Amino Acids

A transition of amyloidogenic protein by alternative folding pathway under certain conditions leads to the formation of protease resistant amyloid fib…

Fucoidan is a sulfated polysaccharide widely distributed in brown seaweed. It exhibits several bioactivities, such as anti-cancer, anti-tumor, anti-microbial, anti-diabetic and anti-oxidant properties. However, the effects of fucoidan in chondrocytes are not well established. Previously, we have reported in vitro and in vivo anti-inflammatory effects of fucoidan. In this study, we evaluated the effects and regulatory mechanism of fucoidan derived from Undaria pinnatifida on the cyclooxygenase-2 (COX-2) and type II collagen in rabbit articular chondrocytes. Using western blotting and alcian blue staining, respectively, fucoidan was shown to induce type II collagen and sulfated proteoglycan in a dose- and time-dependent manner. Moreover, fucoidan inhibited the COX-2 expression in a dose- and time-dependent manner and increased the phosphorylation of extracellular signal-regulated kinase (ERK), p38, and AKT kinases in chondrocytes. The inhibition of p38 and AKT using SB203580 and LY294002, respectively, in the presence of fucoidan decreased the expression of type II collagen. However, ERK inhibition using PD98050 stimulated type II collagen expression. Fucoidan increased COX-2 expression in the presence of inhibitors of ERK, p38, and AKT kinases. These results conclusively suggested that fucoidan regulated type II collagen expression via the p38 and AKT pathways, and COX-2 expression via the p38, ERK and AKT pathways in rabbit articular chondrocytes. Moreover, given its ability to mediate cell differentiation and exert anti-inflammatory activity, fucoidan may represent a potential therapeutic substance for use in inflammatory conditions, including arthritis.

Summary Below This is Dr Ben Lynch giving clinical insights to a common condition - from the cuff - not reading and no teleprompter. Get the FREE video course “Practical Clinical Applications of Methylation and Epigenetics” - https://seekinghealth.org/free-video-course Get the full transcript, go to: https://seekinghealth.org/resource/genetic-tests-whats-the-big-deal/ Join Like-Minded Folks here on Facebook: https://www.facebook.com/SeekingHealthEducation iTunes free podcast: http://apple.co/1GzJiZS Twitter: https://twitter.com/SeekingHealthEI Instagram: https://instagram.com/seekinghealthei/ LinkedIn: http://www.linkedin.com/in/benjaminlynch/ ---------------------------- VIDEO SUMMARY ---------------------------- Learn why you might be getting those MSG headaches after eating Chinese food or your favorite bag of chips. MSG stands for monosodium glutamate. MSG is a common flavor enhancer used in some of your favorite packaged foods and in some Chinese restaurants. Dr. Lynch discusses 3 strategies to rid yourself of MSG-induced headaches: 1) Avoid MSG - hidden sources of MSG on food labels - http://www.truthinlabeling.org/hiddensources.html 2) Find out if you have a GAD (glutamate decarboxylase) gene polymorphism. This gene programs the enzyme that breakds down MSG. You might be susceptible to increase levels of glutamate in your blood. 3) Find other pathways that might effect your ability to breakdown glutamate - including the niacin and homocysteine pathways. 4) Support glutamate breakdown with magnesium, vitamin B6, niacin, eating a healthy balanced diet with healthy oils (fish oil, krill oil, and phosphatidylcholine) Note: There are many different causes of headaches. Please work with your doctor to see if any of these strategies might be right for you. Full Transcript: https://seekinghealth.org/resource/genetic-tests-whats-the-big-deal/ ------------------------------------------- EDUCATIONAL RESOURCE ------------------------------------------ Did you like this video? If you are a doctor and want to learn how to truly optimize your patients' health, check out SHEICON2015 at www.seekinghealth.org/sheicon2015. Join Dr. Ben Lynch and 400 others who want to transform their medical practices. Ready for exponential growth? A SHEI membership gives you access to hours of FREE conference recordings, educational and conference discounts, professional & general public forums and more! Visit http://www.seekinghealth.org/product/membership for more information. All of SHEI education is purely educational. There are NO product recommendations or 'sales pitches'. ------------------------------------------------------------------------------------- ABOUT SEEKING HEALTH EDUCATIONAL INSTITUTE ------------------------------------------------------------------------------------ Seeking Health Educational Institute (SHEI) identifies and assimilates clinically-relevant research in the areas of nutrigenomics and methylation. We then deliver it to the health professional – and layperson – via webinars, seminars, conferences, forums, podcasts, videos and articles. As the leader in nutrigenomics and methylation research interpretation, SHEI is the trusted resource for health professionals and laypersons worldwide. Our Promise To change the healthcare model from disease-based medicine towards an integrative systems approach one healthcare professional at a time. To provide accurate, efficient and effective clinical tools. To strive towards optimizing life. Our Mission Providing education for both health professionals and laypersons in the art of integrating nutrigenomics with the principles of Vis Medicatrix Naturae, Tolle Causum, Tolle Totum and Docere. -------------------------------------------------- RESEARCHED FORMULATIONS ------------------------------------------------ Here is where you will find researched supplement formulations by Dr Lynch: http://www.seekinghealth.com Health professionals are eligible for wholesale pricing: http://www.seekinghealth.com/wholesale

A safe, low-cost compound called N-acetylcysteine has provided millions of people relief from coughing, wheezing, and thick phlegm associated with cold and flu.

