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Neurocognitive Impairment in Long COVID: A Systematic Review
Neurocognitive Impairment in Long COVID: A Systematic Review
Of the 516 studies assessed for eligibility, 36 studies met the inclusion criteria. All included studies support the presence of persistent cognitive changes after COVID-19 disease. Executive function, memory, attention, and processing speed appear to be the cognitive domains that are predominantly associated with long-COVID syndrome, whereas language is an area that has not been sufficiently investigated.
Neurocognitive Impairment in Long COVID: A Systematic Review
Does COVID increase the risk of Alzheimer’s disease?
Does COVID increase the risk of Alzheimer’s disease?
COVID-19, even in mild cases, is linked to changes in Alzheimer’s disease-related brain biomarkers comparable to four years of aging. This study raises concerns about long-term neurological risks and cognitive decline post-COVID.
Does COVID increase the risk of Alzheimer’s disease?
Changes in memory and cognition during the SARS-CoV-2 human challenge study
Changes in memory and cognition during the SARS-CoV-2 human challenge study
Study found that healthy volunteers infected with SARS-CoV-2 had measurably worse cognitive function for up to a year after infection when compared to uninfected controls. Significantly, infected controls did not report any symptoms related to these cognitive deficits, indicating that they were unaware of them.
Changes in memory and cognition during the SARS-CoV-2 human challenge study
Is Covid Rewriting the Rules of Aging? Brain Decline Alarms Doctors
Is Covid Rewriting the Rules of Aging? Brain Decline Alarms Doctors

Five years after the pandemic’s start, millions of Americans are still struggling with long-lasting symptoms of Covid-19. Cognitive difficulties are among the most troubling and common symptoms in people both old and young. These ailments can be severe enough to leave former professionals like Ken Todd unable to work and even diagnosed with a form of mild cognitive impairment.

Is Covid Rewriting the Rules of Aging? Brain Decline Alarms Doctors
Mid and long-term neurological and neuropsychiatric manifestations of…
Mid and long-term neurological and neuropsychiatric manifestations of…
Researchers analyzed 18 studies covering 10,530 patients to assess neurological and mental health symptoms after COVID-19. The most common symptoms were fatigue (37%), brain fog (32%), memory problems (28%), attention issues (22%), muscle pain (17%), loss of smell (12%), taste changes (10%), and headaches (15%). Mental health symptoms included sleep disturbances (31%), anxiety (23%), and depression (17%), which became more common over time
Mid and long-term neurological and neuropsychiatric manifestations of…
Brain abnormalities in survivors of COVID-19 after 2-year recovery: a functional MRI study
Brain abnormalities in survivors of COVID-19 after 2-year recovery: a functional MRI study
This long-term study suggests that individuals recovering from COVID-19 continue to experience cognitive complaints, psychiatric and neurological symptoms, and brain functional alteration. The MRI results indicated that the changes in brain function in regions such as the putamen, temporal lobe, and superior parietal gyrus may contribute to cognitive complaints in individuals with long COVID even 2 years after acute infection.
Brain abnormalities in survivors of COVID-19 after 2-year recovery: a functional MRI study
COVID infections are causing drops in IQ and years of brain aging, studies suggest
COVID infections are causing drops in IQ and years of brain aging, studies suggest
"There are studies that have been done comparing people who had COVID-19, versus people who didn't, and then gave them cognitive testing to measure their ability to cognitively process information and test their IQ. And there's very clear differences in the IQ of people who had been infected with COVID-19 versus people who did not. Even mild COVID can give people about a three-point loss of IQ."
COVID infections are causing drops in IQ and years of brain aging, studies suggest
Does Covid Lead to Dementia? Here's What the Virus May Have Done to Your Brain
Does Covid Lead to Dementia? Here's What the Virus May Have Done to Your Brain
Many of Covid’s earliest and most alarming effects involve the brain, including a lost sense of smell, sluggish thinking, headaches, delirium and strokes. More than four years after the pandemic began, researchers are recognizing the profound impacts Covid can have on brain health, as millions of survivors suffer from persistent issues such as brain fog, depression and cognitive slowing, all of which hinder their ability to work and otherwise function. Scientists now worry that these symptoms may be early indicators of a coming surge in dementia and other mental conditions, prolonging the pandemic’s societal, economic and health burden.
Does Covid Lead to Dementia? Here's What the Virus May Have Done to Your Brain
Covid and the brain: A neurological health crisis
Covid and the brain: A neurological health crisis
Brain fog. Memory lapses. Difficulties focusing or sustaining attention. All these cognitive issues have plagued some who have otherwise recovered from a bout of Covid-19. In this video, Stanford neurologist Michelle Monje describes her work showing how even mild respiratory infections with the SARS-CoV-2 virus may lead to lingering problems with the brain. Monje, who has long treated and studied cancer patients with similar symptoms following chemotherapy, says that the damage isn’t necessarily caused by the virus itself. Instead, her work suggests that inflammatory molecules released in the lungs of someone with Covid may trigger a reaction of immune cells in the brain. These brain cells, called microglia, then start a cascade of signals that alter the behavior of other brain cells, eventually slowing communication between neurons. The good news, Monje says, is that the similarities to what she calls “chemobrain” may mean that many of these persistent cognitive problems will improve with time, just as chemobrain does. READ MORE: Reset: The Science of Crisis & Recovery https://knowablemagazine.org/report/reset ANNUAL REVIEW OF IMMUNOLOGY Neuroinflammation During RNA Viral Infections Some RNA viruses can infiltrate the brain and central nervous system. While the immune response often succeeds in clearing the pathogen, it may also cause inflammation and, in some cases, persistent changes that result in neurologic and psychiatric disease. https://www.annualreviews.org/doi/10.1146/annurev-immunol-042718-041417
Covid and the brain: A neurological health crisis
Long COVID Now Looks like a Neurological Disease, Helping Doctors to …
Long COVID Now Looks like a Neurological Disease, Helping Doctors to …
People with long COVID have symptoms such as pain, extreme fatigue and “brain fog,” or difficulty concentrating or remembering things. As of March 2023, the syndrome was estimated to affect more than 15 million adults in the U.S., and a 2022 report found that it had forced between two million and four million Americans out of the workforce. Long COVID often arises in otherwise healthy young people, and it can follow even a mild initial infection.
Long COVID Now Looks like a Neurological Disease, Helping Doctors to …
Covid-19 ‘brain fog’ likely factor in near head-on train crash
Covid-19 ‘brain fog’ likely factor in near head-on train crash

