SARS-CoV-2 can directly infect bone marrow cells and indirectly affect bone health.
The infection can lead to hypocalcemia, altered bone turnover markers, decreased bone mineral density, and a high prevalence of vertebral fractures.
Analysis thread on Twitter SARS-Cov-2 causes osteoporosis as a consequence of monocyte derived macrophages differentiating into osteoclasts, which participate in bone remodeling. This has been known since this article.
"SARS-CoV-2 can cause quick and significant bone loss—even when infections appear to be mild..."
Mice infected with the virus: Lost 25% of bone mass within 2 weeks Had 63% increase in osteoclasts--cells that cause bone to break down.
