Doctors struggle to treat long Covid patients in India; researchers point to inadequate studies
Dr. Arun Garg (The Medicity, Gurugram, India) said,
"[I notice] a spike in stroke cases among young patients not suffering from known risk factors such as diabetes, hypertension and obesity..
Similarly, we are seeing more cases of encephalopathy, swelling of the brain, without reason and having a confused state of mind following one or two days of fever.
Their MRI scans show no changes.
These patients have increased significantly after Covid..
[Currently,] Other than routine blood tests that measure inflammation, we do antibody tests to look for direct markers.
In many of these patients, we are finding rare antibodies which are very new to us and were not there pre-Covid."
Can I reassert that with SARS-CoV-2 induced brain damage, it won’t be a lessening of intellect that you’ll be seeing first, but behavioural changes such as disinhibition, emotional lability, risk taking & impulsivity.
“Can I reassert that with SARS-CoV-2 induced brain damage, it won’t be a lessening of intellect that you’ll be seeing first, but behavioural changes such as disinhibition, emotional lability, risk taking & impulsivity.
“COVID-19 survivors show signs of significant cognitive deficits which could become dementia even a year after having the virus..
The team [in India] found that more than 80% of people tested reported at least one of four symptoms – depression, anxiety, stress and insomnia – ranging from mild to severe..
At least 6.1% of the patients were diagnosed with mild cognitive impairment and 4% developed dementia.
More than 60% of the patients experienced a loss of taste and smell during the active phase of the infection.
This could alter the function of brain areas linked to cognitive ability and emotional well-being.."
COVID-19 survivors show signs of significant cognitive deficits which could become dementia even a year after having the virus1. They also have an increased risk of depression, anxiety and disrupted sleep.
How long COVID could lift the fog on neurocognitive disorders
‘I’m a shell of myself. My physical issues aren’t half as bad as my brain problems. You can say brain fog, but that doesn’t come close to doing it justice.’”
Pioneering discovery and therapeutics at the brain-vascular-immune interface
A new paper in Cell, “Pioneering discovery and therapeutics at the brain-vascular-immune interface,” describes COVID-19 as a neurological disease alongside multiple sclerosis, Alzheimer’s, stroke and traumatic brain injury.
“COVID-19 can accelerate progression of dementia and induce BBB disruption and inflammatory blood clots causally linked with neuroinflammation and neuronal loss.8 In neurodevelopmental disorders, prematurity and perinatal hypoxia that trigger brain hemorrhage and BBB disruption are risk factors for cerebral palsy, intellectual disability, and autism. Collectively, these risk factors highlight the interconnected vascular and immune triggers of neurological diseases.”
COVID-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study
“COVID-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study”
Study shows that COVID-19 causes cognitive decline among those without long COVID symptoms
“A new study in eClinicalMedicine has found that healthy volunteers infected with SARS-CoV-2 had measurably worse cognitive function for up to a year after infection when compared to uninfected controls. Significantly, infected controls did not report any symptoms related to these cognitive deficits, indicating that they were unaware of them.”
A new study in eClinicalMedicine has found that healthy volunteers infected with SARS-CoV-2 had measurably worse cognitive function for up to a year after infection when compared to uninfected controls. Significantly, infected controls did not report any symptoms related to these cognitive deficits, indicating that they were unaware of them. The net effect is that potentially billions of people worldwide with a his
“But this week 2 new publications have substantially added to our understanding of the extent that Covid can impair cognitive function across the full gamut— from young, healthy individuals with mild infections to older, hospitalized patients with severe Covid.”
Long COVID is not the same for everyone: a hierarchical cluster analysis of Long COVID symptoms 9 and 12 months after SARS-CoV-2 test - BMC Infectious Diseases
“Our results suggest that Long COVID is not the same for everyone.”
Our results suggest that Long COVID is not the same for everyone.
Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK
“Participants had worse cognitive scores than would be expected on the basis of their sociodemographic characteristics across all cognitive domains tested (average score 0·71 SD below the mean [IQR 0·16–1·04]; p<0·0001). Most participants reported at least mild depression (263 [74·5%] of 353), anxiety (189 [53·5%] of 353), fatigue (220 [62·3%] of 353), or subjective cognitive decline (184 [52·1%] of 353), and more than a fifth reported severe depression (79 [22·4%] of 353), fatigue (87 [24·6%] of 353), or subjective cognitive decline (88 [24·9%] of 353). Depression, anxiety, and fatigue were worse at 2–3 years than at 6 months or 12 months, with evidence of both worsening of existing symptoms and emergence of new symptoms. Symptoms at 2–3 years were not predicted by the severity of acute COVID-19 illness, but were strongly predicted by the degree of recovery at 6 months”
Participants had worse cognitive scores than would be expected on the basis of their sociodemographic characteristics across all cognitive domains tested (average score 0·71 SD below the mean [IQR 0·16–1·04]; p<0·0001). Most participants reported at least mild depression (263 [74·5%] of 353), anxiety (189 [53·5%] of 353), fatigue (220 [62·3%] of 353), or subjective cognitive decline (184 [52·1%] of 353), and more than a fifth reported severe depression (79 [22·4%] of 353), fatigue (87 [24·6%] of 353), or subjective cognitive decline (88 [24·9%] of 353). Depression, anxiety, and fatigue were worse at 2–3 years than at 6 months or 12 months, with evidence of both worsening of existing symptoms and emergence of new symptoms. Symptoms at 2–3 years were not predicted by the severity of acute COVID-19 illness, but were strongly predicted by the degree of recovery at 6 months
Research Shows Severe COVID-19 Contributes to Long-Lasting Cognitive Impairment - InventUM
“We found persistent subjective and objective cognitive issues even two years after infection, including brain fog, word-finding problems, working memory deficits and reduced processing speed.”
“Most Patients Have Never Fully Recovered”
“We found persistent subjective and objective cognitive issues even two years after infection, including brain fog, word-finding problems, working memory deficits and reduced processing speed.”
“Most Patients Have Never Fully Recovered”
COVID's Inflammation Linked to Long-Term Brain Effects - Neuroscience News
“A significant portion of COVID-19 survivors, even those who had mild cases, may experience cognitive decline and difficulty concentrating for extended periods after the infection.”
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