Multimodal MRI Reveals Consistent Basal Ganglia and Limbic System Alterations in COVID-19 Survivors
Multimodal MRI Reveals Consistent Basal Ganglia and Limbic System Alterations in COVID-19 Survivors
Thread by @ZdenekVrozina on Thread Reader App
“New brain MRI study (2025): Post-COVID patients show measurable structural changes - even without hospitalization. Participants were not selected for having Long COVID! What was found, why it matters, and how this fits into what we know about hypothalamus-related circuits.”
Harry Spoelstra (@HarrySpoelstra) on X
Long-term neurological and cognitive impact of COVID-19: a systematic review and meta-analysis in over 4 million patients
The Molecular Mechanisms of Cognitive Dysfunction in Long COVID: A Narrative Review
The molecular mechanisms of cognitive dysfunction in Long COVID: A Narrative Review
MRI study spotlights impact of long COVID on the brain | CIDRAP
UAE Exotic Falconry & Finance𓅃 (@FalconryFinance) on X
He’s had COVID six times. He jokes it destroyed his memory. @JennaBushHager laughs. They’re normalizing brain damage on national TV
A Case Report of Normal Pressure Hydrocephalus Developing After COVID-19 Infection
A Case Report of Normal Pressure Hydrocephalus Developing After COVID-19 Infection
A Case Report of Normal Pressure Hydrocephalus Developing After COVID-19 Infection
Unusual Post–COVID-19 Presentation With Tetraventricular Hydrocephalus | Neurology Clinical Practice
“COVID-19 infection is suggested as one of the causes for hydrocephalus (HCP) of unknown etiology. “
COVID-19 infection is suggested as one of the causes for hydrocephalus (HCP) of unknown etiology.
Normal pressure hydrocephalus associated with COVID-19 infection: a case report - BMC Infectious Diseases
Hydrocephalus secondary to COVID-19 infection | QJM: An International Journal of Medicine | Oxford Academic
Normal pressure hydrocephalus associated with COVID-19 infection: a case report
“Other infections such as syphilis, cryptococcosis and Lyme disease have been associated with NPH. Possible mechanisms for NPH after COVID include disruption of choroid plexus cells by direct viral invasion or as a result of neuroinflammation and cytokine release and hypercoagulability leading to venous congestion and abnormalities of CSF flow.”
Other infections such as syphilis, cryptococcosis and Lyme disease have been associated with NPH. Possible mechanisms for NPH after COVID include disruption of choroid plexus cells by direct viral invasion or as a result of neuroinflammation and cytokine release and hypercoagulability leading to venous congestion and abnormalities of CSF flow.
David Lingenfelter, PhD (@dlingenfelter) on X
“Around 30% of those infected with COVID-19 experience lingering symptoms, with young adults showing cognitive impairments even two years after infection. Symptoms include persistent fatigue, trouble concentrating, and memory difficulties.”
1924583162224484586
Scientists find two brain biomarkers in long COVID sufferers that may be causing cognitive issues
“A new study that is the first to compare inflammation and brain stress responses in long COVID-19 patients with individuals who have fully recovered shows that those with continued brain fog and other cognitive issues have a lower ability to adapt to stress and higher levels of inflammation in their brains.”
A new study that is the first to compare inflammation and brain stress responses in long COVID-19 patients with individuals who have fully recovered shows that those with continued brain fog and other cognitive issues have a lower ability to adapt to stress and higher levels of inflammation in their brains.
Post-acute sequelae of COVID infection and cerebral venous outflow disorders: Overlapping symptoms and mechanisms?
“Post-acute sequelae of COVID infection and cerebral venous outflow disorders: Overlapping symptoms and mechanisms?”
