Covid and Brain Damage

Covid and Brain Damage

"#brain injury"
Can I reassert that with SARS-CoV-2 induced brain damage, it won’t be a lessening of intellect that you’ll be seeing first, but behavioural changes such as disinhibition, emotional lability, risk taking & impulsivity.
Can I reassert that with SARS-CoV-2 induced brain damage, it won’t be a lessening of intellect that you’ll be seeing first, but behavioural changes such as disinhibition, emotional lability, risk taking & impulsivity.

“Can I reassert that with SARS-CoV-2 induced brain damage, it won’t be a lessening of intellect that you’ll be seeing first, but behavioural changes such as disinhibition, emotional lability, risk taking & impulsivity.

Frontal lobe damage impairs behavioural regulation.” Thread:

·x.com·
Can I reassert that with SARS-CoV-2 induced brain damage, it won’t be a lessening of intellect that you’ll be seeing first, but behavioural changes such as disinhibition, emotional lability, risk taking & impulsivity.
Cognitive profile following COVID-19 infection: Clinical predictors leading to neuropsychological impairment
Cognitive profile following COVID-19 infection: Clinical predictors leading to neuropsychological impairment

Covid itself causes cognitive impairment. From 2020, prior to Covid vaccination of any kind:

“In our cohort of COVID-19 patients neurologic manifestations were frequent, including cognitive impairment.”

·sciencedirect.com·
Cognitive profile following COVID-19 infection: Clinical predictors leading to neuropsychological impairment
COVID survivors may develop dementia
COVID survivors may develop dementia

“COVID-19 survivors show signs of significant cognitive deficits which could become dementia even a year after having the virus.. The team [in India] found that more than 80% of people tested reported at least one of four symptoms – depression, anxiety, stress and insomnia – ranging from mild to severe.. At least 6.1% of the patients were diagnosed with mild cognitive impairment and 4% developed dementia. More than 60% of the patients experienced a loss of taste and smell during the active phase of the infection. This could alter the function of brain areas linked to cognitive ability and emotional well-being.."

COVID-19 survivors show signs of significant cognitive deficits which could become dementia even a year after having the virus1. They also have an increased risk of depression, anxiety and disrupted sleep.
·nature.com·
COVID survivors may develop dementia
Recorded this video on the microscope yesterday. A single infected cell arrives on the brain inside a blood vessel. Don't underestimate how much neuroinflammation one infected cell can cause.
Recorded this video on the microscope yesterday. A single infected cell arrives on the brain inside a blood vessel. Don't underestimate how much neuroinflammation one infected cell can cause.

“Recorded this video on the microscope yesterday. A single #SARSCoV2 infected cell arrives on the brain inside a blood vessel. Don't underestimate how much neuroinflammation one infected cell can cause. Brain-vascular-immune interface is the future of neuroscience #NeuroCovid”

·x.com·
Recorded this video on the microscope yesterday. A single infected cell arrives on the brain inside a blood vessel. Don't underestimate how much neuroinflammation one infected cell can cause.
Pioneering discovery and therapeutics at the brain-vascular-immune interface
Pioneering discovery and therapeutics at the brain-vascular-immune interface

A new paper in Cell, “Pioneering discovery and therapeutics at the brain-vascular-immune interface,” describes COVID-19 as a neurological disease alongside multiple sclerosis, Alzheimer’s, stroke and traumatic brain injury.

“COVID-19 can accelerate progression of dementia and induce BBB disruption and inflammatory blood clots causally linked with neuroinflammation and neuronal loss.8 In neurodevelopmental disorders, prematurity and perinatal hypoxia that trigger brain hemorrhage and BBB disruption are risk factors for cerebral palsy, intellectual disability, and autism. Collectively, these risk factors highlight the interconnected vascular and immune triggers of neurological diseases.”

