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Understanding the Impact of COVID-19 on Personality and Brain Function: A Grim Reality or a Wake-Up Call?
Understanding the Impact of COVID-19 on Personality and Brain Function: A Grim Reality or a Wake-Up Call?
“A nightmare scenario would be if mankind were targeted by a pathogen that attacks our frontal lobes and changes our personalities. Such a pathogen could bring an end to society as we know it. Unfortunately, the nightmare may be real and taking shape in SARS-CoV-2.”
·infectioncontroltoday.com·
Understanding the Impact of COVID-19 on Personality and Brain Function: A Grim Reality or a Wake-Up Call?
We are currently watching what I can only describe as the early stages of Frontotemporal Dementia on a mass scale playing out in real time. The geopolitical ramifications of this are worrisome. I am in no doubt about what I’m seeing. The cause? Ceaseless SARS-CoV-2 infections pic.twitter.com/0X96poRxHJ— James Throt MBBS, MD, PhD, FRCPath (@JamesThrot) March 1, 2025
We are currently watching what I can only describe as the early stages of Frontotemporal Dementia on a mass scale playing out in real time. The geopolitical ramifications of this are worrisome. I am in no doubt about what I’m seeing. The cause? Ceaseless SARS-CoV-2 infections pic.twitter.com/0X96poRxHJ— James Throt MBBS, MD, PhD, FRCPath (@JamesThrot) March 1, 2025

“We are currently watching what I can only describe as the early stages of Frontotemporal Dementia on a mass scale playing out in real time.

The geopolitical ramifications of this are worrisome.

I am in no doubt about what I’m seeing.

The cause?

Ceaseless SARS-CoV-2 infections” A THREAD WITH STUDIES:

·x.com·
We are currently watching what I can only describe as the early stages of Frontotemporal Dementia on a mass scale playing out in real time. The geopolitical ramifications of this are worrisome. I am in no doubt about what I’m seeing. The cause? Ceaseless SARS-CoV-2 infections pic.twitter.com/0X96poRxHJ— James Throt MBBS, MD, PhD, FRCPath (@JamesThrot) March 1, 2025
Structural brain changes in post-COVID condition and its relationship with cognitive impairment | Brain Communications | Oxford Academic
Structural brain changes in post-COVID condition and its relationship with cognitive impairment | Brain Communications | Oxford Academic
Structural brain changes in post-COVID condition and its relationship with cognitive impairment
·academic.oup.com·
Structural brain changes in post-COVID condition and its relationship with cognitive impairment | Brain Communications | Oxford Academic
Correct ✅ Covid 19 is causing widespread brain damage on a global scale. SARS-CoV-2 damages the brain. FACT. Brain fog, memory issues, more mistakes/crashes/accidents, less empathy, worsening mental health/emotional regulation. The signs are clear. Signed, a neurologist 🧵 https://t.co/CI5p3RsXBu pic.twitter.com/2yMIk966QA— James Throt MBBS, MD, PhD, FRCPath (@JamesThrot) February 14, 2025
Correct ✅ Covid 19 is causing widespread brain damage on a global scale. SARS-CoV-2 damages the brain. FACT. Brain fog, memory issues, more mistakes/crashes/accidents, less empathy, worsening mental health/emotional regulation. The signs are clear. Signed, a neurologist 🧵 https://t.co/CI5p3RsXBu pic.twitter.com/2yMIk966QA— James Throt MBBS, MD, PhD, FRCPath (@JamesThrot) February 14, 2025

“Covid 19 is causing widespread brain damage on a global scale.

SARS-CoV-2 damages the brain. FACT.

Brain fog, memory issues, more mistakes/crashes/accidents, less empathy, worsening mental health/emotional regulation.

The signs are clear.

Signed, a neurologist

🧵”

