"Patients suffering from COVID-19 have been found to exhibit dementia-related biomarkers.. The findings of this study suggest a potential link between mild-to-moderate SARS-CoV-2 infection and the initiation or acceleration of brain β-amyloid pathology, and hint at the possibility of an increased future incidence of Alzheimer’s disease subsequent to the COVID-19 pandemic."
Exploring the Persistence of the Spike Protein along the Skull-Meninges-Brain Axis and the Neurological Effects of COVID-19
This analysis is supported by numerous videos and illustrations.
Researchers used mouse model to study how SARS-CoV-2 infects the brain.
The virus targets neurons but spares blood vessels, triggering neuroinflammation and blood-brain barrier dysfunction.
“SARS-CoV-2 may infect CNS, affecting microglia and brain cells. • Neuroinflammation from SARS-CoV-2 could lead to long COVID memory issues.”
Evidence that a COVID-19 infection can induce neurological sequelae.
The SARSCoV2 spike protein can persist in the brain—skull bone marrow and meninges—to induce neurologic damage
SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it.
In mice, it caused inflammation, anxiety, and worsened brain injuries. Vaccines reduced but did not fully eliminate it.
SARS-CoV-2 can enter human motor neurons primarily through the receptors CD147 and NRP1.
The infection alters the expression of several genes involved in cell survival, metabolism, inflammatory response, and antiviral pathways.
“The Omicron variant of SARS-CoV-2 presents a wide spectrum of neurological manifestations."
"Although there is an improvement in the survival rate of patients with COVID-19, the frequency of neurological manifestations increases."
"The occurrence of delirium, cerebrovascular diseases, and ischemic stroke results in higher mortality."
“Recorded this video on the microscope yesterday. A single #SARSCoV2 infected cell arrives on the brain inside a blood vessel. Don't underestimate how much neuroinflammation one infected cell can cause. Brain-vascular-immune interface is the future of neuroscience #NeuroCovid”
A new paper in Cell, “Pioneering discovery and therapeutics at the brain-vascular-immune interface,” describes COVID-19 as a neurological disease alongside multiple sclerosis, Alzheimer’s, stroke and traumatic brain injury.
“COVID-19 can accelerate progression of dementia and induce BBB disruption and inflammatory blood clots causally linked with neuroinflammation and neuronal loss.8 In neurodevelopmental disorders, prematurity and perinatal hypoxia that trigger brain hemorrhage and BBB disruption are risk factors for cerebral palsy, intellectual disability, and autism. Collectively, these risk factors highlight the interconnected vascular and immune triggers of neurological diseases.”
“MRI scans reveal the damage long Covid does to your brain
Researchers suggested lasting Covid symptoms might be an indirect effect of brainstem inflammatory injury”
Very comprehensive evaluation of known neurological damage from SarsCov2:
“The pathogenesis of neurological disorders caused by SARS-CoV-2 involves several mechanisms. First, SARS-CoV-2 could enter the brain through retrograde transmission & hematogenous routes & disrupt brain function & structure, thus causing or exacerbating neurological disorders…”
