Jess šØš¦ (@MeetJess) on X
Repeat COVID Infections & Dementia
A time bomb no one wants to talk about š§µ
Altered brain glucose metabolism in COVID-19 disease: an activation likelihood estimation meta-analysis of PET studies - PubMed
Radical Centrist,wrathful tantric deityšŗš¦š¹š¼šļø (@RadCentrism) on X
āWeird. If only some people discussed this 4-5 years agoā¦ā
Brain 18F-FDG PET imaging in outpatients with post-COVID-19 conditions: findings and associations with clinical characteristics
āOutpatients with post-COVID-19 conditions exhibited extensive hypometabolic right fronto-temporal clusters. Patients with more numerous symptoms during the initial phase and with a longer duration of symptoms were at higher risk of persistent brain involvement.ā
Outpatients with post-COVID-19 conditions exhibited extensive hypometabolic right fronto-temporal clusters. Patients with more numerous symptoms during the initial phase and with a longer duration of symptoms were at higher risk of persistent brain involvement.
Altered auditory brainstem responses are post-acute sequela of SARS-CoV-2 (PASC)
āPASC subjects showed an increased prevalence of tinnitus and more perceived hearing handicaps despite matched peripheral hearing ability, in addition to increased cognitive fatigue, anxiety, and depression.ā
PASC subjects showed an increased prevalence of tinnitus and more perceived hearing handicaps despite matched peripheral hearing ability, in addition to increased cognitive fatigue, anxiety, and depression. ABR wave V latency differences between the slow and fast click r
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Exploring the Persistence of the Spike Protein along the Skull-Meninges-Brain Axis and the Neurological Effects of COVID-19
This analysis is supported by numerous videos and illustrations.
Structural brain changes in post-COVID condition and its relationship with cognitive impairment | Brain Communications | Oxford Academic
Structural brain changes in post-COVID condition and its relationship with cognitive impairment
Alzheimerās disease-like changes in COVID-19
"The impact I am seeing on my clients post-COVID is something I hadnāt seen previously in the years I have worked in this field. The cognitive decline post-COVID infection is immense, thus confirming the impact this virus has on the brain..."
"The impact I am seeing on my clients post-COVID is something I hadnāt seen previously in the years I have worked in this field. The cognitive decline post-COVID infection is immense, thus confirming the impact this virus has on the brain..."
Clinical and radiological characteristics and 1-year self-reported outcomes from patients with encephalitis and coronavirus disease 2019 - Journal of Medical Case Reports
COVID-19 will never be like the Flu. Never.
āI have spent hundreds of hours in the microscope looking at the worst viruses can do to the brain, including the Zika virus, HIV, Flu, and others. I've never seen the type of damage SARS-CoV-2 leaves behind after infection with other viruses. ā
COVID & the BRAINā¦ a thread š§µ
Hamsters with long Covid exhibits a neurodegenerative signature in the brainstem
āUsing the golden hamster as a model, we provide further evidence that SARS-CoV-2 is neuroinvasive and can persist in the central nervous system, as we found viral RNA and replicative virus in the brainstem after 80 days of infection.ā
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Evidence that a COVID-19 infection can induce neurological sequelae.
The SARSCoV2 spike protein can persist in the braināskull bone marrow and meningesāto induce neurologic damage
SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it.
In mice, it caused inflammation, anxiety, and worsened brain injuries. Vaccines reduced but did not fully eliminate it.
Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss
āCognitive deficits after COVID-19 associated with brain injury biomarkers and volume lossā
Honestly it kinda pisses me off how some people act like we can't talk about the brain damage from Covid, especially on the population level.
āHonestly it kinda pisses me off how some people act like we can't talk about the brain damage from Covid, especially on the population level. Yes, it's important to consider the ableism. But I have brain damage from Covid, including to my emotions, and we need to talk about it...ā
Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron SubvariantsāSingle-Center Study
āThe Omicron variant of SARS-CoV-2 presents a wide spectrum of neurological manifestations."
"Although there is an improvement in the survival rate of patients with COVID-19, the frequency of neurological manifestations increases."
"The occurrence of delirium, cerebrovascular diseases, and ischemic stroke results in higher mortality."
Part 2 of 2
Part 1 of 2
Why people can no longer drive.
