Dr. Sean Mullen (@drseanmullen) on X
“New study just dropped: MRI scans of young kids post-COVID show changes in brain structure—even after mild infection. Here’s what the researchers found, how they did it, and why it matters.”
Multimodal MRI analysis of COVID-19 effects on pediatric brain
Even mild Covid changes children’s brains.
“We speculate that viral-triggered neuroinflammation and immune response contribute to neurotoxic damage in brain regions involved in cognitive processing, ultimately resulting in alterations in cortical morphology and glymphatic function.”
We speculate that viral-triggered neuroinflammation and immune response contribute to neurotoxic damage in brain regions involved in cognitive processing, ultimately resulting in alterations in cortical morphology and glymphatic function.
Thread by @JamesThrot on Thread Reader App
“In neurology/psychiatry, we would call this Apathy.
Brain damage to the frontal lobe (dorsal anterior cingulate cortex) causes apathy & reduces empathy.
SARS-CoV-2 damages this region of the brain. Every. Single. Time.
More infections = more damage = more apathy.”
In neurology/psychiatry, we would call this Apathy.
Brain damage to the frontal lobe (dorsal anterior cingulate cortex) causes apathy & reduces empathy.
SARS-CoV-2 damages this region of the brain. Every. Single. Time.
More infections = more damage = more apathy.
WTF DID SAM GET HIMSELF INTO?? | Hasanabi & Noah Kulwin React
Starting at 4:15: “I’m becoming a bit of a Covid truther. I think we genuinely saw like an IQ drop across the board just of all the people who got hit with Covid. People’s brains I don’t think work as much or as well as they used to.”
SARS-CoV-2 affects Alzheimer’s disease
"Patients suffering from COVID-19 have been found to exhibit dementia-related biomarkers.. The findings of this study suggest a potential link between mild-to-moderate SARS-CoV-2 infection and the initiation or acceleration of brain β-amyloid pathology, and hint at the possibility of an increased future incidence of Alzheimer’s disease subsequent to the COVID-19 pandemic."
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Exploring the Persistence of the Spike Protein along the Skull-Meninges-Brain Axis and the Neurological Effects of COVID-19
This analysis is supported by numerous videos and illustrations.
Understanding the Impact of COVID-19 on Personality and Brain Function: A Grim Reality or a Wake-Up Call?
“A nightmare scenario would be if mankind were targeted by a pathogen that attacks our frontal lobes and changes our personalities. Such a pathogen could bring an end to society as we know it. Unfortunately, the nightmare may be real and taking shape in SARS-CoV-2.”
Correct ✅ Covid 19 is causing widespread brain damage on a global scale. SARS-CoV-2 damages the brain. FACT. Brain fog, memory issues, more mistakes/crashes/accidents, less empathy, worsening mental health/emotional regulation. The signs are clear. Signed, a neurologist 🧵 https://t.co/CI5p3RsXBu pic.twitter.com/2yMIk966QA— James Throt MBBS, MD, PhD, FRCPath (@JamesThrot) February 14, 2025
“Covid 19 is causing widespread brain damage on a global scale.
SARS-CoV-2 damages the brain. FACT.
Brain fog, memory issues, more mistakes/crashes/accidents, less empathy, worsening mental health/emotional regulation.
The signs are clear.
Signed, a neurologist
🧵”
New neuroscience research shows COVID-19 leaves mark on young adult brains
“A new study published in Brain, Behavior, and Immunity has found that young adults who have recovered from COVID-19 show distinct patterns of brain activity during cognitive tasks, even if they perform normally on those tasks. These brain activity changes are similar to those seen in much older adults and are particularly pronounced in individuals reporting ‘brain fog.’”
A new study published in Brain, Behavior, and Immunity has found that young adults who have recovered from COVID-19 show distinct patterns of brain activity during cognitive tasks, even if they perform normally on those tasks. These brain activity changes are similar to those seen in much older adults and are particularly pronounced in individuals reporting “brain fog.”
I’ve spoken about this numerous times since Covid ate brain, but I’m now missing The Gift of Fear. Prior to my dramatic personality/cognitive changes, I had a highly evolved internal warning system that successfully kept me alive. Now I don’t care. It *could* be connected to…
“I’ve spoken about this numerous times since Covid ate brain, but I’m now missing The Gift of Fear. Prior to my dramatic personality/cognitive changes, I had a highly evolved internal warning system that successfully kept me alive. Now I don’t care. It could be connected to knowing nothing is going to be done since our country was hijacked by the 0.1% & deliberately broken long, long ago, & we all know everyone is going to reflexively blame The Other Side while Both Sides work together to fuck us over brunch. Why worry about things we’re going to pretend away?”
