Pioneering discovery and therapeutics at the brain-vascular-immune interface
A new paper in Cell, “Pioneering discovery and therapeutics at the brain-vascular-immune interface,” describes COVID-19 as a neurological disease alongside multiple sclerosis, Alzheimer’s, stroke and traumatic brain injury.
“COVID-19 can accelerate progression of dementia and induce BBB disruption and inflammatory blood clots causally linked with neuroinflammation and neuronal loss.8 In neurodevelopmental disorders, prematurity and perinatal hypoxia that trigger brain hemorrhage and BBB disruption are risk factors for cerebral palsy, intellectual disability, and autism. Collectively, these risk factors highlight the interconnected vascular and immune triggers of neurological diseases.”
COVID-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study
“COVID-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study”
Whoopi Goldberg Commiserates With Fellow-Covid Sufferer Joe Biden: “Sometimes I Go For A Word And It’s Not There”
Whoopi Goldberg, who just had her 4th COVID infection, joked about her post infection brain damage on TV.
“I’m just getting over COVID – again – and I can barely remember anybody’s name. There are times when I go for a word and it’s not there.”
Study shows that COVID-19 causes cognitive decline among those without long COVID symptoms
“A new study in eClinicalMedicine has found that healthy volunteers infected with SARS-CoV-2 had measurably worse cognitive function for up to a year after infection when compared to uninfected controls. Significantly, infected controls did not report any symptoms related to these cognitive deficits, indicating that they were unaware of them.”
A new study in eClinicalMedicine has found that healthy volunteers infected with SARS-CoV-2 had measurably worse cognitive function for up to a year after infection when compared to uninfected controls. Significantly, infected controls did not report any symptoms related to these cognitive deficits, indicating that they were unaware of them. The net effect is that potentially billions of people worldwide with a his
Long COVID is not the same for everyone: a hierarchical cluster analysis of Long COVID symptoms 9 and 12 months after SARS-CoV-2 test - BMC Infectious Diseases
“Our results suggest that Long COVID is not the same for everyone.”
Our results suggest that Long COVID is not the same for everyone.
Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK
“Participants had worse cognitive scores than would be expected on the basis of their sociodemographic characteristics across all cognitive domains tested (average score 0·71 SD below the mean [IQR 0·16–1·04]; p<0·0001). Most participants reported at least mild depression (263 [74·5%] of 353), anxiety (189 [53·5%] of 353), fatigue (220 [62·3%] of 353), or subjective cognitive decline (184 [52·1%] of 353), and more than a fifth reported severe depression (79 [22·4%] of 353), fatigue (87 [24·6%] of 353), or subjective cognitive decline (88 [24·9%] of 353). Depression, anxiety, and fatigue were worse at 2–3 years than at 6 months or 12 months, with evidence of both worsening of existing symptoms and emergence of new symptoms. Symptoms at 2–3 years were not predicted by the severity of acute COVID-19 illness, but were strongly predicted by the degree of recovery at 6 months”
Participants had worse cognitive scores than would be expected on the basis of their sociodemographic characteristics across all cognitive domains tested (average score 0·71 SD below the mean [IQR 0·16–1·04]; p<0·0001). Most participants reported at least mild depression (263 [74·5%] of 353), anxiety (189 [53·5%] of 353), fatigue (220 [62·3%] of 353), or subjective cognitive decline (184 [52·1%] of 353), and more than a fifth reported severe depression (79 [22·4%] of 353), fatigue (87 [24·6%] of 353), or subjective cognitive decline (88 [24·9%] of 353). Depression, anxiety, and fatigue were worse at 2–3 years than at 6 months or 12 months, with evidence of both worsening of existing symptoms and emergence of new symptoms. Symptoms at 2–3 years were not predicted by the severity of acute COVID-19 illness, but were strongly predicted by the degree of recovery at 6 months
Research Shows Severe COVID-19 Contributes to Long-Lasting Cognitive Impairment - InventUM
“We found persistent subjective and objective cognitive issues even two years after infection, including brain fog, word-finding problems, working memory deficits and reduced processing speed.” “Most Patients Have Never Fully Recovered”
“We found persistent subjective and objective cognitive issues even two years after infection, including brain fog, word-finding problems, working memory deficits and reduced processing speed.”
“Most Patients Have Never Fully Recovered”
SARS-CoV-2 is associated with changes in brain structure in UK Biobank
UK researchers scanned the brains of 400 people before and after mild covid, compared them with controls and found:
- greater reduction in grey matter thickness
- greater reduction in global brain size
- greater cognitive decline
- greater change to primary olfactory cortex