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Long-Term Risk of Autoimmune and Autoinflammatory Disorders After COVID-19
Long-Term Risk of Autoimmune and Autoinflammatory Disorders After COVID-19

Korean study of 6.9M people found COVID-19 increases autoimmune disease risk.

Alopecia Totalis was 24 percent higher.

Behçet Disease 45 percent higher.

Crohn Disease 35 percent higher.

Bullous Pemphigoid 62 percent higher.

·jamanetwork.com·
Long-Term Risk of Autoimmune and Autoinflammatory Disorders After COVID-19
POTS and COVID-19: What is the link?
POTS and COVID-19: What is the link?
“there may be a link between COVID-19 and postural orthostatic tachycardia syndrome (POTS). One theory explains that the virus may cause the immune system to attack itself.”
there may be a link between COVID-19 and postural orthostatic tachycardia syndrome (POTS). One theory explains that the virus may cause the immune system to attack itself.
·medicalnewstoday.com·
POTS and COVID-19: What is the link?
COVID-19 worsens Autoimmune Diseases! Study reveals 30 percent spike in antinuclear antibody positivity
COVID-19 worsens Autoimmune Diseases! Study reveals 30 percent spike in antinuclear antibody positivity
“new study has revealed shocking details about the long-term health impacts of COVID-19, particularly concerning autoimmune diseases. The study conducted by Metropolis analyzed data from over 1.2 lakh cases, comparing two critical periods—2019 (pre-COVID) and 2022 (post-COVID). The findings revealed a striking 30% increase in the prevalence of Antinuclear Antibody (ANA) positivity in the Indian population, indicating how the immune system may, in some cases, turn against the body’s own tissues following a COVID-19 infection.”
·financialexpress.com·
COVID-19 worsens Autoimmune Diseases! Study reveals 30 percent spike in antinuclear antibody positivity
‭Multi-ancestry GWAS of Long COVID identifies‬ ‭immune-related loci and etiological links to chronic fatigue‬ syndrome, fibromyalgia and depression‬ ‭
‭Multi-ancestry GWAS of Long COVID identifies‬ ‭immune-related loci and etiological links to chronic fatigue‬ syndrome, fibromyalgia and depression‬ ‭
“Using consented and genotyped data from 23andMe adult research participants, we conducted the largest multi-ancestry meta-analysis of genome-wide association studies of Long COVID across European (42,899 cases, 94,721 controls), Latinx (8,631 cases, 20,351 controls), and African-American (2,234 cases, 5,596 controls) genetic ancestry groups. GWAS of Long COVID identified three genome-wide significant loci (HLA-DQA1 and HLA-DQB, ABO, BPTF:KPAN2:C17orf58). Functional analysis of these genes points to underlying immune and thrombo-inflammatory mechanisms.”
Using consented and genotyped data from 23andMe adult research participants, we conducted the largest multi-ancestry meta-analysis of genome-wide association studies of Long COVID across European (42,899 cases, 94,721 controls), Latinx (8,631 cases, 20,351 controls), and African-American (2,234 cases, 5,596 controls) genetic ancestry groups. GWAS of Long COVID identified three genome-wide significant loci (HLA-DQA1 and HLA-DQB, ABO, BPTF:KPAN2:C17orf58). Functional analysis of these genes points to underlying immune and thrombo-inflammatory mechanisms.
·medrxiv.org·
‭Multi-ancestry GWAS of Long COVID identifies‬ ‭immune-related loci and etiological links to chronic fatigue‬ syndrome, fibromyalgia and depression‬ ‭
SARS-CoV-2 spike aggravates lupus nephritis and lung fibrosis in systemic lupus erythematosus
SARS-CoV-2 spike aggravates lupus nephritis and lung fibrosis in systemic lupus erythematosus

South Korea study suggests SarsCov2 accelerates progression of Lupus.

COVID-19 spike protein worsens lupus, increasing autoantibodies, kidney damage, and lung fibrosis.

