Amino Acids

Fucoidan is a sulfated polysaccharide widely distributed in brown seaweed. It exhibits several bioactivities, such as anti-cancer, anti-tumor, anti-microbial, anti-diabetic and anti-oxidant properties. However, the effects of fucoidan in chondrocytes are not well established. Previously, we have reported in vitro and in vivo anti-inflammatory effects of fucoidan. In this study, we evaluated the effects and regulatory mechanism of fucoidan derived from Undaria pinnatifida on the cyclooxygenase-2 (COX-2) and type II collagen in rabbit articular chondrocytes. Using western blotting and alcian blue staining, respectively, fucoidan was shown to induce type II collagen and sulfated proteoglycan in a dose- and time-dependent manner. Moreover, fucoidan inhibited the COX-2 expression in a dose- and time-dependent manner and increased the phosphorylation of extracellular signal-regulated kinase (ERK), p38, and AKT kinases in chondrocytes. The inhibition of p38 and AKT using SB203580 and LY294002, respectively, in the presence of fucoidan decreased the expression of type II collagen. However, ERK inhibition using PD98050 stimulated type II collagen expression. Fucoidan increased COX-2 expression in the presence of inhibitors of ERK, p38, and AKT kinases. These results conclusively suggested that fucoidan regulated type II collagen expression via the p38 and AKT pathways, and COX-2 expression via the p38, ERK and AKT pathways in rabbit articular chondrocytes. Moreover, given its ability to mediate cell differentiation and exert anti-inflammatory activity, fucoidan may represent a potential therapeutic substance for use in inflammatory conditions, including arthritis.

Lumbrokinase – An Enzyme for More Than Just Circulatory Health! by Martin Kwok, BSc, MSAOM, ND** Townsend Letter, the Examiner of Alternative Medicine alternative medicine magazine articles are written by researchers, health practitioners and patients.

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"Can I take glutathione if I have a CBS snp?"

Boluoke® (lumbrokinase) is the only fully researched oral fibrinolytic supplement on the market. Besides having in vitro studies, animal studies, toxicity studies, and pharmacokinetic studies done, Boluoke® has also been put through all phases of clinical trials (including randomized double blind controlled studies) in China. Lumbrokinase has been studied as a treatment for various clinical conditions, including acute, sub-acaute, and chronic conditions that are associated with the presence of hypercoagulation and hypoperfusion. Boluoke® seems to be beneficial for any illness that has an accompanying hypercoagulable blood state, which has been shown to be present in many chronic illnesses. Some practitioners are also recommending Boluoke® for those who choose to be on hormone replacement therapy or birth control pills, and for those who could not tolerate standard preventative pharmaceutical drugs. Recommended Use As a dietary supplement, if Boluoke® is to be

Glutathione is amazing. Ever the underdog, few people have heard of this molecule, yet it supports nearly every aspect of our health. Consider these incredible properties: By acting as an antioxidant, it prevents wear and tear on your tissues, helping you stay youthful, age gracefully, and remain free of chronic diseases. By supporting every-day detoxification, it does …

