Cancer

602 bookmarks
Newest
The role of melatonin on miRNAs modulation in triple-negative breast cancer cells
The role of melatonin on miRNAs modulation in triple-negative breast cancer cells
Melatonin, a hormone secreted by pineal gland, exerts antimetastatic effects by reducing tumor cell proliferation, migration and invasion. MicroRNAs (miRNAs) are small, non-coding RNAs that play a crucial role in regulation of gene expression and biological processes of the cells. Herein, we search for a link between the tumor/metastatic-suppressive actions of melatonin and miRNA expression in triple-negative breast cancer cells. We demonstrated that melatonin exerts its anti-tumor actions by reducing proliferation, migration and c-Myc expression of triple negative breast cancer cells. By using Taqman-based assays, we analyzed the expression levels of a set of miRNAs following melatonin treatment of triple negative breast cancer cells and we identified 17 differentially expressed miRNAs, 6 down-regulated and 11 up-regulated. We focused on the anti-metastatic miR-148b and the oncogenic miR-210 both up-regulated by melatonin treatment and studied the effect of their modulation on melatonin-mediated impairment of tumor progression. Surprisingly, when miR-148b or miR-210 were depleted in triple-negative breast cancer cells, using a specific miR-148b sponge or anti-miR-210, melatonin effects on migration inhibition and c-myc downregulation were still visible suggesting that the increase of miR-148b and miR-210 expression observed following melatonin treatment was not required for the efficacy of melatonin action. Nevertheless, ours results suggest that melatonin exhibit a compound for metastatic trait inhibition, especially in MDA-MB-231 breast cancer cells even if a direct link between modulation of expression of certain proteins or miRNAs and melatonin effects has still to be established.
·journals.plos.org·
The role of melatonin on miRNAs modulation in triple-negative breast cancer cells
Scientific Focus On Anti-Cancer Effects Of Vitamin C - Dr. Rath Resear (...)
Scientific Focus On Anti-Cancer Effects Of Vitamin C - Dr. Rath Resear (...)
After heart disease, cancer is the second leading cause of death worldwide. One in two men and one in three women will be diagnosed with some type of cancer in their lifetime. Despite novel initiative...
·drrathresearch.org·
Scientific Focus On Anti-Cancer Effects Of Vitamin C - Dr. Rath Resear (...)
Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer | European Journal of Epidemiology
Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer | European Journal of Epidemiology
European Journal of Epidemiology - Light-at-night triggers the decline of pineal gland melatonin biosynthesis and secretion and is an IARC-classified probable breast-cancer risk factor. We applied...
·link.springer.com·
Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer | European Journal of Epidemiology
Melatonin: Avenues in cancer therapy and its nanotechnological advancements - Putta - 2023 - MedComm – Biomaterials and Applications - Wiley Online Library
Melatonin: Avenues in cancer therapy and its nanotechnological advancements - Putta - 2023 - MedComm – Biomaterials and Applications - Wiley Online Library
Melatonin's role in cancer treatment and nanotechnological developments for efficient delivery of the drug to the targeted sites. Natural sources of MLT, its physiological functions and mechanism of ...
·onlinelibrary.wiley.com·
Melatonin: Avenues in cancer therapy and its nanotechnological advancements - Putta - 2023 - MedComm – Biomaterials and Applications - Wiley Online Library