·lupus.bmj.com·
SARS-CoV-2 spike aggravates lupus nephritis and lung fibrosis in systemic lupus erythematosus
Patients With Arthritis, IBD, Experience High Rates of Long Covid Affecting QoL
Patients With Arthritis, IBD, Experience High Rates of Long Covid Affecting QoL
“A significant portion of people with systemic autoimmune disease, including inflammatory arthritis and inflammatory bowel disease, experienced post-acute sequelae of COVID-19 (PASC), which often affected quality of life.”
A significant portion of people with systemic autoimmune disease, including inflammatory arthritis and inflammatory bowel disease, experienced post-acute sequelae of COVID-19 (PASC), which often affected quality of life
·hcplive.com·
Patients With Arthritis, IBD, Experience High Rates of Long Covid Affecting QoL
Efficacy of Repeat Immunoadsorption in Post-COVID ME/CFS Patients with Elevated Β2-Adrenergic Receptor Autoantibodies: A Prospective Cohort Study
Efficacy of Repeat Immunoadsorption in Post-COVID ME/CFS Patients with Elevated Β2-Adrenergic Receptor Autoantibodies: A Prospective Cohort Study
immunoadsorption (removing antibodies from blood) temporarily improves Long COVID symptoms. Strongly underlines the therapeutic potential of targeting autoimmunity:
·papers.ssrn.com·
Efficacy of Repeat Immunoadsorption in Post-COVID ME/CFS Patients with Elevated Β2-Adrenergic Receptor Autoantibodies: A Prospective Cohort Study
Father prepares to lay his daughter to rest after COVID-19 complications a month after testing positive
Father prepares to lay his daughter to rest after COVID-19 complications a month after testing positive

“Amid a rise in COVID-19 cases in Alabama, one father in Arely is preparing to lay his daughter to rest.

Byron Farmer said his daughter Amber tested positive for covid about a month ago, but she just died unexpectedly from complications on Wednesday. After she came down with COVID-19, Byron told WVTM 13 his daughter never fully recovered”

Amid a rise in COVID-19 cases in Alabama, one father in Arely is preparing to lay his daughter to rest. Byron Farmer said his daughter Amber tested positive for covid about a month ago, but she just died unexpectedly from complications on Wednesday. After she came down with COVID-19, Byron told WVTM 13 his daughter never fully recovered
·wvtm13.com·
Father prepares to lay his daughter to rest after COVID-19 complications a month after testing positive
Mild Primary or Breakthrough SARS-CoV-2 Infection Promotes Autoantibody Production in Individuals with and without Neuro-PASC | ImmunoHorizons | American Association of Immunologists
Mild Primary or Breakthrough SARS-CoV-2 Infection Promotes Autoantibody Production in Individuals with and without Neuro-PASC | ImmunoHorizons | American Association of Immunologists

“In this study, we demonstrate that mild SARS-CoV-2 infection increases autoantibodies associated with rheumatic autoimmune diseases and diabetes in most individuals, regardless of vaccination status prior to infection…

…These data highlight the need for additional strategies to decrease the spread of SARS-CoV-2 such as the development of vaccines that can prevent infection rather than decrease severity of acute disease alone.”

·journals.aai.org·
Mild Primary or Breakthrough SARS-CoV-2 Infection Promotes Autoantibody Production in Individuals with and without Neuro-PASC | ImmunoHorizons | American Association of Immunologists
Post-COVID-19 Syndrome Associated With Multiple Autoimmune Diseases (DM I—LADA, Chronic Autoimmune Thyroiditis and Pernicious Anemia): Case Report - Gordana Milic, Masa Ristic, Milica Milosevic, Nikola Mitovic, Ljubica Dimitrijevic, Tanja Jesic Petrovic, Bojana Salovic, 2024
Post-COVID-19 Syndrome Associated With Multiple Autoimmune Diseases (DM I—LADA, Chronic Autoimmune Thyroiditis and Pernicious Anemia): Case Report - Gordana Milic, Masa Ristic, Milica Milosevic, Nikola Mitovic, Ljubica Dimitrijevic, Tanja Jesic Petrovic, Bojana Salovic, 2024

Post-COVID-19 Syndrome Associated With Multiple Autoimmune Diseases (DM I—LADA, Chronic Autoimmune Thyroiditis and Pernicious Anemia): Case Report, 2024

The potential role of SARS-CoV-2 as a trigger for specific autoimmune conditions.

