed a systematic review and meta-analysis to quantify the analgesic effects of pretreatment with fucoidan reported in the available preclinical studies. In addition, we summarized the articles which have studied the therapeutic effects of fucoidan in pathological pain at preclinical and clinical levels. The results of this systematic review reveal that pretreatment with fucoidan is a powerful tool which reduces neutrophil infiltration by 70–90% at early time points. This meta-analysis showed that preventative treatment with fucoidan produced a significant pain reduction. In addition, several preclinical studies have observed that fucoidan treatment reduces the pain that is associated with various pathologies. Finally, fucoidan has also been tested in several clinical trials, with some degree of analgesic efficacy, but they were mostly small pilot studies. Considering all the above information, it can be concluded that fucoidan is not only a preclinical tool for studying the role of neutrophils in pain but also a promising therapeutic strategy for pain treatment.
·mdpi.com·
Marine Drugs | Free Full-Text | Fucoidan as a Promising Drug for Pain Treatment: Systematic Review and Meta-Analysis
How Incense Harms Your Brain - YouTube
How Incense Harms Your Brain - YouTube
Incense is a hidden brain threat. Here's what we know and why you should limit your use, and my top tips on how to protect your brain from incense Key takeaw...
·youtube.com·
How Incense Harms Your Brain - YouTube
Low Molecular Weight Fucoidan Can Inhibit the Fibrosis of Diabetic Kidneys by Regulating the Kidney Lipid Metabolism - Wang - 2021 - Journal of Diabetes Research - Wiley Online Library
Low Molecular Weight Fucoidan Can Inhibit the Fibrosis of Diabetic Kidneys by Regulating the Kidney Lipid Metabolism - Wang - 2021 - Journal of Diabetes Research - Wiley Online Library
In this study, a diabetic kidney disease model was established by placing the test rats on a high-sugar/high-fat diet combined with streptozotocin induction. Histopathological examination (H&E, Masso...
·onlinelibrary.wiley.com·
Low Molecular Weight Fucoidan Can Inhibit the Fibrosis of Diabetic Kidneys by Regulating the Kidney Lipid Metabolism - Wang - 2021 - Journal of Diabetes Research - Wiley Online Library
Serum vitamin C levels and their correlation with chronic kidney disease in adults: a nationwide study - PubMed
Serum vitamin C levels and their correlation with chronic kidney disease in adults: a nationwide study - PubMed
Our findings reveal a correlation between elevated serum vitamin C levels and a decreased risk of developing albuminuria, low eGFR, and CKD. Appropriately increasing serum vitamin C levels may hold promise in protecting renal function, particularly among older individuals.
·pubmed.ncbi.nlm.nih.gov·
Serum vitamin C levels and their correlation with chronic kidney disease in adults: a nationwide study - PubMed
The role of nitric oxide in the protective action of remote ischemic per-conditioning against ischemia/reperfusion-induced acute renal failure in rat - PubMed
The role of nitric oxide in the protective action of remote ischemic per-conditioning against ischemia/reperfusion-induced acute renal failure in rat - PubMed
According to the results, the functional and structural consequences of rIPerC against I/R-induced kidney dysfunction, which is associated with reduction of lipid peroxidation and intensification of anti-oxidant systems, is partially dependent on NO production.
·pubmed.ncbi.nlm.nih.gov·
The role of nitric oxide in the protective action of remote ischemic per-conditioning against ischemia/reperfusion-induced acute renal failure in rat - PubMed
THE END TIME PROPHECIES OF ELAM & PERSIA (IRAN) - YouTube
THE END TIME PROPHECIES OF ELAM & PERSIA (IRAN) - YouTube
In this timely show, JB Hixson and Bill Salus discuss the two end timeprophecies of Iran. Elam in Jeremiah 49:34-39 and Persia in Ezekiel 38. This show point...
·youtube.com·
THE END TIME PROPHECIES OF ELAM & PERSIA (IRAN) - YouTube