2016

Background. Aloe vera has long been considered an anticancer herb in different parts of the world. Objective. To explore the potential mechanism of aloe vera in the treatment of cancer using network pharmacology and molecule docking approaches. Methods. The active ingredients and corresponding protein targets of aloe vera were identified from the TCMSP database. Targets related to cancer were obtained from GeneCards and OMIM databases. The anticancer targets of aloe vera were obtained by intersecting the drug targets with the disease targets, and the process was presented in the form of a Venn plot. These targets were uploaded to the String database for protein-protein interaction (PPI) analysis, and the result was visualized by Cytoscape software. Go and KEGG enrichment were used to analyze the biological process of the target proteins. Molecular docking was used to verify the relationship between the active ingredients of aloe vera and predicted targets. Results. By screening and analyzing, 8 active ingredients and 174 anticancer targets of aloe vera were obtained. The active ingredient-anticancer target network constructed by Cytoscape software indicated that quercetin, arachidonic acid, aloe-emodin, and beta-carotene, which have more than 4 gene targets, may play crucial roles. In the PPI network, AKT1, TP53, and VEGFA have the top 3 highest values. The anticancer targets of aloe vera were mainly involved in pathways in cancer, prostate cancer, bladder cancer, pancreatic cancer, and non-small-cell lung cancer and the TNF signaling pathway. The results of molecular docking suggested that the binding ability between TP53 and quercetin was the strongest. Conclusion. This study revealed the active ingredients of aloe vera and the potential mechanism underlying its anticancer effect based on network pharmacology and provided ideas for further research.

Aloe vera extract and its bioactive compounds possess anti-proliferative properties against cancer cells. However, no detailed molecular mechanism of …

The ever-changing landscape of dieting and its correlation with health outcomes have continued to evolve with time. New diets appear and disappear just as quickly as they gain notoriety. This is...

Methods: Open-label, multicenter, retrospective, noncontrolled analysis of long-term visual acuity and safety in 111 LHON patients treated with idebenone (900 mg/day) in an expanded access program. Eligible patients had a confirmed mitochondrial DNA mutation and had experienced the onset of symptoms (most recent eye) within 1 year before enrollment. Data on visual acuity and adverse events were collected as per normal clinical practice. Efficacy was assessed as the proportion of patients with either a clinically relevant recovery (CRR) or a clinically relevant stabilization (CRS) of visual acuity. In the case of CRR, time to and magnitude of recovery over the course of time were also assessed. Results: At time of analysis, 87 patients had provided longitudinal efficacy data. Average treatment duration was 25.6 months. CRR was observed in 46.0% of patients. Analysis of treatment effect by duration showed that the proportion of patients with recovery and the magnitude of recovery increased with treatment duration. Average gain in best-corrected visual acuity for responders was 0.72 logarithm of the minimal angle of resolution (logMAR), equivalent to more than 7 lines on the Early Treatment Diabetic Retinopathy Study (ETDRS) chart. Furthermore, 50% of patients who had a visual acuity below 1.0 logMAR in at least one eye at initiation of treatment successfully maintained their vision below this threshold by last observation. Idebenone was well tolerated, with most adverse events classified as minor. Conclusions: These data demonstrate the benefit of idebenone treatment in recovering lost vision and maintaining good residual vision in a real-world setting. Together, these findings indicate that idebenone treatment should be initiated early and be maintained more than 24 months to maximize efficacy. Safety results were consistent with the known safety profile of idebenone....

Scientific Reports - Weeklong improved colour contrasts sensitivity...

Covid Care At Synergy Health DPC, our goal is to keep you healthy at home Should you or any of your family seek to prevent becoming ill with Covid, experience the common symptoms of Covid or have lingering effects of Post Covid Syndrome, please be assured that we offer several different Covid protocol options that… Continue reading Covid Care

David Martin specialises in putting humanity back into humans - and business. David's secret of success globally is ‘The Wobble Effect’. Read more...

Checks  can be mailed to: Dr Paul's Fight c/o: Paul Thomas  11790 SW Barnes Rd. Suite 140 Portland Or 97225 Write DrPaulsFight in memo or on a piece of paper

We provide affordable concierge TeleHealth visits to all of our patients ages 12 and up. Our providers often can schedule an acute care visit with limited wait times. We also offer specialized services to address dementia, fibromyalgia and other long term conditions. Additionally, we are available as a health advocate should you or a loved one need hospital or specialist care

In this episode, we have a special surprise. We interviewed one of Dr. Seeds MD students in Cellular Medicine, Dr. Juan Bautista of North Fresno Primary Care, and Owner/Primary Care Physician of Bautista Medical Group, on his incredible experience in treating COVID-19 patients in Fresno on a budget. This truly mind bending conversation is about one of the themes of this podcast-- taking control of your health in your own hands. Dr. Bautista walks us through his priorities when treating patients with very limited budgets. It is a tough world out there, but we're thankful for Dr. Bautista who brings the quality of concierge care into an everyday home. We are in awe of this doctor, you have to hear why. Join us on social media! Facebook: https://www.facebook.com/drwilliamseeds/ Instagram: https://www.instagram.com/williamaseedsmd/ Pinterest: https://www.pinterest.com/williamseedsmd/ Twitter: https://twitter.com/williamseedsmd/

(NaturalHealth365) A union group is calling for COVID rapid tests to be pulled because the test swabs contain a toxic chemical.

Dr. Chetty explains everything is clear now.

Statistician Mathew Crawford talks to me about why he believes that the vaccines are completely ineffective based on the data. He also talks about gaming of the clinical trials to make the data look g

It is more than evident that a significant part of humanity is stampeding to take experimental vaccines for COVID-19. However, the “experimental” vaccines violate all 10 of the Nuremberg Codes, which carry the death penalty for those who seek to break these International Laws. Now, more than ever, we need new trials, not after the... View Article

In this intimate sit down interview with Wolfgang Wodarg, we discuss the broad issue of corruption in the WHO, how we should understand the "pandemic," or lack there of and how we must stop this diabo

A Mississippi doctor said he was fired for attempting to treat COVID-19 patients with ivermectin, which is approved ...

Click here to download the document as a PDF

welcome everyone we love you!

(NaturalHealth365) A U.S. Federal District Judge ruled that the EUA version of the Pfizer shot is not interchangeable with Comirnaty.

Los Angeles Police Department (LAPD) officers used fake online personas to monitor social media users, and, at one ...

Our group has been using the PLUS Cardiac Test (GD Biosciences, Inc, Irvine, CA) a clinically validated measurement of multiple protein biomarkers which generates a score predicting the 5 yr risk (pe

I should have titled this essay the worst story ever told, so fasten your seatbelts because things will only worsen from here. I am afraid that there will be little to no good news from this point forward. Evil is conquering the world, and they have us exactly where they want us. There are no... View Article

(NaturalHealth365) Recently released Pfizer report reveals bombshell evidence that FDA and Pfizer conspired to hide damage by COVID jab.