Amino Acids

Protein supplementation in combination with resistance training may increase muscle mass and muscle strength in elderly subjects. The objective of this study was to assess the influence of post-exercise protein supplementation with collagen peptides v. placebo on muscle mass and muscle function foll …

Dysfunction of the intestinal barrier plays a key role in the pathogenesis of inflammatory bowel disease (IBD) and multiple organ failure. The effect of Alaska pollock skin-derived collagen and its 3 tryptic hydrolytic fractions, HCP (6 kDa retentate), MCP (3 kDa retentate) and LCP (3 kDa permeate) …

This report describes a patient's self-substitution of nattokinase for the vitamin K antagonist warfarin after aortic valve replacement with a mechanical prosthesis. Nattokinase is an enzyme derived from a popular fermented soybean preparation in Japan ...

Do you have asthma? Do you know or love someone who does? Here’s how to use supplemental glutathione (reduced, liposomal, and nebulized) to help with this condition. This is the link to the episode on nitric oxide, mentioned in this episode: https://chrismasterjohnphd.com/2018/01/11/nitric-oxide-genes-blood-pressure-asthma/ How to watch it: Watch it on Facebook . Watch it on YouTube. Listen to the Audio. …

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Learn more about GLUTATHIONE uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain GLUTATHIONE.

Fucoidan is a sulfated polysaccharide widely distributed in brown seaweed. It exhibits several bioactivities, such as anti-cancer, anti-tumor, anti-microbial, anti-diabetic and anti-oxidant properties. However, the effects of fucoidan in chondrocytes are not well established. Previously, we have reported in vitro and in vivo anti-inflammatory effects of fucoidan. In this study, we evaluated the effects and regulatory mechanism of fucoidan derived from Undaria pinnatifida on the cyclooxygenase-2 (COX-2) and type II collagen in rabbit articular chondrocytes. Using western blotting and alcian blue staining, respectively, fucoidan was shown to induce type II collagen and sulfated proteoglycan in a dose- and time-dependent manner. Moreover, fucoidan inhibited the COX-2 expression in a dose- and time-dependent manner and increased the phosphorylation of extracellular signal-regulated kinase (ERK), p38, and AKT kinases in chondrocytes. The inhibition of p38 and AKT using SB203580 and LY294002, respectively, in the presence of fucoidan decreased the expression of type II collagen. However, ERK inhibition using PD98050 stimulated type II collagen expression. Fucoidan increased COX-2 expression in the presence of inhibitors of ERK, p38, and AKT kinases. These results conclusively suggested that fucoidan regulated type II collagen expression via the p38 and AKT pathways, and COX-2 expression via the p38, ERK and AKT pathways in rabbit articular chondrocytes. Moreover, given its ability to mediate cell differentiation and exert anti-inflammatory activity, fucoidan may represent a potential therapeutic substance for use in inflammatory conditions, including arthritis.

Lumbrokinase is used as an oral supplement to support and maintain healthy cardiovascular function, and to treat cardiovascular diseases in clinical for more than 10 years. Up until now, the mechanism of the cardioprotective effects of post-ischemic treatment with lumbrokinase has remained unclear. We therefore investigated the signaling pathways involved in the amelioration of myocardial ischemia-reperfusion (I-R) injury in rats treated with lumbrokinase 20 min after myocardial ischemia. Compared to vehicle-treated rats, post-ischemic treatment with lumbrokinase was associated with significant reductions in myocardial I-R-induced arrhythmias and myocardial damage, and an improvement in cardiac function. Moreover, lumbrokinase significantly upregulated levels of silent information regulator 1 (Sirt1). In addition, lumbrokinase significantly increased manganese-dependent superoxide dismutase expression, decreased Cleaved-Caspase-3 expression, and induced deacetylation of FoxO1. On the other hand, lumbrokinase also significantly downregulated levels of succinate dehydrogenase, cytochrome c oxidase, nuclear factor kappa B (NF-κB) and elevated levels of microtubule-associated protein light chain 3. Notably, the cardioprotective effects of lumbrokinase were abolished by administration of the specific Sirt1 inhibitor EX527. These findings demonstrate that post-ischemic treatment with lumbrokinase attenuates myocardial I-R injury through the activation of Sirt1 signaling, and thu...

