Biome

Research indicates that the ancient spice turmeric may help to mitigate the growing threat of antibiotic resistant infections that the CDC estimates will take 23,000 U.S. lives each year.

Think diseases run in the family? Think again.

Background Microorganisms in the human intestine (i.e. the gut microbiome) have an increasingly recognized impact on human health, including brain functioning. Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder associated with abnormalities in dopamine neurotransmission and deficits in reward processing and its underlying neuro-circuitry including the ventral striatum. The microbiome might contribute to ADHD etiology via the gut-brain axis. In this pilot study, we investigated potential differences in the microbiome between ADHD cases and undiagnosed controls, as well as its relation to neural reward processing. Methods We used 16S rRNA marker gene sequencing (16S) to identify bacterial taxa and their predicted gene functions in 19 ADHD and 77 control participants. Using functional magnetic resonance imaging (fMRI), we interrogated the effect of observed microbiome differences in neural reward responses in a subset of 28 participants, independent of diagnosis. Results For the first time, we describe gut microbial makeup of adolescents and adults diagnosed with ADHD. We found that the relative abundance of several bacterial taxa differed between cases and controls, albeit marginally significant. A nominal increase in the Bifidobacterium genus was observed in ADHD cases. In a hypothesis-driven approach, we found that the observed increase was linked to significantly enhanced 16S-based predicted bacterial gene functionality encoding cyclohexadienyl dehydratase in cases relative to controls. This enzyme is involved in the synthesis of phenylalanine, a precursor of dopamine. Increased relative abundance of this functionality was significantly associated with decreased ventral striatal fMRI responses during reward anticipation, independent of ADHD diagnosis and age. Conclusions Our results show increases in gut microbiome predicted function of dopamine precursor synthesis between ADHD cases and controls. This increase in microbiome function relates to decreased neural responses to reward anticipation. Decreased neural reward anticipation constitutes one of the hallmarks of ADHD.

Colorectal cancer is the second-leading cause of cancer-related deaths in the United States and fourth-leading cause of cancer-related deaths worldwide. While cancer is largely considered to be a disease of genetic and environmental factors, increasing evidence has demonstrated a role for the microbiota (the microorganisms associated with the human body) in shaping inflammatory environments and promoting tumor growth and spread. Herein, we discuss both human data from meta'omics analyses and data from mechanistic studies in cell culture and animal models that support specific bacterial agents as potentiators of tumorigenesis—including Fusobacterium nucleatum, enterotoxigenic Bacteroides fragilis, and colibactin-producing Escherichia coli. Further, we consider how microbes can be used in diagnosing colorectal cancer and manipulating the tumor environment to encourage better patient outcomes in response to immunotherapy treatments.

This guy is saving lives with his poop, and maybe you can, too.

Antibiotics strong enough to kill off gut bacteria can also stop the growth of new brain cells in the hippocampus, a section of the brain associated with memory, reports a new study in mice. Researchers also uncovered a clue to why -- a type of white blood cell seems to act as a communicator between the brain, the immune system, and the gut.

In certain medical conditions, probiotic supplements may actually make things worse. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ Support NutritionFacts.org with a donation at http://www.NutritionFacts.org/donate. This is a link to the video I alluded to: Preventing the Common Cold with Probiotics? (http://nutritionfacts.org/video/preventing-the-common-cold-with-probiotics). I also talk about the potential benefits in my videos Preventing and Treating Diarrhea with Probiotics (https://nutritionfacts.org/video/preventing-and-treating-diarrhea-with-probiotics/) and Gut Feelings: Probiotics and Mental Health (https://nutritionfacts.org/video/gut-feelings-probiotics-and-mental-health/). Perhaps it would be safer and more effective to instead focus on fostering the growth of the good bacteria with have by feeding them prebiotics (fiber and resistant starch): • Prebiotics: Tending Our Inner Garden (https://nutritionfacts.org/video/prebiotics-tending-our-inner-garden) • Boosting Good Bacteria in the Colon Without Probiotics (https://nutritionfacts.org/video/boosting-good-bacteria-in-the-colon-without-probiotics/) • Resistant Starch and Colon Cancer (https://nutritionfacts.org/video/resistant-starch-colon-cancer) • Gut Dysbiosis - Starving Our Microbial Self (https://nutritionfacts.org/video/is-obesity-infectious) • How to Become a Fecal Transplant Super Donor (https://nutritionfacts.org/video/How-to-Become-a-Fecal-Transplant-Super-Donor) • Microbiome: We Are What They Eat (https://nutritionfacts.org/video/Microbiome-We-Are-What-They-Eat) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/culture-shock-questioning-the-efficacy-and-safety-of-probiotics and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/culture-shock-questioning-the-efficacy-and-safety-of-probiotics. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages. To find yours, click on the settings wheel on the lower-right of the video and then "Subtitles/CC." Do you have feedback about the translations in this video? Please share it here along with the title of the video and language: https://nutritionfacts.zendesk.com/hc/requests/new To view the subtitles in transcript format, click on the ellipsis button below the video, choose "Open transcript", and select the language you'd like to view them in. Icons created by Laymik, Tinashe Mugayi, Nikita Kozin, and Tomas Knopp from The Noun Project. Image credit: Kristina DeMuth https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Are osmotic laxatives, like Miralax, a free ride to improved digestion, or is the body was actually paying a price for these interventions?