·x.com·
Correct ✅ Covid 19 is causing widespread brain damage on a global scale. SARS-CoV-2 damages the brain. FACT. Brain fog, memory issues, more mistakes/crashes/accidents, less empathy, worsening mental health/emotional regulation. The signs are clear. Signed, a neurologist 🧵 https://t.co/CI5p3RsXBu pic.twitter.com/2yMIk966QA— James Throt MBBS, MD, PhD, FRCPath (@JamesThrot) February 14, 2025
New neuroscience research shows COVID-19 leaves mark on young adult brains
New neuroscience research shows COVID-19 leaves mark on young adult brains
“A new study published in Brain, Behavior, and Immunity has found that young adults who have recovered from COVID-19 show distinct patterns of brain activity during cognitive tasks, even if they perform normally on those tasks. These brain activity changes are similar to those seen in much older adults and are particularly pronounced in individuals reporting ‘brain fog.’”
A new study published in Brain, Behavior, and Immunity has found that young adults who have recovered from COVID-19 show distinct patterns of brain activity during cognitive tasks, even if they perform normally on those tasks. These brain activity changes are similar to those seen in much older adults and are particularly pronounced in individuals reporting “brain fog.”
·psypost.org·
New neuroscience research shows COVID-19 leaves mark on young adult brains
I’ve spoken about this numerous times since Covid ate brain, but I’m now missing The Gift of Fear. Prior to my dramatic personality/cognitive changes, I had a highly evolved internal warning system that successfully kept me alive. Now I don’t care. It *could* be connected to…
I’ve spoken about this numerous times since Covid ate brain, but I’m now missing The Gift of Fear. Prior to my dramatic personality/cognitive changes, I had a highly evolved internal warning system that successfully kept me alive. Now I don’t care. It *could* be connected to…
“I’ve spoken about this numerous times since Covid ate brain, but I’m now missing The Gift of Fear. Prior to my dramatic personality/cognitive changes, I had a highly evolved internal warning system that successfully kept me alive. Now I don’t care. It could be connected to knowing nothing is going to be done since our country was hijacked by the 0.1% & deliberately broken long, long ago, & we all know everyone is going to reflexively blame The Other Side while Both Sides work together to fuck us over brunch. Why worry about things we’re going to pretend away?”
·x.com·
I’ve spoken about this numerous times since Covid ate brain, but I’m now missing The Gift of Fear. Prior to my dramatic personality/cognitive changes, I had a highly evolved internal warning system that successfully kept me alive. Now I don’t care. It *could* be connected to…
Does COVID increase the risk of Alzheimer’s disease?
Does COVID increase the risk of Alzheimer’s disease?
“Scientists discover that even mild COVID-19 can alter brain proteins linked to Alzheimer’s disease, potentially increasing dementia risk—raising urgent public health concerns.”
Scientists discover that even mild COVID-19 can alter brain proteins linked to Alzheimer’s disease, potentially increasing dementia risk—raising urgent public health concerns.
·news-medical.net·
Does COVID increase the risk of Alzheimer’s disease?
"The impact I am seeing on my clients post-COVID is something I hadn’t seen previously in the years I have worked in this field. The cognitive decline post-COVID infection is immense, thus confirming the impact this virus has on the brain..."
"The impact I am seeing on my clients post-COVID is something I hadn’t seen previously in the years I have worked in this field. The cognitive decline post-COVID infection is immense, thus confirming the impact this virus has on the brain..."
"The impact I am seeing on my clients post-COVID is something I hadn’t seen previously in the years I have worked in this field. The cognitive decline post-COVID infection is immense, thus confirming the impact this virus has on the brain..."
·x.com·
"The impact I am seeing on my clients post-COVID is something I hadn’t seen previously in the years I have worked in this field. The cognitive decline post-COVID infection is immense, thus confirming the impact this virus has on the brain..."
COVID-19 may Enduringly Impact cognitive performance and brain haemodynamics in undergraduate students
COVID-19 may Enduringly Impact cognitive performance and brain haemodynamics in undergraduate students

“COVID-19 may Enduringly Impact cognitive performance and brain haemodynamics in undergraduate students”

“37 % of the undergraduates exhibited impaired cognition up to 17 months post-infection.”

·sciencedirect.com·
COVID-19 may Enduringly Impact cognitive performance and brain haemodynamics in undergraduate students
SARS-CoV-2 infection in microglia and its sequelae: What do we know so far?
SARS-CoV-2 infection in microglia and its sequelae: What do we know so far?

“SARS-CoV-2 may infect CNS, affecting microglia and brain cells. • Neuroinflammation from SARS-CoV-2 could lead to long COVID memory issues.”

SARS-CoV-2 may infect CNS, affecting microglia and brain cells.•Neuroinflammation from SARS-CoV-2 could lead to long COVID memory issues.
·sciencedirect.com·
SARS-CoV-2 infection in microglia and its sequelae: What do we know so far?
Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss
Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss

“Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss”

The study found that patients hospitalized with COVID-19, both with and without acute neurological complications, had worse cognitive scores than expected for their age, sex, and education level. These cognitive deficits were observed across all cognitive domains tested. The cognitive impairment was associated with increased levels of brain injury biomarkers in the blood and reduced volume of a specific brain region (the anterior cingulate cortex) on MRI scans. Factors like the severity of the initial COVID-19 illness and the presence of acute confusion (encephalopathy) were linked to the worst cognitive scores.

Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss
·openread.academy·
Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss
If you’re not noticing the (obvious) cognitive impairment in practically everyone around you, it may be due to your own cognitive decline.
If you’re not noticing the (obvious) cognitive impairment in practically everyone around you, it may be due to your own cognitive decline.

“If you’re not noticing the (obvious) cognitive impairment in practically everyone around you, it may be due to your own cognitive decline.

Or denial is rearing its ugly head once again.

Perhaps it’s easier for me considering my background, but honestly, it’s so bloody palpable.”

·x.com·
If you’re not noticing the (obvious) cognitive impairment in practically everyone around you, it may be due to your own cognitive decline.
Serotonin reduction in post-acute sequelae of viral infection
Serotonin reduction in post-acute sequelae of viral infection

Long COVID is linked to reduced serotonin levels, which are driven by viral RNA-induced type I interferons (IFNs).

