2016

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Gluten Induced Eye Diseases Related to MalnutritionMalabsorption - YouTube
Gluten Induced Eye Diseases Related to MalnutritionMalabsorption - YouTube
Click here to subscribe - https://www.glutenfreesociety.org/wxrn Ophthalmologic manifestations related to malnutrition stem from low levels of vitamin A, vitamin D, and calcium, which are common in celiac disease patients. These include retinopathy, cataract, dry eye, and pseudotumor cerebri: Retinopathy: characterized by yellowish to white lesions studded with tiny holes in the peripheral retina. It is typically caused by a deficiency in vitamin A. The vitamin A deficiency can also lead to night blindness (nyctalopia). Typically, visual function improves after one to four months of vitamin A supplementation. Cataracts: marked by the clouding of the lens of the eye, most cataracts develop slowly over time and cause blurry vision. Cataracts can be caused by a vitamin D deficiency, as a vitamin D deficiency interferes with the absorption of calcium and the resulting hypocalcemia (low blood levels of calcium) contributes to the development of cataracts. In addition, diarrhea common in undiagnosed celiac patients can lead to dehydration. Dehydration can alter the composition of the lens and lead to low levels of calcium in the aqueous humor. This leads to hypocalcemia which can then lead to cataracts. Pseudotumor cerebri: also known as idiopathic intracranial hypertension is characterized by increased intracranial pressure of unknown cause. It is thought to be caused by nutritional, metabolic, endocrinological or hematological disorders. In particular, it is linked with both vitamin A poisoning and vitamin A deficiency, although the mechanisms by which vitamin A deficiency and poisoning results in increased intracranial pressure is still not fully understood. Vitamin A deficiency is a common manifestation of gluten induced intestinal damage. Dry eye: just as it sounds, dry eye results in uncomfortably dry eyes and sometimes small spots present on the whites of the eyes called Bitot’s spots. Vitamin A deficiency is often the root cause behind this condition as well, and research has shown it is more common in celiac disease patients. To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterOsborne/ Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.
·youtube.com·
Gluten Induced Eye Diseases Related to MalnutritionMalabsorption - YouTube
Gluten Mimicking Foods Gluten-Free Society
Gluten Mimicking Foods Gluten-Free Society
If you have a gluten allergy, it’s important to know foods that mimic gluten. Gluten-Free Society is here to answer all of your questions. Call us today!
·glutenfreesociety.org·
Gluten Mimicking Foods Gluten-Free Society
Gluten In Your Mouth - Oral Manifestations & Symptoms of Gluten Sensitivity - YouTube
Gluten In Your Mouth - Oral Manifestations & Symptoms of Gluten Sensitivity - YouTube
Join Dr. Osborne as we discuss oral health problems and gluten on this edition of Pic Dr. Osborne's Brain Gluten In Your Mouth - Oral Manifestations & Symptoms of Gluten Sensitivity When you think about symptoms of gluten sensitivity, your mind might immediately go to digestive disturbances – things like acid reflux, bloating, or diarrhea. Or you might think of other symptoms like skin disturbances or migraines. But did you know that signs of gluten sensitivities can show up in the mouth? It’s true, and in fact, it’s been found that oral health problems are more commonly experienced in adult patients with celiac disease than those without. There are several different ways that gluten exposure can manifest as oral health issues, and each can also have compounding effects on the rest of your health. We’ll dig into this discussion below and also provide some actionable tips for you to optimally manage your oral health. 00:01 - Intro to Tonight's Show: Gluten In Your Mouth & What to look out for 02:00 - Vicious Cycle: Oral Health and Gluten Exposure 08:00 - Symptoms of Gluten Mouth Exposure 14:00 - Genetic Testing for Gluten Sensitivity & Literature Review 18:00 - Nutrient Deficiencies that Impact Your Oral Health 30:00 - Here are 7 Tips for Optimal Oral Health 35:00 - Live Q&A Discussion Prefer to Read, check out this related Article - https://www.glutenfreesociety.org/oral-health-and-gluten/ Mentioned Supplements: Iron - https://www.glutenfreesociety.org/shop/supplements/general-health/ultra-iron/ Vitamin D - https://www.glutenfreesociety.org/shop/supplements/general-health/gluten-free-d/ Zinc - https://www.glutenfreesociety.org/shop/supplements/immune-support/ultra-zinc/ B Vitamins - https://www.glutenfreesociety.org/shop/supplements/general-health/b-complete/ B 12 - https://www.glutenfreesociety.org/shop/supplements/general-health/methylcobalamin-gluten-free-supplement/ Vitamin C - https://www.glutenfreesociety.org/shop/supplements/immune-support/detox-c-gluten-free-vitamin-c-detox-powder/ Vitamin A - https://www.glutenfreesociety.org/shop/supplements/general-health/ultra-a/ To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterO... Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.
