Cannabis

United Patients Group is the leading source for Medical Marijuana & Medical Cannabis Info. Dr. Sulak, Optimal Cannabis Dosing Guidelines Presented by UPG!

Cannabidiol (CBD), a major constituent of Cannabis, has been shown to be a powerful anti-inflammatory and anti-anxiety drug, without exerting a psychotropic effect. However, when given either intraperitoneally or orally as a purified product, a bell-shaped dose-response was observed, which limits its clinical use. In the present study, we have studied in mice the anti-inflammatory and anti-nociceptive activities of standardized plant extracts derived from the Cannabis sativa L., clone 202, which is highly enriched in CBD and hardly contains any psychoactive ingredients. In stark contrast to purified CBD, the clone 202 extract, when given either intraperitoneally or orally, provided a clear correlation between the anti-inflammatory and anti-nociceptive responses and the dose, with increasing responses upon increasing doses, which makes this plant medicine ideal for clinical uses. The clone 202 extract reduced zymosan-induced paw swelling and pain in mice, and prevented TNFα production in vivo. It is likely that other components in the extract synergize with CBD to achieve the desired anti-inflammatory action that may contribute to overcoming the bell-shaped dose-response of purified CBD. We therefore propose that Cannabis clone 202 (Avidekel) extract is superior over CBD for the treatment of inflammatory conditions.

The biggest barrier to reducing toxic pesticides in cannabis is, not surprisingly, the cannabis industry itself. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ For more on the link between the tobacco and marijuana industries, check out: Will Cannabis Turn Into Big Tobacco? (http://nutritionfacts.org/video/will-cannabis-turn-into-big-tobacco) I have a whole catalogue of marijuana videos and I’ve got more to come. Here are the ones that are already up in case you missed any: • The Institute of Medicine Report on the Health Effects of Marijuana (http://nutritionfacts.org/video/The-Institute-of-Medicine-Report-on-the-Health-Effects-of-Marijuana) • Researching the Health Effects of Marijuana (http://nutritionfacts.org/video/Researching-the-Health-Effects-of-Marijuana) • Is Marijuana Addictive? (http://nutritionfacts.org/video/Is-Marijuana-Addictive) • Does Marijuana Cause Health Problems? (http://nutritionfacts.org/video/Does-Marijuana-Cause-Health-Problems) • Does Marijuana Cause Permanent Brain Damage in Teens? (http://nutritionfacts.org/video/Does-Marijuana-Cause-Permanent-Brain-Damage-in-Teens) • Does Marijuana Cause Permanent Brain Damage in Adults? (http://nutritionfacts.org/video/Does-Marijuana-Cause-Permanent-Brain-Damage-in-Adults) • Marijuana Legalization and the Opioid Epidemic (http://nutritionfacts.org/video/Marijuana-Legalization-and-the-Opioid-Epidemic) • Effects of Smoking Marijuana on the Lungs (http://nutritionfacts.org/video/effects-of-smoking-marijuana-on-the-lungs) • Smoking Marijuana vs. Using a Cannabis Vaporizer (http://nutritionfacts.org/video/Smoking-Marijuana-vs-Using-a-Cannabis-Vaporizer) • Does Marijuana Cause Lung Cancer? (http://nutritionfacts.org/video/does-marijuana-cause-lung-cancer) • Can Cannabis Cure Cancer? (http://nutritionfacts.org/video/can-cannabis-cure-cancer) • Are Cannabis Edibles Safe? (http://nutritionfacts.org/video/are-cannabis-edibles-safe) More tobacco industry parallels can be found in Big Food Using the Tobacco Industry Playbook (http://nutritionfacts.org/video/big-food-using-the-tobacco-industry-playbook), American Medical Association Complicity with Big Tobacco (https://nutritionfacts.org/video/american-medical-association-complicity-big-tobacco/), and How Smoking in 1959 is Like Eating in 2019 (http://nutritionfacts.org/video/how-smoking-in-the-50s-is-like-eating-today). Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/pesticides-in-marijuana and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/pesticides-in-marijuana. You’ll also find a transcript and acknowledgments for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages. To find yours, click on the settings wheel on the lower-right of the video and then "Subtitles/CC." Do you have feedback about the translations in this video? Please share it here along with the title of the video and language: https://nutritionfacts.zendesk.com/hc/requests/new To view the subtitles in transcript format, click on the ellipsis button below the video, choose "Open transcript", and select the language you'd like to view them in. Image credit: Andrea / Adobe Stock photos http://www.NutritionFacts.org • Subscribe: http://www.NutritionFacts.org/subscribe • Donate: http://www.NutritionFacts.org/donate • HOW NOT TO DIE: http://nutritionfacts.org/book • Facebook: http://www.facebook.com/NutritionFacts.org • Twitter: http://www.twitter.com/nutrition_facts • Instagram: http://instagram.com/nutrition_facts_org/ • Podcast : http://nutritionfacts.org/audio/