Boluoke® (lumbrokinase) is the only fully researched oral fibrinolytic supplement on the market. Besides having in vitro studies, animal studies, toxicity studies, and pharmacokinetic studies done, Boluoke® has also been put through all phases of clinical trials (including randomized double blind controlled studies) in China. Lumbrokinase has been studied as a treatment for various clinical conditions, including acute, sub-acaute, and chronic conditions that are associated with the presence of hypercoagulation and hypoperfusion. Boluoke® seems to be beneficial for any illness that has an accompanying hypercoagulable blood state, which has been shown to be present in many chronic illnesses. Some practitioners are also recommending Boluoke® for those who choose to be on hormone replacement therapy or birth control pills, and for those who could not tolerate standard preventative pharmaceutical drugs. Recommended Use As a dietary supplement, if Boluoke® is to be

Coined “The Mother of All Antioxidants” by Mark Hyman, MD, glutathione is one of the hottest topics in both natural health and medical circles today. Pronounced “gloota-thigh-own,” nearly 117,000 peer-reviewed scientific articles have addressed this powerhouse molecule, and experts are now recognizing that an alarming rate of people are deficient because of: Pre-mature aging Infections Chronic stress Injuries Environmental toxins So-called “health foods” Genetically modified foods Artificial sweeteners Overuse of antibiotics And radiation therapy that is all too easily given to cancer patients today. What Is Glutathione? Reduced glutathione, commonly known as glutathione or GSH, is a tripeptide consisting of L-glutamine, L-cysteine, and glycine. It is ubiquitous in living systems. Glutathione bio-synthesis can be affected by biochemical individuality and/or dietary factors. Chronic oxidative stress can also deplete cellular glutathione. Glutathione is naturally synthesized from N-Acetyl Cysteine (NAC) in the human body. Precursors to glutathione, such as whey protein, vitamin C, and glutamine, are also recommended to boost glutathione levels in the body; however, results are inconsistent. Biological individuality is such that not every body has equivalent ability to metabolize the precursor to raise glutathione.* Why Not Give Pure Glutathione? Unfortunately, most oral forms of glutathione are foul smelling, but more importantly, the majority of an oral dose is oxidized before it can be absorbed and used by the cells. Two different formula's offer a unique preparation of glutathione that overcomes these usual limitations. The stability of S-acetylglutathione and Liposomal Glutathione through the intestinal wall and the plasma is well documented. Oral intake of S-acetyl glutathione increases total glutathione and percent-reduced glutathione. Percent-reduced glutathione is a very significant biomarker of health status.* [1-5] The Two Most Absorbable Forms of Oral Glutathione* HormoneSynergy® S-acetyl glutathione or S-Acetyl Glutathione ULTRA, a lipid-like compound, is taken up intact by chylomicrons in the gut. The acetyl bond is placed on its thiol group or sulfur group, which prevents oxidation and allows the molecule to pass diffusively into the cell after absorption in the gut. The bond is then cleaved by non-specific enzymes inside the cell. Acetylation prevents the breakdown of glutathione, and S-acetyl glutathione does not require energy expenditure to be cleaved to reduced glutathione once it crosses the cell wall.* [1-8 S-Acetyl Glutathione S-Acetyl Glutathione ULTRA w/ NAC HormoneSynergy® Liposomal Glutathione Synergy  provides 500 mg of pure glutathione and activated B vitamin cofactors delivered in phosphatidylcholine liposomes for optimal absorption and bioavailability support.* Liposomal Glutathione Antioxidant Activity Glutathione functions extensively in tissues and organs throughout the body. It plays critical roles in protecting the body from oxidative stress, maintaining cellular functions, and supporting healthy immune function. [1,4] Many factors can increase cellular exposure to oxidative insult, and therefore increase cellular consumption of nutrients—such as glutathione—that provide antioxidant activity. This may result in a fierce cycle of oxidative stress and challenges to detoxification. Complete bio-transformation and protection from oxidative stress are important to maintaining cellular integrity and tissue health.* [2,5]

Glutathione, a powerful endogenous antioxidant, has been the subject of growing scientific interest. Deficiency is increasingly recognized as a risk factor in heart disease, asthma, neurodegenerative disorders and various types of cancer. Supplementation can greatly improve management of many of these conditions.

Editor's note: This post was originally published in August 2016. It has been updated and republished in February 2019. What is glutathione? It may be the most important molecule you need to stay healthy and prevent disease. It's known for its anti-aging power as well as its benefit in fighting cancer, heart disease, dementia, and other chronic diseases. It's also important for treating everything from autism and Alzheimer's disease and more. What is Glutathione and What Does it Do? Glutathione is a combination of three simple building blocks of protein or amino acids − cysteine, glycine, and glutamine − and is

"Can I take glutathione if I have a CBS snp?"

