Biome

Similar to the use of GcMAF, degalactosylated/desialylated bovine colostrum can be used as a potential macrophage activator for various immunotherapies.

Chronic inflammation represents one of the most consistent biologic features of aging. However, the precise etiology of persistent low-grade increases in inflammation remains unclear. Recent evidence suggests that the gut microbiome may play a key role in age-related inflammation. Indeed, several studies have indicated that older adults display an altered composition of the gut microbiota, and early evidence indicates that this dysbiosis is associated with the presence of several key circulating inflammatory analytes. The present review summarizes knowledge on age-related inflammation and discusses how potential relationships with gut dysbiosis may lead to novel treatment strategies in the future.“The pattern of disease is an expression of the response of man to his total environment (physical, biological, and social); this response is, therefore, determined by anything that affects man himself or his environment.” – Rene Dubos, 1961

A new literature review suggests that nutrition and diet have a profound impact on the microbial composition of the gut.

Probiotic supplements protected female mice from the loss of bone density that occurs after having their ovaries removed, researchers have shown. The findings suggest that probiotic bacteria may have potential as an inexpensive treatment for post-menopausal osteoporosis.

Science says eating just one meal per day can improve your health. Learn more at https://highintensityhealth.com/OMAD ----- Access the Show Notes & Download the Audio: http://highintensityhealth.com/digestion-gut-microbiome-probiotics-prebiotics-russell-jaffe-md-phd-ccn/ Key Points: 15:15 Antibiotics Lay Waste to our Microbiome. This is well explained in When Antibiotics Fail: Restoring the Ecology of the Body, a book by Mark Lappe’ and in Michael Schmidt’s work. You need to work intensively replenishing every day for 3 to 6 months after antibiotic exposure using multiple healthy organisms, fermented food and active supplements. Dr. Jaffe uses the power of billions of live CFU, colony forming units, in human implantable strains. Live bugs work and dead bugs don’t. 16:43 We Can Make Our Own: We can make our own prebiotic foods with high fiber to feed the good bugs. We can take in enough probiotic organisms to replenish those expended from stress and toxin exposure, and symbiotic foods, nutrients like recycled glutamine, which helps repair the digestive tract. Prebiotics, probiotics and symbiotics form a triad. 17:33 Renaissance of Proactive Primary Prevention: For the past 3 years, throughout the world there have been public health initiatives to get more prebiotic high fiber, probiotic organisms, and symbiotics into our diets. The lining of the intestinal tract is one of the most vulnerable places in the body. It replaces itself about every 3 days. A healthy person’s digestive tract, if laid out flat, would be as large as a tennis court. Most American adults suffer from atrophy of their digestive tract because they have not been nourishing and nurturing it. This means that they only have a few square feet. The good news is that this can nearly always be rehabilitated. 18:57 The Age Myth: It is a lie that once we begin to decline with age that it can be slowed and symptoms can be suppressed, but the decline is irreversible and inescapable. The age myth is about the proportion of unhealthy people at certain stages of life. Dr. Jaffe has tested groups of 90 to 100 year olds and healthy 20 to 30 year olds, drawing their blood, culturing their white cells, culturing muscles and other cells, and the groups are indistinguishable from each other. 20:48 A Detailed Description of Digestion: Digestion begins with your eyes. They tell your gut and your brain, what you will be consuming. As we chew, small bits of food escape through the mucosa to inform the brain and the gut as to what digestive juices will be needed for this meal. The stomach churns and produces acid. People with ulcers have low stomach acid and healthy people have lots of stomach acid. Proton pump inhibitors are prescribed all the time. Often, if you believe they will work, they will work just slightly better than placebos. When you inhibit stomach acid production, you set up a chain of events of maldigestion, often with the sensitization of the immune system. It is essential that we have an amino acid called histadine that donates the proton, the acid that keeps the stomach acidic so that pepsin, the enzyme that loves to be in that acid environment, begins to open the food particles, especially the proteins and the concentrated foods. The acid in the chyme, which is the stuff that comes out of the stomach and is delivered to the small intestine, triggers a bicarbonate and digestive enzyme release from the pancreas. . We meet the bicarbonate and digestive enzymes that pour out of the pancreas to neutralize the stomach acid and begin the next phase. At a small duct, bile comes in to emulsify fats, bringing fat soluble vitamins and nutrients into the body. For the next 20 feet, nutrients are taken up selectively. Then it is on to the large intestine, which should not have digestive remnants. By the time we get to the ileocecal valve that separates the small intestine from the large, the food should be broken down to non-immune reactive building blocks that get assimilated. There should be enough fiber to bind toxins and remove them from the body. These toxins are putrescine, cadaverine, and other polyamines, which can form when digestive transit time is longer than the healthy 12 to 18 hours. 25:17 Digestive Transit Time: Typical Americans have a 72 hour to 144 hour transit time from entrance to exit. If you are, you will want to increase the fiber in your diet, you eat foods that you can digest, assimilate and eliminate without immune burden, if you have some sense of portion control, so we do not overwhelm the body. Only about 1 in 20 Americans, or about 5% of our population, has a healthy transit time of 12 to 18 hours and a healthy digestion. Maldigestion, dysbiosis, inflammatory atrophy and enteropathy of the digestive mechanisms is at epidemic proportions and has been for many decades. These digestive disorders are most often the cause of chronic degenerative autoimmune and inflammatory conditions.