Peripheral serotonin deficiency impairs cognition by reducing vagal nerve signaling, affecting hippocampal responses and memory.

·cell.com·
Serotonin reduction in post-acute sequelae of viral infection
Ugh. The more we learn about it, the uglier it looks.
Ugh. The more we learn about it, the uglier it looks.

“Ugh. The more we learn about it, the uglier it looks.

This, again, speaks to my point about tail risk in an emergent situation: it’s at least as bad as it looks. It may be worse.

We are badly underestimating the consequences of delayed risk. It’s a reckless approach. (1/)”

·x.com·
Ugh. The more we learn about it, the uglier it looks.
Worse, most people don’t even notice it has happened to themselves.
Worse, most people don’t even notice it has happened to themselves.

“Worse, most people don’t even notice it has happened to themselves.

But I can tell you we who continue to mask and have many fewer COVID infections can see the growing cognitive damage in more and more people around us.

Memory problems, like recall and word finding delays. Weakness and fatigue and motor control impairment. Growing executive function and emotional regulation deficits.

More and more friends disables and forced out of work or school by Long COVID symptoms.

It’s scary to witness the broad societal decline, and dispiriting to see so many governments and Public Health agencies persist in minimizing the growing problem.”

·x.com·
Worse, most people don’t even notice it has happened to themselves.
Doctors struggle to treat long Covid patients in India; researchers point to inadequate studies
Doctors struggle to treat long Covid patients in India; researchers point to inadequate studies

Dr. Arun Garg (The Medicity, Gurugram, India) said, "[I notice] a spike in stroke cases among young patients not suffering from known risk factors such as diabetes, hypertension and obesity.. Similarly, we are seeing more cases of encephalopathy, swelling of the brain, without reason and having a confused state of mind following one or two days of fever. Their MRI scans show no changes. These patients have increased significantly after Covid.. [Currently,] Other than routine blood tests that measure inflammation, we do antibody tests to look for direct markers. In many of these patients, we are finding rare antibodies which are very new to us and were not there pre-Covid."

·thehindu.com·
Doctors struggle to treat long Covid patients in India; researchers point to inadequate studies
Can I reassert that with SARS-CoV-2 induced brain damage, it won’t be a lessening of intellect that you’ll be seeing first, but behavioural changes such as disinhibition, emotional lability, risk taking & impulsivity.
Can I reassert that with SARS-CoV-2 induced brain damage, it won’t be a lessening of intellect that you’ll be seeing first, but behavioural changes such as disinhibition, emotional lability, risk taking & impulsivity.

“Can I reassert that with SARS-CoV-2 induced brain damage, it won’t be a lessening of intellect that you’ll be seeing first, but behavioural changes such as disinhibition, emotional lability, risk taking & impulsivity.

Frontal lobe damage impairs behavioural regulation.” Thread:

·x.com·
Can I reassert that with SARS-CoV-2 induced brain damage, it won’t be a lessening of intellect that you’ll be seeing first, but behavioural changes such as disinhibition, emotional lability, risk taking & impulsivity.
Cognitive profile following COVID-19 infection: Clinical predictors leading to neuropsychological impairment
Cognitive profile following COVID-19 infection: Clinical predictors leading to neuropsychological impairment

Covid itself causes cognitive impairment. From 2020, prior to Covid vaccination of any kind:

“In our cohort of COVID-19 patients neurologic manifestations were frequent, including cognitive impairment.”

·sciencedirect.com·
Cognitive profile following COVID-19 infection: Clinical predictors leading to neuropsychological impairment
COVID survivors may develop dementia
COVID survivors may develop dementia

“COVID-19 survivors show signs of significant cognitive deficits which could become dementia even a year after having the virus.. The team [in India] found that more than 80% of people tested reported at least one of four symptoms – depression, anxiety, stress and insomnia – ranging from mild to severe.. At least 6.1% of the patients were diagnosed with mild cognitive impairment and 4% developed dementia. More than 60% of the patients experienced a loss of taste and smell during the active phase of the infection. This could alter the function of brain areas linked to cognitive ability and emotional well-being.."

COVID-19 survivors show signs of significant cognitive deficits which could become dementia even a year after having the virus1. They also have an increased risk of depression, anxiety and disrupted sleep.
·nature.com·
COVID survivors may develop dementia
COVID Linked to Lower IQ, Poor Memory and Other Negative Impacts on Brain Health
COVID Linked to Lower IQ, Poor Memory and Other Negative Impacts on Brain Health
“COVID-19 poses a serious risk to brain health, even in mild cases, and the effects are now being revealed at the population level,"
COVID-19 poses a serious risk to brain health, even in mild cases, and the effects are now being revealed at the population level,"
·people.com·
COVID Linked to Lower IQ, Poor Memory and Other Negative Impacts on Brain Health