Glutathione is amazing. Ever the underdog, few people have heard of this molecule, yet it supports nearly every aspect of our health. Consider these incredible properties: By acting as an antioxidant, it prevents wear and tear on your tissues, helping you stay youthful, age gracefully, and remain free of chronic diseases. By supporting every-day detoxification, it does …

COVID-19 Update 70 with Roger Seheult, MD Our Update 71 is available at https://www.medcram.com/courses/coronavirus-outbreak-symptoms-treatment As many states in the US make arrangements to re-open their economies, Dr. Seheult discusses some recent trends in COVID-19 infections and deaths. Glutathione is a substance produced naturally by the liver- and is also found in vegetables, fruits, and meats. Dr. Seheult discusses some interesting case reports from New York and Russia that suggest glutathione deficiency may be related to COVID-19 severity. More studies are needed to assess if supplementation of NAC and glutathione could aid in the prevention and treatment of COVID-19 (This video was recorded May 14th, 2020) ------------------------------------------- Links referenced in this video: Johns Hopkins Tracker - https://coronavirus.jhu.edu/map.html https://www.worldometers.info/coronavirus/ HHS - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999661/ ABC - https://abcnews.go.com/Business/states-coronavirus-reopening-plan/story?id=70565409 US News - https://www.usnews.com/news/health-news/articles/2020-05-12/covid-19-now-reaching-into-rural-america Reuters - https://graphics.reuters.com/HEALTH-CORONAVIRUS/USA-TRENDS/dgkvlgkrkpb/ ResearchGate (Dr. Polonikov from Russia) - https://www.researchgate.net/publication/340917045_Endogenous_deficiency_of_glutathione_as_the_most_likely_cause_of_serious_manifestations_and_death_in_patients_with_the_novel_coronavirus_infection_COVID-19_a_hypothesis_based_on_literature_data_and_ow ClinicalTrials - https://clinicaltrials.gov/ct2/show/NCT04374461 Circulation - https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.027290 Medicine - https://journals.lww.com/md-journal/FullText/2018/11090/N_acetylcysteine_improves_oxidative_stress_and.35.aspx NIH - https://pubmed.ncbi.nlm.nih.gov/32322478/?from_term=glutathione+coronavirus&from_pos=9 New York Post - https://nypost.com/2020/05/09/new-york-mom-with-coronavirus-saved-by-medical-student-son/ ------------------------------------------- Some previous videos from this series (visit MedCram.com for the full series): - Coronavirus Pandemic Update 71: New Data on Adding Zinc to Hydroxychloroquine + Azithromycin: https://www.medcram.com/courses/coronavirus-outbreak-symptoms-treatment - Coronavirus Pandemic Update 69: "NAC" Supplementation and COVID-19 (N-Acetylcysteine) https://youtu.be/Dr_6w-WPr0w - Coronavirus Pandemic Update 68: Kawasaki Disease; Minority Groups & COVID-19: https://youtu.be/Ja-jhcXMGj0 - Coronavirus Pandemic Update 67: COVID-19 Blood Clots - Race, Blood Types, & Von Willebrand Factor https://youtu.be/JOlVkES_kC8 - Coronavirus Pandemic Update 66: ACE-Inhibitors and ARBs - Hypertension Medications with COVID-19 https://youtu.be/OudhmwulJHY - Coronavirus Pandemic Update 65: COVID-19 and Oxidative Stress (Prevention & Risk Factors) https://youtu.be/gzx8LH4Fjic - Coronavirus Pandemic Update 64: Remdesivir COVID-19 Treatment Update https://youtu.be/Z2hfGcTokiY - Coronavirus Pandemic Update 63: Is COVID-19 a Disease of the Endothelium (Blood Vessels and Clots)? https://youtu.be/Aj2vB_VITXQ - Coronavirus Pandemic Update 62: Treatment with Famotidine (Pepcid)? https://youtu.be/DtPwfihjyrY - Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress https://youtu.be/22Bn8jsGI54 - Coronavirus Pandemic Update 60: Hydroxychloroquine Update; NYC Data; How Widespread is COVID-19? https://www.medcram.com/courses/coronavirus-outbreak-symptoms-treatment - Coronavirus Pandemic Update 59: Dr. Seheult's Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC) https://youtu.be/NM2A2xNLWR4 - Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID 19 (V/Q vs Shunt vs Diffusion) https://youtu.be/nO4xgcIaPeA - Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces? https://www.medcram.com/courses/coronavirus-outbreak-symptoms-treatment All coronavirus updates are at MedCram.com (including a discussion of that data for coronavirus UK, coronavirus NYC, and other locations) and we offer many other medical topics (ECG Interpretation, strokes, thrombosis, pulmonary embolism, myocardial infarction, hypercoagulation, hypertension, anticoagulation, DKA, acute kidney injury, influenza, measles, mechanical ventilation, etc.). ------------------------------------------- Speaker: Roger Seheult, MD Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine. MedCram provides videos to a variety of medical schools, education programs, and institutions (please contact us at customers@medcram.com if you are interested) Media Contact: customers@medcram.com Media contact info: https://www.medcram.com/pages/media-contact MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor. #COVID19 #SARSCoV2 #FOAMed

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IT’S THE MOST IMPORTANT MOLECULE you need to stay healthy and prevent disease — yet you’ve probably never heard of it. It’s the secret to prevent aging, cancer, heart disease, […]