Cannabis

Waldo was six months old he was diagnosed with a rare form of eye cancer and was facing an uncertain future. Doctors said he had a 50 percent chance of losing his eye. Today Waldo is tumor free, an active, outgoing kid full of energy, thanks in part, his parents say, to cannabis oil.

Cannabis is the most widely used illicit drug worldwide. Regular cannabis use has been associated with a range of acute and chronic mental health problems, such as anxiety, depression, psychotic symptoms and neurocognitive impairments and their neural mechanisms need to be examined. This review summ …

Walacea is crowdfunding a clinical trial in 30 patients investigating cannabis in the treatment of cancer. Cannabinoids have anti-cancer activity.

The French beekeeper has self-medicated with cannabis since a very early age and he defines himself as someone that is passionate about nature and training all kinds o...

Picking the seeds and stems out of the Bible.

Medical marijuana is having a positive impact on the bottom line of Medicare's prescription drug benefit program in states that have legalized its use for medicinal purposes, according to new research.The savings, due to lower prescription drug use, were estimated to be $165.2 million in 2013, a year when 17 states and the District of Columbia had implemented medical marijuana laws.

Europe PMC is an archive of life sciences journal literature.

Dr David Allen talks to Medical Marijuana 411 about his experience with cannabis, strokes, stroke prevention and the human endocannabinoid system. Dr Allen is one of the featured medical professionals in the Medical Marijuana 411 online education courses for medical professionals, patients and dispensary technicians. This is an example of the video content that is part of the online education. With more thank 800 peer reviewed citations, downloadable graphics, Medical Marijuana 411 is the leader in cannabis education. Check out the entire list of certifications and courses offered at http://www.medicalmarijuana411.com

Cannabidiol (CBD), a major constituent of Cannabis, has been shown to be a powerful anti-inflammatory and anti-anxiety drug, without exerting a psychotropic effect. However, when given either intraperitoneally or orally as a purified product, a bell-shaped dose-response was observed, which limits its clinical use. In the present study, we have studied in mice the anti-inflammatory and anti-nociceptive activities of standardized plant extracts derived from the Cannabis sativa L., clone 202, which is highly enriched in CBD and hardly contains any psychoactive ingredients. In stark contrast to purified CBD, the clone 202 extract, when given either intraperitoneally or orally, provided a clear correlation between the anti-inflammatory and anti-nociceptive responses and the dose, with increasing responses upon increasing doses, which makes this plant medicine ideal for clinical uses. The clone 202 extract reduced zymosan-induced paw swelling and pain in mice, and prevented TNFα production in vivo. It is likely that other components in the extract synergize with CBD to achieve the desired anti-inflammatory action that may contribute to overcoming the bell-shaped dose-response of purified CBD. We therefore propose that Cannabis clone 202 (Avidekel) extract is superior over CBD for the treatment of inflammatory conditions.