COVID-19 Update 70 with Roger Seheult, MD Our Update 71 is available at https://www.medcram.com/courses/coronavirus-outbreak-symptoms-treatment As many states in the US make arrangements to re-open their economies, Dr. Seheult discusses some recent trends in COVID-19 infections and deaths. Glutathione is a substance produced naturally by the liver- and is also found in vegetables, fruits, and meats. Dr. Seheult discusses some interesting case reports from New York and Russia that suggest glutathione deficiency may be related to COVID-19 severity. More studies are needed to assess if supplementation of NAC and glutathione could aid in the prevention and treatment of COVID-19 (This video was recorded May 14th, 2020) ------------------------------------------- Links referenced in this video: Johns Hopkins Tracker - https://coronavirus.jhu.edu/map.html https://www.worldometers.info/coronavirus/ HHS - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999661/ ABC - https://abcnews.go.com/Business/states-coronavirus-reopening-plan/story?id=70565409 US News - https://www.usnews.com/news/health-news/articles/2020-05-12/covid-19-now-reaching-into-rural-america Reuters - https://graphics.reuters.com/HEALTH-CORONAVIRUS/USA-TRENDS/dgkvlgkrkpb/ ResearchGate (Dr. Polonikov from Russia) - https://www.researchgate.net/publication/340917045_Endogenous_deficiency_of_glutathione_as_the_most_likely_cause_of_serious_manifestations_and_death_in_patients_with_the_novel_coronavirus_infection_COVID-19_a_hypothesis_based_on_literature_data_and_ow ClinicalTrials - https://clinicaltrials.gov/ct2/show/NCT04374461 Circulation - https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.027290 Medicine - https://journals.lww.com/md-journal/FullText/2018/11090/N_acetylcysteine_improves_oxidative_stress_and.35.aspx NIH - https://pubmed.ncbi.nlm.nih.gov/32322478/?from_term=glutathione+coronavirus&from_pos=9 New York Post - https://nypost.com/2020/05/09/new-york-mom-with-coronavirus-saved-by-medical-student-son/ ------------------------------------------- Some previous videos from this series (visit MedCram.com for the full series): - Coronavirus Pandemic Update 71: New Data on Adding Zinc to Hydroxychloroquine + Azithromycin: https://www.medcram.com/courses/coronavirus-outbreak-symptoms-treatment - Coronavirus Pandemic Update 69: "NAC" Supplementation and COVID-19 (N-Acetylcysteine) https://youtu.be/Dr_6w-WPr0w - Coronavirus Pandemic Update 68: Kawasaki Disease; Minority Groups & COVID-19: https://youtu.be/Ja-jhcXMGj0 - Coronavirus Pandemic Update 67: COVID-19 Blood Clots - Race, Blood Types, & Von Willebrand Factor https://youtu.be/JOlVkES_kC8 - Coronavirus Pandemic Update 66: ACE-Inhibitors and ARBs - Hypertension Medications with COVID-19 https://youtu.be/OudhmwulJHY - Coronavirus Pandemic Update 65: COVID-19 and Oxidative Stress (Prevention & Risk Factors) https://youtu.be/gzx8LH4Fjic - Coronavirus Pandemic Update 64: Remdesivir COVID-19 Treatment Update https://youtu.be/Z2hfGcTokiY - Coronavirus Pandemic Update 63: Is COVID-19 a Disease of the Endothelium (Blood Vessels and Clots)? https://youtu.be/Aj2vB_VITXQ - Coronavirus Pandemic Update 62: Treatment with Famotidine (Pepcid)? https://youtu.be/DtPwfihjyrY - Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress https://youtu.be/22Bn8jsGI54 - Coronavirus Pandemic Update 60: Hydroxychloroquine Update; NYC Data; How Widespread is COVID-19? https://www.medcram.com/courses/coronavirus-outbreak-symptoms-treatment - Coronavirus Pandemic Update 59: Dr. Seheult's Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC) https://youtu.be/NM2A2xNLWR4 - Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID 19 (V/Q vs Shunt vs Diffusion) https://youtu.be/nO4xgcIaPeA - Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces? https://www.medcram.com/courses/coronavirus-outbreak-symptoms-treatment All coronavirus updates are at MedCram.com (including a discussion of that data for coronavirus UK, coronavirus NYC, and other locations) and we offer many other medical topics (ECG Interpretation, strokes, thrombosis, pulmonary embolism, myocardial infarction, hypercoagulation, hypertension, anticoagulation, DKA, acute kidney injury, influenza, measles, mechanical ventilation, etc.). ------------------------------------------- Speaker: Roger Seheult, MD Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine. MedCram provides videos to a variety of medical schools, education programs, and institutions (please contact us at customers@medcram.com if you are interested) Media Contact: customers@medcram.com Media contact info: https://www.medcram.com/pages/media-contact MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor. #COVID19 #SARSCoV2 #FOAMed

Glutathione supplements may offer some health benefits from their antioxidant content. But be aware glutathione side effects can result from improper use.

IT’S THE MOST IMPORTANT MOLECULE you need to stay healthy and prevent disease — yet you’ve probably never heard of it. It’s the secret to prevent aging, cancer, heart disease, […]

The enzyme serrapeptase is used to relieve pain and inflammation; its effects on heart health are also being researched. Learn more here.

This report describes a patient's self-substitution of nattokinase for the vitamin K antagonist warfarin after aortic valve replacement with a mechanical prosthesis. Nattokinase is an enzyme derived from a popular fermented soybean preparation in Japan ...

