Diabetes Type 1

I am a retired physician living with Type 1 diabetes since 1998. I follow a ketogenic diet for diabetes management, and maintain nutritional ketosis. I participate in endurance sports.

Chronic hyperglycemia underlies microvascular complications in patients with type 1 diabetes. The mechanisms leading to these vascular complications are not fully understood. Recently, we observed that acute hyperglycemia results in endothelial glycocalyx damage. To establish whether glycocalyx is associated with microvascular damage, we performed glycocalyx perturbation volume measurements in type 1 diabetic patients with microalbuminuria (DM1-MA group; n = 7), without microalbuminuria (DM1-NA group; n = 7), and in age-matched control subjects (CON; n = 7). Systemic glycocalyx volume was determined comparing intravascular distribution volume of a glycocalyx-permeable tracer (dextran 40) to that of a glycocalyx-impermeable tracer (labeled erythrocytes). Sublingual capillaries were visualized using orthogonal polarization spectral microscopy to estimate microvascular glycocalyx. Patients and control subjects were matched according to age and BMI. Glycocalyx volume decreased in a stepwise fashion from CON, DM1-NA, and finally DM1-MA subjects (1.5 ± 0.1, 0.8 ± 0.4, and 0.2 ± 0.1 l, respectively, P < 0.05). Microvascular glycocalyx in sublingual capillaries was also decreased in type 1 diabetes versus the control group (0.5 ± 0.1 vs. 0.9 ± 0.1 μm, P < 0.05). Plasma hyaluronan, a principal glycocalyx constituent, and hyaluronidase were increased in type 1 diabetes. In conclusion, type 1 diabetic patients are characterized by endothelial glycocalyx damage, the severity of which is increased in presence of microalbuminuria.

Fenugreek is one of the oldest recorded medicinal plants. The recorded use of fenugreek goes back to Egypt in 1500 BCE. It was also used in Greek, Arabian, Indian and Chinese medicine.

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Background This study was to investigate the effect and its possible mechanism of fucoidan on the development of spontaneous autoimmune diabetes in non-obese diabetic (NOD) mice. Methods 7-week-old NOD mice were randomly divided into three groups: control group, low-dose (300 mg/kg) and high-dose (600 mg/kg) fucoidan-treatment groups. After 5 weeks of treatment, 10 mice per group were randomly selected to be sacrificed after feces collection. The remaining 12 mice per group were fed until 26 weeks of age to assess the incidence of diabetes. Results Treatment with fucoidan increased serum insulin level, delayed the onset and decreased the development of diabetes in NOD mice. Fucoidan reduced the levels of strong Th1 proinflammatory cytokines, but induced Th2-bias ed. cytokine response. And dentridic cells (DCs) in fucoidan treatment group were characterized as low expression of MHC class II and CD86 molecules. TLR4 expressions and the downstream molecules in pancreas were down-regulated in fucoidan-treated groups. There were significant differences in the composition of gut flora between NOD control group and fucoidan group. Lactobacillus and Akkermansia were significantly enriched in fucoidan group. Conclusions Fucoidan could prevent the development of autoimmune diabetes in NOD mice via regulating DC/Treg induced immune tolerance, improving gut microecology, down-regulating TLR4 signaling pathway, and maintaining pancreatic internal environment.

Ray Peat

Investigative Journalism

Why are the recommendations to people with diabetes to eat a high-carb diet a bad idea? How does it likely increase the risk of complications massively? And what is the alternative? This is one of the most personal and powerful presentations from the recent Low Carb USA conference.

