Eyes

As we age our eyes gradually cloud over, with unchecked cataracts the leading cause of blindness. Here are 4 simple things you can do to make sure your eyes stay youthful late into life

Aloe vera contains multiple pharmacologically active substances which are capable of modulating cellular phenotypes and functions. Aloe vera ethanol and ethyl acetate extracts may be used in eye drops to treat inflammations and other ailments of external parts of the eye such as the cornea.

Increased expression of the angiogenic factor VEGF-A promotes three common aging-related eye conditions - both versions of age-related macular degeneration and also cataracts - in an animal model, report scientists.

Trehalose is a natural disaccharide synthesized in various life forms, but not found in vertebrates. An increasing body of evidence demonstrates exceptional bioprotective characteristics of trehalose. This review discusses the scientific findings on potential functions of trehalose in oxidative stress, protein clearance, and inflammation, with an emphasis on animal models and clinical trials in ophthalmology. The main objective is to help understand the beneficial effects of trehalose in clinical trials and practice, especially in patients suffering from ocular surface disease. The discussion is supplemented with an overview of patents for the use of trehalose in dry eye and with prospects for the 2020s.

New research shows that people with blue eyes have a single, common ancestor. Scientists have tracked down a genetic mutation which took place 6,000-10,000 years ago and is the cause of the eye color of all blue-eyed humans alive on the planet today.

It's important to know the causes of blurred vision to aid in prevention. This guide takes you through both the painless and painful causes of hazy vision.

If you’re experiencing deteriorating vision as you age and don’t want to believe that it’s an unavoidable reality, the results of a recent study on macular degeneration will give you good reasons to get wide-eyed: coconut oil can now add “retina protection” to its long list of health benefits

Purpose To compare the efficacy of trehalose-HA eye drops versus 0.1% hyaluronic acid for the treatment of dry eye. Methods This prospective, comparative, contralateral eye study included sixty eligible patients (mean age 44.13 ± 14.53 years). Patients having a SPEED questionnaire score of 16 or above, objective scatter index (OSI) > 1 and non-invasive tear break up time (NIBUT) of 10 s or less were included in the study. Eyes were randomized to receive 0.1% hyaluronic acid (HA) in one eye and trehalose-HA eye drops in the contralateral eye. At baseline, 1- and 3-month follow-ups, OSI, NIBUT, MG loss, tear meniscus height (TMH) and tear film osmolarity (TFO) were evaluated using non-invasive modalities Results There was a statistically significant improvement in NIBUT, TMH, OSI, SPEED questionnaire score in the trehalose-HA compared to the 0.1% HA group at both 1- and 3-month visits (p

This data supports the addition of trehalose to HA-containing eyedrop solutions to provide better symptomatic relief from moderate to severe DED, based on an OSDI score of

Contact lenses may alter the natural microbial community of the eyes, according to a study. In a study of 58 adults seeking outpatient eye care, researchers found that contact lenses make the eye microbiome more skin-like, with higher proportions of skin bacteria.

Vision loss due to glaucoma or optic nerve damage is generally considered irreversible. Now a new prospective, randomized, multi-center clinical trial demonstrates significant vision improvement in partially blind patients after 10 days of noninvasive, transorbital alternating current stimulation. In addition to activation of their residual vision, patients also experienced improvement in vision-related quality of life such as acuity, reading, mobility or orientation.

Purpose To assess the safety and efficacy of multi-ingredient trehalose emulsion eye drops (TEED) designed to target (1) tear film instability, (2) tear hyperosmolarity, and (3) ocular surface damag...

The brilliant Dr Jerry Tenant , a genius in so many fields discusses his book "Healing is Voltage" and his view on Fulvic Acid Minerals. For more information on Fulvic Acid Minerals visit www.ancientpurity.com

From infants to elders, Dr. Berne offers a road map to help you deepen the connection to your eyes and increase your health.

Purpose. This randomized, observer-masked, crossover study investigated the effect of two hyaluronic acid/trehalose-based containing formulations, with different physical properties, on the signs and symptoms in patients with moderate to severe dry eye disease (DED). Methods. In one group, patients received a mixture of sodium hyaluronate and trehalose (HT, Thealoz Duo®) for use during the day. In the other group, patients received a more viscous formulation consisting of hyaluronic acid, trehalose, and carbomer (HTC-gel, Thealoz Duo Gel) to use pro re nata. Both groups used HTC-gel before going to bed. Clinical standard tests for DED were performed at the beginning and end of each one-week period. Further, patient satisfaction including quality of sleep was assessed using a visual analogue scale. Results. Corneal fluorescein and conjunctival lissamine green staining scores decreased, and tear breakup time (BUT) increased for both groups ( each). Mean instillation frequency was 3.1 ± 2.6 drops/day when using HT and 1.9 ± 2.2 drops/day when using HTC-gel (). A significant improvement in the quality of sleep was observed with both treatments (). Conclusions. Our results show improvement in signs and symptoms of DED in both groups. While instillation of HTC-gel resulted in a lower instillation frequency, both formulations of trehalose showed good clinical efficacy. This trial is registered with NCT02980913.

Reinhart et al. show that 20 min of direct-current stimulation can change visual acuity. Subjects’ event-related potentials showed the same pattern of amplitude changes observed with behavior. Finally, subjects with the worst visual acuity showed the largest improvements following anodal stimulation of visual cortex.

NIH-funded clinical trial shows Eylea, Avastin, and Lucentis perform similarly when vision loss is mild.