·youtube.com·
Gluten In Your Mouth - Oral Manifestations & Symptoms of Gluten Sensitivity - YouTube
Gluten Causes Brain Damage and Behavior Problems in Kids - YouTube
Gluten Causes Brain Damage and Behavior Problems in Kids - YouTube
Click here to subscribe - https://www.glutenfreesociety.org/wxrn Identifying Gluten Sensitivity in children is best done through genetic testing - https://www.glutenfreesociety.org/genetic-testing-for-gluten-sensitivity/ As kids are growing and their brains are developing, they may develop behavioral issues. Right now there is a lot of pressure for their parents to then put them on drugs. However, there are a lot of studies that show that if you change the diet, you change the behavior. It is important to understand that normal brain function depends on nutrients. To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterOsborne/ Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.
·youtube.com·
Gluten Causes Brain Damage and Behavior Problems in Kids - YouTube
Gluten and Your Vision - YouTube
Gluten and Your Vision - YouTube
Click here to subscribe - https://www.glutenfreesociety.org/wxrn Before discussing whether or not gluten can cause eye problems, let’s address some important background information. Celiac disease is often thought of as a disease that only affects the small intestine, creating symptoms like diarrhea, intestinal pain, cramping, weight loss, and malabsorption. While that is true, approximately half of all celiac disease patients present with extra-intestinal (non-gastrointestinal) symptoms, such as anemia, osteoporosis, neurological disorders, infertility, skin concerns, and vision or eyesight problems. Ocular (eye) symptoms caused by gluten can vary according to a person’s genetic predisposition, immune status, gender, and age at onset. This video will focus on how non celiac gluten sensitivity and celiac disease can manifest as ophthalmic concerns, which can be derived from both malnutrition or malabsorption and immune alterations. Gluten Induced Eye Diseases (00:30) Retinopathy (01:16) Cataracts (03:20) Pseudotumor Cerebri (03:55) Dry Eye (05:50) Autoimmune Diseases that can affect the eye (08:08) Thyroiditis (08:58) Orbital Myositis (09:49) Uveitis (11:26) Brain Occipital Calcification (13:51) Nutritional Deficiencies & Eye Health (14:40) Vitamin C and E as Antioxidants (14:50) Beta Carotene and Vitamin A (16:20) Zinc and Eye Function (18:45) Lutein and Zeaxanthin (21:25) Omega 3's and Inflammation Regulation (22:07) Copper, Folate, and B12 (24:18) Live Q&A (28:12) If you have been diagnosed with celiac disease or non celiac gluten sensitivity, it is wise to be vigilant in testing for, consuming, and supplementing as necessary with nutrients needed for eye health, as they are often found to be depleted even in patients who have been strictly following a gluten-free diet. If you need guidance for following a TRUE gluten free diet, check out my Ultimate MasterClass on Going Gluten Free - https://glutenology.net/registration/ For those who want to read more on gluten and eye health, check out this article - https://www.glutenfreesociety.org/eyesight-problems-gluten-might-be-a-factor/ Looking for the mentioned supplements? These are my premium true gluten and grain free formulas: Focus - https://www.glutenfreesociety.org/shop/supplements/immune-support/focus/ Vitamin A - https://www.glutenfreesociety.org/shop/supplements/general-health/ultra-a/ Vitamin C - https://www.glutenfreesociety.org/shop/supplements/immune-support/detox-c-gluten-free/ Vitamin D - https://www.glutenfreesociety.org/shop/supplements/general-health/gluten-free-d/ Vitamin E - https://www.glutenfreesociety.org/shop/supplements/immune-support/ultra-vitamin-e/ Vitamin B12 - https://www.glutenfreesociety.org/shop/supplements/general-health/methylcobalamin-gluten-free-supplement/ Ultra Iron - https://www.glutenfreesociety.org/shop/supplements/general-health/ultra-iron/ Ultra Zinc - https://www.glutenfreesociety.org/shop/supplements/immune-support/ultra-zinc/ Omega Max - https://www.glutenfreesociety.org/shop/supplements/general-health/omega-max-gluten-free-omega-3/ Copper - https://www.glutenfreesociety.org/shop/supplements/general-health/ultra-copper/ Folate - https://www.glutenfreesociety.org/shop/supplements/general-health/5-mthf/ L-Glutamine - https://www.glutenfreesociety.org/shop/supplements/digestive-health/l-glutamine/ B.C.A.A - https://www.glutenfreesociety.org/shop/supplements/general-health/bcaa/ Ultra Biotic Defense - https://www.glutenfreesociety.org/shop/supplements/immune-support/ultra-biotic-defense-3/ To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterOsborne/ Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.
·youtube.com·
Gluten and Your Vision - YouTube
Should Your Child Be Gluten Free Symptom Of Celiac and Gluten Intolerance in Kids - YouTube
Should Your Child Be Gluten Free Symptom Of Celiac and Gluten Intolerance in Kids - YouTube
Get your GF Kids Essential Bundle here: https://www.glutenfreesociety.org/shop/supplements/all-supplements/gf-kids-essentials-bundle/ Sign up for Glutenology - The FREE Ultimate Masterclass On Gluten here: https://www.glutenfreesociety.org/masterclass/ 00:00 - intro and overview 01:39 - gluten and infertility 05:30 - gluten's relation to low birth weight and premature babies 08:10 - malnutrition in the infant 12:00 - cesarean sections and the importance of a birthing plan 15:00 - symptoms of gluten sensitivity in infants 24:00 - symptoms of gluten sensitivity in toddlers & young children 31:01 - food and behavior 39:16 - identify the diagnostic differences 45:43 - overcoming challenges 48:55 - Q&A To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterO... Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.
·youtube.com·
Should Your Child Be Gluten Free Symptom Of Celiac and Gluten Intolerance in Kids - YouTube
Gluten Causes Low Thyroid, Slowed Metabolism, Accelerated Aging, & Slow Healing - YouTube
Gluten Causes Low Thyroid, Slowed Metabolism, Accelerated Aging, & Slow Healing - YouTube
Click here to subscribe - https://www.glutenfreesociety.org/wxrn Take our online gluten sensitivity quiz: https://www.glutenfreesociety.org/gluten-sensitivity-intolerance-self-test/ Gluten Causes Low Thyroid, Slowed Metabolism, Accelerated Aging, & Slow Healing Metabolism is the sum of two things. Metabolism equals catabolism plus anabolism. If these are new words for you, catabolism, these are chemical reactions that break things down, break down where anabolic or anabolism is chemical reactions that build. Remember that your body is in constant breaking down and building mode. So the sum of the quantity of how much you break down old tissue to replace it with new tissue, this is anabolic response and catabolic response. They kind of seesaw back and forth. If you only had reactions that were building you'd get cancer and you die. If you only had reactions that would break you down, your body would do it all the way to nothing. So there's a balance when you have old skin cells, you know, your skin is brand new about every 28 days. So what happens? How do we get rid of old skin cells? We have catabolic reactions that break those old cells down, and then we have anabolic reactions that help to come in and build new skin cells. And that's why when we have a slower metabolism, we actually slow down the body's ability to heal. And it's not just skin. 00:00 - What is metabolism? 03:00 - The autoimmune process 04:27 - Test your gluten sensitivity 05:00 - Two ways gluten causes thyroid disease To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterO... Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.