Revolutionary research illuminates that a new frontier of personalized medicine lies in the virome. Rather than harbingers of disease, viruses are intrinsic to immune modulation and to disease susceptibility.

Background and Aim Acid suppressive agents including proton pump inhibitors (PPIs) are used as first-line treatment for various acid-related gastrointestinal disorders. Although known to profoundly ...

Kombucha is the rage among health food lovers. Now researchers have gathered 75 studies attesting to its proven health properties

An extraordinary Facebook Live with Dr. Mike Hoaglin, MD from uBiome. You’ll understand: ✓ What the microbiome is and why it’s a huge clue into your health status. ✓ What it impacts and how you can change your microbiome and change the course of your health. ✓ The best evidenced-based way to test your microbiome. ✓ What your weight has to do with your microbiome. ✓ The number one change you can make right now to alter your microbiome, and so much more...

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Background Urbanization is associated with an increased risk for a number of diseases, including obesity, diabetes, and cancer, which all also show associations with the microbiome. While microbial community composition has been shown to vary across continents and in traditional versus Westernized societies, few studies have examined urban-rural differences in neighboring communities within a single country undergoing rapid urbanization. In this study, we compared the gut microbiome, plasma metabolome, dietary habits, and health biomarkers of rural and urban people from a single Chinese province. Results We identified significant differences in the microbiota and microbiota-related plasma metabolites in rural versus recently urban subjects from the Hunan province of China. Microbes with higher relative abundance in Chinese urban samples have been associated with disease in other studies and were substantially more prevalent in the Human Microbiome Project cohort of American subjects. Furthermore, using whole metagenome sequencing, we found that urbanization was associated with a loss of microbial diversity and changes in the relative abundances of Viruses, Archaea, and Bacteria. Gene diversity, however, increased with urbanization, along with the proportion of reads associated with antibiotic resistance and virulence, which were strongly correlated with the presence of Escherichia and Shigella. Conclusions Our data suggest that urbanization has produced convergent evolution of the gut microbial composition in American and urban Chinese populations, resulting in similar compositional patterns of abundant microbes through similar lifestyles on different continents, including a loss of potentially beneficial bacteria and an increase in potentially harmful genes via increased relative abundance of Escherichia and Shigella.

Long-term survival of lung transplant recipients (LTRs) is limited by the occurrence of bronchiolitis obliterans syndrome (BOS). Recent evidence suggests a role for microbiome alterations in the occurrence of BOS, although the precise mechanisms are unclear. In this study we evaluated the relationship between the airway microbiome and distinct subsets of immunoregulatory myeloid-derived suppressor cells (MDSCs) in LTRs.

