2016

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Introduction: Trehalose is a naturally occurring disaccharide of two glucose molecules that has been suggested as a potential therapeutic agent to reduce blood glucose and ameliorate diabetes-related complications in type 2 diabetes (T2D). This study aimed to determine the efficacy of...

Metformin is one of the most commonly prescribed medications on the planet. It is considered a “first-line” therapy for lowering blood glucose in the treatment of type-2 diabetes and has …

(NaturalHealth365) UK government data shows COVID vaxxed kids have significantly higher risk of death than unvaxxed counterparts.

Fucoidan is a highly sulfated polysaccharide with a wide range of bioactivities, including anti-pathogenic activity. However, the relationship between…

In this presentation, Sasha Latypova covers the pseudo-legal structure, the organizational structure and the money flow of the COVID criminal enterprise. Latypova and I both highly recommend that you subscribe to Katherine Watt’s Bailiwick News Substack. This is the Transcript of Latypova’s conversation with Katherine Watt on November 4, 2022. Here are the DOD contracts for “COVID Countermeasures”. *** NOTES The topic of my presentation today is “Intent to Harm” and I’m going to discuss evidence of conspiracy – which is not a theory – of US Department of Defense, Health and Human Services, other government agencies and other governments all over the world, … Continue reading →

In this minireview, we examine the ability of modified citrus pectin (MCP), a complex water soluble indigestible polysaccharide obtained from the peel and pulp of citrus fruits and modified by means of high pH and temperature treatment, to affect numerous rate-limiting steps in cancer metastasis. Th …

Dr Isaac Eliaz's Modified Citrus Pectin Research to support your understanding of why this ingredient is so effective in supporting healthy cells and body system.

Highlights • In 2 different mouse models, AKI increased Gal-3 expression and induced cardiac dysfunction, cardiac and systemic inflammation, cardiac macrophage infiltration, and fibrosis. • Cardiac...

Objective: Ventricular remodeling is considered the basis of heart failure and is involved in myocardial fibrosis. This study aimed to assess perindopril and a galectin-3 inhibitor (modified citrus pectin, MCP) for their effects on ventricular remodeling and myocardial fibrosis in rabbits wit …

Tumor-associated macrophages (TAMs) have been shown to be associated with poor prognosis of cancer and are predominately localized in the hypoxia regions of tumor. We demonstrated in this study that hypoxia increases the synthesis and secretion of galectin-3 by TAMs. The increased expression of gale …

Background Galectin-3 (Gal-3) is a pleiotropic glycan-binding protein shown to be involved in sepsis and acute kidney injury (AKI). However, its role has never been elucidated in sepsis-associated AKI (S-AKI). We aimed to explore Gal-3’s role and its potential utility as a therapeutic target in S-AKI. Methods In 57 patients admitted to the intensive care unit (ICU) with sepsis, serum Gal-3 was examined as a predictor of ICU mortality and development of AKI. In a rat model of S-AKI induced by cecal ligation and puncture (CLP), 7-day mortality and serum Gal-3, Interleukin-6 (IL-6), and creatinine were examined at 2, 8, and 24 hours (h) post-CLP. Two experimental groups received the Gal-3 inhibitor modified citrus pectin (P-MCP) at 400 mg/kg/day and 1200 mg/kg/day, while the control group received water only (n = 18 in each group). Results Among 57 patients, 27 developed AKI and 8 died in the ICU. Serum Gal-3 was an independent predictor of AKI (OR = 1.2 [95% CI 1.1–1.4], p = 0.01) and ICU mortality (OR = 1.4 [95% CI 1.1–2.2], p = 0.04) before and after controlling for age, AKI, and acute physiology and chronic health evaluation (APACHE II) score. In the CLP rat experiment, serum Gal-3 peaked earlier than IL-6. Serum Gal-3 was significantly lower in both P-MCP groups compared to control at 2 h post-CLP (400 mg: p = 0.003; 1200 mg: p = 0.002), and IL-6 was significantly lower in both P-MCP groups at all time points with a maximum difference at 24 h post-CLP (400 mg: p = 0.015; 1200 mg: p = 0.02). In the Gal-3 inhibitor groups, 7-day mortality was significantly reduced from 61% in the control group to 28% (400 mg P-MCP: p = 0.03) and 22% (1200 mg P-MCP: p = 0.001). Rates of AKI per RIFLE criteria were significantly reduced from 89% in the control group to 44% in both P-MCP groups (400 mg: p = 0.007; 1200 mg: p = 0.007). Conclusions This translational study demonstrates the importance of Gal-3 in the pathogenesis of S-AKI, and its potential utility as a therapeutic target. Graphic abstract

