The long-recognized fact that oxidative stress within mitochondria is a hallmark of mitochondrial dysfunction has stimulated the development of mitochondria-targeted antioxidant therapies. Melatonin should be included among the pharmacological agents able to modulate mitochondrial functions in cancer, given that a number of relevant melatonin-dependent effects are triggered by targeting mitochondrial functions. Indeed, melatonin may modulate the mitochondrial respiratory chain, thus antagonizing the cancer highly glycolytic bioenergetic pathway of cancer cells. Modulation of the mitochondrial respiratory chain, together with Ca2+ release and mitochondrial apoptotic effectors, may enhance the spontaneous or drug-induced apoptotic processes. Given that melatonin may efficiently counteract the Warburg effect while stimulating mitochondrial differentiation and mitochondrial-based apoptosis, it is argued that the pineal neurohormone could represent a promising new perspective in cancer treatment strategy.

A combination of cannabis oil and chemotherapy healed this man’s “incurable inoperable” lung cancer.

ReferenceEl-Haggar SM, El-Shitany NA, Mostafa MF, El-Bassiouny NA. Metformin may protect nondiabetic breast cancer women from metastasis. Clin Exp Metastasis. 2016;33(4):339-357. ObjectiveTo investigate the impact of adding metformin to breast cancer adjuvant therapy in nondiabetic womenStudy Design and ParticipantsParticipants included women aged 40 to 65 from Damanhour Oncology Center (Damanhour, Egypt) with newly diagnosed breast cancer.

The International Scientific Research Organization for Science, Engineering and Technology (ISROSET) is a Non-Profit Organization; The ISROSET is dedicated to improvement in academic sectors of Science (Chemistry, Bio-chemistry, Zoology, Botany, Biotechnology, Pharmaceutical Science, Bioscience, Bioinformatics, Biometrics, Biostatistics, Microbiology, Environmental Management, Medical Science, Forensic Science, Home Science, Library Science, Material Science Military Science, Physical Science, Physical Education Science, Educational Science, Fisheries, seed technology, Agriculture, Forestry Science, Mathematics, Physics, Statistics and Geology/Earth Science), Computer Science, Engineering and Information Technology, Commerce, Management, Economics Sociology and Social Science.

City of Hope has been deemed one of the nation's elite cancer hospitals by U.S. News & World Report and is recognized as a leading cancer hospital in the West. City of Hope also pioneers cancer and diabetes research, including clinical trials, and compassionate patient care.

Epithelia are protected from adverse conditions by a mucous barrier. The secreted and transmembrane mucins that constitute the mucous barrier are largely unrecognized as effectors of carcinogenesis. However, both types of mucins are intimately involved ...

Objectives We aimed to characterise the microbial changes associated with histological stages of gastric tumourigenesis. Design We performed 16S rRNA gene analysis of gastric mucosal samples from 81 cases including superficial gastritis (SG), atrophic gastritis (AG), intestinal metaplasia (IM) and gastric cancer (GC) from Xi’an, China, to determine mucosal microbiome dysbiosis across stages of GC. We validated the results in mucosal samples of 126 cases from Inner Mongolia, China. Results We observed significant mucosa microbial dysbiosis in IM and GC subjects, with significant enrichment of 21 and depletion of 10 bacterial taxa in GC compared with SG (q

Sodium bicarbonate is an excellent agent for a natural alkaline approach in the treatment for all sickness and disease, including cancer.  S...

A new therapeutic approach gives promising results for the treatment of multiple myeloma, a cancer of the bone marrow currently considered incurable with conventional chemotherapy. The study resulted in a total cure rate of 41 percent, a record level using this strategy. Moreover, patients in complete remission six months after the allograft had a relapse-free survival rate of 60 percent.

http://www.connersclinic.com

Study of colorectal, lung cancer cells treated with low-dose naltrexone (LDN) and chemotherapy. LDN had anticancer activity during treatment schedules.

An experimental nanoparticle therapy that combines low-density lipoproteins (LDL) and fish oil preferentially kills primary liver cancer cells without harming healthy cells, researchers report.

