Brain

Glioblastoma presents significant challenges in neuro-oncology due to its aggressive nature, drug resistance, and restrictions imposed by the blood–brain barrier. Ivermectin (IVM), known for its antiparasitic properties, has been highlighted as a promising treatment for tumors and an alternative therapy for glioma, although it exhibits low oral bioavailability. Therefore, we investigated the in vivo effect of IVM encapsulation in organic and inorganic nanosystems, first screened in vitro against different tumor cells and subsequently evaluated in vitro and in vivo glioma models. We produced IVM-loaded poly(ε-caprolactone) nanocapsules (IVM-NC) using the interfacial deposition method, and IVM-loaded nanostructured silica particles (IVM-MCM) by loading IVM into commercial MCM-41 silica using the incipient wetness method. IVM-NC had a nanometric size (190 nm), a unimodal size distribution (span <2), and a high encapsulation efficiency (100% at 1 mg/mL). IVM-MCM exhibited a well-organized hexagonal mesoporous structure and high drug loading (0.12 mg/mg). Nanoencapsulated IVM significantly reduced the viability of various cancer cell lines, particularly glioma cell lines, which led us to evaluate them in a preclinical glioma model. We implanted adult male Wistar rats with C6 cells. Intranasal delivery of IVM-NC (60 μg/rat/day for 10 days) resulted in a larger decrease in tumor size compared with the group treated with free IVM, along with histopathological improvements. Treatment with IVM-MCM did not decrease the tumor size. However, both treatments were well-tolerated, with no adverse effects on weight, biochemical, or hematological parameters, or lung histology. Furthermore, the effective equivalent dose of IVM (26 μg/kg) in the rat glioma model was lower than the approved human dose for parasitic infections. This study marks the first exploration of IVM delivery to the brain. In summary, nasal administration of nanoencapsulated IVM via nanocapsules presents a promising avenue for targeted therapy against glioblastoma, with potential implications for clinical translation.

The 3,000th person has been treated by neurosurgeons using minimally invasive laser image-guided interstitial thermotherapy (LITT) (NeuroBlate System;

Glioma, the most predominant primary malignant brain tumor, remains uncured due to the absence of effective treatments. Hence, it is imperative to develop successful therapeutic agents. This study aimed to explore the antitumor effects and mechanisms of ivermectin (IVM) in glioma cells in vitro and …

Researchers have discovered that the FDA-approved anti-fungal drug, sulconazole, exhibits anti-cancer properties towards glioblastoma cells. An in-depth investigation of this compound revealed that it competes with biotin (Vitamin H), an important co-factor for metabolic enzymes and modifier of histones, allowing it to inhibit the normal function of biotin-dependent metabolic enzymes and specific histone modification-associated gene expression.

Trehalose Liposomes Inhibit the Growth of Glioblastoma Cell In vitro and In vivo, Keiji Kuwabara, Hideaki Ichihara, Yoko Matsumoto

The altered metabolism of two essential amino acids helps drive the development of the most common and lethal form of brain cancer, new research has discovered. The findings suggest new ways to treat the malignancy, slow its progression and reveal its extent more precisely. The study shows that in glioblastoma, the essential amino acids methionine and tryptophan are abnormally metabolized due to the loss of key enzymes in GBM cells.

Dr. Burton Berkson, an integrative physician from New Mexico, relates his vast experience with LDN in treating pancreatic cancer and autoimmune disease.

An important case study of a 47 year old woman suffering from multiple tumors of the brain showed how important hydrogen medicine will be in the future of medicine and modern oncology. In my book on Hydrogen Medicine I have already written on using hydrogen for cancer patients. This study sustains what I have written... View Article

Hydrogen gas inhalation is a powerful yet gentle therapeutic process. Conditions improve faster if hydrogen and oxygen are fed continuously. Hydrogen is the ultimate warrior against death and disease.

A study providing new information about neuropathic pain afflicting some 90 percent of cancer patients who have had nerve damage caused by tumors, surgery, chemotherapy or radiation indicates gene therapy as a possible treatment.