Alzheimer’s disease-like changes in COVID-19
Covid 'brain fog' likely factor in train's near-miss
Covid-19 ‘brain fog’ likely factor in near head-on train crash
"The impact I am seeing on my clients post-COVID is something I hadn’t seen previously in the years I have worked in this field. The cognitive decline post-COVID infection is immense, thus confirming the impact this virus has on the brain..."
"The impact I am seeing on my clients post-COVID is something I hadn’t seen previously in the years I have worked in this field. The cognitive decline post-COVID infection is immense, thus confirming the impact this virus has on the brain..."
The Impact of the COVID-19 Pandemic on Dementia Risk: Potential Pathways to Cognitive Decline
“The Impact of the COVID-19 Pandemic on Dementia Risk: Potential Pathways to Cognitive Decline”
Mounting research shows that COVID-19 leaves its mark on the brain, including significant drops in IQ scores - 3 Quarks Daily
“Mounting research shows that COVID-19 leaves its mark on the brain, including significant drops in IQ scores
Amyloid-forming potential of Betacoronavirus including SARS-CoV-2
“Amyloid-forming potential of Betacoronavirus including SARS-CoV-2”
Amyloid-forming potential of Betacoronavirus including SARS-CoV-2
"Widespread use of metal caused estimated 2- to 3-point drop in IQ for nearly 180 years of Pax Romana"
"Widespread use of metal caused estimated 2- to 3-point drop in IQ for nearly 180 years of Pax Romana"
Meanwhile, #Covid in 5 years: "Participants with persistent symptoms had a 6-point loss in IQ, while those who had been admitted to an ICU experienced a 9-point loss in IQ."
Clinic evaluation of cognitive impairment in post-COVID syndrome: Performance on legacy pen-and-paper and new digital cognitive tests
“Post-Covid cognitive impairment affects daily function and quality of life. • ACE-III fails to detect cognitive impairment in most post-Covid patients. • 89% of patients have impaired attention, executive function, processing speed on novel tests. • New tests are needed for post-Covid cognitive assessment in clinical practice.”
Post-Covid cognitive impairment affects daily function and quality of life.•ACE-III fails to detect cognitive impairment in most post-Covid patients.•89% of patients have impaired attention, executive function, processing speed on novel tests.•New tests are needed for post-Covid cognitive assessment in clinical practice.
What We Know About Covid’s Impact on Your Brain?
Brain shrinkage is observed even in mild or asymptomatic cases of Covid and impacts cognition.
Even mild COVID can cause brain shrinkage and affect mental function, new study shows
“Brain changes including shrinkage, weakened connections and poorer performance on thinking and memory tests could explain ‘brain fog’ after COVID – even after ‘mild’ cases.”
Frontiers | The impact of COVID-19 on accelerating of immunosenescence and brain aging
COVID-19 induces chronic inflammation, immunosenescence, and neuroinflammation.
COVID-19 may Enduringly Impact cognitive performance and brain haemodynamics in undergraduate students
“COVID-19 may Enduringly Impact cognitive performance and brain haemodynamics in undergraduate students”
“37 % of the undergraduates exhibited impaired cognition up to 17 months post-infection.”
COVID & the BRAIN… a thread 🧵
SARS-CoV-2 infection in microglia and its sequelae: What do we know so far?
“SARS-CoV-2 may infect CNS, affecting microglia and brain cells. • Neuroinflammation from SARS-CoV-2 could lead to long COVID memory issues.”
SARS-CoV-2 may infect CNS, affecting microglia and brain cells.•Neuroinflammation from SARS-CoV-2 could lead to long COVID memory issues.
Long COVID: SARS-CoV-2 spike protein accumulation linked to long-lasting brain effects
“The study shows that the SARS-CoV-2 spike protein remains in the brain's protective layers, the meninges, and the skull's bone marrow for up to four years after infection. This persistent presence of the spike protein could trigger chronic inflammation in affected individuals and increase the risk of neurodegenerative diseases.”
The study shows that the SARS-CoV-2 spike protein remains in the brain's protective layers, the meninges, and the skull's bone marrow for up to four years after infection. This persistent presence of the spike protein could trigger chronic inflammation in affected individuals and increase the risk of neurodegenerative diseases.
Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss
“Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss”
The study found that patients hospitalized with COVID-19, both with and without acute neurological complications, had worse cognitive scores than expected for their age, sex, and education level. These cognitive deficits were observed across all cognitive domains tested. The cognitive impairment was associated with increased levels of brain injury biomarkers in the blood and reduced volume of a specific brain region (the anterior cingulate cortex) on MRI scans. Factors like the severity of the initial COVID-19 illness and the presence of acute confusion (encephalopathy) were linked to the worst cognitive scores.
Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss
Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss
“Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss”
Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants—Single-Center Study
“The Omicron variant of SARS-CoV-2 presents a wide spectrum of neurological manifestations."
"Although there is an improvement in the survival rate of patients with COVID-19, the frequency of neurological manifestations increases."
"The occurrence of delirium, cerebrovascular diseases, and ischemic stroke results in higher mortality."
Part 2 of 2
Part 1 of 2
Why people can no longer drive.
Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
“We identified dysregulation of mitochondrial and synaptic pathways in deep-layer excitatory neurons and upregulation of neuroinflammation in glia, consistent across both mRNA and protein. Remarkably, these alterations overlapped substantially with changes in age-related neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease”
We identified dysregulation of mitochondrial and synaptic pathways in deep-layer excitatory neurons and upregulation of neuroinflammation in glia, consistent across both mRNA and protein. Remarkably, these alterations overlapped substantially with changes in age-related neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease
Cognition and Memory after Covid-19 in a Large Community Sample | NEJM
Cognition and Memory after Covid-19 in a Large Community Sample
Cognition and Memory after Covid-19 in a Large Community Sample
Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction - PubMed
“Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction”
Posthospitalization
If you’re not noticing the (obvious) cognitive impairment in practically everyone around you, it may be due to your own cognitive decline.
“If you’re not noticing the (obvious) cognitive impairment in practically everyone around you, it may be due to your own cognitive decline.
Or denial is rearing its ugly head once again.
Perhaps it’s easier for me considering my background, but honestly, it’s so bloody palpable.”
Mounting research shows that COVID-19 leaves its mark on the brain, including significant drops in IQ scores : r/news
“Mounting research shows that COVID-19 leaves its mark on the brain, including significant drops in IQ scores"
From COVID to Cognition | Kentucky researchers find COVID-19 could lead to Alzheimer's
“From COVID to Cognition | Kentucky researchers find COVID-19 could lead to Alzheimer's”
From COVID to Cognition | Kentucky researchers find COVID-19 could lead to Alzheimer's
Serotonin reduction in post-acute sequelae of viral infection
Long COVID is linked to reduced serotonin levels, which are driven by viral RNA-induced type I interferons (IFNs).
Peripheral serotonin deficiency impairs cognition by reducing vagal nerve signaling, affecting hippocampal responses and memory.
The buddy from college I talk about every now and again.
“The buddy from college I talk about every now and again.
He’s prolly 50 or so. He posted this a few days ago. He has already had a rough go of it, he has a daughter he is devoted to, and who loves him immensely.
I am as sad as I am angry. “
Ugh. The more we learn about it, the uglier it looks.
“Ugh. The more we learn about it, the uglier it looks.
This, again, speaks to my point about tail risk in an emergent situation: it’s at least as bad as it looks. It may be worse.
We are badly underestimating the consequences of delayed risk. It’s a reckless approach. (1/)”