Covid + Immune System

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Immune damage in Long Covid | Science
Immune damage in Long Covid | Science
Acute infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause a respiratory illness that can be associated with systemic immune cell activation and inflammation, widespread multiorgan dysfunction, and thrombosis. Not everyone fully recovers from COVID-19, leading to Long Covid, the treatment of which is a major unmet clinical need (1). Long Covid can affect people of all ages, follows severe as well as mild disease, and involves multiple organs.
Immune damage in Long Covid | Science
Rates of infection with other pathogens after a positive COVID-19 test versus a negative test in US veterans (November, 2021, to December, 2023): a retrospective cohort study
Rates of infection with other pathogens after a positive COVID-19 test versus a negative test in US veterans (November, 2021, to December, 2023): a retrospective cohort study

In a cohort of 836,913 people (231,899 with a positive Covid test and 605,014 without), the people who tested positive and were not hospitalized for it had:

  • 17% higher risk of outpatient infection (bacteria,l fungal or viral)
  • 46% higher risk of outpatient respiratory infection
  • 41% higher risk of admission to hospital for infectious disease
Rates of infection with other pathogens after a positive COVID-19 test versus a negative test in US veterans (November, 2021, to December, 2023): a retrospective cohort study
SARS-CoV-2 evolution on a dynamic immune landscape
SARS-CoV-2 evolution on a dynamic immune landscape
Nature - A modelling approach predicts SARS-CoV-2 variant dynamics on the basis of immunity and cross-neutralization, which was shaped by a region’s SARS-CoV-2 infection history.
SARS-CoV-2 evolution on a dynamic immune landscape
Why is EVERYONE more SICK?
Why is EVERYONE more SICK?

Why does everyone keep getting sick? Spring flu, summer flu, concert flu, colds, endless coughing, mysterious bugs, allergies - why do our immune systems suck now?? What's with all the new health issues like diabetes, high cholesterol and fatigue? Why are more athletes having heart attacks? Why do so many have brain fog, memory problems and can't think as well as before? Is our gut microbiome health worse? Are we all just more tired and ill than before for no reason?

Well, spoiler– it's not "lockdowns" or "immunity debt" or "thejab" or not exercising or not enough essential oils or vitamins or natural remedies or not thinking enough positive, high-vibration, wellness thoughts. It's something you may have never even heard of thanks to public health and governments not doing their jobs, but something you've probably already had a lot of encounters with, something you know ~deep down~ is not as over as the mainstream media or your profit-minded employer says it is, something that will not go away just because we wish it really hard..

This video essay offers a useful primer to this syndrome that is already affecting tens (likely hundreds) of millions of people across the world. Please share this information with your community and advocate for authorities to start taking our health seriously, because we all deserve so much better.. Subscribing, liking the video and commenting also helps out in satisfying the Youtube gods and getting this content to reach more people.

If this is your first time hearing about it, your emotional impulse might be to say that it can't be real, that it must be an exaggeration or conspiracy. If that's the case, we assure you we have only used high-quality, credible, reputable sources and research, which we recommend checking out in the reference list below. The PDF has short summaries for all the studies included, to make it as easy to understand and accessible as possible, with some bonus resources for those of you who like deep diving into topics.

Reference list: https://www.dropbox.com/scl/fi/d4dzdprw7rrcdsii6xvlq/Lola-Germs-Reference-List-light-mode.pdf?rlkey=ufy6cp1kq7qd1b6ovhko938o1&st=oettjgvf&dl=0

Why is EVERYONE more SICK?
How COVID-19 alters the immune system
How COVID-19 alters the immune system
COVID-19 reduces the numbers and functional competence of certain types of immune cells in the blood, say researchers. This could affect responses to secondary infections.
How COVID-19 alters the immune system
How your first brush with COVID warps your immunity
How your first brush with COVID warps your immunity
Nature - The immune system responds more strongly to the strain of a virus that it first met, weakening response to other strains. Can this ‘imprinting’ be overcome?
How your first brush with COVID warps your immunity
Acquired Immune Deficiency Syndrome correlation with SARS-CoV-2 N genotypes
Acquired Immune Deficiency Syndrome correlation with SARS-CoV-2 N genotypes
"The hypothesis is consistent with the mutagenic deriving observed on the in-silico assay, which reveals that genotypes N/120 and N/152 are determinant to reduce the Immune Response of the host infecting lymphocytes, allowing the virus persists indefinitely and causing an Acquire Immune Deficiency Syndrome."
Acquired Immune Deficiency Syndrome correlation with SARS-CoV-2 N genotypes
Analysis reveals global post-covid surge in infectious diseases
Analysis reveals global post-covid surge in infectious diseases
A large post-covid global surge in common communicable diseases including influenza, measles, tuberculosis, and whooping cough has been identified in a new analysis of data from 60 organisations and public health agencies. Since the beginning of 2022, 44 countries have experienced a 10-fold increase in the incidence of at least one of 13 infectious diseases compared with a pre-pandemic baseline, according to the analysis1 by the UK based disease forecasting firm Airfinity and the US news website Bloomberg. Experts said that with no historical precedent, they can’t fully explain the resurgence in infectious diseases. Jeremy Farrar, World Health Organization chief scientist, told The BMJ , “We’ve not had an acute, fast moving, and devastating pandemic in the modern scientific era. The last major devastating pandemic was in 1918 when …
Analysis reveals global post-covid surge in infectious diseases
The immunology of long COVID
The immunology of long COVID
Nature Reviews Immunology - SARS-CoV-2 infection can lead to a diverse array of chronic symptoms, collectively termed ‘long COVID’. In this Review, Altmann and colleagues explore...
The immunology of long COVID
Multiple early factors anticipate post-acute COVID-19 sequelae - PubMed
Multiple early factors anticipate post-acute COVID-19 sequelae - PubMed
Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However, quantifiable risk factors for PASC and their biological associations are poorly resolved. We executed a deep multi-omic, longitudinal investigation of 309 COVID-19 patients from initial diagnosis to convalescence (2 …
Multiple early factors anticipate post-acute COVID-19 sequelae - PubMed
Distinguishing features of long COVID identified through immune profiling - PubMed
Distinguishing features of long COVID identified through immune profiling - PubMed
Post-acute infection syndromes may develop after acute viral disease1. Infection with SARS-CoV-2 can result in the development of a post-acute infection syndrome known as long COVID. Individuals with long COVID frequently report unremitting fatigue, post-exertional malaise, and a variety …
Distinguishing features of long COVID identified through immune profiling - PubMed
MSK Library Guides: COVID Impacts: Immune
MSK Library Guides: COVID Impacts: Immune

One of the most concerning long-term impacts of COVID-19 is immune dysregulation and dysfunction. Immune system impacts were heavily documented, even in the first waves of the pandemic, however there was a lack of understanding as to what exactly COVID-19 infections were doing to the immune system, and what that might mean both during acute infection and long-term.

MSK Library Guides: COVID Impacts: Immune
Claims of an Immunity Debt in Children Owe Us Evidence
Claims of an Immunity Debt in Children Owe Us Evidence
At the beginning of the fifth season of the television show Buffy the Vampire Slayer, we the audience are introduced to a character, Dawn, we have never seen before. Intriguingly, every character
Claims of an Immunity Debt in Children Owe Us Evidence
COVID-19: Study Suggests Long-term Damage to Immune System
COVID-19: Study Suggests Long-term Damage to Immune System
NIH News Release: "...findings suggest that SARS-CoV-2 infection damages the CD8+ T cell response, an effect akin to that observed in earlier studies showing long-term damage to the immune system after infection with viruses such as hepatitis C or HIV."
COVID-19: Study Suggests Long-term Damage to Immune System