The biggest barrier to reducing toxic pesticides in cannabis is, not surprisingly, the cannabis industry itself. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ For more on the link between the tobacco and marijuana industries, check out: Will Cannabis Turn Into Big Tobacco? (http://nutritionfacts.org/video/will-cannabis-turn-into-big-tobacco) I have a whole catalogue of marijuana videos and I’ve got more to come. Here are the ones that are already up in case you missed any: • The Institute of Medicine Report on the Health Effects of Marijuana (http://nutritionfacts.org/video/The-Institute-of-Medicine-Report-on-the-Health-Effects-of-Marijuana) • Researching the Health Effects of Marijuana (http://nutritionfacts.org/video/Researching-the-Health-Effects-of-Marijuana) • Is Marijuana Addictive? (http://nutritionfacts.org/video/Is-Marijuana-Addictive) • Does Marijuana Cause Health Problems? (http://nutritionfacts.org/video/Does-Marijuana-Cause-Health-Problems) • Does Marijuana Cause Permanent Brain Damage in Teens? (http://nutritionfacts.org/video/Does-Marijuana-Cause-Permanent-Brain-Damage-in-Teens) • Does Marijuana Cause Permanent Brain Damage in Adults? (http://nutritionfacts.org/video/Does-Marijuana-Cause-Permanent-Brain-Damage-in-Adults) • Marijuana Legalization and the Opioid Epidemic (http://nutritionfacts.org/video/Marijuana-Legalization-and-the-Opioid-Epidemic) • Effects of Smoking Marijuana on the Lungs (http://nutritionfacts.org/video/effects-of-smoking-marijuana-on-the-lungs) • Smoking Marijuana vs. Using a Cannabis Vaporizer (http://nutritionfacts.org/video/Smoking-Marijuana-vs-Using-a-Cannabis-Vaporizer) • Does Marijuana Cause Lung Cancer? (http://nutritionfacts.org/video/does-marijuana-cause-lung-cancer) • Can Cannabis Cure Cancer? (http://nutritionfacts.org/video/can-cannabis-cure-cancer) • Are Cannabis Edibles Safe? (http://nutritionfacts.org/video/are-cannabis-edibles-safe) More tobacco industry parallels can be found in Big Food Using the Tobacco Industry Playbook (http://nutritionfacts.org/video/big-food-using-the-tobacco-industry-playbook), American Medical Association Complicity with Big Tobacco (https://nutritionfacts.org/video/american-medical-association-complicity-big-tobacco/), and How Smoking in 1959 is Like Eating in 2019 (http://nutritionfacts.org/video/how-smoking-in-the-50s-is-like-eating-today). Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/pesticides-in-marijuana and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/pesticides-in-marijuana. You’ll also find a transcript and acknowledgments for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages. To find yours, click on the settings wheel on the lower-right of the video and then "Subtitles/CC." Do you have feedback about the translations in this video? Please share it here along with the title of the video and language: https://nutritionfacts.zendesk.com/hc/requests/new To view the subtitles in transcript format, click on the ellipsis button below the video, choose "Open transcript", and select the language you'd like to view them in. Image credit: Andrea / Adobe Stock photos http://www.NutritionFacts.org • Subscribe: http://www.NutritionFacts.org/subscribe • Donate: http://www.NutritionFacts.org/donate • HOW NOT TO DIE: http://nutritionfacts.org/book • Facebook: http://www.facebook.com/NutritionFacts.org • Twitter: http://www.twitter.com/nutrition_facts • Instagram: http://instagram.com/nutrition_facts_org/ • Podcast : http://nutritionfacts.org/audio/

In this installment of Cannabis Conversations, Dr. Ethan Russo discusses clinical endocannabinoid deficiency and ways to target the endocannabinoid system for therapeutic benefit.

United Patients Group is the leading source for Medical Marijuana & Medical Cannabis Info. Dr. Sulak, Optimal Cannabis Dosing Guidelines Presented by UPG!

Scientia Pharmaceutica, an international, peer-reviewed Open Access journal.

This is a true story about Barry Shoda, a man diagnosed with an aggressive cancer and a deadly brain tumor. His doctor told him he had only a short time to live. Barry did several things to save his life, including taking a CBD oil made from hemp. This documentary provides hope that people with cancer can have an effective alternative to chemotherapy and radiation treatments. When I learned that Barry's brain tumor had stopped growing after taking CBD hemp oil, I knew I had to tell his story. I directed, filmed, produced and edited this 8-minute documentary as my culminating project for New Vista High School in Boulder, Colorado. I know many people who have cancer in their family. I hope this documentary can be valuable as another way to deal with cancer, and possibly to save people's lives.