Background Transforming growth factor (TGF) family members play important roles in the regulation of corneal integrity, and the pathogenesis of corneal fibrosis. Currently, there are no effective agents targeting TGF-β signaling to diminish corneal fibrosis. Glucosamine (GlcN), which is widely used in the treatment of osteoarthritis, abrogates the morphologic effects of TGF-β2 on retinal pigmented epithelial cells in a mouse disease model. Here, we sought to determine whether GlcN would exert beneficial effects against TGF-β1-induced corneal fibrosis. Methods In human corneal fibroblasts (HCFs) treated with GlcN, the expression of Krüppel-like factor 4 (KLF4) and its downstream signaling effects were determined in the presence and absence of TGF-β1 using immunoblot analysis. We further explored GlcN inhibition of fibroblast-to-myofibroblast differentiation via KLF4 siRNA. The effect of cycloheximide on KLF4 protein levels with or without GlcN administration was assessed to determine whether GlcN affects the stability of the KLF4 protein. Results In HCFs, GlcN induced the expression of KLF4, which regulated the maturation and maintenance of the ocular surface. GlcN partially suppressed the TGF-β1-induced expression of alpha-smooth muscle actin (α-SMA) and reduced the collagen contraction capacity in HCFs, suggesting a decrease in fibroblast-to-myofibroblast differentiation. This effect appeared to be mediated through suppression of Smad2 phosphorylation and ERK-dependent signaling. The levels of KLF4 mRNA were increased by GlcN and decreased by TGF-β1 and the TGF-β1-induced α-SMA mRNA expression was upregulated when the KLF4 gene was silenced. GlcN also appeared to stabilize the KLF4 protein, reducing its turnover in corneal fibroblasts. Conclusion These findings shed light on a novel mechanism by which GlcN suppresses TGF-β1-induced fibroblast-to-myofibroblast differentiation through the upregulation of KLF4 expression. Current strategies for treating corneal fibrosis were not effective. Elevating KLF4 levels through the use of GlcN might provide an effective alternative to alleviate the development and progression of corneal fibrosis.

Click here to subscribe - https://www.glutenfreesociety.org/wxrn Before discussing whether or not gluten can cause eye problems, let’s address some important background information. Celiac disease is often thought of as a disease that only affects the small intestine, creating symptoms like diarrhea, intestinal pain, cramping, weight loss, and malabsorption. While that is true, approximately half of all celiac disease patients present with extra-intestinal (non-gastrointestinal) symptoms, such as anemia, osteoporosis, neurological disorders, infertility, skin concerns, and vision or eyesight problems. Ocular (eye) symptoms caused by gluten can vary according to a person’s genetic predisposition, immune status, gender, and age at onset. This video will focus on how non celiac gluten sensitivity and celiac disease can manifest as ophthalmic concerns, which can be derived from both malnutrition or malabsorption and immune alterations. Gluten Induced Eye Diseases (00:30) Retinopathy (01:16) Cataracts (03:20) Pseudotumor Cerebri (03:55) Dry Eye (05:50) Autoimmune Diseases that can affect the eye (08:08) Thyroiditis (08:58) Orbital Myositis (09:49) Uveitis (11:26) Brain Occipital Calcification (13:51) Nutritional Deficiencies & Eye Health (14:40) Vitamin C and E as Antioxidants (14:50) Beta Carotene and Vitamin A (16:20) Zinc and Eye Function (18:45) Lutein and Zeaxanthin (21:25) Omega 3's and Inflammation Regulation (22:07) Copper, Folate, and B12 (24:18) Live Q&A (28:12) If you have been diagnosed with celiac disease or non celiac gluten sensitivity, it is wise to be vigilant in testing for, consuming, and supplementing as necessary with nutrients needed for eye health, as they are often found to be depleted even in patients who have been strictly following a gluten-free diet. If you need guidance for following a TRUE gluten free diet, check out my Ultimate MasterClass on Going Gluten Free - https://glutenology.net/registration/ For those who want to read more on gluten and eye health, check out this article - https://www.glutenfreesociety.org/eyesight-problems-gluten-might-be-a-factor/ Looking for the mentioned supplements? These are my premium true gluten and grain free formulas: Focus - https://www.glutenfreesociety.org/shop/supplements/immune-support/focus/ Vitamin A - https://www.glutenfreesociety.org/shop/supplements/general-health/ultra-a/ Vitamin C - https://www.glutenfreesociety.org/shop/supplements/immune-support/detox-c-gluten-free/ Vitamin D - https://www.glutenfreesociety.org/shop/supplements/general-health/gluten-free-d/ Vitamin E - https://www.glutenfreesociety.org/shop/supplements/immune-support/ultra-vitamin-e/ Vitamin B12 - https://www.glutenfreesociety.org/shop/supplements/general-health/methylcobalamin-gluten-free-supplement/ Ultra Iron - https://www.glutenfreesociety.org/shop/supplements/general-health/ultra-iron/ Ultra Zinc - https://www.glutenfreesociety.org/shop/supplements/immune-support/ultra-zinc/ Omega Max - https://www.glutenfreesociety.org/shop/supplements/general-health/omega-max-gluten-free-omega-3/ Copper - https://www.glutenfreesociety.org/shop/supplements/general-health/ultra-copper/ Folate - https://www.glutenfreesociety.org/shop/supplements/general-health/5-mthf/ L-Glutamine - https://www.glutenfreesociety.org/shop/supplements/digestive-health/l-glutamine/ B.C.A.A - https://www.glutenfreesociety.org/shop/supplements/general-health/bcaa/ Ultra Biotic Defense - https://www.glutenfreesociety.org/shop/supplements/immune-support/ultra-biotic-defense-3/ To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterOsborne/ Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.