Alzheimer’s disease-like changes in COVID-19
Covid-19 ‘brain fog’ likely factor in near head-on train crash
Vaccination Does Not Impact Long COVID Neurological Symptoms
“Vaccination prior to COVID-19 infection does not significantly affect neurological symptoms in patients with postacute sequelae of SARS-CoV-2 infection, according to a study published online Jan. 7 in Brain Communications”
Vaccination prior to COVID-19 infection does not significantly affect neurological symptoms in patients with postacute sequelae of SARS-CoV-2 infection, according to a study published online Jan. 7 in Brain Communications.Shreya Mukherjee, from the Northwestern University Feinb
Neurological syndromes associated with COVID-19: a multicenter study in Brazil - BMC Infectious Diseases
“197 patients were included, presenting with vascular syndromes (81), encephalopathy (68), encephalitis (19), Guillain-Barré syndrome (13), other neuropathies (12), and myelitis (4). The incidence curve of neurocovid mirrored that of COVID-19. Neurological syndromes were present regardless of COVID-19 severity. The median time from COVID-19 to onset of neurological symptoms was 14 days, suggesting a post-infectious immune-mediated mechanism.”
Clinical and radiological characteristics and 1-year self-reported outcomes from patients with encephalitis and coronavirus disease 2019 - Journal of Medical Case Reports
The Impact of the COVID-19 Pandemic on Dementia Risk: Potential Pathways to Cognitive Decline
“The Impact of the COVID-19 Pandemic on Dementia Risk: Potential Pathways to Cognitive Decline”
Mounting research shows that COVID-19 leaves its mark on the brain, including significant drops in IQ scores - 3 Quarks Daily
“Mounting research shows that COVID-19 leaves its mark on the brain, including significant drops in IQ scores
When SARS-CoV-2 INFECTION can facilitate an ATTACK on our BRAIN, by PRIONS and AMYLOIDS.
“When SARS-CoV-2 INFECTION can facilitate an ATTACK on our BRAIN, by PRIONS and AMYLOIDS. (🧵mega-thread 8 studies)”
COVID-19 will never be like the Flu. Never.
“I have spent hundreds of hours in the microscope looking at the worst viruses can do to the brain, including the Zika virus, HIV, Flu, and others. I've never seen the type of damage SARS-CoV-2 leaves behind after infection with other viruses. “
How COVID Might Sow Chaos in the Brain
How COVID Might Sow Chaos in the Brain
SARS-CoV-2 appears to travel widely across the cerebral cortex
Headaches, hallucinations, vivid dreams, smell & taste anomalies, strokes and seizures
80% of COVID patients encountered neurological complications
The widespread 🧠 neuro issues I’m witnessing can’t be overstated; a tipping point of previously healthy adults into early Parkinson’s/ GBS/ dementia/ ALS/ serious 👁️ issues/ strokes/ tremors/ vertigo / intractable anosmia & tinnitus etc
“The widespread 🧠 neuro issues I’m witnessing can’t be overstated; a tipping point of previously healthy adults into early Parkinson’s/ GBS/ dementia/ ALS/ serious 👁️ issues/ strokes/ tremors/ vertigo / intractable anosmia & tinnitus etc
An unparalleled horror show & crime.”
"Widespread use of metal caused estimated 2- to 3-point drop in IQ for nearly 180 years of Pax Romana"
"Widespread use of metal caused estimated 2- to 3-point drop in IQ for nearly 180 years of Pax Romana"
Meanwhile, #Covid in 5 years: "Participants with persistent symptoms had a 6-point loss in IQ, while those who had been admitted to an ICU experienced a 9-point loss in IQ."
Even mild COVID can cause brain shrinkage and affect mental function, new study shows
“Brain changes including shrinkage, weakened connections and poorer performance on thinking and memory tests could explain ‘brain fog’ after COVID – even after ‘mild’ cases.”
COVID-19 may Enduringly Impact cognitive performance and brain haemodynamics in undergraduate students
“COVID-19 may Enduringly Impact cognitive performance and brain haemodynamics in undergraduate students”
“37 % of the undergraduates exhibited impaired cognition up to 17 months post-infection.”
COVID & the BRAIN… a thread 🧵
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Evidence that a COVID-19 infection can induce neurological sequelae.
The SARSCoV2 spike protein can persist in the brain—skull bone marrow and meninges—to induce neurologic damage
SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it.
In mice, it caused inflammation, anxiety, and worsened brain injuries. Vaccines reduced but did not fully eliminate it.
Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss
“Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss”
The study found that patients hospitalized with COVID-19, both with and without acute neurological complications, had worse cognitive scores than expected for their age, sex, and education level. These cognitive deficits were observed across all cognitive domains tested. The cognitive impairment was associated with increased levels of brain injury biomarkers in the blood and reduced volume of a specific brain region (the anterior cingulate cortex) on MRI scans. Factors like the severity of the initial COVID-19 illness and the presence of acute confusion (encephalopathy) were linked to the worst cognitive scores.
Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss
Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss
“Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss”
Honestly it kinda pisses me off how some people act like we can't talk about the brain damage from Covid, especially on the population level.
“Honestly it kinda pisses me off how some people act like we can't talk about the brain damage from Covid, especially on the population level. Yes, it's important to consider the ableism. But I have brain damage from Covid, including to my emotions, and we need to talk about it...”
SARS-CoV-2 infection in hiPSC-derived neurons is cathepsin-dependent and causes accumulation of HIF1alpha and phosphorylated tau
SARS-CoV-2 infects neurons using cathepsins, causing tau changes linked to Alzheimer’s and neuron death within days
This suggests neurodegenerative risks and potential for cathepsin inhibitors as treatment