Visit the Mercola Video Library By Dr. Mercola The US Food and Drug Administration (FDA) recently issued a warning that fluoroquinolone antibiotics, taken by mouth or injection, carry a risk for permanent peripheral neuropathy. The safety announcement states:1 “The U.S. Food and Drug Administration (FDA) has required the drug labels and Medication Guides for all fluoroquinolone antibacterial drugs be updated to better describe the serious side effect of peripheral neuropathy. This serious nerve damage potentially caused by fluoroquinolones may occur soon after these drugs are taken and may be permanent… The topical formulations of fluoroquinolones, applied to the ears or … Continue reading →

Similar to the use of GcMAF, degalactosylated/desialylated bovine colostrum can be used as a potential macrophage activator for various immunotherapies.

What we eat determines what kind of bacteria we foster the growth of in our gut, which can increase or decrease our risk of some of our leading killer diseases. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ If that was the supplement industry’s response, how did the egg industry react? See my video Egg Industry Response to Choline and TMAO (http://nutritionfacts.org/video/egg-industry-response-to-choline-and-tmao). For more background on TMAO, see Carnitine, Choline, Cancer, and Cholesterol: The TMAO Connection (http://nutritionfacts.org/video/carnitine-choline-cancer-and-cholesterol-the-tmao-connection/). Our gut flora are what we eat! Check out: • Microbiome: The Inside Story (http://nutritionfacts.org/video/microbiome-the-inside-story) • Prebiotics: Tending Our Inner Garden (http://nutritionfacts.org/video/prebiotics-tending-our-inner-garden) • What’s Your Gut Microbiome Enterotype? (http://nutritionfacts.org/video/whats-your-gut-microbiome-enterotype) • How to Change Your Enterotype (http://nutritionfacts.org/video/how-to-change-your-enterotype) • Paleopoo: What We Can Learn from Fossilized Feces (http://nutritionfacts.org/video/paleopoo-what-we-can-learn-from-fossilized-feces/) • Gut Dysbiosis - Starving Our Microbial Self (http://nutritionfacts.org/video/gut-dysbiosis-starving-microbial-self) • Is Obesity Infectious? (http://nutritionfacts.org/video/is-obesity-infectious) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/how-to-develop-a-healthy-gut-ecosystem and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/how-to-develop-a-healthy-gut-ecosystem. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credit: MelSi via pixabay. Image has been modified. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Should we be concerned about high-choline plant foods such as broccoli producing the same toxic TMAO that results from eating high-choline animal foods such as eggs? Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ Support NutritionFacts.org with a donation at http://www.NutritionFacts.org/donate. That was a fun video to record. Can you hear the frustration in my voice reading paper after paper proposing these ridiculous (but profitable!) answers when the safe, simple, side-effect free solution was staring them in the face the whole time? Makes me think of so many parallels, to the least of which are: • How Not to Die from Heart Disease (https://nutritionfacts.org/video/how-not-to-die-from-heart-disease/) • How Not to Die from Diabetes (https://nutritionfacts.org/video/how-not-to-die-from-diabetes/) • How Not to Die from High Blood Pressure (https://nutritionfacts.org/video/how-not-to-die-from-high-blood-pressure/) For more on TMAO, the “smoking gun” of diet-microbiome-disease interactions, see: • Eggs, Choline, and Cancer (httpss://nutritionfacts.org/video/eggs-choline-and-cancer/) • Carnitine, Choline, Cancer, and Cholesterol: The TMAO Connection (https://nutritionfacts.org/video/carnitine-choline-cancer-and-cholesterol-the-tmao-connection/) • Egg Industry Response to Choline and TMAO (https://nutritionfacts.org/video/egg-industry-response-to-choline-and-tmao) • How to Develop a Healthy Gut Ecosystem (httpss://nutritionfacts.org/video/how-to-develop-a-healthy-gut-ecosystem/) • How to Treat Heart Failure and Kidney Failure with Diet (https://nutritionfacts.org/video/How-to-Treat-Heart-Failure-and-Kidney-Failure-with-Diet) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/how-to-reduce-your-tmao-levels and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/how-to-reduce-your-tmao-levels. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credit: Sally Plank via Flickr https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