ReferenceRapado-Castro M, Berk M, Venugopal K, Bush AI, Dodd S, Dean OM. Towards stage specific treatments: effects of duration of illness on therapeutic response to adjunctive treatment with N-acetyl cysteine in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2015;3(57):69-75. DesignA double-blind, placebo-controlled trial to investigate whether duration of illness was a factor in modulating the response to N-acetylcysteine (NAC). ParticipantsThe study included 121 participants who were randomized to receive placebo (n=62) or N-acetylcysteine (NAC; n=59) for 24 weeks.

Researchers have reported they have identified a biochemical pathway linking oxidative stress and the amino acid cysteine in Huntington's disease.

Researchers have reported they have identified a biochemical pathway linking oxidative stress and the amino acid cysteine in Huntington's disease.

Solid supported membranes (SSMs) are usually formed by an hybrid octadecanethiol/phosphatidylcholine (PC) bilayer supported by a gold electrode. Recently, it was shown that phosphatidylserine (PS) in place of PC can promote a more effective accumulation of lipid vesicles on the SSM surface when Ca …

A compound abundant in red meat and added as a supplement to popular energy drinks has been found to promote atherosclerosis -- or the hardening or clogging of the arteries.

Chronic stress makes us worn-out, anxious, depressed, and according to a new study, causes damage to critical brain neurons. Researchers report that mice exposed to prolonged stress develop structu…

BACKGROUND: Ischaemia/reperfusion (I/R) of the intestine causes mucosal injury associated with a high death rate in rats. AIM: To investigate whether nitric oxide (NO) might be implicated in the recovery of the intestinal mucosa after ischaemic insult. ...

PAD4 has been observed in cancers but its role was unclear. An Oxford University team have found that PAD4 citrullinates protein E2F-1, which causes it to form a protein complex with BRD4 that drives expression of inflammatory genes.

What Is Alpha GPC Powder? Alpha GPC powder (L-alpha glycerylphosphorylcholine powder) is a choline compound and phospholipid. Alpha GPC is a precursor to acetylcholine and is regarded for its ability to deliver choline across the blood-brain barrier. It is also often used among athletes to help with strength and to ele

Buy Phosphatidylserine in bulk at BulkSupplements.com. What is Phosphatidylserine, benefits, dosage, side effects, and customer reviews. Memory supplements.

Patients with acute heart failure often have high levels of the metabolite trimethylamine N-oxide (TMAO) – of which red meat is a major dietary source - according to researchers.

Why we may want to strive not to exceed the recommended intake of protein. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ So rather than Do Vegetarians Get Enough Protein? (https://nutritionfacts.org/video/do-vegetarians-get-enough-protein), the question shifts to how do omnivores not get too much? This may help explain some of the benefits of plant-based proteins: • What Diet Should Physicians Recommend? (https://nutritionfacts.org/video/what-diet-should-physicians-recommend) • The Okinawa Diet: Living to 100 (https://nutritionfacts.org/video/the-okinawa-diet-living-to-100) • Do Flexitarians Live Longer? (https://nutritionfacts.org/video/do-flexitarians-live-longer) • Caloric Restriction vs. Plant-Based Diets (https://nutritionfacts.org/video/caloric-restriction-vs-plant-based-diets) • Plant-Based Diets and Diabetes (https://nutritionfacts.org/video/plant-based-diets-and-diabetes) • Plant-Based Diets Recognized by Diabetes Associations (http://nutritionfacts.org/video/plant-based-diets-recognized-by-diabetes-associations) Of course the best way to treat type 2 diabetes is to get rid of it by treating the underlying cause: How Not to Die from Diabetes (https://nutritionfacts.org/video/how-not-to-die-from-diabetes/). Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/are-bcaa-branched-chain-amino-acids-healthy and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/are-bcaa-branched-chain-amino-acids-healthy. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages. To find yours, click on the settings wheel on the lower-right of the video and then "Subtitles/CC." Do you have feedback about the translations in this video? Please share it here along with the title of the video and language: https://nutritionfacts.zendesk.com/hc/requests/new Image credit: Dustin & Harbin / wikipedia https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Independent and unbiased analysis of serrapeptase as a supplement, including benefits, side effects, dosage, and more.

Two forms of a peptide derived from a naturally-occurring human protein can force tumors to shrink significantly in an animal model of metastatic ovarian cancer, according to a team of researchers.