Cannabis

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Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents
Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents
Children affected by primary hyperlipidemia have a high risk of developing cardiovascular diseases (CVDs) during adulthood. Several studies have repor…
·sciencedirect.com·
Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents
Cannabinoid hyperemesis and the cyclic vomiting syndrome in adults rec (...)
Cannabinoid hyperemesis and the cyclic vomiting syndrome in adults rec (...)
The cannabinoid hyperemesis syndrome (CHS) and the cyclic vomiting syndrome in adults (CVS) are both characterized by recurrent episodes of heavy nausea, vomiting and frequently abdominal pain. Both syndromes are barely known among physicians. Literature ...
·ncbi.nlm.nih.gov·
Cannabinoid hyperemesis and the cyclic vomiting syndrome in adults rec (...)
Expert Interview with Dr. Greg Gerdeman - YouTube
Expert Interview with Dr. Greg Gerdeman - YouTube
Watch the Healing Brain Watch Party here → http://bit.ly/2whtBf4 (airing free through EOD Sun, May 26th, 2019) Discover exactly HOW to use the sacred plant to treat several brain conditions, including Alzheimer's, Dementia, Parkinson's, Stroke, and many more... Go here for all the details → http://bit.ly/2WkMkol Dr. Gerdeman is a neuroscientist and educator with a Ph.D. in Biology. In this expert interview, he speaks of his interest in the endocannabinoid system (ENC) and how it operates within our brain. Watch Dr. Gerdeman translate complex neuroscientific ideas about the ENC into everyday language and hear how he believes our brain has co-evolved with the sacred plant. If you need expert guidance and support with using medical cannabis for a brain disorder, consider our Healing Brain Masterclass. SAVE up to 60% OFF this weekend only → http://bit.ly/2WkMkol
·youtube.com·
Expert Interview with Dr. Greg Gerdeman - YouTube
FDA Outlaws CBD Oils snopes.com
FDA Outlaws CBD Oils snopes.com
The FDA hasn't banned the sale of cannabidiol oils because a drug company is interested in marketing them.
·snopes.com·
FDA Outlaws CBD Oils snopes.com
FOX5 San Diego - Howards visit UCSD's Muotri Lab - YouTube
FOX5 San Diego - Howards visit UCSD's Muotri Lab - YouTube
About three months ago, Harper died from complications of a rare form of childhood epilepsy known as CDKL5. The Howards were quick to act in donating her brain and skin cells to the Muotri Lab in La Jolla, California. The lab, part of UCSD’s Department of Pediatrics, is headed by Dr. Alysson Muotri, UCSD’s lead stem cell researcher.
·youtube.com·
FOX5 San Diego - Howards visit UCSD's Muotri Lab - YouTube
Cannabinoid receptors are involved in the protective effect of a novel (...)
Cannabinoid receptors are involved in the protective effect of a novel (...)
Liver fibrosis is one of the major causes of morbidity and mortality worldwide and lacks efficient therapy. Recent studies suggest the curcumin protects liver from fibrosis. However, curcumin itself is in low bioavailable concentration when administered orally, and the protective mechanism remains p …
·ncbi.nlm.nih.gov·
Cannabinoid receptors are involved in the protective effect of a novel (...)
Frontiers 9-THC intoxication by cannabidiol-enriched cannabis extract (...)
Frontiers 9-THC intoxication by cannabidiol-enriched cannabis extract (...)
Animal studies and preliminary clinical trials have shown that cannabidiol (CBD)-enriched extracts may have beneficial effects for children with treatment-resistant epilepsy. However, these compounds are not yet registered as medicines by regulatory agencies. We describe the cases of two children with treatment-resistant epilepsy (Case A with left frontal dysplasia and Case B with Dravet Syndrome) with initial symptom improvement after the introduction of CBD extracts followed by seizure worsening after a short time. The children presented typical signs of intoxication by Δ9-THC (inappropriate laughter, ataxia, reduced attention, and eye redness) after using a CBD-enriched extract. The extract was replaced by the same dose of purified CBD with no Δ9-THC in both cases, which led to improvement in intoxication signs and seizure remission. These cases support pre-clinical and preliminary clinical evidence suggesting that CBD may be effective for some patients with epilepsy. Moreover, the cases highlight the need for randomized clinical trials using high-quality and reliable substances to ascertain the safety and efficacy of cannabinoids as medicines.