Within hours of eating an unhealthy meal, we can get a spike in inflammation, crippling our artery function, thickening our blood, and causing a fight-or-flight nerve response. But there are foods we can eat at every meal to counter this reaction. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ Previously I’ve covered the effect adding berries to a meal has on blood sugar responses in If Fructose is Bad, What About Fruit? (http://nutritionfacts.org/video/if-fructose-is-bad-what-about-fruit). That raises the question How Much Fruit is Too Much? (http://nutritionfacts.org/video/how-much-fruit-is-too-much/). In addition to the all-fruit jam question, in my next video I’ll cover The Effects of Avocados and Red Wine on Postprandial Inflammation (http://nutritionfacts.org/video/The-Effects-of-Avocados-and-Red-Wine-on-Postprandial-Inflammation). Vinegar my also help: Can Vinegar Help with Blood Sugar Control? (http://nutritionfacts.org/video/can-vinegar-help-with-blood-sugar-control). Maybe this explains part of the longevity benefit to nut consumption. See Nuts May Help Prevent Death (http://nutritionfacts.org/video/nuts-may-help-prevent-death/). I also talked about that immediate inflammatory reaction to unhealthy food choices in my recent video Best Foods to Improve Sexual Function (http://nutritionfacts.org/video/best-foods-to-improve-sexual-function). Surprised by the chicken and butter reaction? Same thing happens with tunafish and other meat. Check out my video Paleo Diets May Negate Benefits of Exercise (http://nutritionfacts.org/video/paleo-diets-may-negate-benefits-of-exercise/). Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/how-to-prevent-blood-sugar-and-triglyceride-spikes-after-meals and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/how-to-prevent-blood-sugar-and-triglyceride-spikes-after-meals. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credit: Kristina DeMuth. Image has been modified. Icons created by Persheid, mikicon, unlimicon, Pavel Melnikov, ProSymbols, Imogen Oh, hatayas, Nikita Kozin, retinaicon, and Marco Galtarossa from the Noun Project. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Learn techniques for reversing insulin resistance in type 1 and type 2 diabetes through diet and exercise.

TYPEONEGRIT has 3,508 members. ABOUT: TypeOneGrit is a (not-so) small FB group of type ONE diabetics who have read, "Dr. Bernstein's Diabetes Solution" and are CURRENTLY following his protocol which...

My personal experience with managing my type 1 diabetes with a ketogenic diet and exercise

Listen to Dr Carrie Diulus, US board-certified orthopaedic spinal surgeon and a thriving type 1 diabetic explain how she uses the vegan ketogenic diet and insulin strategies to manage her diabetes. This episode is great for type 1 diabetics or vegan/vegetarians wondering if low carb/keto diets could work for them.

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Can you dramatically improve blood-sugar control in type 1 diabetes through a diet change? Yes, absolutely. Here’s an excerpt from my interview with Hanna Boëthius, who’s had type 1 diabetes since she was 2 years old.

Aims To compare the effects of a low carbohydrate diet (LCD  250 g carbohydrate/d) on glycaemic control and cardiovascular risk factors in ...

Could long sought-after support for type 1 diabetes be as close as your kitchen cupboard? An accumulating body of scientific research appears to point in exactly that direction

Eating meat during breastfeeding is associated with an increased risk of type 1 diabetes, a consequence perhaps of meat glycotoxins or paratuberculosis bacteria that may be passed though breast milk. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ What’s this about paraTB bacteria having been found in the bloodstream of the majority of tested diabetics tested? You must have missed the last video, Does Paratuberculosis in Milk Trigger Type 1 Diabetes? (http://nutritionfacts.org/video/does-paratuberculosis-in-milk-trigger-type-1-diabetes). I will further explore this hypothesis in my follow-up video Does Paratuberculosis in Meat Trigger Type 1 Diabetes? (http://nutritionfacts.org/video/does-paratuberculosis-in-meat-trigger-type-1-diabetes). The vast majority of cases of diabetes in the U.S. are type 2, though. Ironically, meat may also play a role there. See Why is Meat a Risk Factor for Diabetes? (http://nutritionfacts.org/video/why-is-meat-a-risk-factor-for-diabetes) and How May Plants Protect Against Diabetes? (http://nutritionfacts.org/video/how-may-plants-protect-against-diabetes/). A good short summary can be found in How Not to Die from Diabetes (http://nutritionfacts.org/video/how-not-to-die-from-diabetes/). Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/meat-consumption-and-the-development-of-type-1-diabetes and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/meat-consumption-and-the-development-of-type-1-diabetes. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credit: Alden Chadwick via flickr. Image has been modified. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Can tattoos embrace technology in order to make the skin interactive?The DermalAbyss project was the result of a collaboration between MIT researchers Katia ...

The deleterious effects of a Paleolithic diet appear to undermine the positive effects of a Crossfit-based high-intensity circuit training exercise program.

This topic contains 24 study abstracts on Beta Cell Regeneration with in-depth information on the following Topics: Glibenclamide, Diabetes Mellitus: Type 1, and A1C

The human body has over 60 trillion cells, and every one of them is vulnerable to the development of multiple diseases. One of the biggest problems facing medicine is how to diagnose these diseases earlier, in order to improve the chances of stopping and reversing them.