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Fiber isn’t the only thing our good gut bacteria can eat; starch can also act as a prebiotic. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ This is a follow-up to my video Is the Fiber Theory Wrong?(http://nutritionfacts.org/video/is-the-fiber-theory-wrong) What is this butyrate stuff of which I speak? See: • Bowel Wars: Hydrogen Sulfide vs. Butyrate (http://nutritionfacts.org/video/bowel-wars-hydrogen-sulfide-vs-butyrate/) • Prebiotics: Tending Our Inner Garden (http://nutritionfacts.org/video/prebiotics-tending-our-inner-garden) • Treating Ulcerative Colitis with Diet (http://nutritionfacts.org/video/treating-ulcerative-colitis-with-diet) For videos on optimizing your gut flora, see: • Microbiome: The Inside Story (http://nutritionfacts.org/video/microbiome-the-inside-story) • What’s Your Gut Microbiome Enterotype?http://nutritionfacts.org/video/whats-your-gut-microbiome-enterotype • How to Change Your Enterotype (http://nutritionfacts.org/video/how-to-change-your-enterotype/) More on preventing colon cancer in: • Starving Cancer with Methionine Restriction (http://nutritionfacts.org/video/starving-cancer-with-methionine-restriction/) • Stool pH and Colon Cancer (http://nutritionfacts.org/video/stool-ph-and-colon-cancer/) • Solving a Colon Cancer Mystery (http://nutritionfacts.org/video/solving-a-colon-cancer-mystery/) If you’re eating healthy do you need a colonoscopy? Find out in Should We All Get Colonoscopies Starting at Age 50? (http://nutritionfacts.org/video/should-we-all-get-colonoscopies-starting-at-age-50). When regular starches are cooked and then cooled, some of the starch recrystallizes into resistant starch. For this reason, pasta salad can be healthier than hot pasta and potato salad healthier than a baked potato. Find out more in my next video Getting Starch to Take the Path of Most Resistance (http://nutritionfacts.org/video/Getting-starch-to-take-the-path-of-most-resistance). Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/resistant-starch-and-colon-cancer/ and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/resistant-starch-and-colon-cancer/. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image Credit: Ed Uthman via flickr. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org #coloncancer #hownottodie #drgreger

Think diseases run in the family? Think again.

Do Antibiotics Cause Celiac Disease? Some researchers say yes they can. Especially in those with genetic susceptibility to gluten sensitivity. Antibiotics cause a yeast overgrowth, and emerging research shows that yeast - AKA candida, can create a protein that mimics gluten, causing an intestinal reaction leading to the development of celiac disease. To connect with Dr. Osborne visit: Facebook: https://www.facebook.com/DoctorPeterO... Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.

(2016). Resistant starch reduces colonic and urinary p-cresol in rats fed a tyrosine-supplemented diet, whereas konjac mannan does not. Bioscience, Biotechnology, and Biochemistry: Vol. 80, No. 10, pp. 1995-2000.

Background Mortality from chronic liver disease is rising exponentially. The liver is intimately linked to the gut via the portal vein, and exposure to gut microbiota and their metabolites transloca...

Researchers have made the first direct demonstration that fecal donor microbes remained in recipients for months or years after a transplant to treat the diarrhea and colitis caused by recurrent Clostridium difficile infections -- a serious and stubborn cause of diarrhea after an antibiotic treatment for some other illness.

The human intestinal microbiome is thought to influence tumor development and progression in the gastrointestinal tract by various mechanisms. Therefore, by better understanding the microbiome in eso...

Reported values in the literature on the number of cells in the body differ by orders of magnitude and are very seldom supported by any measurements or calculations. Here, we integrate the most up-to-date information on the number of human and bacterial ...