An investigation has found brain fog from Covid-19 likely played a role in a KiwiRail coal train’s near miss with another train.

Investigators concluded the locomotive engineer was likely still suffering the after-effects of Covid-19 early last year when they failed to stop at a red signal and entered a main line, which was occupied by another train.

Covid-19 ‘brain fog’ likely factor in near head-on train crash
Long Covid and Impaired Cognition — More Evidence and More Work to Do | NEJM
Long Covid and Impaired Cognition — More Evidence and More Work to Do | NEJM
As compared with uninfected participants (control), cognitive deficit — commensurate with a 3-point loss in IQ — was evident even in participants who had had mild Covid-19 with resolved symptoms. Participants with unresolved persistent symptoms had the equivalent of a 6-point loss in IQ, and those who had been admitted to the intensive care unit had the equivalent of a 9-point loss in IQ. Of importance, these deficits were associated with many of the other symptoms that have been reported by persons with long Covid.
Long Covid and Impaired Cognition — More Evidence and More Work to Do | NEJM
Your Mental Health May Impact Your Long COVID Risk, a New Study Suggests
Your Mental Health May Impact Your Long COVID Risk, a New Study Suggests
During the study, 6% of the participants (3,752 people) reported testing positive for COVID and about 44% of them said they experienced long COVID symptoms, such as lingering fatigue, problems with their taste or smell, shortness of breath, brain fog, and memory issues. All of the emotional states listed above were associated with a greater risk of long COVID—between 32% to 46%—but people who had “high levels” of two or more types of psychological distress before their infection had a nearly 50% higher risk of long COVID compared to those who did not feel a significant dip in their mood.
Your Mental Health May Impact Your Long COVID Risk, a New Study Suggests
COVID survivors may develop dementia | NATURE
COVID survivors may develop dementia | NATURE
COVID-19 survivors show signs of significant cognitive deficits which could become dementia even a year after having the virus1. They also have an increased risk of depression, anxiety and disrupted sleep.
COVID survivors may develop dementia | NATURE
Even mild cases of COVID-19 can leave a mark on the brain, such as reductions in gray matter – a neuroscientist explains emerging research
Even mild cases of COVID-19 can leave a mark on the brain, such as reductions in gray matter – a neuroscientist explains emerging research

"The team found marked differences in gray matter – or the neurons that process information in the brain – between those who had been infected with COVID-19 and those who had not. Specifically, the thickness of the gray matter tissue in brain regions known as the frontal and temporal lobes was reduced in the COVID-19 group, differing from the typical patterns seen in the people who hadn’t had a COVID-19 infection.

In the general population, it is normal to see some change in gray matter volume or thickness over time as people age. But the changes were more extensive than normal in those who had been infected with COVID-19."

Even mild cases of COVID-19 can leave a mark on the brain, such as reductions in gray matter – a neuroscientist explains emerging research
More than “Brain Fog”: Cognitive Dysfunction and the Role... : Cardiopulmonary Physical Therapy Journal
More than “Brain Fog”: Cognitive Dysfunction and the Role... : Cardiopulmonary Physical Therapy Journal
This paper dives deep into the complexities of cognitive dysfunction in people with Long COVID—what many call “brain fog” but what is actually a much more debilitating symptom. It’s not just about forgetting where you left your keys; it’s about struggling to work, parent, or even read without triggering post-exertional symptom exacerbation (PESE)—a worsening of symptoms after even minor physical, cognitive, or emotional effort.
More than “Brain Fog”: Cognitive Dysfunction and the Role... : Cardiopulmonary Physical Therapy Journal
Cerebromicrovascular mechanisms contributing to long COVID: implications for neurocognitive health
Cerebromicrovascular mechanisms contributing to long COVID: implications for neurocognitive health
This review investigates key pathophysiological mechanisms contributing to cerebrovascular dysfunction in long COVID and their impacts on brain health. We discuss how endothelial tropism of SARS-CoV-2 and direct vascular infection trigger endothelial dysfunction, impaired neurovascular coupling, and blood–brain barrier disruption, resulting in compromised cerebral perfusion. Furthermore, the infection appears to induce mitochondrial dysfunction, enhancing oxidative stress and inflammation within cerebral endothelial cells. Autoantibody formation following infection also potentially exacerbates neurovascular injury, contributing to chronic vascular inflammation and ongoing blood–brain barrier compromise. These factors collectively contribute to the emergence of white matter hyperintensities, promote amyloid pathology, and may accelerate neurodegenerative processes, including Alzheimer’s disease.
Cerebromicrovascular mechanisms contributing to long COVID: implications for neurocognitive health
Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: an analysis of 2-year retrospective cohort studies including 1 284 437 patients
Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: an analysis of 2-year retrospective cohort studies including 1 284 437 patients
Lancet study shows extreme increases in strokes, seizures, cognitive deficits (including dementia), psychotic disorders and brain swelling in kids and young people 2 years after acute infection.
Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: an analysis of 2-year retrospective cohort studies including 1 284 437 patients