Antiparasitic Drug Ivermectin Has Remarkable Anti-Cancer Activity.

Evidence of a relationship between bras and breast cancer may rethink the societal convention of wearing bras.

When women are fully informed about the risks and benefits of mammograms, 70% may choose not to get screen, but you may be in that 30% and have a right to decide for yourself. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ You can check out my Doc Note under the first video (http://nutritionfacts.org/video/9-out-of-10-Women-misinformed-about-Mammograms) in this series to get a sense why I chose to spend so much time on this topic. This is the 2nd video in a 14-part series. If you missed the first one, check it out here: 9 out of 10 Women Misinformed about Mammograms (http://nutritionfacts.org/video/9-out-of-10-Women-misinformed-about-Mammograms). Stay tuned for: • Should Women Get Mammograms Starting at Age 40? (http://nutritionfacts.org/video/Should-Women-Get-Mammograms-Starting-at-Age-40) • Do Mammograms Save Lives? (http://nutritionfacts.org/video/Do-Mammograms-Save-Lives) • Consequences of False-Positive Mammogram Results (http://nutritionfacts.org/video/Consequences-of-False-Positive-Mammogram-Results) • Do Mammograms Hurt? (http://nutritionfacts.org/video/Do-Mammograms-Hurt) • Can Mammogram Radiation Cause Breast Cancer? (http://nutritionfacts.org/video/Can-Mammogram-radiation-Cause-Breast-Cancer) • Understanding the Mammogram Paradox (http://nutritionfacts.org/video/Understanding-the-Mammogram-Paradox) • Overtreatment of Stage 0 Breast Cancer DCIS (http://nutritionfacts.org/video/Overtreatment-of-Stage-0-Breast-Cancer-DCIS) • Women Deserve to Know the Truth About Mammograms (http://nutritionfacts.org/video/Women-Deserve-to-Know-the-Truth-About-Mammograms) • Breast Cancer and the 5-Year Survival Rate Myth (http://nutritionfacts.org/video/breast-Cancer-and-the-5-Year-Survival-Rate-Myth) • Why Mammograms Don’t Appear to Save Lives (http://nutritionfacts.org/video/Why-Mammograms-Don) • Why Patients Aren’t Informed About Mammograms (http://nutritionfacts.org/video/Why-Patients-Arent-Informed-About-Mammograms) • The Pros and Cons of Mammograms (http://nutritionfacts.org/video/The-Pros-and-Cons-of-Mammograms) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/mammogram-recommendations-why-the-conflicting-guidelines and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/mammogram-recommendations-why-the-conflicting-guidelines. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages. To find yours, click on the settings wheel on the lower-right of the video and then "Subtitles/CC." Do you have feedback about the translations in this video? Please share it here along with the title of the video and language: https://nutritionfacts.zendesk.com/hc/requests/new To view the subtitles in transcript format, click on the ellipsis button below the video, choose "Open transcript", and select the language you'd like to view them in. Image credit: Rhoda Baer / Wikimedia https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

The global juggernaut of unremitting and unapologetic breast cancer overdiagnosis and overtreatment persists.

Melatonin has significant inhibitory effects in numerous cancers, especially breast cancer. In estrogen receptor (ER)-positive human breast cancer, th…

Breast cancer is the most common cancer among women and has a high mortality rate. Adverse conditions in the tumor microenvironment, such as hypoxia and acidosis, may exert selective pressure on the tumor, selecting subpopulations of tumor cells with advantages for survival in this environment. In this context, therapeutic agents that can modify these conditions, and consequently the intratumoral heterogeneity need to be explored. Melatonin, in addition to its physiological effects, exhibits important anti-tumor actions which may associate with modification of hypoxia and Warburg effect. In this study, we have evaluated the action of melatonin on tumor growth and tumor metabolism by different markers of hypoxia and glucose metabolism (HIF-1α, glucose transporters GLUT1 and GLUT3 and carbonic anhydrases CA-IX and CA-XII) in triple negative breast cancer model. In an in vitro study, gene and protein expressions of these markers were evaluated by quantitative real-time PCR and immunocytochemistry, respectively. The effects of melatonin were also tested in a MDA-MB-231 xenograft animal model. Results showed that melatonin treatment reduced the viability of MDA-MB-231 cells and tumor growth in Balb/c nude mice (p

Thunder Biotech is developing new therapies that help re-educate a patient’s immune system, restoring its ability to recognize and destroy cancer cells.