Visit the Mercola Video Library By Dr. Mercola The US Food and Drug Administration (FDA) recently issued a warning that fluoroquinolone antibiotics, taken by mouth or injection, carry a risk for permanent peripheral neuropathy. The safety announcement states:1 “The U.S. Food and Drug Administration (FDA) has required the drug labels and Medication Guides for all fluoroquinolone antibacterial drugs be updated to better describe the serious side effect of peripheral neuropathy. This serious nerve damage potentially caused by fluoroquinolones may occur soon after these drugs are taken and may be permanent… The topical formulations of fluoroquinolones, applied to the ears or … Continue reading →

Healthy digestion within a resilient, repair-enabled microbiome is essential for 21st century survival. The human microbiome will be explained in functional and practical terms. Issues such as leaky gut, SIBO and IBS will be explored.Those who are proactive about their health, particularly about what they eat and drink, think and do can achieve a healthy microbiome. Eating and drinking what can be digested, assimilated and eliminated without immune burden provides a context for this presentation.

The incidence of diabetes mellitus is rapidly increasing throughout the world. Although the exact cause of the disease is not fully clear, perhaps, genetics, ethnic origin, obesity, age, and lifestyle are considered as few of many contributory factors for the disease pathogenesis. In recent years, the disease progression is particularly linked with functional and taxonomic alterations in the gastrointestinal tract microbiome. A change in microbial diversity, referred as microbial dysbiosis, alters the gut fermentation profile and intestinal wall integrity and causes metabolic endotoxemia, low-grade inflammation, autoimmunity, and other affiliated metabolic disorders. This article aims to summarize the role of the gut microbiome in the pathogenesis of diabetes. Additionally, we summarize gut microbial dysbiosis in preclinical and clinical diabetes cases reported in literature in the recent years.

What effect do artificial sweeteners such as sucralose (Splenda), saccharin (Sweet & Low), aspartame (Nutrasweet) and acesulfame K (Sweet One) have on our gut bacteria? Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ Can’t get enough of artificial sweeteners? Check out • Diet Soda and Preterm Birth (http://nutritionfacts.org/video/diet-soda-and-preterm-birth/) • Aspartame Induced Fibromyalgia (http://nutritionfacts.org/video/aspartame-induced-fibromyalgia/) • Aspartame and the Brain (http://nutritionfacts.org/video/Aspartame-and-the-Brain) Even for nontoxic low calorie sweeteners like erythritol (Erythritol May Be a Sweet Antioxidant http://nutritionfacts.org/video/erythritol-may-be-a-sweet-antioxidant/), there are some caveats. See: • How Diet Soda Can Make Us Gain Weight (http://nutritionfacts.org/video/how-diet-soda-could-make-us-gain-weight/) • Neurobiology of Artificial Sweeteners (http://nutritionfacts.org/video/neurobiology-of-artificial-sweeteners/) • Unsweetening the Diet (http://nutritionfacts.org/video/unsweetening-the-diet/) Who cares if our gut flora gets disrupted? Wait until you see how important the little puppies are: • Microbiome: The Inside Story (http://nutritionfacts.org/video/microbiome-the-inside-story) • Prebiotics: Tending Our Inner Garden (http://nutritionfacts.org/video/prebiotics-tending-our-inner-garden) • What’s Your Gut Microbiome Enterotype? (http://nutritionfacts.org/video/whats-your-gut-microbiome-enterotype) • How to Change Your Enterotype (http://nutritionfacts.org/video/how-to-change-your-enterotype) • Paleopoo: What We Can Learn from Fossilized Feces (http://nutritionfacts.org/video/paleopoo-what-we-can-learn-from-fossilized-feces) Have a question for Dr. Greger about this video? Leave it in the comment section at http://nutritionfacts.org/video/effect-of-sucralose-splenda-on-the-microbiome and he'll try to answer it! Image Credit: Dave Crosby via Flickr. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Chinese Medical Journal, a publication of Chinese Medical Association, is a peer-reviewed online journal with semi-monthly print on demand compilation of issues published. The journal's full text is available online at http://www.cmj.org. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository.