Found 97 bookmarks
Newest
Thread by @JamesThrot on Thread Reader App
Thread by @JamesThrot on Thread Reader App

“Let’s talk about COVID, brain damage & society.

Specifically, what happens when a neurotropic virus repeatedly infects the population, targeting the frontal lobe & almost nobody talks about the consequences?

This thread is for the skeptics.

I’m a neurologist, stay with me 🧵”

Let’s talk about COVID, brain damage & society. Specifically, what happens when a neurotropic virus repeatedly infects the population, targeting the frontal lobe & almost nobody talks about the consequences? This thread is for the skeptics. I’m a neurologist, stay with me 🧵
#Brain#Covid Isn't Over#Post-Acute Conditions#consequences#frontal lobe#brain dysfunction#cognition#cognitive decline#Long Covid#neurological#Post-Acute Sequelae of COVID-19#Cognitive Impairment#white matter#grey matter shrinkage#olfactory damage#working memory#Discussion#analysis#James Throt
·threadreaderapp.com·
Thread by @JamesThrot on Thread Reader App
Human challenge study reveals lasting cognitive decline after mild COVID-19
Human challenge study reveals lasting cognitive decline after mild COVID-19

“significant memory and executive function decline lasting up to a year, despite no reported subjective symptoms, prompting new questions about the virus’s long-term cognitive effects.”

Unvaccinated volunteers who contracted COVID-19 in a human challenge study showed
#cognitive decline#memory#long covid#cognition#Cognitive Impairment#Brain Fog#Long Covid#Post-Acute Conditions#Brain#neurological
·news-medical.net·
Human challenge study reveals lasting cognitive decline after mild COVID-19
Frontiers | Serum angiotensin type-1 receptor autoantibodies and neurofilament light chain as markers of neuroaxonal damage in post-COVID patients
Frontiers | Serum angiotensin type-1 receptor autoantibodies and neurofilament light chain as markers of neuroaxonal damage in post-COVID patients
“Dysregulation of autoimmune responses and the presence of autoantibodies (AA), particularly those related to the renin-angiotensin system (RAS), have been implicated in the acute phase of COVID-19, and persistent dysregulation of brain RAS by RAS-related autoantibodies may also contribute to neurological symptoms of post-COVID.”
Dysregulation of autoimmune responses and the presence of autoantibodies (AA), particularly those related to the renin-angiotensin system (RAS), have been implicated in the acute phase of COVID-19, and persistent dysregulation of brain RAS by RAS-related autoantibodies may also contribute to neurological symptoms of post-COVID.
#autoimmunity#neurological#Post-Acute Conditions#Long Covid#Immune system#brain#Neuroaxonal damage
·frontiersin.org·
Frontiers | Serum angiotensin type-1 receptor autoantibodies and neurofilament light chain as markers of neuroaxonal damage in post-COVID patients
Mapping brain changes in post-COVID-19 cognitive decline via FDG PET hypometabolism and EEG slowing
Mapping brain changes in post-COVID-19 cognitive decline via FDG PET hypometabolism and EEG slowing
Cognitive decline is a common symptom of post-COVID-19 syndrome. However, the mechanisms underlying this deficit remain poorly understood. This study aims to investigate the relationship between brain metabolic and neurophysiological alteration patterns in patients with persistent subjective cognitive decline after mild COVID-19 using joint FDG-PET and EEG analyses.
Cognitive decline is a common symptom of post-COVID-19 syndrome. However, the mechanisms underlying this deficit remain poorly understood. This study aims to investigate the relationship between brain metabolic and neurophysiological alteration patterns in patients with persistent subjective cognitive decline after mild COVID-19 using joint FDG-PET and EEG analyses.
#Cognitive Impairment#brain changes#cognitive decline#hypometabolism#Post-Acute Conditions#brain dysfunction#brain#neuroimaging#EEG slowing#cognition
·nature.com·
Mapping brain changes in post-COVID-19 cognitive decline via FDG PET hypometabolism and EEG slowing
Unusual Post–COVID-19 Presentation With Tetraventricular Hydrocephalus | Neurology Clinical Practice
Unusual Post–COVID-19 Presentation With Tetraventricular Hydrocephalus | Neurology Clinical Practice
“COVID-19 infection is suggested as one of the causes for hydrocephalus (HCP) of unknown etiology. “
COVID-19 infection is suggested as one of the causes for hydrocephalus (HCP) of unknown etiology.
#Normal Pressure Hydrocephalus#Brain#Post-Acute Conditions#brain#neurological
·neurology.org·
Unusual Post–COVID-19 Presentation With Tetraventricular Hydrocephalus | Neurology Clinical Practice
Normal pressure hydrocephalus associated with COVID-19 infection: a case report
Normal pressure hydrocephalus associated with COVID-19 infection: a case report
“Other infections such as syphilis, cryptococcosis and Lyme disease have been associated with NPH. Possible mechanisms for NPH after COVID include disruption of choroid plexus cells by direct viral invasion or as a result of neuroinflammation and cytokine release and hypercoagulability leading to venous congestion and abnormalities of CSF flow.”
Other infections such as syphilis, cryptococcosis and Lyme disease have been associated with NPH. Possible mechanisms for NPH after COVID include disruption of choroid plexus cells by direct viral invasion or as a result of neuroinflammation and cytokine release and hypercoagulability leading to venous congestion and abnormalities of CSF flow.
#Brain#Post-Acute Conditions#Normal Pressure Hydrocephalus
·pmc.ncbi.nlm.nih.gov·
Normal pressure hydrocephalus associated with COVID-19 infection: a case report
Expert warns common virus dramatically raises risk of early dementia
Expert warns common virus dramatically raises risk of early dementia
“Top scientists have warned that those who've had Covid may be at greater risk of developing dementia before they reach 70.”
Top scientists have warned that those who've had Covid may be at greater risk of developing dementia before they reach 70.
#dementia#Brain#cognitive decline#cognition#Memory#memory loss#consequences#Post-Acute Conditions#Alzheimers
·dailymail.co.uk·
Expert warns common virus dramatically raises risk of early dementia
newsGP - How COVID-19 leaves its mark on the brain
newsGP - How COVID-19 leaves its mark on the brain
“Mounting research shows the disease can lead to an array of problems, including significant drops in IQ scores, writes Dr Ziyad Al-Aly.”
Mounting research shows the disease can lead to an array of problems, including significant drops in IQ scores, writes Dr Ziyad Al-Aly.
#brain#cognition#Post-Acute Conditions#memory loss#brain changes#brain dysfunction#cognitive decline#neurological#Memory#IQ#Ziyad Al-Aly
·www1.racgp.org.au·
newsGP - How COVID-19 leaves its mark on the brain
Brain 18F-FDG PET imaging in outpatients with post-COVID-19 conditions: findings and associations with clinical characteristics
Brain 18F-FDG PET imaging in outpatients with post-COVID-19 conditions: findings and associations with clinical characteristics
“Outpatients with post-COVID-19 conditions exhibited extensive hypometabolic right fronto-temporal clusters. Patients with more numerous symptoms during the initial phase and with a longer duration of symptoms were at higher risk of persistent brain involvement.”
Outpatients with post-COVID-19 conditions exhibited extensive hypometabolic right fronto-temporal clusters. Patients with more numerous symptoms during the initial phase and with a longer duration of symptoms were at higher risk of persistent brain involvement.
#Long Covid#Post-Acute Conditions#brain#neuroimaging#hypometabolism#Cognitive Impairment#neurological
·link.springer.com·
Brain 18F-FDG PET imaging in outpatients with post-COVID-19 conditions: findings and associations with clinical characteristics
Altered auditory brainstem responses are post-acute sequela of SARS-CoV-2 (PASC)
Altered auditory brainstem responses are post-acute sequela of SARS-CoV-2 (PASC)
“PASC subjects showed an increased prevalence of tinnitus and more perceived hearing handicaps despite matched peripheral hearing ability, in addition to increased cognitive fatigue, anxiety, and depression.”
PASC subjects showed an increased prevalence of tinnitus and more perceived hearing handicaps despite matched peripheral hearing ability, in addition to increased cognitive fatigue, anxiety, and depression. ABR wave V latency differences between the slow and fast click r
#Ears#Post-Acute Conditions#Auditory System#Long Covid#Brain#PASC#neurological#long covid#hearing loss#tinnitus#Fatigue#ANA test#Depression#cognitive decline
·nature.com·
Altered auditory brainstem responses are post-acute sequela of SARS-CoV-2 (PASC)
Thread by @JamesThrot on Thread Reader App
Thread by @JamesThrot on Thread Reader App

“In neurology/psychiatry, we would call this Apathy.

Brain damage to the frontal lobe (dorsal anterior cingulate cortex) causes apathy & reduces empathy.

SARS-CoV-2 damages this region of the brain. Every. Single. Time.

More infections = more damage = more apathy.”

In neurology/psychiatry, we would call this Apathy. Brain damage to the frontal lobe (dorsal anterior cingulate cortex) causes apathy & reduces empathy. SARS-CoV-2 damages this region of the brain. Every. Single. Time. More infections = more damage = more apathy.
#Brain#brain injury#frontal lobe injury#apathy#frontal lobe#Post-Acute Conditions#consequences#inevitable effects of Forever Covid#Covid Isn't Over#empathy#empathy burnout
·threadreaderapp.com·
Thread by @JamesThrot on Thread Reader App
Investigating the Neuroimmune, Cerebrovascular, and Cognitive Disturbances Associated with SARS‑CoV‑2 Infection: A Systematic Review of Post‑Acute Outcomes | Research Square
Investigating the Neuroimmune, Cerebrovascular, and Cognitive Disturbances Associated with SARS‑CoV‑2 Infection: A Systematic Review of Post‑Acute Outcomes | Research Square
“A systematic review of 73,435 COVID-19 survivors found that 42% had persistent neuroinflammation, 22% had cerebrovascular injury, and 58% had cognitive impairment.”
#Neuroinflammation#Post-Acute Conditions#neurological#Brain#Covid-19 Cognitive Impairment#Cognitive Impairment#cognition#cerebrovascular disease#vascular#cerebral blood flow#cerebrovascular injury
·researchsquare.com·
Investigating the Neuroimmune, Cerebrovascular, and Cognitive Disturbances Associated with SARS‑CoV‑2 Infection: A Systematic Review of Post‑Acute Outcomes | Research Square
SARS-CoV-2 affects Alzheimer’s disease
SARS-CoV-2 affects Alzheimer’s disease

"Patients suffering from COVID-19 have been found to exhibit dementia-related biomarkers.. The findings of this study suggest a potential link between mild-to-moderate SARS-CoV-2 infection and the initiation or acceleration of brain β-amyloid pathology, and hint at the possibility of an increased future incidence of Alzheimer’s disease subsequent to the COVID-19 pandemic."

#Alzheimers#Brain#Post-Acute Conditions#dementia#cognition#cognitive decline#Amyloid#Neuroinflammation#brain changes#brain injury
·nature.com·
SARS-CoV-2 affects Alzheimer’s disease
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19

Exploring the Persistence of the Spike Protein along the Skull-Meninges-Brain Axis and the Neurological Effects of COVID-19

This analysis is supported by numerous videos and illustrations.

#Brain#Long Covid#Neuroinflammation#Post-Acute Conditions#brain injury#meninges#neurologic changes#neurological#spike protein#skull
·cell.com·
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Have you developed symptoms of ADHD since 2020? Or has your ADHD deteriorated since 2020? The frontal lobe is the largest part of the brain affected by ADHD, often maturing at a slower pace with disrupted activity & connectivity. Covid damages the frontal & temporal lobes. 🧵 https://t.co/Jhu5XWJjfE— James Throt MBBS, MD, PhD, FRCPath (@JamesThrot) March 3, 2025
Have you developed symptoms of ADHD since 2020? Or has your ADHD deteriorated since 2020? The frontal lobe is the largest part of the brain affected by ADHD, often maturing at a slower pace with disrupted activity & connectivity. Covid damages the frontal & temporal lobes. 🧵 https://t.co/Jhu5XWJjfE— James Throt MBBS, MD, PhD, FRCPath (@JamesThrot) March 3, 2025

“Have you developed symptoms of ADHD since 2020?

Or has your ADHD deteriorated since 2020?

The frontal lobe is the largest part of the brain affected by ADHD, often maturing at a slower pace with disrupted activity & connectivity.

Covid damages the frontal & temporal lobes.

🧵”

#Brain#Post-Acute Conditions#brain dysfunction#frontal lobe injury#James Throt#Discussion#analysis#ADHD
·x.com·
Have you developed symptoms of ADHD since 2020? Or has your ADHD deteriorated since 2020? The frontal lobe is the largest part of the brain affected by ADHD, often maturing at a slower pace with disrupted activity & connectivity. Covid damages the frontal & temporal lobes. 🧵 https://t.co/Jhu5XWJjfE— James Throt MBBS, MD, PhD, FRCPath (@JamesThrot) March 3, 2025
Structural brain changes in post-COVID condition and its relationship with cognitive impairment | Brain Communications | Oxford Academic
Structural brain changes in post-COVID condition and its relationship with cognitive impairment | Brain Communications | Oxford Academic
Structural brain changes in post-COVID condition and its relationship with cognitive impairment
#Brain#Brain shrinkage#brain atrophy#Long Covid#Post-Acute Conditions#cognitive decline#cognition#organ damage
·academic.oup.com·
Structural brain changes in post-COVID condition and its relationship with cognitive impairment | Brain Communications | Oxford Academic