Summary Below This is Dr Ben Lynch giving clinical insights to a common condition - from the cuff - not reading and no teleprompter. Get the FREE video course “Practical Clinical Applications of Methylation and Epigenetics” - https://seekinghealth.org/free-video-course Get the full transcript, go to: https://seekinghealth.org/resource/genetic-tests-whats-the-big-deal/ Join Like-Minded Folks here on Facebook: https://www.facebook.com/SeekingHealthEducation iTunes free podcast: http://apple.co/1GzJiZS Twitter: https://twitter.com/SeekingHealthEI Instagram: https://instagram.com/seekinghealthei/ LinkedIn: http://www.linkedin.com/in/benjaminlynch/ ---------------------------- VIDEO SUMMARY ---------------------------- Learn why you might be getting those MSG headaches after eating Chinese food or your favorite bag of chips. MSG stands for monosodium glutamate. MSG is a common flavor enhancer used in some of your favorite packaged foods and in some Chinese restaurants. Dr. Lynch discusses 3 strategies to rid yourself of MSG-induced headaches: 1) Avoid MSG - hidden sources of MSG on food labels - http://www.truthinlabeling.org/hiddensources.html 2) Find out if you have a GAD (glutamate decarboxylase) gene polymorphism. This gene programs the enzyme that breakds down MSG. You might be susceptible to increase levels of glutamate in your blood. 3) Find other pathways that might effect your ability to breakdown glutamate - including the niacin and homocysteine pathways. 4) Support glutamate breakdown with magnesium, vitamin B6, niacin, eating a healthy balanced diet with healthy oils (fish oil, krill oil, and phosphatidylcholine) Note: There are many different causes of headaches. Please work with your doctor to see if any of these strategies might be right for you. Full Transcript: https://seekinghealth.org/resource/genetic-tests-whats-the-big-deal/ ------------------------------------------- EDUCATIONAL RESOURCE ------------------------------------------ Did you like this video? If you are a doctor and want to learn how to truly optimize your patients' health, check out SHEICON2015 at www.seekinghealth.org/sheicon2015. Join Dr. Ben Lynch and 400 others who want to transform their medical practices. Ready for exponential growth? A SHEI membership gives you access to hours of FREE conference recordings, educational and conference discounts, professional & general public forums and more! Visit http://www.seekinghealth.org/product/membership for more information. All of SHEI education is purely educational. There are NO product recommendations or 'sales pitches'. ------------------------------------------------------------------------------------- ABOUT SEEKING HEALTH EDUCATIONAL INSTITUTE ------------------------------------------------------------------------------------ Seeking Health Educational Institute (SHEI) identifies and assimilates clinically-relevant research in the areas of nutrigenomics and methylation. We then deliver it to the health professional – and layperson – via webinars, seminars, conferences, forums, podcasts, videos and articles. As the leader in nutrigenomics and methylation research interpretation, SHEI is the trusted resource for health professionals and laypersons worldwide. Our Promise To change the healthcare model from disease-based medicine towards an integrative systems approach one healthcare professional at a time. To provide accurate, efficient and effective clinical tools. To strive towards optimizing life. Our Mission Providing education for both health professionals and laypersons in the art of integrating nutrigenomics with the principles of Vis Medicatrix Naturae, Tolle Causum, Tolle Totum and Docere. -------------------------------------------------- RESEARCHED FORMULATIONS ------------------------------------------------ Here is where you will find researched supplement formulations by Dr Lynch: http://www.seekinghealth.com Health professionals are eligible for wholesale pricing: http://www.seekinghealth.com/wholesale

A safe, low-cost compound called N-acetylcysteine has provided millions of people relief from coughing, wheezing, and thick phlegm associated with cold and flu.

ReferenceRapado-Castro M, Berk M, Venugopal K, Bush AI, Dodd S, Dean OM. Towards stage specific treatments: effects of duration of illness on therapeutic response to adjunctive treatment with N-acetyl cysteine in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2015;3(57):69-75. DesignA double-blind, placebo-controlled trial to investigate whether duration of illness was a factor in modulating the response to N-acetylcysteine (NAC). ParticipantsThe study included 121 participants who were randomized to receive placebo (n=62) or N-acetylcysteine (NAC; n=59) for 24 weeks.

Researchers have reported they have identified a biochemical pathway linking oxidative stress and the amino acid cysteine in Huntington's disease.

Solid supported membranes (SSMs) are usually formed by an hybrid octadecanethiol/phosphatidylcholine (PC) bilayer supported by a gold electrode. Recently, it was shown that phosphatidylserine (PS) in place of PC can promote a more effective accumulation of lipid vesicles on the SSM surface when Ca …