·journals.sagepub.com·
Post-COVID-19 Syndrome Associated With Multiple Autoimmune Diseases (DM I—LADA, Chronic Autoimmune Thyroiditis and Pernicious Anemia): Case Report - Gordana Milic, Masa Ristic, Milica Milosevic, Nikola Mitovic, Ljubica Dimitrijevic, Tanja Jesic Petrovic, Bojana Salovic, 2024
Laura Miers on Twitter
Laura Miers on Twitter

Detailed thread on Twitter covering autoimmune encephalitis "We may be entering an era of heightened autoimmune encephalitis. These occurrences may be post-infectious in nature at this point of the pandemic."

·twitter.com·
Laura Miers on Twitter
High risk of autoimmune diseases after COVID-19
High risk of autoimmune diseases after COVID-19

Three new studies give us good estimates of a heightened risk of auto-immune disease after COVID-19 infection. Risk increases of between 20 and 40%

This data franks earlier evidence about lots of self-directed antibodies seen in people post-COVID

·nature.com·
High risk of autoimmune diseases after COVID-19
High risk of autoimmune diseases after COVID-19
High risk of autoimmune diseases after COVID-19
"Two studies that use large cohorts now highlight that SARS-CoV-2 infection is linked to a substantially increased risk of developing a diverse spectrum of new-onset autoimmune diseases."
·nature.com·
High risk of autoimmune diseases after COVID-19
Pmc9830133
Pmc9830133
RISK of AUTOIMMUNE DISEASES in patients with COVID-19: A retrospective cohort study
·ncbi.nlm.nih.gov·
Pmc9830133
A Comprehensive Review of COVID-19–Associated Endocrine Manifestations
A Comprehensive Review of COVID-19–Associated Endocrine Manifestations
As result of the COVID-19 infections, "Thyroid dysfunction with subacute thyroiditis, Graves’ disease & hypothyroidism caused by primary autoimmune thyroiditis has been reported. Pancreatic damage leads to type 1 DM because of the autoimmune nature of the disease and type 2 DM because of postinflammatory insulin resistance."
·ncbi.nlm.nih.gov·
A Comprehensive Review of COVID-19–Associated Endocrine Manifestations
laurie allee on Twitter
laurie allee on Twitter
“Recent research suggests people with long Covid are more likely to have markers of autoimmune disease in their blood a year after infection.”
·twitter.com·
laurie allee on Twitter
Mw on Twitter
Mw on Twitter

Detailed Twitter thread: IBD is an autoimmune condition, which studies have shown increases a person’s chances of Long Covid. Now doctors are seeing both de novo IBD after Covid and worsening of existing IBD. (see this thread). More research is needed. Another reason for high grade mask & ventilation.

·twitter.com·
Mw on Twitter
Radiological images confirm 'COVID-19 can cause the body to attack itself': Imaging illustrates severity, long-term prognosis of COVID-19-related muscle, joint pain
Radiological images confirm 'COVID-19 can cause the body to attack itself': Imaging illustrates severity, long-term prognosis of COVID-19-related muscle, joint pain
"We've realized that the COVID virus can trigger the body to attack itself in different ways, which may lead to rheumatological issues that require lifelong management,"
·sciencedaily.com·
Radiological images confirm 'COVID-19 can cause the body to attack itself': Imaging illustrates severity, long-term prognosis of COVID-19-related muscle, joint pain