It is in Your Head! - Structural Changes to The Brain from COVID-19
Recent studies have identified several structural changes in the brains of Long COVID patients...
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
“ COVID-19 results in acute elevation of serum markers of brain injury”
Mini-Strokes, Gut Problems: Scientists See Links to an Old Bout of Covid
COVID-19 linked to higher dementia risk in older adults, study finds
Short- and long-term neuropsychiatric outcomes in long COVID in South Korea and Japan
We investigated whether SARS-CoV-2 infection is associated with short- and long-term neuropsychiatric sequelae.
We investigated whether SARS-CoV-2 infection is associated with short- and long-term neuropsychiatric sequelae.
SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19
“Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease 2019 (COVID-19), can induce a plethora of neurological complications in some patients. However, it is still under debate whether SARS-CoV-2 directly infects the brain or whether CNS sequelae result from systemic inflammatory responses triggered in the periphery. By using high-resolution microscopy, we investigated whether SARS-CoV-2 reaches the brain and how viral neurotropism can be modulated by aging in a non-human primate model of COVID-19.”
2023
SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges- Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19 Zhouyi Rong1,2,15†, Hongcheng Mai1,2,15†, Saketh Kapoor1†, Victor G. Puelles3,4,13,14,
It's always good to remember that 60% of us who had COVID still might have viral protein accumulation in the skull and brain, which can have implications for . The image and video below are from 's work.
Sources
Dumb and Dumber?
Dumb and Dumber? IQ loss on every COVID-19 infection?
⁃Your doctor & surgeon ⁃Your pilot ⁃Your heads of state ⁃Driver in the car next to you ⁃Your brain 🧠?
Studies have provided substantial evidence that COVID-19 damages the brain, revealing a range of cognitive and neurological damage:
Covid-19 will make you stupid
Cognitive dysfunctions in the course of SARS‑CoV‑2 virus infection, including NeuroCOVID, frontal syndrome and cytokine storm (Review)
𝘾𝙤𝙜𝙣𝙞𝙩𝙞𝙫𝙚 𝙙𝙮𝙨𝙛𝙪𝙣𝙘𝙩𝙞𝙤𝙣𝙨 𝙞𝙣 𝙩𝙝𝙚 𝙘𝙤𝙪𝙧𝙨𝙚 𝙤𝙛 𝙎𝘼𝙍𝙎‑𝘾𝙤𝙑‑2 𝙫𝙞𝙧𝙪𝙨 𝙞𝙣𝙛𝙚𝙘𝙩𝙞𝙤𝙣, 𝙞𝙣𝙘𝙡𝙪𝙙𝙞𝙣𝙜 𝙉𝙚𝙪𝙧𝙤𝘾𝙊𝙑𝙄𝘿, 𝙛𝙧𝙤𝙣𝙩𝙖𝙡 𝙨𝙮𝙣𝙙𝙧𝙤𝙢𝙚 𝙖𝙣𝙙 𝙘𝙮𝙩𝙤𝙠𝙞𝙣𝙚 𝙨𝙩𝙤𝙧𝙢
Since a lot of people don't have access to articles (what happened to free access for manuscripts?). Here goes the most important part:
Neurocognitive defects post acute Covid infections
Long Covid Patients Twice As Likely To Suffer From Depression & Anxiety
NF-κB links COVID-19 to PD | JIR
Role of Inflammation in the Development of COVID-19 to Parkinson’s Disease
Unraveling the enigma of long COVID: novel aspects in pathogenesis, diagnosis, and treatment protocols
“The nervous system, particularly the brain, can become infected by SARS-CoV-2 early in the course of COVID-19 via viral access through the cribriform plate located at the upper part of the nose.. this route is more ominous than previously thought. The pits of the cribriform plate and areas beneath the olfactory bulb including potential spaces such as the air sinuses can be a reservoir for not only viral persistence, but also its replication.. the upper part of the nose and the structures surrounding it appear to be ideal sites for access to the CNS (central nervous system).. This can cause a low-grade inflammation in the meninges and deeper tissues in the neuronal environment triggering neuroinflammation.. [This can cause] Symptoms such as brain fog, cognitive deficits, prolonged anosmia, memory deficits, and deposition of amyloid-like fibrils that cause premature aging in patients with long COVID.."