After a century of banishment, both euphoric (“marijuana”) and non-euphoric (“industrial hemp”) classes of Cannabis sativa are attracting billions of dollars of investment as new legitimate crops. Most domesticated C. sativa is very tall, a phenotype that is desirable only for hemp fibre obtained from the stems. However, because the principal demands today are for chemicals from the inflorescence and oilseeds from the infructescence, an architecture maximizing reproductive tissues while minimizing stems is appropriate. Such a design was the basis of the greatest short-term increases in crop productivity in the history of agriculture: the creation of short-stature (“semi-dwarf”), high-harvest-index grain cultivars, especially by ideotype breeding, as demonstrated during the “Green Revolution.” This paradigm has considerable promise for C. sativa. The most critical dwarfing character for breeding such productivity into C. sativa is contraction of internodes. This reduces stem tissues (essentially a waste product except for fibre hemp) and results in compact inflorescences (which, on an area basis, maximize cannabinoid chemicals) and infructescences (which maximize oilseed production), as well as contributing to ease of harvesting and efficiency of production on an area basis. Four sources of germplasm useful for breeding semi-dwarf biotypes deserve special attention: (1) Naturally short northern Eurasian wild plants (often photoperiodically day-neutral, unlike like most biotypes) adapted to the stress of very short seasons by maximizing relative development of reproductive tissues. (2) Short, high-harvest-index, oilseed plants selected in northern regions of Eurasia. (3) “Indica type” marijuana, an ancient semi-dwarf cultigen tracing to the Afghanistan-Pakistan area. (4) Semi-dwarf strains of marijuana bred illegally in recent decades to avoid detection when grown clandestinely indoors for the black market. Although the high THC content in marijuana strains limits their usage as germplasm for low-THC cultivars, modern breeding techniques can control this variable. The current elimination of all marijuana germplasm from breeding of hemp cultivars is short-sighted because marijuana biotypes possess a particularly wide range of genes. There is an urgent need to develop public gene bank collections of Cannabis.

Researchers have presented the first findings of a large study of cannabidiol for treating seizures.

The objective was to investigate the effects of heat pretreatment and simulated gastrointestinal digestion on potential antioxidant, anticancer and an…

(2016). Effects of Ethephon on Terpenoids in Cannabis sativa L. in Vegetative Stage. Journal of Essential Oil Bearing Plants: Vol. 19, No. 1, pp. 94-102.

Background Cervical cancer remains a global health related issue among females of Sub-Saharan Africa, with over half a million new cases reported each year. Different therapeutic regimens have been suggested in various regions of Africa, however, over a quarter of a million women die of cervical cancer, annually. This makes it the most lethal cancer amongst black women and calls for urgent therapeutic strategies. In this study we compare the anti-proliferative effects of crude extract of Cannabis sativa and its main compound cannabidiol on different cervical cancer cell lines. Methods To achieve our aim, phytochemical screening, MTT assay, cell growth analysis, flow cytometry, morphology analysis, Western blot, caspase 3/7 assay, and ATP measurement assay were conducted. Results Results obtained indicate that both cannabidiol and Cannabis sativa extracts were able to halt cell proliferation in all cell lines at varying concentrations. They further revealed that apoptosis was induced by cannabidiol as shown by increased subG0/G1 and apoptosis through annexin V. Apoptosis was confirmed by overexpression of p53, caspase 3 and bax. Apoptosis induction was further confirmed by morphological changes, an increase in Caspase 3/7 and a decrease in the ATP levels. Conclusions In conclusion, these data suggest that cannabidiol rather than Cannabis sativa crude extracts prevent cell growth and induce cell death in cervical cancer cell lines.

Background The approval of 9-δ-tetrahydocannabinol and cannabidiol (THC:CBD) oromucosal spray (Sativex) for the management of treatment-resistant multiple sclerosis (MS) spasticity opened a new opportunity for many patients. The aim of our study was to describe Sativex effectiveness and adverse events profile in a large population of Italian patients with MS in the daily practice setting. Methods We collected data of all patients starting Sativex between January 2014 and February 2015 from the mandatory Italian medicines agency (AIFA) e-registry. Spasticity assessment by the 0–10 numerical rating scale (NRS) scale is available at baseline, after 1 month of treatment (trial period), and at 3 and 6 months. Results A total of 1615 patients were recruited from 30 MS centres across Italy. After one treatment month (trial period), we found 70.5% of patients reaching a ≥20% improvement (initial response, IR) and 28.2% who had already reached a ≥30% improvement (clinically relevant response, CRR), with a mean NRS score reduction of 22.6% (from 7.5 to 5.8). After a multivariate analysis, we found an increased probability to reach IR at the first month among patients with primary and secondary progressive MS, (n=1169, OR 1.4 95% CI 1.04 to 1.9, p=0.025) and among patients with >8 NRS score at baseline (OR 1.8 95% CI 1.3–2.4 p