·cell.com·
Pioneering discovery and therapeutics at the brain-vascular-immune interface
Quantitative susceptibility mapping at 7 T in COVID-19: brainstem effects and outcome associations | Brain | Oxford Academic
Quantitative susceptibility mapping at 7 T in COVID-19: brainstem effects and outcome associations | Brain | Oxford Academic
“In COVID-19 survivors, the MR susceptibility increased in the medulla, pons and midbrain regions of the brainstem. Specifically, there was increased susceptibility in the inferior medullary reticular formation and the raphe pallidus and obscurus. In these regions, patients with higher tissue susceptibility had worse acute disease severity, higher acute inflammatory markers, and significantly worse functional recovery.”
In COVID-19 survivors, the MR susceptibility increased in the medulla, pons and midbrain regions of the brainstem. Specifically, there was increased susceptibility in the inferior medullary reticular formation and the raphe pallidus and obscurus. In these regions, patients with higher tissue susceptibility had worse acute disease severity, higher acute inflammatory markers, and significantly worse functional recovery.
·academic.oup.com·
Quantitative susceptibility mapping at 7 T in COVID-19: brainstem effects and outcome associations | Brain | Oxford Academic
COVID-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study
COVID-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study
“COVID-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study”
·nature.com·
COVID-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study
Driving Under the Cognitive Influence of COVID-19: Exploring the Impact of Acute SARS-CoV-2 Infection on Road Safety | Neurology
Driving Under the Cognitive Influence of COVID-19: Exploring the Impact of Acute SARS-CoV-2 Infection on Road Safety | Neurology
"The study suggests that acute COVID-19, regardless of Long COVID status, is linked to an increased risk of car crashes presumably due to neurologic changes caused by SARS-CoV-2."
·neurology.org·
Driving Under the Cognitive Influence of COVID-19: Exploring the Impact of Acute SARS-CoV-2 Infection on Road Safety | Neurology
Severe Covid infections can inflame brain’s ‘control centre’, research says
Severe Covid infections can inflame brain’s ‘control centre’, research says
“Severe Covid infections can drive inflammation in the brain’s ‘control centre’ researchers say, leading to damage that may explain the long-term breathlessness, fatigue and anxiety some patients experience.
·theguardian.com·
Severe Covid infections can inflame brain’s ‘control centre’, research says
Whoopi Goldberg Commiserates With Fellow-Covid Sufferer Joe Biden: “Sometimes I Go For A Word And It’s Not There”
Whoopi Goldberg Commiserates With Fellow-Covid Sufferer Joe Biden: “Sometimes I Go For A Word And It’s Not There”

Whoopi Goldberg, who just had her 4th COVID infection, joked about her post infection brain damage on TV.

“I’m just getting over COVID – again – and I can barely remember anybody’s name. There are times when I go for a word and it’s not there.”

·deadline.com·
Whoopi Goldberg Commiserates With Fellow-Covid Sufferer Joe Biden: “Sometimes I Go For A Word And It’s Not There”
Emerging signs of Alzheimer‐like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID‐19
Emerging signs of Alzheimer‐like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID‐19
Emerging signs of Alzheimer’s-like pathology in brains if people recovered from COVID-19, even though no direct SARS-CoV-2 invasion was detected
·onlinelibrary.wiley.com·
Emerging signs of Alzheimer‐like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID‐19
Study shows that COVID-19 causes cognitive decline among those without long COVID symptoms
Study shows that COVID-19 causes cognitive decline among those without long COVID symptoms
“A new study in eClinicalMedicine has found that healthy volunteers infected with SARS-CoV-2 had measurably worse cognitive function for up to a year after infection when compared to uninfected controls. Significantly, infected controls did not report any symptoms related to these cognitive deficits, indicating that they were unaware of them.”
A new study in eClinicalMedicine has found that healthy volunteers infected with SARS-CoV-2 had measurably worse cognitive function for up to a year after infection when compared to uninfected controls. Significantly, infected controls did not report any symptoms related to these cognitive deficits, indicating that they were unaware of them. The net effect is that potentially billions of people worldwide with a his
·wsws.org·
Study shows that COVID-19 causes cognitive decline among those without long COVID symptoms
French doctors warn that even mild COVID-19 can cause acute Cerebellitis that is difficult to diagnose - Thailand Medical News
French doctors warn that even mild COVID-19 can cause acute Cerebellitis that is difficult to diagnose - Thailand Medical News
French doctors warn that even mild COVID-19 can cause acute Cerebellitis that is difficult to diagnose and life-threatening
·thailandmedical.news·
French doctors warn that even mild COVID-19 can cause acute Cerebellitis that is difficult to diagnose - Thailand Medical News
Covid Brain
Covid Brain
“But this week 2 new publications have substantially added to our understanding of the extent that Covid can impair cognitive function across the full gamut— from young, healthy individuals with mild infections to older, hospitalized patients with severe Covid.”
·erictopol.substack.com·
Covid Brain
Long COVID is not the same for everyone: a hierarchical cluster analysis of Long COVID symptoms 9 and 12 months after SARS-CoV-2 test - BMC Infectious Diseases
Long COVID is not the same for everyone: a hierarchical cluster analysis of Long COVID symptoms 9 and 12 months after SARS-CoV-2 test - BMC Infectious Diseases
“Our results suggest that Long COVID is not the same for everyone.”
Our results suggest that Long COVID is not the same for everyone.
·bmcinfectdis.biomedcentral.com·
Long COVID is not the same for everyone: a hierarchical cluster analysis of Long COVID symptoms 9 and 12 months after SARS-CoV-2 test - BMC Infectious Diseases
Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK
Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK
“Participants had worse cognitive scores than would be expected on the basis of their sociodemographic characteristics across all cognitive domains tested (average score 0·71 SD below the mean [IQR 0·16–1·04]; p<0·0001). Most participants reported at least mild depression (263 [74·5%] of 353), anxiety (189 [53·5%] of 353), fatigue (220 [62·3%] of 353), or subjective cognitive decline (184 [52·1%] of 353), and more than a fifth reported severe depression (79 [22·4%] of 353), fatigue (87 [24·6%] of 353), or subjective cognitive decline (88 [24·9%] of 353). Depression, anxiety, and fatigue were worse at 2–3 years than at 6 months or 12 months, with evidence of both worsening of existing symptoms and emergence of new symptoms. Symptoms at 2–3 years were not predicted by the severity of acute COVID-19 illness, but were strongly predicted by the degree of recovery at 6 months”
Participants had worse cognitive scores than would be expected on the basis of their sociodemographic characteristics across all cognitive domains tested (average score 0·71 SD below the mean [IQR 0·16–1·04]; p<0·0001). Most participants reported at least mild depression (263 [74·5%] of 353), anxiety (189 [53·5%] of 353), fatigue (220 [62·3%] of 353), or subjective cognitive decline (184 [52·1%] of 353), and more than a fifth reported severe depression (79 [22·4%] of 353), fatigue (87 [24·6%] of 353), or subjective cognitive decline (88 [24·9%] of 353). Depression, anxiety, and fatigue were worse at 2–3 years than at 6 months or 12 months, with evidence of both worsening of existing symptoms and emergence of new symptoms. Symptoms at 2–3 years were not predicted by the severity of acute COVID-19 illness, but were strongly predicted by the degree of recovery at 6 months
·thelancet.com·
Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK
Neurological complications caused by SARS-CoV-2
Neurological complications caused by SARS-CoV-2