·youtube.com·
Gluten Causes Low Thyroid, Slowed Metabolism, Accelerated Aging, & Slow Healing - YouTube
Gluten and Pain - The Autoimmune Connection Most Doctors Ignore - YouTube
Gluten and Pain - The Autoimmune Connection Most Doctors Ignore - YouTube
Think you might have a gluten sensitivity? Take the quiz right here: https://www.glutenfreesociety.org/GlutenSensitivitySelfTest 00:00 - show overview 01:30 - statistical data and projections 03:20 - The Prescription Pain Trap 08:00 - grains lead to "death by medicine" 10:00 - drugs that cause gut dysfunction 19:42 - known causes of leaky gut 21:21 - Autoimmune pain and arthritis conditions related to gluten 24:31 - evidence and research samples 29:40 - Psoriasis and psoriatic arthritis 32:30 - Don't wait on your doctor...it's up to you to arm yourself with info! 33:20 - "Grainbesity" 38:00 - Other things found in grain 42:00 - The vicious cycle 43:21 - Nutrient deficiencies that lead to chronic pain 54:46 - Q&A To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterO... Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.
·youtube.com·
Gluten and Pain - The Autoimmune Connection Most Doctors Ignore - YouTube
Support lung function with nutrition! - YouTube
Support lung function with nutrition! - YouTube
Click here to subscribe - https://www.glutenfreesociety.org/wxrn It is important to note that gluten can contribute to malabsorption of vitamins and minerals leading to deficiencies that can disrupt health and normal body function. Two deficiencies that should be noted as it relates to asthma are vitamin D and vitamin C. Research has shown that low levels of these nutrients are both linked to asthma, but can also make asthma symptoms worse. To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterOsborne/ Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.
·youtube.com·
Support lung function with nutrition! - YouTube
Gluten and Kidney Disease - The Surprising Connection - YouTube
Gluten and Kidney Disease - The Surprising Connection - YouTube
Click here to subscribe - https://www.glutenfreesociety.org/wxrn Gluten and Kidney Disease - The Surprising Connection To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterOsborne/ Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association. To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterOsborne/ Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.
·youtube.com·
Gluten and Kidney Disease - The Surprising Connection - YouTube
Gluten and Cancer – What is the Connection - YouTube
Gluten and Cancer – What is the Connection - YouTube
Click here to subscribe - https://www.glutenfreesociety.org/wxrn Does gluten cause cancer? Do those with gluten sensitivity and celiac disease have an increased risk for developing this deadly disease? We will get to that shortly. First let’s dive into some statistics and facts around this deadly disease. Cancer is the second leading cause of death in the United States, with more than 1.5 million new cases diagnosed per year. About 40% of American adults are expected to develop cancer at some point in their life. And the World Health Organization predicts cases worldwide to rise by 70% over the next 30 years. All that being said, it is estimated that 1/2 of all cancers are caused by lifestyle choices such as diet and exercise. To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterOsborne/ Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association. To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterOsborne/ Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.
·youtube.com·
Gluten and Cancer – What is the Connection - YouTube
Gluten and Autism - YouTube
Gluten and Autism - YouTube
Click here to subscribe - https://www.glutenfreesociety.org/wxrn The popularity of the gluten free diet has grown dramatically. More and more parents are turning toward a gluten free diet to help alleviate symptoms of autism and other learning disorders in their children. To a large degree, many in the medical community have ridiculed this, stating that diet and the autistic spectrum have nothing to do with one another. Medical research and anecdotal evidence however shows that thousands of people have had improvement with diet alterations. Tune in to this episode of Pick Dr. Osborne's Brain to find out more! 00:00 - intro and overview: autistic spectrum disorders, leaky brain, and gluten 01:16 - can a gluten free diet help with autism? 02:42 - Why autism is NOT genetic 08:06 - the connection between celiac disease and autism 11:58 - the opiod theory 15:30 - nutritional deficiencies linked to autism 18:32 - autism rates vs use of glyphosate 23:22 - Toxic heavy metals and neurotoxicity 29:00 - The multiple reasons gluten can be blamed 31:22 - Q&A To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterOsborne/ Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.
