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Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging. The pathological hallmark of PD is neuronal inclusions termed Lewy bodies whose main component is alpha-synuclein protein. The finding of these Lewy bodies in the intestinal enteric nerves led to the hypothesis that the intestine might be an early site of PD disease in response to an environmental toxin or pathogen. One potential mechanism for environmental toxin(s) and proinflammatory luminal products to gain access to mucosal neuronal tissue and promote oxidative stress is compromised intestinal barrier integrity. However, the role of intestinal permeability in PD has never been tested. We hypothesized that PD subjects might exhibit increased intestinal permeability to proinflammatory bacterial products in the intestine. To test our hypothesis we evaluated intestinal permeability in subjects newly diagnosed with PD and compared their values to healthy subjects. In addition, we obtained intestinal biopsies from both groups and used immunohistochemistry to assess bacterial translocation, nitrotyrosine (oxidative stress), and alpha-synuclein. We also evaluated serum markers of endotoxin exposure including LPS binding protein (LBP). Our data show that our PD subjects exhibit significantly greater intestinal permeability (gut leakiness) than controls. In addition, this intestinal hyperpermeability significantly correlated with increased intestinal mucosa staining for E. coli bacteria, nitrotyrosine, and alpha-synuclein as well as serum LBP levels in PD subjects. These data represent not only the first demonstration of abnormal intestinal permeability in PD subjects but also the first correlation of increased intestinal permeability in PD with intestinal alpha–synuclein (the hallmark of PD), as well as staining for gram negative bacteria and tissue oxidative stress. Our study may thus shed new light on PD pathogenesis as well as provide a new method for earlier diagnosis of PD and suggests potential therapeutic targets in PD subjects. Trial Registration Clinicaltrials.gov NCT01155492
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Parkinson's TOTALLY Arrested: New Research Transforms our Approach to this Devastating Condition - YouTube
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Internet Usage May Reduce Dementia Risk - David Perlmutter M.D.
In our book, Brain Wash, Dr. Austin Perlmutter and I warned about the potential risk of extensive Internet usage, especially as it relates to adolescents using excessively involved in social …
Canola Oil Increases Risk Of Dementia | NaturalHealth365
(NaturalHealth365) Scientific research reveals the way canola oil can damage the brain and increase your risk of dementia.
Phosphatidylcholine Benefits, Uses, Forms and Side Effects - Dr. Axe
Phosphatidylcholine benefits several parts of the body, including the brain, gut and more. Find out what it is, how to take it and more.
Acetylcholine: Function, Benefits, Dosage and Side Effects - Dr. Axe
If you're familiar with nootropics supplements, you may have come across the compound called acetylcholine. So what is it and what does it do? Find out.
Dementia Linked To Liver Disease | NaturalHealth365
! 1 Healing Parkinsons
In this podcast episode, Dr. Ardis discusses strategies for preventing and treating Parkinson's disease. He highlights supplements like taurine, selenium, and a foreign protein cleanse as potential ai
EPA Ignores Paraquat-Parkinson's Link | NaturalHealth365
(NaturalHealth365) As evidence of the weed killer’s toxicity continues to pour in, the EPA turns its head and supports the use of paraquat.
Fatty Acids Shield Against Cognitive Decline | NaturalHealth365
(NaturalHealth365) A recent study has found a connection between fatty acids in the bloodstream and a reduced risk of Alzheimer's.
Alzheimer's Disease Linked to H. pylori Bacteria | NaturalHealth365
(NaturalHealth365) Alzheimer's disease affects 40 million people worldwide. A new review shows links to H. pylori bacteria.
Insomnia, Short Sleep Affect Brain Health and dementia | NaturalHealth365
(NaturalHealth365) A new study reveals short sleep and insomnia negatively impacts the brain. Discover how to improve your sleep quality.
Decoding Dementia eBook
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Awakening from Alzheimer's
The biggest myth about Alzheimer's and dementia is that they’re untreatable. If you or someone you care about is suffering from memory loss, dementia,…
Clinical Studies & Research | Dementia Trial
1 Brain Health Breakthroughs – Awakening from Alzheimer's
Precision Medicine Approach to Alzheimer’s Disease: Successful Pilot Project - IOS Press
Background: Effective therapeutics for Alzheimer’s disease are needed. However, previous clinical trials have pre-determined a single treatment modality, such as a drug candidate or therapeutic procedure, which may be unrelated to the primary drivers
! 1 The Intriguing Connection Between the Gut Microbiome and Parkinson's Disease - David Perlmutter M.D.
For years, the medical community has viewed Parkinson’s Disease (PD) primarily as a neurological disorder, defined by its hallmark motor symptoms such as tremors, rigidity, and postural instability. However, recent …
Integrated Multimodal Omics and Dietary Approaches for the Management of Neurodegeneration
Neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, are caused by a combination of multiple events that damage neuronal function. A well-characterized biomarker of neurodegeneration is the accumulation of proteinaceous aggregates in the brain. However, the gradually worsening symptoms of neurodegenerative diseases are unlikely to be solely due to the result of a mutation in a single gene, but rather a multi-step process involving epigenetic changes. Recently, it has been suggested that a fraction of epigenetic alternations may be correlated to neurodegeneration in the brain. Unlike DNA mutations, epigenetic alterations are reversible, and therefore raise the possibilities for therapeutic intervention, including dietary modifications. Additionally, reactive oxygen species may contribute to the pathogenesis of Alzheimer’s disease and Parkinson’s disease through epigenetic alternation. Given that the antioxidant properties of plant-derived phytochemicals are likely to exhibit pleiotropic effects against ROS-mediated epigenetic alternation, dietary intervention may be promising for the management of neurodegeneration in these diseases. In this review, the state-of-the-art applications using single-cell multimodal omics approaches, including epigenetics, and dietary approaches for the identification of novel biomarkers and therapeutic approaches for the treatment of neurodegenerative diseases are discussed.
The Health Benefits of Creatine Supplementation - David Perlmutter M.D.
Should you take a creatine supplement? This is a frequent question I get asked when I lecture, as well as on various online forums. Ultimately, I think it makes a …
Eat Your (Dark Green) Vegetables for Better Brain Health - David Perlmutter M.D.
We’ve heard for years that a diet rich in fruits and vegetables is the cornerstone of good health. In recent years, a particular group of vegetables – dark green leafy …
Poor Gut Health Linked To Parkinson’s Disease | NaturalHealth365
(NaturalHealth365) A new study links poor gut health to the increased risk of Parkinson's disease. Find out how to reduce your risk.
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Probiotic Strain May Slow Cognitive Decline | NaturalHealth365
(NaturalHealth365) Research reveals that the benefits of this specific probiotic strain go well beyond gut health.
Constipation May Signal Cognitive Decline | NaturalHealth365
(NaturalHealth365) Evidence is emerging that chronic constipation is a sign that one’s cognitive functionality is worsening.