It's certainly ominous that SARS-CoV-2 can infect my brain instantly and silently.”
Cell invasive amyloid assemblies from SARS-CoV-2 peptides can form multiple polymorphs with varying neurotoxicity
𝘼𝙢𝙮𝙡𝙤𝙞𝙙 𝙖𝙜𝙜𝙧𝙚𝙜𝙖𝙩𝙚𝙨 𝙛𝙧𝙤𝙢 𝙎𝘼𝙍𝙎-𝘾𝙤𝙑-2 𝙥𝙚𝙥𝙩𝙞𝙙𝙚𝙨 𝙧𝙚𝙖𝙙𝙞𝙡𝙮 𝙚𝙣𝙩𝙚𝙧 𝙣𝙚𝙪𝙧𝙤𝙣𝙖𝙡 𝙘𝙚𝙡𝙡𝙨, 𝘢𝘯𝘥 𝘵𝘩𝘪𝘴 𝘤𝘢𝘶𝘴𝘦𝘴 𝘢 𝘳𝘦𝘥𝘶𝘤𝘵𝘪𝘰𝘯 𝘪𝘯 𝘵𝘩𝘦𝘪𝘳 𝘮𝘪𝘵𝘰𝘤𝘩𝘰𝘯𝘥𝘳𝘪𝘢𝘭 𝘳𝘦𝘴𝘱𝘪𝘳𝘢𝘵𝘪𝘰𝘯.
Covid, study reveals: here's how the virus can increase Parkinson's risks
Covid, study reveals: here's how the virus can increase Parkinson's risks
SARS-CoV-2 infection as a cause of neurodegeneration
🧠 Long COVID and Your Brain 🧠
🧠 Long COVID and Your Brain 🧠
Brain abnormalities in survivors of COVID-19 after 2-year recovery: a functional MRI study
Even 27 months after recovering from COVID-19, many people still suffer from brain-related issues like cognitive failures and mental fatigue. A recent study used brain scans (fMRI) to investigate why.
Chris Turnbull on Twitter / X
Long COVID: From olfactory dysfunctions to viral Parkinsonism
Long COVID: From olfactory dysfunctions to viral Parkinsonism
“Long COVID: From olfactory dysfunctions to viral Parkinsonism”
Long COVID: From olfactory dysfunctions to viral Parkinsonism
SARS-CoV-2 infects cells lining the blood-retinal barrier and induces a hyperinflammatory immune response in the retina via systemic exposure | PLOS Pathogens
SARS-CoV-2 infects cells lining the blood-retinal barrier and induces a hyperinflammatory immune response in the retina via systemic exposure
SARS-CoV-2 infects cells lining the blood-retinal barrier and induces a hyperinflammatory immune response in the retina via systemic exposure
COVID-19 Leaves Its Mark on the Brain. Significant Drops in IQ Scores Are Noted.
NYC man's fatal brain disease linked to COVID-19: 'Highly likely'
“Doctors from Mount Sinai Queens’ said it’s ‘highly likely’ COVID contributed to a New York City man developing fatal prion disease.”
Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization
“we identified two distinct biomarker profiles measured during the acute admission, which predict cognitive outcomes 6 and 12 months after COVID-19.”
Severe acute respiratory syndrome coronavirus 2 infection leads to Tau pathological signature in neurons
“It is now evident that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection results in a wide range of long-term neurological symptoms and is worryingly associated with the aggravation of Alzheimer’s disease. Little is known about the molecular basis of these manifestations.”
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importance of neuropsychology in the early rehabilitation of patients with critical illness after acute COVID infection