Chronic inflammation in Long COVID relationship to autoimmune diseases
Reminder: Long COVID drives autoimmune diseases through chronic inflammation and immune dysregulation.
➡️Many studies have suggested that systemic chronic inflammation caused by residual viral components may be one of the pathophysiologic mechanisms of Long COVID.
➡️In this paper, they reviewed the autoimmune diseases caused by chronic inflammation.
Neurologic Impacts of Long COVID, an Autoimmune Syndrome: Igor Koralnik, MD
“We believe Long COVID is a new autoimmune syndrome, which occurs when the immune system becomes confused by the virus and begins to attack the body..”
COVID-19 worsens Autoimmune Diseases! Study reveals 30 percent spike in antinuclear antibody positivity
“new study has revealed shocking details about the long-term health impacts of COVID-19, particularly concerning autoimmune diseases. The study conducted by Metropolis analyzed data from over 1.2 lakh cases, comparing two critical periods—2019 (pre-COVID) and 2022 (post-COVID). The findings revealed a striking 30% increase in the prevalence of Antinuclear Antibody (ANA) positivity in the Indian population, indicating how the immune system may, in some cases, turn against the body’s own tissues following a COVID-19 infection.”
Multi-ancestry GWAS of Long COVID identifies immune-related loci and etiological links to chronic fatigue syndrome, fibromyalgia and depression
“Using consented and genotyped data from 23andMe adult research participants, we conducted the largest multi-ancestry meta-analysis of genome-wide association studies of Long COVID across European (42,899 cases, 94,721 controls), Latinx (8,631 cases, 20,351 controls), and African-American (2,234 cases, 5,596 controls) genetic ancestry groups. GWAS of Long COVID identified three genome-wide significant loci (HLA-DQA1 and HLA-DQB, ABO, BPTF:KPAN2:C17orf58). Functional analysis of these genes points to underlying immune and thrombo-inflammatory mechanisms.”
Using consented and genotyped data from 23andMe adult research participants, we conducted the largest multi-ancestry meta-analysis of genome-wide association studies of Long COVID across European (42,899 cases, 94,721 controls), Latinx (8,631 cases, 20,351 controls), and African-American (2,234 cases, 5,596 controls) genetic ancestry groups. GWAS of Long COVID identified three genome-wide significant loci (HLA-DQA1 and HLA-DQB, ABO, BPTF:KPAN2:C17orf58). Functional analysis of these genes points to underlying immune and thrombo-inflammatory mechanisms.
Patients With Arthritis, IBD, Experience High Rates of Long Covid Affecting QoL
“A significant portion of people with systemic autoimmune disease, including inflammatory arthritis and inflammatory bowel disease, experienced post-acute sequelae of COVID-19 (PASC), which often affected quality of life.”
A significant portion of people with systemic autoimmune disease, including inflammatory arthritis and inflammatory bowel disease, experienced post-acute sequelae of COVID-19 (PASC), which often affected quality of life
Efficacy of Repeat Immunoadsorption in Post-COVID ME/CFS Patients with Elevated Β2-Adrenergic Receptor Autoantibodies: A Prospective Cohort Study
immunoadsorption (removing antibodies from blood) temporarily improves Long COVID symptoms. Strongly underlines the therapeutic potential of targeting autoimmunity:
Mild Primary or Breakthrough SARS-CoV-2 Infection Promotes Autoantibody Production in Individuals with and without Neuro-PASC | ImmunoHorizons | American Association of Immunologists
“In this study, we demonstrate that mild SARS-CoV-2 infection increases autoantibodies associated with rheumatic autoimmune diseases and diabetes in most individuals, regardless of vaccination status prior to infection…
…These data highlight the need for additional strategies to decrease the spread of SARS-CoV-2 such as the development of vaccines that can prevent infection rather than decrease severity of acute disease alone.”
Detailed Twitter thread:
IBD is an autoimmune condition, which studies have shown increases a person’s chances of Long Covid. Now doctors are seeing both de novo IBD after Covid and worsening of existing IBD. (see this thread). More research is needed. Another reason for high grade mask & ventilation.
How Effects on the Brain Can Produce Long COVID - Neuroscience News
"scientists believe some symptoms may be caused by autoimmunity—in which the immune system is turned on to fight an incoming pathogen, but mistakenly recognizes the body’s own cells as targets.
How Effects on the Brain Can Produce Long COVID -