A new literature review suggests that nutrition and diet have a profound impact on the microbial composition of the gut.

Did you know that probiotic bacteria are capable of helping you detoxify the most noxious chemicals known to humankind?

Science says eating just one meal per day can improve your health. Learn more at https://highintensityhealth.com/OMAD ----- Access the Show Notes & Download the Audio: http://highintensityhealth.com/digestion-gut-microbiome-probiotics-prebiotics-russell-jaffe-md-phd-ccn/ Key Points: 15:15 Antibiotics Lay Waste to our Microbiome. This is well explained in When Antibiotics Fail: Restoring the Ecology of the Body, a book by Mark Lappe’ and in Michael Schmidt’s work. You need to work intensively replenishing every day for 3 to 6 months after antibiotic exposure using multiple healthy organisms, fermented food and active supplements. Dr. Jaffe uses the power of billions of live CFU, colony forming units, in human implantable strains. Live bugs work and dead bugs don’t. 16:43 We Can Make Our Own: We can make our own prebiotic foods with high fiber to feed the good bugs. We can take in enough probiotic organisms to replenish those expended from stress and toxin exposure, and symbiotic foods, nutrients like recycled glutamine, which helps repair the digestive tract. Prebiotics, probiotics and symbiotics form a triad. 17:33 Renaissance of Proactive Primary Prevention: For the past 3 years, throughout the world there have been public health initiatives to get more prebiotic high fiber, probiotic organisms, and symbiotics into our diets. The lining of the intestinal tract is one of the most vulnerable places in the body. It replaces itself about every 3 days. A healthy person’s digestive tract, if laid out flat, would be as large as a tennis court. Most American adults suffer from atrophy of their digestive tract because they have not been nourishing and nurturing it. This means that they only have a few square feet. The good news is that this can nearly always be rehabilitated. 18:57 The Age Myth: It is a lie that once we begin to decline with age that it can be slowed and symptoms can be suppressed, but the decline is irreversible and inescapable. The age myth is about the proportion of unhealthy people at certain stages of life. Dr. Jaffe has tested groups of 90 to 100 year olds and healthy 20 to 30 year olds, drawing their blood, culturing their white cells, culturing muscles and other cells, and the groups are indistinguishable from each other. 20:48 A Detailed Description of Digestion: Digestion begins with your eyes. They tell your gut and your brain, what you will be consuming. As we chew, small bits of food escape through the mucosa to inform the brain and the gut as to what digestive juices will be needed for this meal. The stomach churns and produces acid. People with ulcers have low stomach acid and healthy people have lots of stomach acid. Proton pump inhibitors are prescribed all the time. Often, if you believe they will work, they will work just slightly better than placebos. When you inhibit stomach acid production, you set up a chain of events of maldigestion, often with the sensitization of the immune system. It is essential that we have an amino acid called histadine that donates the proton, the acid that keeps the stomach acidic so that pepsin, the enzyme that loves to be in that acid environment, begins to open the food particles, especially the proteins and the concentrated foods. The acid in the chyme, which is the stuff that comes out of the stomach and is delivered to the small intestine, triggers a bicarbonate and digestive enzyme release from the pancreas. . We meet the bicarbonate and digestive enzymes that pour out of the pancreas to neutralize the stomach acid and begin the next phase. At a small duct, bile comes in to emulsify fats, bringing fat soluble vitamins and nutrients into the body. For the next 20 feet, nutrients are taken up selectively. Then it is on to the large intestine, which should not have digestive remnants. By the time we get to the ileocecal valve that separates the small intestine from the large, the food should be broken down to non-immune reactive building blocks that get assimilated. There should be enough fiber to bind toxins and remove them from the body. These toxins are putrescine, cadaverine, and other polyamines, which can form when digestive transit time is longer than the healthy 12 to 18 hours. 25:17 Digestive Transit Time: Typical Americans have a 72 hour to 144 hour transit time from entrance to exit. If you are, you will want to increase the fiber in your diet, you eat foods that you can digest, assimilate and eliminate without immune burden, if you have some sense of portion control, so we do not overwhelm the body. Only about 1 in 20 Americans, or about 5% of our population, has a healthy transit time of 12 to 18 hours and a healthy digestion. Maldigestion, dysbiosis, inflammatory atrophy and enteropathy of the digestive mechanisms is at epidemic proportions and has been for many decades. These digestive disorders are most often the cause of chronic degenerative autoimmune and inflammatory conditions.