·journal.frontiersin.org·
Frontiers 9-THC intoxication by cannabidiol-enriched cannabis extract (...)
Cannabinoid-induced autophagy protective or death role
Cannabinoid-induced autophagy protective or death role
Autophagy, the “self-digestion” mechanism of the cells, is an evolutionary conserved catabolic process that targets portions of cytoplasm, damaged org…
·sciencedirect.com·
Cannabinoid-induced autophagy protective or death role
Frontiers An orally active Cannabis extract with high content in cann (...)
Frontiers An orally active Cannabis extract with high content in cann (...)
Anecdotal and scientific evidence suggests that Cannabis use may be beneficial in inflammatory bowel disease (IBD) patients. Here, we have investigated the effect of a standardized Cannabis sativa extract with high content of cannabidiol (CBD), here named CBD BDS for “CBD botanical drug substance,” on mucosal inflammation and hypermotility in mouse models of intestinal inflammation. Colitis was induced in mice by intracolonic administration of dinitrobenzenesulfonic acid (DNBS). Motility was evaluated in the experimental model of intestinal hypermotility induced by irritant croton oil. CBD BDS or pure CBD were given - either intraperitoneally or by oral gavage – after the inflammatory insult (curative protocol). The amounts of CBD in the colon, brain, and liver after the oral treatments were measured by high-performance liquid chromatography coupled to ion trap-time of flight mass spectrometry. CBD BDS, both when given intraperitoneally and by oral gavage, decreased the extent of the damage (as revealed by the decrease in the colon weight/length ratio and myeloperoxidase activity) in the DNBS model of colitis. It also reduced intestinal hypermotility (at doses lower than those required to affect transit in healthy mice) in the croton oil model of intestinal hypermotility. Under the same experimental conditions, pure CBD did not ameliorate colitis while it normalized croton oil-induced hypermotility when given intraperitoneally (in a dose-related fashion) or orally (only at...
·journal.frontiersin.org·
Frontiers An orally active Cannabis extract with high content in cann (...)
Frontiers Cannabis sativa The Plant of the Thousand and One Molecules (...)
Frontiers Cannabis sativa The Plant of the Thousand and One Molecules (...)
Cannabis sativa L. is an important herbaceous species originating from Central Asia, which has been used in folk medicine and as a source of textile fiber since the dawn of times. This fast-growing plant has recently seen a resurgence of interest because of its multi-purpose applications: it is indeed a treasure trove of phytochemicals and a rich source of both cellulosic and woody fibers. Equally highly interested in this plant are the pharmaceutical and construction sectors, since its metabolites show potent bioactivities on human health and its outer and inner stem tissues can be used to make bioplastics and concrete-like material, respectively. In this review, the rich spectrum of hemp phytochemicals is discussed by putting a special emphasis on molecules of industrial interest, including cannabinoids, terpenes and phenolic compounds, and their biosynthetic routes. Cannabinoids represent the most studied group of compounds, mainly due to their wide range of pharmaceutical effects in humans, including psychotropic activities. The therapeutic and commercial interests of some terpenes and phenolic compounds, and in particular stilbenoids and lignans, are also highlighted in view of the most recent literature data. Biotechnological avenues to enhance the production and bioactivity of hemp secondary metabolites are proposed by discussing the power of plant genetic engineering and tissue culture. In particular two systems are reviewed, i.e., cell suspension and hairy root cu...
·journal.frontiersin.org·
Frontiers Cannabis sativa The Plant of the Thousand and One Molecules (...)
Frontiers Evaluating the effects of gamma-irradiation for decontamina (...)
Frontiers Evaluating the effects of gamma-irradiation for decontamina (...)
In several countries with a National medicinal cannabis program, pharmaceutical regulations specify that herbal cannabis products must adhere to strict safety standards regarding microbial contamination. Treatment by gamma irradiation currently seems the only method available to meet these requirements. We evaluated the effects of irradiation treatment of four different cannabis varieties covering different chemical compositions. Samples were compared before and after standard gamma-irradiation treatment by performing quantitative UPLC analysis of major cannabinoids, as well as qualitative GC analysis of full cannabinoid and terpene profiles. In addition, water content and microscopic appearance of the cannabis flowers was evaluated. This study found that treatment did not cause changes in the content of THC and CBD, generally considered as the most important therapeutically active components of medicinal cannabis. Likewise, the water content and the microscopic structure of the dried cannabis flowers were not altered by standard irradiation protocol in the cannabis varieties studied. The effect of gamma-irradiation was limited to a reduction of some terpenes present in the cannabis, but keeping the terpene profile qualitatively the same. Based on the results presented in this report, gamma irradiation of herbal cannabis remains the recommended method of decontamination, at least until other more generally accepted methods have been developed and validated.