Conventional medicine offers little hope in the fight against deadly malignant melanoma, but there are multiple foods, botanicals, and vitamins with proven anti-melanoma activity within nature’s pharmacopeia

Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA Resistance to chemotherapy is a significant impediment to the treatment of breast cancer. More than 30% of breast cancer patients present with intrinsic resistance to chemotherapy; almost all who initially respond will develop acquired resistance. Resistant tumors frequently exhibit constitutive activation of numerous survival signaling pathways, including ERK, AKT, NF-kB, and STAT3. We have reported that the circadian hormone melatonin inhibits the growth of both ERá+/ERá- breast cancers and, as well as the daytime induced phospho-activation of ERK1/2, AKT and NF-kB in breast tumor xenografts. We also demonstrated that dim light at night (dLAN), by decreasing nocturnal melatonin, resulted in constitutive phospho-activation of ERK1/2, CREB, NF-kB, and STAT3, promoting resistance to tamoxifen and doxorubicin therapy. Here we tested the hypothesis that dLAN, via phospho-activation of ERK1/2 and STAT3, promotes resistance to paclitaxel (Pax). Female nude rats with “tissue-isolated” MCF-7 breast cancer xenografts were housed in photoperiodic conditions of either LD 12:12, 12:12dLAN (0.2 lux), or 12:12dLAN supplemented with nighttime melatonin (0.05 õg/ml) in the drinking water, with lights on at 0600 hrs and off at 1800 hrs. When estimated tumor weights reached 2.5 g, animals were treated daily with either diluent or Pax i.p. (4õã/kg) 2 h prior to onset of dLAN or dLAN with nighttime melatonin supplementation. Blood samples collected during the mid-dark phase (2400 hrs) showed elevated nocturnal melatonin in the LD 12:12 group, but significantly suppressed melatonin in the dLAN group. Tumor xenografts from rats housed in dLAN showed a 3-fold decrease in latency-to-onset and a 2.8-fold increased growth rates vs. those from rats receiving melatonin supplementation. Tumor cAMP levels, linoleic acid, and tumor metabolism (Warburg effect) were significantly elevated in dLAN tumors. Numerous signaling pathways including ERK1/2, RSK2, and STAT3, were phospho-activated and others including AKT and HER2/3 were elevated at 2400 hrs by dLAN but repressed in dLAN melatonin supplemented tumors. Tumors from dLAN rats showed intrinsic resistance to Pax, whereas those in LD 12:12 or dLAN and supplemented with nighttime melatonin rapidly regressed. These findings show that temporally coordinated and integrated metabolic and signal transduction mechanisms, particularly the STAT3 pathway, underlying human breast cancer growth, can be activated by the host's exposure to LAN with profound effects culminating in rapid tumor progression and the development of resistance to chemotherapy. Citation Format: Steven M. Hill, Shulin Xiang, Robert T. Dauchy, Lulu mao, Lin Yuan, Adam Hauch, Victoria P. Belancio, Melissa A. Wren-Dail, David Pointer, Peter W. Lundberg, Whitney M. Summers, David E. Blask. Circadian/melatonin disruption by dim light at night drives paclitaxel resistance in breast cancer via activation of stat3. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 874.

This Naturopathic Oncology course contains a turnkey cancer treatment program that can be set up by any practitioner, clinic, spa, or hospital and even by patients and their families at home. If you need more information: https://drsircus.com/conquering-cancer-course/

Every cell in our body contains the complete DNA library. So-called methyl groups regulate that in body tissues only the genetic information is expressed that is indeed needed in this tissue. Now, for the first time, researchers verified that a lack of methyl groups in the gene body leads to an incorrect gene activation and, as a consequence, may lead to the emergence of cancer.

This case report suggests a new concept of cancer treatment using local destruction of cancer tissue, in this case conducted with SDT and TTF therapy, to be used in combination with serum GcMAF and colostrum MAF immunotherapy as a systemic treatment.

A simple change in diet could boost vitamin D levels for millions of Americans suffering from Type 2 diabetes, according to new research.