Background Cervical cancer remains a global health related issue among females of Sub-Saharan Africa, with over half a million new cases reported each year. Different therapeutic regimens have been suggested in various regions of Africa, however, over a quarter of a million women die of cervical cancer, annually. This makes it the most lethal cancer amongst black women and calls for urgent therapeutic strategies. In this study we compare the anti-proliferative effects of crude extract of Cannabis sativa and its main compound cannabidiol on different cervical cancer cell lines. Methods To achieve our aim, phytochemical screening, MTT assay, cell growth analysis, flow cytometry, morphology analysis, Western blot, caspase 3/7 assay, and ATP measurement assay were conducted. Results Results obtained indicate that both cannabidiol and Cannabis sativa extracts were able to halt cell proliferation in all cell lines at varying concentrations. They further revealed that apoptosis was induced by cannabidiol as shown by increased subG0/G1 and apoptosis through annexin V. Apoptosis was confirmed by overexpression of p53, caspase 3 and bax. Apoptosis induction was further confirmed by morphological changes, an increase in Caspase 3/7 and a decrease in the ATP levels. Conclusions In conclusion, these data suggest that cannabidiol rather than Cannabis sativa crude extracts prevent cell growth and induce cell death in cervical cancer cell lines.

After a century of banishment, both euphoric (“marijuana”) and non-euphoric (“industrial hemp”) classes of Cannabis sativa are attracting billions of dollars of investment as new legitimate crops. Most domesticated C. sativa is very tall, a phenotype that is desirable only for hemp fibre obtained from the stems. However, because the principal demands today are for chemicals from the inflorescence and oilseeds from the infructescence, an architecture maximizing reproductive tissues while minimizing stems is appropriate. Such a design was the basis of the greatest short-term increases in crop productivity in the history of agriculture: the creation of short-stature (“semi-dwarf”), high-harvest-index grain cultivars, especially by ideotype breeding, as demonstrated during the “Green Revolution.” This paradigm has considerable promise for C. sativa. The most critical dwarfing character for breeding such productivity into C. sativa is contraction of internodes. This reduces stem tissues (essentially a waste product except for fibre hemp) and results in compact inflorescences (which, on an area basis, maximize cannabinoid chemicals) and infructescences (which maximize oilseed production), as well as contributing to ease of harvesting and efficiency of production on an area basis. Four sources of germplasm useful for breeding semi-dwarf biotypes deserve special attention: (1) Naturally short northern Eurasian wild plants (often photoperiodically day-neutral, unlike like most biotypes) adapted to the stress of very short seasons by maximizing relative development of reproductive tissues. (2) Short, high-harvest-index, oilseed plants selected in northern regions of Eurasia. (3) “Indica type” marijuana, an ancient semi-dwarf cultigen tracing to the Afghanistan-Pakistan area. (4) Semi-dwarf strains of marijuana bred illegally in recent decades to avoid detection when grown clandestinely indoors for the black market. Although the high THC content in marijuana strains limits their usage as germplasm for low-THC cultivars, modern breeding techniques can control this variable. The current elimination of all marijuana germplasm from breeding of hemp cultivars is short-sighted because marijuana biotypes possess a particularly wide range of genes. There is an urgent need to develop public gene bank collections of Cannabis.

Scientia Pharmaceutica, an international, peer-reviewed Open Access journal.

Cannabidiol (CBD), a major non-psychotropic constituent of fiber-type cannabis plant, has been reported to possess diverse biological activities, incl…

The objective was to investigate the effects of heat pretreatment and simulated gastrointestinal digestion on potential antioxidant, anticancer and an…

(2016). Effects of Ethephon on Terpenoids in Cannabis sativa L. in Vegetative Stage. Journal of Essential Oil Bearing Plants: Vol. 19, No. 1, pp. 94-102.

The cannabinoid hyperemesis syndrome (CHS) and the cyclic vomiting syndrome in adults (CVS) are both characterized by recurrent episodes of heavy nausea, vomiting and frequently abdominal pain. Both syndromes are barely known among physicians. Literature ...

Background The approval of 9-δ-tetrahydocannabinol and cannabidiol (THC:CBD) oromucosal spray (Sativex) for the management of treatment-resistant multiple sclerosis (MS) spasticity opened a new opportunity for many patients. The aim of our study was to describe Sativex effectiveness and adverse events profile in a large population of Italian patients with MS in the daily practice setting. Methods We collected data of all patients starting Sativex between January 2014 and February 2015 from the mandatory Italian medicines agency (AIFA) e-registry. Spasticity assessment by the 0–10 numerical rating scale (NRS) scale is available at baseline, after 1 month of treatment (trial period), and at 3 and 6 months. Results A total of 1615 patients were recruited from 30 MS centres across Italy. After one treatment month (trial period), we found 70.5% of patients reaching a ≥20% improvement (initial response, IR) and 28.2% who had already reached a ≥30% improvement (clinically relevant response, CRR), with a mean NRS score reduction of 22.6% (from 7.5 to 5.8). After a multivariate analysis, we found an increased probability to reach IR at the first month among patients with primary and secondary progressive MS, (n=1169, OR 1.4 95% CI 1.04 to 1.9, p=0.025) and among patients with >8 NRS score at baseline (OR 1.8 95% CI 1.3–2.4 p

Children affected by primary hyperlipidemia have a high risk of developing cardiovascular diseases (CVDs) during adulthood. Several studies have repor…

A combination of cannabis oil and chemotherapy healed this man’s “incurable inoperable” lung cancer.

