Multimodal MRI analysis of COVID-19 effects on pediatric brain
Even mild Covid changes children’s brains.
“We speculate that viral-triggered neuroinflammation and immune response contribute to neurotoxic damage in brain regions involved in cognitive processing, ultimately resulting in alterations in cortical morphology and glymphatic function.”
We speculate that viral-triggered neuroinflammation and immune response contribute to neurotoxic damage in brain regions involved in cognitive processing, ultimately resulting in alterations in cortical morphology and glymphatic function.
Vaccination Does Not Impact Long COVID Neurological Symptoms
“Vaccination prior to COVID-19 infection does not significantly affect neurological symptoms in patients with postacute sequelae of SARS-CoV-2 infection, according to a study published online Jan. 7 in Brain Communications”
Vaccination prior to COVID-19 infection does not significantly affect neurological symptoms in patients with postacute sequelae of SARS-CoV-2 infection, according to a study published online Jan. 7 in Brain Communications.Shreya Mukherjee, from the Northwestern University Feinb
Clinical and radiological characteristics and 1-year self-reported outcomes from patients with encephalitis and coronavirus disease 2019 - Journal of Medical Case Reports
“I have spent hundreds of hours in the microscope looking at the worst viruses can do to the brain, including the Zika virus, HIV, Flu, and others. I've never seen the type of damage SARS-CoV-2 leaves behind after infection with other viruses. “
Doctors struggle to treat long Covid patients in India; researchers point to inadequate studies
Dr. Arun Garg (The Medicity, Gurugram, India) said,
"[I notice] a spike in stroke cases among young patients not suffering from known risk factors such as diabetes, hypertension and obesity..
Similarly, we are seeing more cases of encephalopathy, swelling of the brain, without reason and having a confused state of mind following one or two days of fever.
Their MRI scans show no changes.
These patients have increased significantly after Covid..
[Currently,] Other than routine blood tests that measure inflammation, we do antibody tests to look for direct markers.
In many of these patients, we are finding rare antibodies which are very new to us and were not there pre-Covid."
Recorded this video on the microscope yesterday. A single infected cell arrives on the brain inside a blood vessel. Don't underestimate how much neuroinflammation one infected cell can cause.
“Recorded this video on the microscope yesterday. A single #SARSCoV2 infected cell arrives on the brain inside a blood vessel. Don't underestimate how much neuroinflammation one infected cell can cause.
Brain-vascular-immune interface is the future of neuroscience #NeuroCovid”
Pioneering discovery and therapeutics at the brain-vascular-immune interface
A new paper in Cell, “Pioneering discovery and therapeutics at the brain-vascular-immune interface,” describes COVID-19 as a neurological disease alongside multiple sclerosis, Alzheimer’s, stroke and traumatic brain injury.
“COVID-19 can accelerate progression of dementia and induce BBB disruption and inflammatory blood clots causally linked with neuroinflammation and neuronal loss.8 In neurodevelopmental disorders, prematurity and perinatal hypoxia that trigger brain hemorrhage and BBB disruption are risk factors for cerebral palsy, intellectual disability, and autism. Collectively, these risk factors highlight the interconnected vascular and immune triggers of neurological diseases.”
Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK
“Participants had worse cognitive scores than would be expected on the basis of their sociodemographic characteristics across all cognitive domains tested (average score 0·71 SD below the mean [IQR 0·16–1·04]; p<0·0001). Most participants reported at least mild depression (263 [74·5%] of 353), anxiety (189 [53·5%] of 353), fatigue (220 [62·3%] of 353), or subjective cognitive decline (184 [52·1%] of 353), and more than a fifth reported severe depression (79 [22·4%] of 353), fatigue (87 [24·6%] of 353), or subjective cognitive decline (88 [24·9%] of 353). Depression, anxiety, and fatigue were worse at 2–3 years than at 6 months or 12 months, with evidence of both worsening of existing symptoms and emergence of new symptoms. Symptoms at 2–3 years were not predicted by the severity of acute COVID-19 illness, but were strongly predicted by the degree of recovery at 6 months”
Participants had worse cognitive scores than would be expected on the basis of their sociodemographic characteristics across all cognitive domains tested (average score 0·71 SD below the mean [IQR 0·16–1·04]; p<0·0001). Most participants reported at least mild depression (263 [74·5%] of 353), anxiety (189 [53·5%] of 353), fatigue (220 [62·3%] of 353), or subjective cognitive decline (184 [52·1%] of 353), and more than a fifth reported severe depression (79 [22·4%] of 353), fatigue (87 [24·6%] of 353), or subjective cognitive decline (88 [24·9%] of 353). Depression, anxiety, and fatigue were worse at 2–3 years than at 6 months or 12 months, with evidence of both worsening of existing symptoms and emergence of new symptoms. Symptoms at 2–3 years were not predicted by the severity of acute COVID-19 illness, but were strongly predicted by the degree of recovery at 6 months
Very comprehensive evaluation of known neurological damage from SarsCov2:
“The pathogenesis of neurological disorders caused by SARS-CoV-2 involves several mechanisms. First, SARS-CoV-2 could enter the brain through retrograde transmission & hematogenous routes & disrupt brain function & structure, thus
causing or exacerbating neurological disorders…”
The brain/neural inflammation that comes after a covid infection can be intense. I was constantly rageful for 2-3 months after my infection. My mom noticed it. She said I was like a completely different person. But that's not the worst part ...
“The brain/neural inflammation that comes after a covid infection can be intense. I was constantly rageful for 2-3 months after my infection. My mom noticed it. She said I was like a completely different person.”
Today, , decided to publish a story on a study purposefully designed to produce lies funded by with the intention of lying to the public to convince them that schools closing for a few weeks in 2020 caused changes in the brains of children.
“Today, @CNN, @UW decided to publish a story on a study purposefully designed to produce lies funded by @JeffBezos with the intention of lying to the public to convince them that schools closing for a few weeks in 2020 caused changes in the brains of children.”
Study uncovers the basis of COVID-19-related brain fog | University of Minnesota
EXTREME and incomplete oversimplification of the many complex neurological issues caused by SarsCov2, but important facet of the vaguely defined “brain fog” of Long Covid and post-acute Covid lingering symptoms.
“Neurological symptoms have been widely observed in COVID-19 patients, with many survivors exhibiting persistent neurological and cognitive impairment. New research from the University of Minnesota found that COVID-19 triggers inflammation in the brain, which is linked to many COVID-related symptoms such as fatigue and ‘brain fog.’”
