Allulose

Natural rare sugars are an alternative category of sweeteners with positive physiologic and metabolic effects both in in vitro and animal models. D-allulose is a D-fructose epimer that combines 70% sucrose sweetness with the advantage of an extremely low energy content. However, there are no data about the effect of D-allulose against adipose dysfunction; thus, it remains to be confirmed whether D-allulose is useful in the prevention and in treatment of adipose tissue alterations. With this aim, we evaluated D-allulose’s preventive effects on lipid accumulation in 3T3-L1 murine adipocytes exposed to palmitic acid (PA), a trigger for hypertrophic adipocytes. D-allulose in place of glucose prevented adipocyte hypertrophy and the activation of adipogenic markers C/EBP-β and PPARγ induced by high PA concentrations. Additionally, D-allulose pretreatment inhibited the NF-κB pathway and endoplasmic reticulum stress caused by PA, through activation of the Nrf2 pathway. Interestingly, these effects were also observed as D-allulose post PA treatment. Although our data need to be confirmed through in vivo models, our findings suggest that incorporating D-allulose as a glucose substitute in the diet might have a protective role in adipocyte function and support a unique mechanism of action in this sugar as a preventive or therapeutic compound against PA lipotoxicity through the modulation of pathways connected to lipid transport and metabolism.

Sugar consumption is known to be associated with a whole range of adverse health effects, including overweight status and type II diabetes mellitus. In 2015, the World Health Organization issued a guideline recommending the reduction of sugar intake. In this context, alternative sweeteners have gained interest as sugar substitutes to achieve this goal without loss of the sweet taste. This review aims to provide an overview of the scientific literature and establish a reference tool for selected conventional sweeteners (sucrose, glucose, and fructose) and alternative sweeteners (sucralose, xylitol, erythritol, and D-allulose), specifically focusing on their important metabolic effects. The results show that alternative sweeteners constitute a diverse group, and each substance exhibits one or more metabolic effects. Therefore, no sweetener can be considered to be inert. Additionally, xylitol, erythritol, and D-allulose seem promising as alternative sweeteners due to favorable metabolic outcomes. These alternative sweeteners replicate the benefits of sugars (e.g., sweetness and gastrointestinal hormone release) while circumventing the detrimental effects of these substances on human health.

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Delicious, Plant-based Certified, Non-GMO Project Verified, Keto Certified Allulose Sugar  Zero Calories Zero Net Carbs Zero Sugar Alcohols Zero Stevia Zero Monk Fruit Zero Erythritol RxSugar®. There Is No Substitute.® Non-GMO Project Verified Grain-Free/Gluten-Free Certified Keto Certified FODMAP Friendly Certified Blood Sugar Friendly Safe for People With Diabetes  1.25 cups RxSugar® Allulose Sugar = 1 cup Refined Sugar *You may receive packaging that looks different while we transition designs.   ◄Ingredients Non-GMO Allulose RxSugar® is made from Allulose, a low calorie plant-based sugar, is different from other sugars in that it is not metabolized by the human body in the same way as table sugar. RxSugar® does not affect your blood sugar levels. Allulose, is proven to have zero net carbohydrate impact; this is why the Allulose carbohydrates are subtracted from the Total Carbs to produce zero net carbohydrates. How To Calculate Net

Metabolic changes have been linked to the development of inflammatory bowel disease (IBD), which includes colitis. Allulose, an endogenous bioactive m…

D-Allulose is a rare sugar that exists in nature. It is a food ingredient with nearly zero calories (

It tastes pretty sweet and looks a lot like sugar, but is it good for you? This episode features audio from:https://nutritionfacts.org/video/does-the-sweeten...

#allulose #sweetener #sugarsubstitute Allulose is gaining in popularity but does the latest evidence support the described health benefits? More importantly ...

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BulkSupplements Allulose is a natural sweetener perfect for baking and adding sweetness to food and drinks without all of the excess sugar. It can also replace other sweeteners in recipes, allowing you to eat the same treats but with fewer calories and carbohydrates! This allulose is gluten free and filler free, making it safe for people with dietary restrictions. It's also incredibly easy to use - just substitute one cup of your usual sweetener with two-thirds of a cup of BulkSupplements Allulose and enjoy the same flavor without all of the unhealthy sugar content. If you're looking for a sugar substitute or want to cut down on your daily calorie intake, then try BulkSupplements Allulose today! You won't regret it!

Allulose in human diet: the knowns and the unknowns - Volume 128 Issue 2

Micro Ingredients Pure Allulose Sweetener, 3 Pounds (48 Ounces), Plant Based Brown Sugar Alternative, No After Taste, Keto Diet and Vegan Friendly. Fine Granules, Keto Friendly, Sugar Alternative, Zero Calorie Sweetener. Great for Tea, Coffee, Drinks, Baking, Cooking and More. Scoop included to get the measurement ever

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D-allulose, a rare sugar, has been proposed to have potential benefits in addressing metabolic disorders such as obesity and type 2 diabetes (T2D). However, the precise mechanisms underlying these effects remain poorly understood. We aimed to elucidate the mechanisms by which D-allulose influences obesity-induced insulin resistance. We conducted gene set enrichment analysis on the liver and white adipose tissue of mice exposed to a high-fat diet (HFD) along with the white adipose tissue of individuals with obesity. Our study revealed that D-allulose effectively suppressed IFN-γ, restored chemokine signaling, and enhanced macrophage function in the livers of HFD-fed mice. This implies that D-allulose curtails liver inflammation, alleviating insulin resistance and subsequently impacting adipose tissue. Furthermore, D-allulose supplementation improved mitochondrial NADH homeostasis and translation in both the liver and white adipose tissue of HFD-fed mice. Notably, we observed decreased NADH homeostasis and mitochondrial translation in the omental tissue of insulin-resistant obese subjects compared to their insulin-sensitive counterparts. Taken together, these results suggest that supplementation with allulose improves obesity-induced insulin resistance by mitigating the disruptions in macrophage and mitochondrial function. Furthermore, our data reinforce the crucial role that mitochondrial energy expenditure plays in the development of insulin resistance triggered by obesity.

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Non-GMO Project Verified, Keto Certified, Grain-Free/Gluten-Free Certified, FODMAP Friendly Certified, Kosher, Halal, Plant-Based and Naturally Vegan. RxSugar®. There Is No Substitute™. RxSugar® is Sugar Reimagined®! Live Swealthy™ - Sweet & Healthy!

We tried all six flavors of the "adult cereal" to see how it compares to its sugary counterparts.