·youtube.com·
Gluten and Autism - YouTube
Evaluation of the effect of the administration of an N-acetyl-glucosam (...)
Evaluation of the effect of the administration of an N-acetyl-glucosam (...)
Background: To evaluate the chondroprotective action of an N-acetyl-glucosamine (GlcNAc)-containing supplement on the joint health of healthy individuals without symptoms of arthritis, we conducted a randomized double-blind placebo-controlled clinical trial.  Methods: Subjects (n=100, 51.3 ± 1.0 years (mean ± SE)) without symptoms of arthritis were randomly assigned to receive a 1000 mg GlcNAc-containing diet (GlcNAc group) or a placebo diet (placebo group) once a day for 16 weeks, and the effect on the cartilage metabolism was evaluated by analyzing the ratio of type II collagen degradation to synthesis using type II collagen degradation (C2C) and synthesis (PIICP) markers. Results: The results indicated that the changes in the C2C/PIICP ratios from the baseline were slightly suppressed in the GlcNAc group compared with those in the placebo group at weeks 16 during the intervention and 4 weeks after the intervention. However, there was no significant difference between the two groups. To make the effect of GlcNAc even more clear, the subjects with joint loading and impaired cartilage metabolism were evaluated. Interestingly, the changes in the C2C/PIICP ratios from the baseline were significantly suppressed in the GlcNAc group compared with the placebo group at weeks 16 during the intervention and 4 weeks after the intervention. Moreover, test supplement-related adverse events were not essentially observed during and after the intervention. Conclusions: These observations suggest that the oral administration of GlcNAc at a dose of 1000 mg/day exerts a chondroprotective action on the healthy individuals by lowering the C2C/PIICP ratio, which indicates relative reduction of type II collagen degradation and increase of type II collagen synthesis, without apparent adverse effect.  Key words: N-acetyl-glucosamine, biomarker, cartilage metabolism, joint health
·ffhdj.com·
Evaluation of the effect of the administration of an N-acetyl-glucosam (...)
Evaluation of the effect of N-acetyl-glucosamine
Evaluation of the effect of N-acetyl-glucosamine
Background: To evaluate the chondroprotective action of an N-acetyl-glucosamine (GlcNAc)-containing supplement on the joint health of healthy individuals without symptoms of arthritis, we conducted a randomized double-blind placebo-controlled clinical trial.  Methods: Subjects (n=100, 51.3 ± 1.0 years (mean ± SE)) without symptoms of arthritis were randomly assigned to receive a 1000 mg GlcNAc-containing diet (GlcNAc group) or a placebo diet (placebo group) once a day for 16 weeks, and the effect on the cartilage metabolism was evaluated by analyzing the ratio of type II collagen degradation to synthesis using type II collagen degradation (C2C) and synthesis (PIICP) markers. Results: The results indicated that the changes in the C2C/PIICP ratios from the baseline were slightly suppressed in the GlcNAc group compared with those in the placebo group at weeks 16 during the intervention and 4 weeks after the intervention. However, there was no significant difference between the two groups. To make the effect of GlcNAc even more clear, the subjects with joint loading and impaired cartilage metabolism were evaluated. Interestingly, the changes in the C2C/PIICP ratios from the baseline were significantly suppressed in the GlcNAc group compared with the placebo group at weeks 16 during the intervention and 4 weeks after the intervention. Moreover, test supplement-related adverse events were not essentially observed during and after the intervention. Conclusions: These observations suggest that the oral administration of GlcNAc at a dose of 1000 mg/day exerts a chondroprotective action on the healthy individuals by lowering the C2C/PIICP ratio, which indicates relative reduction of type II collagen degradation and increase of type II collagen synthesis, without apparent adverse effect.  Key words: N-acetyl-glucosamine, biomarker, cartilage metabolism, joint health
·ffhdj.com·
Evaluation of the effect of N-acetyl-glucosamine
Geroprotectors Glucosamine – LEAF
Geroprotectors Glucosamine – LEAF
What is glucosamine? Glucosamine is a polysaccharide that naturally occurs in cartilaginous joint tissues and is involved in protein and lipid synthesis. […]
·leafscience.org·
Geroprotectors Glucosamine – LEAF
Evaluation of the effect of N-acetyl-glucosamine administration on bio (...)