Cognition and Memory after Covid-19 in a Large Community Sample | NEJM
Cognition and Memory after Covid-19 in a Large Community Sample
Cognition and Memory after Covid-19 in a Large Community Sample
A case-control study of reaction time deficits in a 3D virtual reality in patients with Post-COVID syndrome
āA case-control study of reaction time deficits in a 3D virtual reality in patients with Post-COVID syndromeā
A case-control study of reaction time deficits in a 3D virtual reality in patients with Post-COVID syndrome
Limbic system damage following SARS-CoV2 infection | Brain Communications | Oxford Academic
Limbic system damage from Covid:
SARS-CoV-2 is a neurotropic virus that may cause long-term neurological symptoms by damaging the limbic system.
This research shows that COVID-19 can impair emotion recognition, memory, and olfactory abilities, with altered brain connectivity patterns.
SARS-CoV-2 Invasion and Pathological Links to Prion Disease
Nearly half of those infected with SARS-CoV-2 experience long-term neurological problems, including brain fog and memory issues.
An infection may accelerate or exacerbate prion diseases like CreutzfeldtāJakob disease, leading to rapid neurodegeneration.
Worse, most people donāt even notice it has happened to themselves.
āWorse, most people donāt even notice it has happened to themselves.
But I can tell you we who continue to mask and have many fewer COVID infections can see the growing cognitive damage in more and more people around us.
Memory problems, like recall and word finding delays. Weakness and fatigue and motor control impairment. Growing executive function and emotional regulation deficits.
More and more friends disables and forced out of work or school by Long COVID symptoms.
Itās scary to witness the broad societal decline, and dispiriting to see so many governments and Public Health agencies persist in minimizing the growing problem.ā
Cognitive profile following COVID-19 infection: Clinical predictors leading to neuropsychological impairment
Covid itself causes cognitive impairment. From 2020, prior to Covid vaccination of any kind:
āIn our cohort of COVID-19 patients neurologic manifestations were frequent, including cognitive impairment.ā
COVID survivors may develop dementia
āCOVID-19 survivors show signs of significant cognitive deficits which could become dementia even a year after having the virus.. The team [in India] found that more than 80% of people tested reported at least one of four symptoms ā depression, anxiety, stress and insomnia ā ranging from mild to severe.. At least 6.1% of the patients were diagnosed with mild cognitive impairment and 4% developed dementia. More than 60% of the patients experienced a loss of taste and smell during the active phase of the infection. This could alter the function of brain areas linked to cognitive ability and emotional well-being.."
COVID-19 survivors show signs of significant cognitive deficits which could become dementia even a year after having the virus1. They also have an increased risk of depression, anxiety and disrupted sleep.
How long COVID could lift the fog on neurocognitive disorders
āIām a shell of myself. My physical issues arenāt half as bad as my brain problems. You can say brain fog, but that doesnāt come close to doing it justice.āā
Quantitative susceptibility mapping at 7 T in COVID-19: brainstem effects and outcome associations | Brain | Oxford Academic
āIn COVID-19 survivors, the MR susceptibility increased in the medulla, pons and midbrain regions of the brainstem. Specifically, there was increased susceptibility in the inferior medullary reticular formation and the raphe pallidus and obscurus. In these regions, patients with higher tissue susceptibility had worse acute disease severity, higher acute inflammatory markers, and significantly worse functional recovery.ā
In COVID-19 survivors, the MR susceptibility increased in the medulla, pons and midbrain regions of the brainstem. Specifically, there was increased susceptibility in the inferior medullary reticular formation and the raphe pallidus and obscurus. In these regions, patients with higher tissue susceptibility had worse acute disease severity, higher acute inflammatory markers, and significantly worse functional recovery.
Driving Under the Cognitive Influence of COVID-19: Exploring the Impact of Acute SARS-CoV-2 Infection on Road Safety | Neurology
"The study suggests that acute COVID-19, regardless of Long COVID status, is linked to an increased risk of car crashes presumably due to neurologic changes caused by SARS-CoV-2."
A 43% increase since 2019.
A 43% increase cognitive disabilities since 2019.
āThis is tragic and horrifying. And itās going to get progressively worse as weāre all systematically reinfected.ā