·journal.frontiersin.org·
Frontiers Evaluating the effects of gamma-irradiation for decontamina (...)
Frontiers Impact of Cannabis, Cannabinoids, and Endocannabinoids in t (...)
Frontiers Impact of Cannabis, Cannabinoids, and Endocannabinoids in t (...)
Since the identification of cannabinoid receptors in the 1990s, a research field has been dedicated to exploring the role of the cannabinoid system in immunity and the inflammatory response in human tissues and animal models. Although the cannabinoid system is present and crucial in many human tissues, studying the impact of cannabinoids on the lungs is particularly relevant because of their contact with exogenous cannabinoids in the context of marijuana consumption. In the past two decades, the scientific community has gathered a large body of evidence supporting that the activation of the cannabinoid system alleviates pain and reduces inflammation. In the context of lung inflammation, exogenous and endogenous cannabinoids have shown therapeutic potential because of their inhibitory effects on immune cell recruitment and functions. On the other hand, cannabinoids were shown to be deleterious to lung function and to impact respiratory pathogen clearance. In this review, we present the existing data on the regulation of lung immunity and inflammation by phytocannabinoids, synthetic cannabinoids and endocannabinoids.
·journal.frontiersin.org·
Frontiers Impact of Cannabis, Cannabinoids, and Endocannabinoids in t (...)
Cannabinoids remove plaque-forming Alzheimer's proteins from brain cel (...)
Cannabinoids remove plaque-forming Alzheimer's proteins from brain cel (...)
Scientists have found preliminary evidence that tetrahydrocannabinol (THC) and other compounds found in marijuana can promote the cellular removal of amyloid beta, a toxic protein associated with Alzheimer's disease.
·sciencedaily.com·
Cannabinoids remove plaque-forming Alzheimer's proteins from brain cel (...)
63. A study of cortical and spinal excitability in patients affected b (...)
63. A study of cortical and spinal excitability in patients affected b (...)
The therapeutic efficacy of oromucosal cannabinoid spray (THC/CBD) for the treatment of spasticity is well documented by clinical trials, and THC/CBD has been approved in Italy for the treatment of spasticity in multiple sclerosis (MS). Our study aims to assess the neurophysiological correlates of the THC/CBD effect on spasticity in MS. We enrolled 16 MS patients who underwent a neurological examination (together with modified Ashworth scale) and neurophysiological testing. For the assessment of the cortical and spinal excitability, we performed duble-pulse TMS to evaluate LICI, SICI and ICF; we also studied CSP, H/M ratio and H reflex recovery cycle. Clinical and neurophysiological results were tested before and after one month of THC/CBD spray treatment and compared with data obtained from 10 healthy controls. Patients referred a subjective decrease of spasticity after THC/CBD, confirmed by modified Ashworth scale, and showed a significant difference of the H recovery cycle (at ISI 500ms) and LICI compared to controls, that normalized after THC/CBD. CSP did not differ from healthy subjects. Our data showed that THC/CBD oromucosal spray is effective in spasticity treatment and that it probably acts at spinal and subcortical level by modulating the GABA-ergic inhibitory circuitry.
·infona.pl·
63. A study of cortical and spinal excitability in patients affected b (...)
Health Authorities Data Collection of THCCBD Oromucosal Spray (L'Agenz (...)
Health Authorities Data Collection of THCCBD Oromucosal Spray (L'Agenz (...)
The results of the AIFA e-registry analysis align with those of other THC:CBD observational projects and reaffirm the characteristics of this therapeutic option in the management of treatment-resistant MS spasticity, a frequently overlooked symptom.
·ncbi.nlm.nih.gov·
Health Authorities Data Collection of THCCBD Oromucosal Spray (L'Agenz (...)
Health Benefits of Cannabis Essential Oil Organic Facts
Health Benefits of Cannabis Essential Oil Organic Facts
CBD oil possesses cannabidiol; while THC is psychoactive, CBD is not, thereby helping relieve pain and depression, fighting cancer, and reducing anxiety.
·organicfacts.net·
Health Benefits of Cannabis Essential Oil Organic Facts