Evaluation of the effect of N-acetyl-glucosamine administration on bio (...)
The present study aimed to evaluate the effect of N‑acetyl‑glucosamine (GlcNAc) on the joint health of healthy individuals without arthritic symptoms. A randomized double‑blind placebo‑controlled clinical trial was performed to investigate the effect of oral administration of a GlcNAc‑containing test supplement (low dose, 500 mg/day and high dose, 1,000 mg/day) on cartilage metabolism in healthy individuals with a mean age of 48.6±1.3 years (range, 23‑64 years) by analyzing the ratio of type II collagen degradation to type II collagen synthesis using type II collagen degradation (C2C) and synthesis (PIICP) markers. The results indicated that the changes in C2C/PIICP ratios from the baseline were suppressed in the treated with low and high doses of GlcNAc, compared with the placebo group at week 16 during intervention. To further elucidate the effect of GlcNAc, subjects with impaired cartilage metabolism were evaluated. Notably, the changes in the C2C/PIICP ratios were markedly suppressed in the groups treated with low and high doses of GlcNAc at week 16. Finally, to exclude the effect of heavy body weight on joint loading, subjects weighing
·spandidos-publications.com·
Evaluation of the effect of N-acetyl-glucosamine administration on bio (...)
Efficacy of Glucosamine Sulphate in Skin Ageing Results from an ex viv (...)
Efficacy of Glucosamine Sulphate in Skin Ageing Results from an ex viv (...)
Background: Glucosamine sulphate (GS) is essential in the biosynthesis of glycolipids, glycoproteins, glycosaminoglycans (GAGs), hyaluronate, and proteoglycans. Connective tissues primarily contain collagen and proteoglycans and play an important role in skin ageing. Objective: The objectives were to assess ex vivo the impact of GS on skin ageing p
·karger.com·
Efficacy of Glucosamine Sulphate in Skin Ageing Results from an ex viv (...)
Glucosamine LEAF
Glucosamine LEAF
What is glucosamine? Glucosamine is a polysaccharide that naturally occurs in cartilaginous joint tissues and is involved in protein and lipid synthesis. […]
·leafscience.org·
Glucosamine LEAF
Effect of Glucosamine Conjugate-Functionalized Liposomes on Glioma Cell and Healthy Brain An Insight for Future Application in Brain Infusion SpringerLink
Effect of Glucosamine Conjugate-Functionalized Liposomes on Glioma Cell and Healthy Brain An Insight for Future Application in Brain Infusion SpringerLink
Conjugation of D-glucosamine with lipophilic moiety can ease its application in surface modification of liposomes. Interestingly, although D-glucosamine is safe, studies have shed light on “toxic effect” of its conjugates on cancer cells and highlighted its application in targeting glioma. However, understanding the safety of such conjugates for local delivery to the brain is unavailable. Herein, after successful synthesis of D-glucosamine conjugate (GC), the toxicity of functionalized liposome was evaluated both in vitro and in vivo. The study revealed a significant effect on cytotoxicity and apoptosis in vitro as assessed on grade IV-resistant glioma cell lines, SF268, U87MG, using MTT assay and PI staining. Additionally, this effect was not observed on normal human erythrocytes in the hemolysis assay. Furthermore, we demonstrated that GC liposomes were non-toxic to the normal brain tissues of healthy Sprague-Dawley rats. Successful functionalization yielded liposome with uniform particle size, stability, and cellular uptake. With
·link.springer.com·
Effect of Glucosamine Conjugate-Functionalized Liposomes on Glioma Cell and Healthy Brain An Insight for Future Application in Brain Infusion SpringerLink
Effects of glucosamine against morphine-induced antinociceptive tolerance and dependence in mice Journal of Biomedical Science Full Text
Effects of glucosamine against morphine-induced antinociceptive tolerance and dependence in mice Journal of Biomedical Science Full Text
