Coronavirus

Rationale Pre-clinical and autopsy studies have fueled the hypothesis that a dysregulated vascular endothelium might play a central role in the pathogenesis of ARDS and multi-organ failure in COVID-19. Objectives To comprehensively characterize and quantify microvascular alterations in patients with COVID-19. Methods Hospitalized adult patients with moderate-to-severe or critical COVID-19 (n = 23) were enrolled non-consecutively in this prospective, observational, cross-sectional, multi-center study. Fifteen healthy volunteers served as controls. All participants underwent intravital microscopy by sidestream dark field imaging to quantify vascular density, red blood cell velocity (VRBC), and glycocalyx dimensions (perfused boundary region, PBR) in sublingual microvessels. Circulating levels of endothelial and glycocalyx-associated markers were measured by multiplex proximity extension assay and enzyme-linked immunosorbent assay. Measurements and main results COVID-19 patients showed an up to 90% reduction in vascular density, almost exclusively limited to small capillaries (diameter 4–6 µm), and also significant reductions of VRBC. Especially, patients on mechanical ventilation showed severe glycocalyx damage as indicated by higher PBR values (i.e., thinner glycocalyx) and increased blood levels of shed glycocalyx constituents. Several markers of endothelial dysfunction were increased and correlated with disease severity in COVID-19. PBR (AUC 0.75, p = 0.01), ADAMTS13 (von Willebrand factor-cleaving protease; AUC 0.74, p = 0.02), and vascular endothelial growth factor A (VEGF-A; AUC 0.73, p = 0.04) showed the best discriminatory ability to predict 60-day in-hospital mortality. Conclusions Our data clearly show severe alterations of the microcirculation and the endothelial glycocalyx in patients with COVID-19. Future therapeutic approaches should consider the importance of systemic vascular involvement in COVID-19.

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Nebulizing Magnesium and other natural medicinals as Iodine, Sodium Bicarbonate, peroxide and glutathione are strong treatment options that deliver the medicinals directly to the tracheobronchial tree.

Will the Covid Casedemic be Over by April? I hope So.

Have you ever pondered the fact that the current COVID lockdown, masks, and fear may be a result of official “facts” that are not facts at all but are, well, actually lies? In our opinion, the propaganda campaign surrounding this so-called “pandemic” has achieved its goal. Inundated with voluminous amounts of contradictory information coming from all angles, people in general have succumbed to “analysis paralysis,” confusion and fear. Many have given up trying to actually understand the situation and apparently have decided that, regardless of how insane or illogical the directives may be, it’s just easier to act like

It’s been over six weeks since Iowa dropped all state-level COVID restrictions, and surprise, surprise, hospitalized patients are down 54 percent. But if you try to Google this information, all you will see is death, dying, and it must be the end of the world because of COVID, which miraculously seems to be a cure... View Article

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Ivor Cummins reveals the data showing that the lockdowns have not had a net positive effect in the countries implementing them; to the contrary, they have caused massive harm.

A German team of researchers this week said they may have discovered what causes rare blood clots in ...

Large-scale population screening can provide insights to levels of ongoing SARS-CoV-2 transmission. Here, the authors report a citywide screening of ~10,000,000 residents of Wuhan and show that SARS-CoV-2 infection prevalence was very low five to eight weeks after the end of lockdown.

Hundreds of people across the United States have been complaining that they are receiving calls from clinics and medical offices claiming that they have confirmed positive for C0VlD but those people say they were never tested. Is this just an internet rumor or is it really happening? We're investigating. Check out our new free speech platform https://ISE.Media Invest in ISE Media: https://wefunder.com/ise.media ---------------- Support Truth in Media by visiting our sponsors: ISE.Media: https://ISE.Media Pulse Cellular: Use code "TRUTH" for 10% every plan for life. https://truthinmedia.com/phone Pure VPN: Military grade vpn protection. https://truthinmedia.com/vpn Brave Browser: Open source and built by a team of privacy focused, performance oriented pioneers of the web. https://truthinmedia.com/brave #benswann

Before we look at those places around the world with soft approaches to the pandemic, and the successes they have had, everyone needs to know that the pandemic has taken on a shroud of fantasy. Its an illusion, many say, a scam even though the virus is real, though probably man-made.   We still hear... View Article

Even though the COVID-19 curve has been flattened, mainstream media outlets continue to push doomsday predictions of an impending explosion of deaths

'It's unfortunate that a propaganda war has been waged on the commonly prescribed drug which is not based on medical facts.'

This Safety Communication describes the risk of false results, particularly false negative results, with the Curative SARS-Cov-2 test.

In medicine, we are taught not to guess when we can know, but that basic ethos for safe practice and the sharing of accurate information has not been applied to COVID-19

Whether you live in the USA or most of Europe, one thing remains true: Covid-19 testing regimes are being aggressively pushed onto populations

Ivermectin has been repurposed as highly effective antiviral drug. Sadly, this is being ignored by US Medicine.