We hope you enjoy this clip from “Eastern Medicine: Journey Through ASIA!” Today we join Dr. Pan Nien Chung to talk about the removal of cancer stem cells with a special acupuncture. Acupuncture is a staple of traditional Chinese medicine, and utilizes energy pathways, called meridians, to improve the flow of energy, called chi. Dr. Pan Nien Chung describes a special kind of acupuncture which focuses on solar alignment. The energy provided by the sun is called neutrino energy and is an integral part of acupuncture therapy in Asia. Combining neutrino energy and acupuncture can help the body eliminate cancer stem cells. Exposing the patient to the neutrino energy from the sun, in combination with utilizing four special acupuncture points, causes the patient to excrete cancer stem cells in their urine. See the rest of this episode in the full series: http://bit.ly/buy-eastern-medicine. In the summer of 2018, we traveled through Japan, Taiwan, Philippines, Singapore, Malaysia, Thailand, and India. Asia is the birthplace of natural medicine with records as old as the 3rd century BCE showing the use of specific natural remedies. Remarkably, we still use some of them today! Over 60 experts, medical doctors, herbalists, and cancer survivors tell us what they did, how they did it, and what their results were in “Eastern Medicine: Journey Through ASIA.” ---------------------------------------------------------- Meet the Expert: Dr. Pan Nien Chung ---------------------------------------------------------- Dr. Pan Nien Chung, MD, Ph.D., DSC, originally from Laos, has been in Taiwan for 50 years. During this period, he has attended high school and medical school, and worked at the general hospital and National Research Institute. -------------------------------------------------------------------------------------------------- Join TTAC's 1 million+ FB fans - http://bit.ly/official-ttac-fb Follow us on PINTEREST - http://bit.ly/official-ttac-pinterest Find us on INSTAGRAM - http://bit.ly/official-ttac-ig Visit our website: http://bit.ly/official-ttac-site -------------------------------------------------- About The Truth About Cancer -------------------------------------------------- The Truth About Cancer’s mission is to inform, educate, and eradicate the pandemic of cancer in our modern world. Every single day, tens of thousands of people just like you are curing cancer (and/or preventing it) from destroying their bodies. It’s time to take matters into your own hands and educate yourself on real cancer prevention and treatments. It could save your life or the life of someone you love. ------------------------------------------------ About Ty & Charlene Bollinger ------------------------------------------------ Ty & Charlene Bollinger are devoted Christians, health freedom advocates, health researchers, documentary film producers, and best-selling authors. After losing several family members to conventional cancer treatments, they set out to learn the truth about cancer and the cancer industry, working together tirelessly to help others to learn the truth that sets them free to live healthy, happy lives. Ty & Charlene's heartbreak and grief coupled with their firm belief that chemotherapy, radiation, and surgery were NOT the most effective treatments available for cancer patients, led them on a path of discovery. On their journey, they interviewed cutting-edge scientists, leading alternative doctors, and groundbreaking researchers to learn about hidden alternative cancer treatments. What they uncovered helped to create The Truth About Cancer and its three awe-inspiring docu-series: ”The Quest for The Cures”, “The Quest for the Cures Continues”, “The Truth About Cancer: A Global Quest”, and "Eastern Medicine: Journey through ASIA." Their message is clear: CANCER IS NOT A DEATH SENTENCE. THERE IS ALWAYS HOPE.

The lack of oxygen in tumor cells changes the cells' gene expression, thereby contributing to the growth of cancer, suggest researchers. The findings are far-reaching, as the study also proved that maintaining a proper oxygen supply in tumors inhibits these so-called 'epigenetic aberrations.'

What do cancer cells and a runny nose have in common? Researchers say the answer may hold the key to making cancer treatment better. They have discovered a new gene target -- a chink in pancreatic cancer's defensive armor. Their discovery may point to new targeted therapies and a way to help make current treatments for this deadly cancer more effective.

Cancer is big business, no doubt about it. But did you know that the treatment your doctor orders could actually increase the likelihood that you will become a repeat customer? Conventional cancer treatments such as chemotherapy and radiation actually promote cancer. Yes, you read that correctly... they promote cancer! Cancer is increasingly becoming a survivable disease, yet the treatments cause considerable collateral damage – including initiating new, second cancers. Second cancers are cancers unrelated to the original cancer, which can be triggered by the very same imbalances or cancer-causing agents that led to the first cancer. In fact, doctors sometimes refer to

The greedy metabolism of cancer cells to target kidney cell carcinomas, which kill more than 100,000 Americans each year, has been exploited by researchers. The team showed that the majority of renal cell cancers rewire their metabolism in a way that leaves them addicted to the nutrient cystine. By depriving the cancer cells of cystine, the researchers were able to trigger a form of cell death called necrosis in tumor cells.

Providing Advanced Nutritional Support for Cancer Patients and Survivors

igvir in substage IB, IIA, IIB and IIC melanoma patients on time to progression and overall survival. White patients (N=79) who had undergone surgical excision of the primary melanoma tumour were included in this study. All patients were free from disease after surgery and classified into substages IB, IIA, IIB and IIC. Circulating levels of clinical chemistry parameters were recorded. Survival was analysed by Cox regression. Rigvir significantly (P