Background The most important limitations of morphine in pain therapy are its tolerance and dependence. In this study, we evaluated the protective effect of glucosamine against morphine-induced tolerance and dependence in mice. Methods Mice received twice daily morphine (20 mg/kg, s.c.) alone, or along with orally administered glucosamine (500, 1000 and 2000 mg/kg), for 9 continuous days. To assess antinociceptive effect of morphine, percentage of maximal possible effect (%MPE) of animals exposed to thermal stimulus was measured in the hot plate test, 30 min after morphine administration. Test was performed on days 1, 3, 5, 7 and 9. The effect of glucosamine on the naloxone (5 mg/kg, i.p.)-precipitated morphine withdrawal, was also evaluated. Changes in brain gene expression levels of induced nitric oxide synthase (iNOS), enzyme responsible for nitric oxide generation, as well as pro-inflammatory mediator, tumor necrosis alpha (TNF-α) were measured in morphine tolerated animals, as well as after withdrawal by real-time polymerase chain reaction (RT-PCR). Protein content of TNF-α was evaluated via ELISA assay. Results Tolerance to antinociceptive effect of morphine was developed after 7 days of morphine treatment. The concurrent administration of glucosamine (500, 1000 and 2000 mg/kg) with morphine, significantly inhibited tolerance development, on days 7 and 9. In addition, glucosamine ameliorated the naloxone-precipitated opioid withdrawal symptoms (tremor, jumping, teeth chattering, grooming). However, diarrhea was significantly improved only with the dose of 500 mg/kg. Increased mRNA expression of iNOS as well as TNF-α mRNA expression and protein, after both morphine tolerance and withdrawal, were considerably reduced by glucosamine (1000 mg/kg) in the morphine withdrawal animals. Conclusion These data support the utility of glucosamine in attenuating both tolerance to nociceptive effects of morphine as well as withdrawal-induced behavioral profile. Anti-oxidant and anti-inflammatory effects are responsible, at least in part, for the protective effects of this drug.
·jbiomedsci.biomedcentral.com·
Effects of glucosamine against morphine-induced antinociceptive tolerance and dependence in mice Journal of Biomedical Science Full Text
Comparison of Glucosamine-Chondroitin Sulfate with and without Methyls (...)
Comparison of Glucosamine-Chondroitin Sulfate with and without Methyls (...)
Background: Glucosamine, chondroitinsulfate are frequently used to prevent further joint degeneration in osteoarthritis (OA). Methylsulfonylmethane (MSM) is a supplement containing organic sulphur and also reported to slow anatomical joint progressivity in the knee OA. The MSM is often combined with glucosamine and chondroitin sulfate. However, there are controversies whether glucosamine-chondroitin sulfate or their combination with methylsulfonylmethane could effectively reduce pain in OA. This study is aimed to compare clinical outcome of glucosamine-chondroitin sulfate (GC), glucosamine-chondroitin sulfate-methylsulfonylmethane (GCM), and placeboin patients with knee osteoarthritis (OA) Kellgren-Lawrence grade I-II. Methods: a double blind, randomized controlled clinical trial was conducted on 147 patients with knee OA Kellgren-Lawrence grade I-II. Patients were allocated by permuted block randomization into three groups: GC (n=49), GCM (n=50), or placebo (n=48) groups. GC group received 1500 mg of glucosamine + 1200 mg of chondroitin sulfate + 500 mg of saccharumlactis; GCM group received 1500 mg of glucosamine + 1200 mg of chondroitin sulfate + 500 mg of MSM; while placebo group received three matching capsules of saccharumlactis. The drugs were administered once daily for 3 consecutive months VAS and WOMAC scores were measured before treatment, then at 4th, 8th and 12th week after treatment. Results: on statistical analysis it was found that at the 12th week, there are significant difference between three treatment groups on the WOMAC score (p=0.03) and on the VAS score (p=0.004). When analyzed between weeks, GCM treatment group was found statistically significant on WOMAC score (p=0.01) and VAS score (p
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Comparison of Glucosamine-Chondroitin Sulfate with and without Methyls (...)