We evaluated Galectin-3 (Gal-3) as a potential early biomarker of acute kidney disease (AKI), and the effect of Gal-3 inhibition by modified citrus pe…

Large amounts of tumor-associated macrophages (TAM), which are predominately localized in hypoxia area of the tumor tissue, are associated with the malignant progression of the tumor. In the present study, we investigated the inhibitory effects of modified citrus pectin (MCP), a natural dietary poly …

Modified citrus pectin (MCP) is a specific inhibitor of galectin-3 (Gal-3) that is regarded as a new biomarker of cardiac hypertrophy, but its effect is unclear. The aim of this study is to investigate the role and mechanism of MCP in isoproterenol (ISO)-induced cardiac hypertrophy. Rats were inject …

Galectin-3 represents one of the fastest-growing fields of medical research, with over 3,000 published studies showing its far-reaching impacts on aging and chronic disease.

(NaturalHealth365) CDC data suggests that the United States suffered nearly 350,000 excess deaths. Are the COVID shots to blame?

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Background There is a paucity of high-quality evidence of the efficacy and safety of cannabis-based medicinal products in treatment of treatment-resistant epilepsy (TRE) in children. Methods A case series of children(

Even one night of better sleep may help your brain. KEY POINTS Sleep has known positive associations with long-term health, but it also seems to significantly enhance short-term brain function. Sleep may help us to balance out our emotional state, especially when it comes to negativity. Research shows that sleep is key to long-term memory storage, and may also help enhance short-term focus. Getting good sleep may help promote our creative abilities, especially by increasing insight in problem-so

Two powerful strategies to reclaim a brain-healthy breakfast By Austin Perlmutter, MD KEY POINTS Most "breakfast" foods are anything but healthy for our bodies and brains Try replacing processed carbs and added sugar with fiber, protein and healthy fat Look to incorporate key brain-boosting nutrients in your breakfast to jumpstart your brain health each day! You’ve heard it before: “breakfast is the most important meal of the day.” But the reality is that for most people, what we call “breakfast

New research shows how inflammation may alter your view of the world. KEY POINTS Chronic inflammation is a major risk factor for our most common diseases Excess inflammation may also negatively impact our brain health Inflammation in the brain may lead us to make more impulsive decisions Inflammation in the brain may also increase our risk for conditions like depression In the last several decades, we’ve increasingly understood that chronic inflammation plays a major negative role in our health,

3 pathways connecting your gut microbes to your thoughts and mood KEY POINTS Microbes in your gut (aka: the gut microbiome) may change the way you think and feel Microbes in the gut may be capable of changing brain function through their effects on the vagus nerve Changes in immune function that affect our brain function may be driven by gut microbes Breakdown products of gut microbes (like short-chain fatty acids) may have a variety of effects on our brain state In the mid-1880’s, a pediatricia

The Association of American Physicians and Surgeons (AAPS) filed its motion and amicus brief Thursday evening with the federal district court in Galveston urging it to allow the lawsuit to proceed against the FDA for […]

Graves Thyrotoxicosis Treated with Iodine/Lithium Combination.

Iodine as First Line Treatment for Graves' Hyperthyroidism is Accepted in Japan.

Modern endocrinology fails to address the auto-immune component.

Abnormal Mammograms Driving Clinical Concerns and More Testing