The tumor growth inhibition and anti-metastatic effects of peach polyphenolics were investigated in vivo using a xenograft model and MDA-MB-435 breast cancer cells. Results showed that tumor growth and lung metastasis were inhibited in vivo by peach polyphenolics in a dose range of 0.8-1.6 mg/day, a …

Our study identifies TFEB as a master regulator of TAMs in breast cancer. TFEB controls TAM gene expression and function through multiple autophagy/lysosome-dependent and independent pathways. Therefore, pharmacological activation of TFEB would be a promising therapeutic approach to improve the effi …

Recent research studies have shown that the intestinal flora are related to the occurrence and progress of breast cancer. This study investigates the effect of fucoidan on intestinal flora and intestinal barrier function in rats with 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancers. Sixty female

Europe PMC is an archive of life sciences journal literature.

Fact Boxes can quantify benefits and harms in a clear and accessible format. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ This wraps up my series on mammograms, the rest is up to you. How important are false-positives or overdiagnosis to you? That’s something you have to answer for yourself. To review any of my in-depth mammogram series, here they all are: • 9 out of 10 Women Misinformed about Mammograms ((http://nutritionfacts.org/video/9-out-of-10-Women-misinformed-about-Mammograms) • Mammogram Recommendations - Why the Conflicting Guidelines (http://nutritionfacts.org/video/Mammogram-Recommendations-Why-the-Conflicting-Guidelines) • Should Women Get Mammograms Starting at Age 40? (http://nutritionfacts.org/video/Should-Women-Get-Mammograms-Starting-at-Age-40) • Do Mammograms Save Lives? (http://nutritionfacts.org/video/Do-Mammograms-Save-Lives) • Consequences of False-Positive Mammogram Results (http://nutritionfacts.org/video/Consequences-of-False-Positive-Mammogram-Results) • Do Mammograms Hurt? (http://nutritionfacts.org/video/do-mammograms-hurt) • Can Mammogram Radiation Cause Breast Cancer? (http://nutritionfacts.org/video/Can-Mammogram-radiation-Cause-Breast-Cancer) • Understanding the Mammogram Paradox (http://nutritionfacts.org/video/Understanding-the-Mammogram-Paradox) • Overtreatment of Stage 0 Breast Cancer DCIS (http://nutritionfacts.org/video/overtreatment-of-stage-0-breast-cancer-dcis) • Women Deserve to Know the Truth About Mammograms (http://nutritionfacts.org/video/Women-Deserve-to-Know-the-Truth-About-Mammograms) • Breast Cancer and the 5-Year Survival Rate Myth (http://nutritionfacts.org/video/breast-Cancer-and-the-5-Year-Survival-Rate-Myth) • Why Mammograms Don’t Appear to Save Lives (http://nutritionfacts.org/video/Why-Mammograms-Don) • Why Patients Aren’t Informed About Mammograms (http://nutritionfacts.org/video/why-patients-arent-informed-about-mammograms) I’ve got tons of videos on diet and lifestyle approaches to preventing and treating breast cancer, just stick it in the search bar up top and all will be revealed. Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/the-pros-and-cons-of-mammograms and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/the-pros-and-cons-of-mammograms. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages. To find yours, click on the settings wheel on the lower-right of the video and then "Subtitles/CC." Do you have feedback about the translations in this video? Please share it here along with the title of the video and language: https://nutritionfacts.zendesk.com/hc/requests/new To view the subtitles in transcript format, click on the ellipsis button below the video, choose "Open transcript", and select the language you'd like to view them in. Image credit: Steel Wool / flickr https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Melatonin, a hormone secreted by pineal gland, exerts antimetastatic effects by reducing tumor cell proliferation, migration and invasion. MicroRNAs (miRNAs) are small, non-coding RNAs that play a crucial role in regulation of gene expression and biological processes of the cells. Herein, we search for a link between the tumor/metastatic-suppressive actions of melatonin and miRNA expression in triple-negative breast cancer cells. We demonstrated that melatonin exerts its anti-tumor actions by reducing proliferation, migration and c-Myc expression of triple negative breast cancer cells. By using Taqman-based assays, we analyzed the expression levels of a set of miRNAs following melatonin treatment of triple negative breast cancer cells and we identified 17 differentially expressed miRNAs, 6 down-regulated and 11 up-regulated. We focused on the anti-metastatic miR-148b and the oncogenic miR-210 both up-regulated by melatonin treatment and studied the effect of their modulation on melatonin-mediated impairment of tumor progression. Surprisingly, when miR-148b or miR-210 were depleted in triple-negative breast cancer cells, using a specific miR-148b sponge or anti-miR-210, melatonin effects on migration inhibition and c-myc downregulation were still visible suggesting that the increase of miR-148b and miR-210 expression observed following melatonin treatment was not required for the efficacy of melatonin action. Nevertheless, ours results suggest that melatonin exhibit a compound for metastatic trait inhibition, especially in MDA-MB-231 breast cancer cells even if a direct link between modulation of expression of certain proteins or miRNAs and melatonin effects has still to be established.