Antibiotics can be a controversial topic. While they can help tremendously for some specific infections in the body, they can also wreak your gut.

ReferenceKang DW, Adams JB, Gregory AC, et al. Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study. Microbiome. 2017 Jan 23;5(1):10.DesignProspective, open-label, uncontrolled pilot studyParticipantsEighteen children between the ages of 7 and 16 with an autism spectrum disorder (ASD) diagnosis and moderate to severe gastrointestinal (GI) problems.

An extraordinary Facebook Live with Dr. Mike Hoaglin, MD from uBiome. You’ll understand: ✓ What the microbiome is and why it’s a huge clue into your health status. ✓ What it impacts and how you can change your microbiome and change the course of your health. ✓ The best evidenced-based way to test your microbiome. ✓ What your weight has to do with your microbiome. ✓ The number one change you can make right now to alter your microbiome, and so much more...

Background Type II diabetes is a chronic health condition which is associated with skin conditions including chronic foot ulcers and an increased incidence of skin infections. The skin microbiome is thought to play important roles in skin defence and immune functioning. Diabetes affects the skin environment, and this may perturb skin microbiome with possible implications for skin infections and wound healing. This study examines the skin and wound microbiome in type II diabetes. Methods Eight type II diabetic subjects with chronic foot ulcers were followed over a time course of 10 weeks, sampling from both foot skin (swabs) and wounds (swabs and debrided tissue) every two weeks. A control group of eight control subjects was also followed over 10 weeks, and skin swabs collected from the foot skin every two weeks. Samples were processed for DNA and subject to 16S rRNA gene PCR and sequencing of the V4 region. Results The diabetic skin microbiome was significantly less diverse than control skin. Community composition was also significantly different between diabetic and control skin, however the most abundant taxa were similar between groups, with differences driven by very low abundant members of the skin communities. Chronic wounds tended to be dominated by the most abundant skin Staphylococcus, while other abundant wound taxa differed by patient. No significant correlations were found between wound duration or healing status and the abundance of any particular taxa. Discussion The major difference observed in this study of the skin microbiome associated with diabetes was a significant reduction in diversity. The long-term effects of reduced diversity are not yet well understood, but are often associated with disease conditions.

Long-term survival of lung transplant recipients (LTRs) is limited by the occurrence of bronchiolitis obliterans syndrome (BOS). Recent evidence suggests a role for microbiome alterations in the occurrence of BOS, although the precise mechanisms are unclear. In this study we evaluated the relationship between the airway microbiome and distinct subsets of immunoregulatory myeloid-derived suppressor cells (MDSCs) in LTRs.

Do Antibiotics Cause Celiac Disease? Some researchers say yes they can. Especially in those with genetic susceptibility to gluten sensitivity. Antibiotics cause a yeast overgrowth, and emerging research shows that yeast - AKA candida, can create a protein that mimics gluten, causing an intestinal reaction leading to the development of celiac disease. To connect with Dr. Osborne visit: Facebook: https://www.facebook.com/DoctorPeterO... Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.

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Researchers have made the first direct demonstration that fecal donor microbes remained in recipients for months or years after a transplant to treat the diarrhea and colitis caused by recurrent Clostridium difficile infections -- a serious and stubborn cause of diarrhea after an antibiotic treatment for some other illness.