COVID-19 linked to long-term risk for autoimmune, autoinflammatory disease
“COVID-19 linked to long-term risk for autoimmune, autoinflammatory disease”
COVID-19 linked to long-term risk for autoimmune, autoinflammatory disease
Understanding autoimmune response after SARS-CoV-2 infection and the pathogenesis/mechanisms of long COVID
Key finding: Long COVID linked to new autoimmune disorders like lupus, myasthenia gravis.
COVID-19 worsens Autoimmune Diseases! Study reveals 30 percent spike in antinuclear antibody positivity
“new study has revealed shocking details about the long-term health impacts of COVID-19, particularly concerning autoimmune diseases. The study conducted by Metropolis analyzed data from over 1.2 lakh cases, comparing two critical periods—2019 (pre-COVID) and 2022 (post-COVID). The findings revealed a striking 30% increase in the prevalence of Antinuclear Antibody (ANA) positivity in the Indian population, indicating how the immune system may, in some cases, turn against the body’s own tissues following a COVID-19 infection.”
Multi-ancestry GWAS of Long COVID identifies immune-related loci and etiological links to chronic fatigue syndrome, fibromyalgia and depression
“Using consented and genotyped data from 23andMe adult research participants, we conducted the largest multi-ancestry meta-analysis of genome-wide association studies of Long COVID across European (42,899 cases, 94,721 controls), Latinx (8,631 cases, 20,351 controls), and African-American (2,234 cases, 5,596 controls) genetic ancestry groups. GWAS of Long COVID identified three genome-wide significant loci (HLA-DQA1 and HLA-DQB, ABO, BPTF:KPAN2:C17orf58). Functional analysis of these genes points to underlying immune and thrombo-inflammatory mechanisms.”
Using consented and genotyped data from 23andMe adult research participants, we conducted the largest multi-ancestry meta-analysis of genome-wide association studies of Long COVID across European (42,899 cases, 94,721 controls), Latinx (8,631 cases, 20,351 controls), and African-American (2,234 cases, 5,596 controls) genetic ancestry groups. GWAS of Long COVID identified three genome-wide significant loci (HLA-DQA1 and HLA-DQB, ABO, BPTF:KPAN2:C17orf58). Functional analysis of these genes points to underlying immune and thrombo-inflammatory mechanisms.
This is live on 23&Me.
HLA-DRB1 gene and Long Covid
SARS-CoV-2 spike aggravates lupus nephritis and lung fibrosis in systemic lupus erythematosus
South Korea study suggests SarsCov2 accelerates progression of Lupus.
COVID-19 spike protein worsens lupus, increasing autoantibodies, kidney damage, and lung fibrosis.
Patients With Arthritis, IBD, Experience High Rates of Long Covid Affecting QoL
“A significant portion of people with systemic autoimmune disease, including inflammatory arthritis and inflammatory bowel disease, experienced post-acute sequelae of COVID-19 (PASC), which often affected quality of life.”
A significant portion of people with systemic autoimmune disease, including inflammatory arthritis and inflammatory bowel disease, experienced post-acute sequelae of COVID-19 (PASC), which often affected quality of life
Efficacy of Repeat Immunoadsorption in Post-COVID ME/CFS Patients with Elevated Β2-Adrenergic Receptor Autoantibodies: A Prospective Cohort Study
immunoadsorption (removing antibodies from blood) temporarily improves Long COVID symptoms. Strongly underlines the therapeutic potential of targeting autoimmunity:
Mild Primary or Breakthrough SARS-CoV-2 Infection Promotes Autoantibody Production in Individuals with and without Neuro-PASC | ImmunoHorizons | American Association of Immunologists
“In this study, we demonstrate that mild SARS-CoV-2 infection increases autoantibodies associated with rheumatic autoimmune diseases and diabetes in most individuals, regardless of vaccination status prior to infection…
…These data highlight the need for additional strategies to decrease the spread of SARS-CoV-2 such as the development of vaccines that can prevent infection rather than decrease severity of acute disease alone.”
The intersection of microbiome and autoimmunity in long COVID-19: Current insights and future directions
Research suggests #longcovid linked to autoimmune responses and imbalances in the microbiome.
Probiotics may help reduce symptoms, but more research is needed.