Jess 🇨🇦 (@MeetJess) on X
Repeat COVID Infections & Dementia
A time bomb no one wants to talk about 🧵
Altered brain glucose metabolism in COVID-19 disease: an activation likelihood estimation meta-analysis of PET studies - PubMed
Radical Centrist,wrathful tantric deity🇺🇦🇹🇼🎗️ (@RadCentrism) on X
“Weird. If only some people discussed this 4-5 years ago…”
Is Covid Rewriting the Rules of Aging? Brain Decline Alarms Doctors
“Millions of long-Covid patients continue to struggle with cognitive difficulties”
Millions of long-Covid patients continue to struggle with cognitive difficulties
Kathryn (@kadamssl) on X
“That feeling when you know COVID can cause damage to the orbitofrontal cortex and you also know that this is almost certainly contributing to loss of empathy, increased impulsivity, and a prevalent inability to learn that changed circumstances warrant changed behaviour. 👇”
Expert warns common virus dramatically raises risk of early dementia
“Top scientists have warned that those who've had Covid may be at greater risk of developing dementia before they reach 70.”
Top scientists have warned that those who've had Covid may be at greater risk of developing dementia before they reach 70.
How COVID Impacts the Brain: Danielle Beckman and David Joffe
“How does COVID-19 impact the brain? Neuroscientist Danielle Beckman and expert David Joffe discuss direct neuronal effects and sleep disorders in Long COVID patients, and the importance of thorough evaluations for accurate diagnoses.”
Dr. Sean Mullen (@drseanmullen) on X
“New study just dropped: MRI scans of young kids post-COVID show changes in brain structure—even after mild infection. Here’s what the researchers found, how they did it, and why it matters.”
Multimodal MRI analysis of COVID-19 effects on pediatric brain
Even mild Covid changes children’s brains.
“We speculate that viral-triggered neuroinflammation and immune response contribute to neurotoxic damage in brain regions involved in cognitive processing, ultimately resulting in alterations in cortical morphology and glymphatic function.”
We speculate that viral-triggered neuroinflammation and immune response contribute to neurotoxic damage in brain regions involved in cognitive processing, ultimately resulting in alterations in cortical morphology and glymphatic function.
2025
University of Texas researchers found that Omicron BA.1 caused lasting neurological issues in hACE2 mice, linked to blood-brain barrier breakdown, clotting, and inflammation.
Viral RNA and spike protein lingered in the brain even without live virus.
newsGP - How COVID-19 leaves its mark on the brain
“Mounting research shows the disease can lead to an array of problems, including significant drops in IQ scores, writes Dr Ziyad Al-Aly.”
Mounting research shows the disease can lead to an array of problems, including significant drops in IQ scores, writes Dr Ziyad Al-Aly.
Brain 18F-FDG PET imaging in outpatients with post-COVID-19 conditions: findings and associations with clinical characteristics
“Outpatients with post-COVID-19 conditions exhibited extensive hypometabolic right fronto-temporal clusters. Patients with more numerous symptoms during the initial phase and with a longer duration of symptoms were at higher risk of persistent brain involvement.”
Outpatients with post-COVID-19 conditions exhibited extensive hypometabolic right fronto-temporal clusters. Patients with more numerous symptoms during the initial phase and with a longer duration of symptoms were at higher risk of persistent brain involvement.
Altered auditory brainstem responses are post-acute sequela of SARS-CoV-2 (PASC)
“PASC subjects showed an increased prevalence of tinnitus and more perceived hearing handicaps despite matched peripheral hearing ability, in addition to increased cognitive fatigue, anxiety, and depression.”
PASC subjects showed an increased prevalence of tinnitus and more perceived hearing handicaps despite matched peripheral hearing ability, in addition to increased cognitive fatigue, anxiety, and depression. ABR wave V latency differences between the slow and fast click r
Thread by @JamesThrot on Thread Reader App
“In neurology/psychiatry, we would call this Apathy.
Brain damage to the frontal lobe (dorsal anterior cingulate cortex) causes apathy & reduces empathy.
SARS-CoV-2 damages this region of the brain. Every. Single. Time.
More infections = more damage = more apathy.”
In neurology/psychiatry, we would call this Apathy.
Brain damage to the frontal lobe (dorsal anterior cingulate cortex) causes apathy & reduces empathy.
SARS-CoV-2 damages this region of the brain. Every. Single. Time.
More infections = more damage = more apathy.
WTF DID SAM GET HIMSELF INTO?? | Hasanabi & Noah Kulwin React
Starting at 4:15: “I’m becoming a bit of a Covid truther. I think we genuinely saw like an IQ drop across the board just of all the people who got hit with Covid. People’s brains I don’t think work as much or as well as they used to.”