Cannabinoids have been used for many centuries to ease pain and in the past decade, the endocannabinoid system has been implicated in a number of path…

Cannabis and Cannabinoid Research

Liver fibrosis is one of the major causes of morbidity and mortality worldwide and lacks efficient therapy. Recent studies suggest the curcumin protects liver from fibrosis. However, curcumin itself is in low bioavailable concentration when administered orally, and the protective mechanism remains p …

Watch the Healing Brain Watch Party here → http://bit.ly/2whtBf4 (airing free through EOD Sun, May 26th, 2019) Discover exactly HOW to use the sacred plant to treat several brain conditions, including Alzheimer's, Dementia, Parkinson's, Stroke, and many more... Go here for all the details → http://bit.ly/2WkMkol Dr. Gerdeman is a neuroscientist and educator with a Ph.D. in Biology. In this expert interview, he speaks of his interest in the endocannabinoid system (ENC) and how it operates within our brain. Watch Dr. Gerdeman translate complex neuroscientific ideas about the ENC into everyday language and hear how he believes our brain has co-evolved with the sacred plant. If you need expert guidance and support with using medical cannabis for a brain disorder, consider our Healing Brain Masterclass. SAVE up to 60% OFF this weekend only → http://bit.ly/2WkMkol

The therapeutic efficacy of oromucosal cannabinoid spray (THC/CBD) for the treatment of spasticity is well documented by clinical trials, and THC/CBD has been approved in Italy for the treatment of spasticity in multiple sclerosis (MS). Our study aims to assess the neurophysiological correlates of the THC/CBD effect on spasticity in MS. We enrolled 16 MS patients who underwent a neurological examination (together with modified Ashworth scale) and neurophysiological testing. For the assessment of the cortical and spinal excitability, we performed duble-pulse TMS to evaluate LICI, SICI and ICF; we also studied CSP, H/M ratio and H reflex recovery cycle. Clinical and neurophysiological results were tested before and after one month of THC/CBD spray treatment and compared with data obtained from 10 healthy controls. Patients referred a subjective decrease of spasticity after THC/CBD, confirmed by modified Ashworth scale, and showed a significant difference of the H recovery cycle (at ISI 500ms) and LICI compared to controls, that normalized after THC/CBD. CSP did not differ from healthy subjects. Our data showed that THC/CBD oromucosal spray is effective in spasticity treatment and that it probably acts at spinal and subcortical level by modulating the GABA-ergic inhibitory circuitry.

Autophagy, the “self-digestion” mechanism of the cells, is an evolutionary conserved catabolic process that targets portions of cytoplasm, damaged org…

The FDA hasn't banned the sale of cannabidiol oils because a drug company is interested in marketing them.

About three months ago, Harper died from complications of a rare form of childhood epilepsy known as CDKL5. The Howards were quick to act in donating her brain and skin cells to the Muotri Lab in La Jolla, California. The lab, part of UCSD’s Department of Pediatrics, is headed by Dr. Alysson Muotri, UCSD’s lead stem cell researcher.

This unjustly demonized plant is about to change the scope of medicine and disease management as we know it

Animal studies and preliminary clinical trials have shown that cannabidiol (CBD)-enriched extracts may have beneficial effects for children with treatment-resistant epilepsy. However, these compounds are not yet registered as medicines by regulatory agencies. We describe the cases of two children with treatment-resistant epilepsy (Case A with left frontal dysplasia and Case B with Dravet Syndrome) with initial symptom improvement after the introduction of CBD extracts followed by seizure worsening after a short time. The children presented typical signs of intoxication by Δ9-THC (inappropriate laughter, ataxia, reduced attention, and eye redness) after using a CBD-enriched extract. The extract was replaced by the same dose of purified CBD with no Δ9-THC in both cases, which led to improvement in intoxication signs and seizure remission. These cases support pre-clinical and preliminary clinical evidence suggesting that CBD may be effective for some patients with epilepsy. Moreover, the cases highlight the need for randomized clinical trials using high-quality and reliable substances to ascertain the safety and efficacy of cannabinoids as medicines.

Cannabis kills brain cells, right? Think again... Here are 7 ways cannabis can protect the brain and nervous system…