A powerful new Lancet study reveals that the so-called breast cancer susceptibility genes -- BRCA 1 and BRCA 2 -- do not, in fact, cause breast cancer. Jolie's prophylactic mastectomy, for instance, was for naught.

(2018). Therapeutic potential of melatonin for breast cancer radiation therapy patients. International Journal of Radiation Biology: Vol. 94, No. 5, pp. 472-477.

Our results confirm the role of melatonin in the regulation of miR-148a-3p and decrease of angiogenic factors.

The inhibitory effects of trehalose liposomes (TL) comprising l-α-dimyristoylphosphatidylcholine (DMPC) and α-D-glucopyranosyl-α-D-glucopyranoside monomyritate (TreC14) were investigated on breast cancer MDA-MB-453 cells in vitro and in vivo. The IC50 values of TL for MDA-MB-453 cells wer …

You found the Chris Beat Cancer blog! I created this resource to help you heal or prevent cancer holistically. Welcome to the Chris Beat Cancer family!

If doctors don’t understand health statistics how can they possibly counsel patients properly? Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ Many doctors display a similar ignorance about nutrition. See, for example, Physicians May Be Missing their Most Important Tool (https://nutritionfacts.org/video/physicians-may-be-missing-their-most-important-tool/). There’s just one more mammogram video to help you decide: The Pros and Cons of Mammograms (http://nutritionfacts.org/video/The-Pros-and-Cons-of-Mammograms). In case you missed any of the first dozen, check them out: • 9 out of 10 Women Misinformed about Mammograms ((http://nutritionfacts.org/video/9-out-of-10-Women-misinformed-about-Mammograms) • Mammogram Recommendations - Why the Conflicting Guidelines (http://nutritionfacts.org/video/Mammogram-Recommendations-Why-the-Conflicting-Guidelines) • Should Women Get Mammograms Starting at Age 40? (http://nutritionfacts.org/video/Should-Women-Get-Mammograms-Starting-at-Age-40) • Do Mammograms Save Lives? (http://nutritionfacts.org/video/Do-Mammograms-Save-Lives) • Consequences of False-Positive Mammogram Results (http://nutritionfacts.org/video/Consequences-of-False-Positive-Mammogram-Results) • Do Mammograms Hurt? (http://nutritionfacts.org/video/do-mammograms-hurt) • Can Mammogram Radiation Cause Breast Cancer? (http://nutritionfacts.org/video/Can-Mammogram-radiation-Cause-Breast-Cancer) • Understanding the Mammogram Paradox (http://nutritionfacts.org/video/Understanding-the-Mammogram-Paradox) • Overtreatment of Stage 0 Breast Cancer DCIS (http://nutritionfacts.org/video/overtreatment-of-stage-0-breast-cancer-dcis) • Women Deserve to Know the Truth About Mammograms (http://nutritionfacts.org/video/Women-Deserve-to-Know-the-Truth-About-Mammograms) • Breast Cancer and the 5-Year Survival Rate Myth (http://nutritionfacts.org/video/breast-Cancer-and-the-5-Year-Survival-Rate-Myth) • Why Mammograms Don’t Appear to Save Lives (http://nutritionfacts.org/video/Why-Mammograms-Don) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/why-patients-arent-informed-about-mammograms and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/why-patients-arent-informed-about-mammograms. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages. To find yours, click on the settings wheel on the lower-right of the video and then "Subtitles/CC." Do you have feedback about the translations in this video? Please share it here along with the title of the video and language: https://nutritionfacts.zendesk.com/hc/requests/new To view the subtitles in transcript format, click on the ellipsis button below the video, choose "Open transcript", and select the language you'd like to view them in. Image credit: Jean-François Chénier / flickr https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Millions equate a breast cancer diagnosis with a possible death sentence, doing anything from removing their breasts (and ovaries) with added radiation and chemotherapy treatments, when, in fact, the truth is much more forgiving.