Very comprehensive evaluation of known neurological damage from SarsCov2:

“The pathogenesis of neurological disorders caused by SARS-CoV-2 involves several mechanisms. First, SARS-CoV-2 could enter the brain through retrograde transmission & hematogenous routes & disrupt brain function & structure, thus causing or exacerbating neurological disorders…”

·journals.asm.org·
Neurological complications caused by SARS-CoV-2
Research Shows Severe COVID-19 Contributes to Long-Lasting Cognitive Impairment - InventUM
Research Shows Severe COVID-19 Contributes to Long-Lasting Cognitive Impairment - InventUM

“We found persistent subjective and objective cognitive issues even two years after infection, including brain fog, word-finding problems, working memory deficits and reduced processing speed.” “Most Patients Have Never Fully Recovered”

“We found persistent subjective and objective cognitive issues even two years after infection, including brain fog, word-finding problems, working memory deficits and reduced processing speed.” “Most Patients Have Never Fully Recovered”
·news.med.miami.edu·
Research Shows Severe COVID-19 Contributes to Long-Lasting Cognitive Impairment - InventUM
“Their research found patients who had COVID-19 were 60% more likely to suffer from mental health problems than those who were not infected. When hospitalized, the likelihood jumped to 86%.”
“Their research found patients who had COVID-19 were 60% more likely to suffer from mental health problems than those who were not infected. When hospitalized, the likelihood jumped to 86%.”

Another great thread by Laura Miers:

“Their research found patients who had COVID-19 were 60% more likely to suffer from mental health problems than those who were not infected. When hospitalized, the likelihood jumped to 86%.”

We are deliberately ignoring this & normalizing reinfection.”

·x.com·
“Their research found patients who had COVID-19 were 60% more likely to suffer from mental health problems than those who were not infected. When hospitalized, the likelihood jumped to 86%.”
One infection in ‘22, took Paxlovid. Still got TBI. Not recovered. Was ultra marathon runner, cyclist, executive. Fit, active. Everyone is at risk of poor outcome, even infants. Thanks for raising awareness.
One infection in ‘22, took Paxlovid. Still got TBI. Not recovered. Was ultra marathon runner, cyclist, executive. Fit, active. Everyone is at risk of poor outcome, even infants. Thanks for raising awareness.
“One infection in ‘22, took Paxlovid. Still got TBI. Not recovered. Was ultra marathon runner, cyclist, executive. Fit, active. Everyone is at risk of poor outcome, even infants.”
·x.com·
One infection in ‘22, took Paxlovid. Still got TBI. Not recovered. Was ultra marathon runner, cyclist, executive. Fit, active. Everyone is at risk of poor outcome, even infants. Thanks for raising awareness.
Kentucky research links long COVID brain fog to Alzheimer’s | Lexingt…
Kentucky research links long COVID brain fog to Alzheimer’s | Lexingt…
“Some patients with COVID see similar brain changes to people with such neurodegenerative disorders as Alzheimer’s, according to University of Kentucky researchers.”
Some patients with COVID see similar brain changes to people with such neurodegenerative disorders as Alzheimer’s, according to University of Kentucky researchers.
·archive.is·
Kentucky research links long COVID brain fog to Alzheimer’s | Lexingt…
Does Covid Lead to Dementia? Here's What the Virus May Have Done to Y…
Does Covid Lead to Dementia? Here's What the Virus May Have Done to Y…
Non paywall version of catalogued Bloomberg article
Scientists are worried that persisting cognitive issues may signal a coming surge of dementia and other mental conditions
·archive.is·
Does Covid Lead to Dementia? Here's What the Virus May Have Done to Y…